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Sleep Scoring‐Aid Service www AseegaOnline com www.AseegaOnline.com

AseegaOnline Service Guide AseegaOnline Service Guide Physiological Signal Processing

© PHYSIP


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Welcome to AseegaOnline.com

Introduction

Physip is a European research company which designs innovative algorithms using the  Ph i i E h hi h d i i ti l ith i th latest digital signal processing technology for the sleep analysis and vigilance  monitoring fields Our flagship product, Aseega, is a fast, time‐saving automatic sleep scoring aid tool. It results from 35 years of sleep analysis research. Aseega has been clinically  validated (*) and is already being used in cutting‐edge sleep research (**) Aseega is now accessible through our web‐based service AseegaOnline and is open to  researchers carrying out studies primarily on healthy cohorts Thank you for considering Physip for your sleep scoring needs Thank you for considering Physip for your sleep scoring needs

(*) Sleep 2007;30:1587‐95 (**) Science 2009;324:516‐9

Physiological Signal Processing

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About this guide

Introduction

This « AseegaOnline Service Guide » complements the information provided on the  AseegaOnline and Physip websites Intended audience This guide consists of general information concerning the procedure for using the  service and the service output. Practical information on how to optimize the performance of Aseega and interpret  its results reliably can be found in the How to Use Aseega document its results reliably can be found in the How to Use Aseega document Document feedback Physip welcomes your suggestions for improving our documentation. If you have  Physip welcomes your suggestions for improving our documentation If you have any comments, please send your feedback to: feedback@AseegaOnline.com

2009‐07‐06 version 2.1PF

Physiological Signal Processing

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A guide to AseegaOnline

Content

How to use o to use the service • Subscribing S b ibi • Setup & Calibration • Upload & Launch • Results & Payment • Service overview

Analysis a ys s results • Result overview R l i • Sample report • Statistical studies • Recording quality  check

Physiological Signal Processing

A Appendix di

• More about Aseega M b A • Recording transfer

2.0

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Subscribing

Using AseegaOnline 

Aseega technology is at your fingertips ... When you are ready to use AseegaOnline: When you are ready to use AseegaOnline: e

Subscribe, in four easy steps, via the « create account » field

e

A Service User Agreement will be sent to you: 

e

y

this agreement does not oblige you to use our service but establishes the  conditions of our future working partnership.

y

there is no minimum volume

On return by post of the signed Service User Agreement y

user account details will be sent

Physiological Signal Processing

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Setup & Calibration

e

Login on AseegaOnline.com y

e

Using AseegaOnline

Use the User Id and Password that has been sent to you y

Technical calibration phase (*)  y

Ensure that your recording protocol meets our EEG recording  recommendations (see How To Use Aseega)

y

p g g g Upload a minimum of two EEG all‐night recording files for a recording  calibration test

y

After Email confirmation of compliance – you are ready for upload

(*) Calibration is only necessary for your first use or when equipment has changed

Physiological Signal Processing

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Upload & Launch

e

e

e

Using AseegaOnline 

Batch preparation y

Upload your EEG recordings p y g

y

Select required analysis package: Essential, Lab or Research (see Results overview p. 3.1)

Batch quotation y

Once you are all set, submit your batch request for a pricing quote

y

Volume discounts are applied pp

Batch launching y

Acceptance of our quote by Email launches the analysis

Physiological Signal Processing

2.3

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Results & Payment

e

e

Using AseegaOnline 

Results y

You will receive an Email notification when your results are available y for downloading

y

Login on AseegaOnline.com to retrieve your results securely

Payment y

Invoice sent to the billing address supplied at account creation, with a copy  f h for the user

y

Payment terms as detailed in the Service User Agreement

Physiological Signal Processing

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Process Overview

Using AseegaOnline

Subscribing

Setup & Calibration Setup & Calibration

Create Account on AseegaOnline.com

Follow EEG Recordings Recommendations

Service User Agreement Sent 

Login on AseegaOnline.com

Return of Signed Service User Agreement

Technical Calibration Phase 

User Account Details Supplied

Confirmation of Calibration Success

Upload & Launch Upload & Launch                                  Results & Payment Results & Payment Upload Recordings and Select Packages

Email Notifying Results Ready for Retrieval

Quote Supplied for Confirmation

Analysis Download

Acceptance of Quote

Invoice to Billing Address Supplied

Launch of Aseega Analyses

Confirmation of Receipt of Payment

Physiological Signal Processing

2.5

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A guide to AseegaOnline

Content

How to use o to use the service • Subscribing S b ibi • Setup & Calibration • Upload & Launch • Results & Payment • Service overview

