reviews While there seems to be no obvious change in any of the proteins that process miRNA, they are still somehow being under-expressed, implying a separate pathway for regulation that has yet to be discovered . Though it is difficult to predict the types of pros and cons these tiny miRNAs may bring into the field of medicine, the venture – given more time and inquiry – is filled with substantial promise.
References 1. Song, B. and Ju, J. (2010) Impact of miRNAs in gastrointestinal cancer diagnosis and prognosis. Expert Reviews in Molecular Medicine, 12, e33. doi:10.1017/S1462399410001663. 2. Meltzer, P.S. (2005) Small RNAs with big impacts. Nature, 435, 745-746. doi:10.1038/435745a. 3. Boni, V., et al. (2010). Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan. The Pharmacogenomics Journal. doi: 10.1038/tpj.2010.58. 4. Lu, J., et al. (2005). MicroRNA expression profiles classify human cancers. Nature, 435, 834-838. doi:10.1038/nature03702. 5. Andrea Schmidt. (September 29, 2009). Jingfang Ju, Ph.D., Associate Professor. Retrieved March 11, 2011, from http:// www.stonybrookmedicalcenter.org/pathology/faculty/ju. 6. Xi, Y., Edwards, J.R., and Ju, J. (2007). Investigation of miRNA biology by bioinformatics tools and impact of miRNAs in colorectal cancer – regulatory relationship of c-Myc and p53 with miRNAs. Cancer Informatics, 3, 245-253. 7. Kelly, T.K., Carvalho D.D.D., and Jones, P.A. (2010). Epigenetic modifications as therapeutic targets. Nature Biotechnology, 28, 1069-1078. doi:10.1038/nbt.1678. 8. Bhatnagar, N., et al. (2010). Downregulation of miR-205 and miR-31 confers resistance to c h e m o t h e r a p y - i n d u c e d apoptosis in prostate cancer cells. Cell Death and Disease, 1, e105. doi:10.1038/cddis.2010.85 9. Lin, P.Y., Yu S.L., Yang, P.C. (2010). MicroRNA in lung cancer. British Journal of Cancer, 103, 1144-1148. doi:10.1038/ sj.bjc.6605901. As a result of writing this review, Olesya developed an interest in miRNA and was accepted to a summer research program at Pennsylvania State University during the summer of 2011 to work on a new miRNA project. Congratulations Olesya!
The Stony Brook Young Investigators Review, Fall 2011