Page 1

Fall 2014

2 Church Street South, Suite 114 | New Haven, Connecticut 06519 | p 203.785.3482 | f 203.737.2480

Implementing a Vision for Clinical and Translational Research

Inside This Issue

3 New Recruitment Services Increase Help Us Discover Momentum

Events Calendar

5 Making the Most of the Yale Brand 6 Clinical Trial Ads 8 New Pilot RFA Awards for Promising Research Concepts 9 Guide to Yale Clinical Research Resources Research Expertise and Methods 12 Research Implementation and Participation 12 A New Approach to Subject Payments 18 Training to Support Research 19 Connections with Other Resources 20 Clinical Research Resource Directory

Almost ten years ago, Robert J. Alpern, md, Dean of the School of Medicine, invited senior faculty members to participate in strategic planning to examine how to make the most of Yale’s strengths in basic research, clinical research and clinical medicine. During this process, it emerged that the success of these investigators was largely attributable to the infrastructure that each of them had built. It became clear that developing a robust infrastructure to support investigators and promote innovative and collaborative research would be critical to expanding Yale’s research program. About a year later, the National Institutes of Health (nih) launched the Clinical and Translational Science Awards (ctsa), and Yale was among the first 12 institutions in the country to receive an award. The ctsa program is now under the auspices of the National Center for Advancing Translational Sciences (ncats), and is focused on speeding up the delivery of more effective prevention, diagnosis, and treatment of diseases. Meanwhile, ycci has evolved into a home for clinical and translational research on the health campus as well as a hub for research taking place across the entire Yale New Haven Health System. The growth of Yale’s clinical and translational research enterprise during the intervening years—there has been a 300 percent increase in industry-sponsored trials—is a reflection of the tremendous expansion of Yale’s clinical faculty and clinical practice combined with unwavering institutional support. Five years ago, ycci annually supported about 176 projects involving 140 faculty members; today it annually supports about a thousand projects, mostly sponsored by the nih, involving more than 500 faculty members. “After approving the strategic plan, I had a vision of what ycci would encompass and how it would support investigators,” said Dean Alpern. “The progress that’s been made has exceeded my expectations. I couldn’t be more pleased with what ycci has been able to accomplish on behalf of our faculty.”

Photo Terry Dagradi

In an effort to improve quality and efficiency across the translational research continuum, ycci has made concerted efforts to eliminate barriers to conducting research and to facilitate an environment that fosters multidisciplinary collaboration. The center has developed a wealth of programs and resources to address every aspect of the research process. ycci has also helped expand Yale’s state-of-the-art core facilities in imaging, gene sequencing, and other areas and has partnered with other centers to develop such programs as the Yale Center for Biomedical and Interventional Technology (cbit), an interdisciplinary initiative that brings together expertise from across the institution to develop novel technical approaches to address pressing clinical needs.

Photo Harold Shapiro

Director’s Corner When I first began my career in research, investigators had to build their own infrastructure. Although there were some resources available, such as the gcrc, there was no single office or body of knowledge to guide researchers. I was excited by the opportunity to serve as director of ycci and pi for the ctsa because I was convinced that Yale needed to develop an infrastructure that would support cutting-edge research. I think the progress we’ve made in less than a decade is noteworthy. We have created or expanded an array of resources to aid investigators from the time they conceive an idea to the publication of their results. What’s more, we are constantly evaluating and examining both the research process and our services. Our Executive Board has yearly retreats to strategize how best to realize the task we’ve undertaken in executing the School of Medicine’s strategic plan and our mission under the ctsa. ycci has gone well beyond the gcrc, which for 40 years was a safe place in which to carry out studies. It has provided a nimble infrastructure that has been reorganized several times in response to our recognition of the changing needs of Yale’s research community. During the last several years we have recruited so many new faculty members that we thought now is an opportune time to publish a guide to ycci’s resources—an updated version of the one we published in 2008. We hope that you will find it useful as you navigate a research landscape that has become increasingly complex and demanding. I encourage you to peruse this issue to learn what we have to offer and to visit ycci.yale.edu to learn more. I think you’ll agree that ycci is a valuable resource that you shouldn’t miss out on.

Robert Sherwin, md ycci Director

Robert J. Alpern, md, Dean, Yale School of Medicine

continued on page 2

New YCCI Pilot RFA Offers Funding for Innovative Research Projects See page 8 to learn about funding categories. Written by Jill Max

SPECIAL EXPAN DED CLINICAL RESEARCH RESOURCES ISSUE Fall 2014 | 1

2014 - Fall YCCI newsletter  

In this issue: (1)Implementing a Vision for Clinical and Translational Research (2)New Recruitment Services Increase Help Us Discover Moment...