Analysis a ys s results • Result overview R lt i • Sample report • Statistical studies • Recording quality  check

Physiological Signal Processing

A Appendix di

• More about Aseega M b A • Recording transfer

3.0

© PHYSIP


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Results Overview

e

Analysis results

Three analysis packages are proposed:

Aseega Essential

Aseega Lab

Aseega for Research

Basic wake/sleep analysis

Classic sleep studies

In‐depth sleep studies

• 2‐state scoring

• 5‐state and 2‐state scoring

• 10‐, 5‐ and 2‐state scoring

• Basic sleep parameters

• Extensive sleep parameters

• Raw 10‐state scoring

• EEGWatch spectral analysis

• Sleep cycle analysis

• Extensive sleep parameters

• Artifact density

• Microstructures detection

• Sleep cycle analysis

• FFT spectral analysis

• Microstructures detection

• EEGWatch spectral analysis

• Microstructures details

• Artifact density 

• FFT spectral analysis • EEGWatch spectral analysis • Spectral power in bands

e

Analysis report available in Word document and in numerical data format (see How To Use Aseega)

Physiological Signal Processing

• Artifact density 

3.1

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Aseega for Research Sample Report ( 1/3 )

Analysis results

sample report available on AseegaOnline.com Physiological Signal Processing

3.2

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Aseega for Research Sample Report ( 2/3 )

Physiological Signal Processing

Analysis results

3.3

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Aseega for Research Sample Report ( 3/3 )

Physiological Signal Processing

Analysis results

3.4

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Statistical Studies

Analysis results

e

Statistical studies can be carried out on your data using the numerical results files  provided by Aseega

e

Numerical results files are provided in Matlab©‐compatible (MAT‐file), Microsoft  Excel© (XLS‐file) and ASCII (TEXT‐file) format for further computation

e

See the How To Use Aseega document for a brief overview of this open format

e

A detailed format description guide (Aseega Analysis File Format) is available for  download on our website 

Physiological Signal Processing

3.5

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Aseega Recording Quality Check

e

Analysis results

Aseega analysis provides several recording quality indicators (warnings*), giving the  user feedback on their data: y

Signal recording level

y

Presence of artifacts in the signal

y

Saturation of the signal Saturation of the signal

y

Constant or null signal

e

These warnings enable a prior evaluation of the reliability of the analysis results These warnings enable a prior evaluation of the reliability of the analysis results 

e

Aseega outputs an artifact density at the epoch time‐scale. The artifact detection  methods used include temporal as well as spectral analysis

e

If the quality of the signal is considered to be insufficient: no hypnogram calculated

(*) See How To Use Aseega

Physiological Signal Processing

3.6

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A guide to AseegaOnline

Content

How to use o to use the service • Subscribing S b ibi • Setup & Calibration • Upload & Launch • Results & Payment • Service overview

Analysis a ys s results • Result overview R l i • Sample report • Statistical studies • Recording quality  check

Physiological Signal Processing

A Appendix di

• More about Aseega M b tA • Recording transfer

Appendix

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More About Aseega

Appendix A

e

Aseega is an automatic sleep analysis technology resulting from 35 years of research

e

B d Based on EEG signal processing, Aseega technology involves 3 successive steps: EEG i l i A t h l i l 3 i t

Aseega

Sleep p EEG

1. Preprocessing

Artifact rejection Frequency  q y band tuning Non‐uniform filter banks

2. Analysis

3. Classification

Spectral feature  extraction Microstructure  detection Awakening identification

Fuzzy classification

Contextual rule  smoothing

REM identification

Sleep scoring

Physiological Signal Processing

A.1

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Secured Recording Transfer

e

Access to your data is restricted via your confidential password

e

All data is encrypted by the Secure Socket Layer (SSL) protocol

e

Transfer your recordings simply, but securely, via the proposed interface

Physiological Signal Processing

Appendix B

B.1

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Thank you for your interest in AseegaOnline

For further information concerning our technology, research, clinical validations  and recording recommendations, please visit our websites and recording recommendations, please visit our websites www.physip.fr www.AseegaOnline.com www.AseegaOnline.com 

Physip SA y p 6, rue Gobert 75011 Paris France

The information contained in this document is subject to change without notice. This document contains trademarks that belong to PHYSIP S.A. and other companies. © 2009 PHYSIP S.A. All rights reserved. SG09AOL/201PF, July 2009. Physiological Signal Processing © PHYSIP

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