Endoc r i nesi nvol vesmyr i adar r ayofs ec r et or yhor monespr oduc edr i ghtf r om hypot hal amust o gonads . Thes ehor monespl ayi mpor t antr ol ei nr egul at i on ofvas tf unc t i on ofbodys uc h asgr owt h, devel opment , r epr oduc t i on, ener gybal anc e, met abol i s m andbodywei ghtr egul at i on. I nr ec enty ear st her ear emanyi nc i denc esofendoc r i nemal f unc t i oni ngr el at i ngt or educ eds ec r et i on orhyper s ec r et i on. Thei mbal anc ei nphy s i ol ogyofhor monepr oduc t i onl eadst oc ompl i c at i onf r om bei ngmi l dt os ever el i f et hr eat eni ngr i s kper t ai ni ngt or epr oduc t i vei mpai r ment ,c ogni t i vedec i t s , met abol i cdi s eas esand di s or der sand var i ousc anc er s .Ther ehasbeen i nc r eas ed i nc i denc eof di abet es ,t hyr oi d&r epr oduc t i vedi s or der smos t l ys eenaffec t i ngy oungerpopul at i on.Reas onc oul d bedi et , s t r es s&l i f es t yl e. Buti tc an’ tber ul edoutt hatenvi r onmental s opl ay ss i gnic antr ol e. Ther ei s r ai s i ngi s s ueofEndoc r i nedi s r upt orc ompounds ,s ubs t anc est hati nt er f er ewi t hal t er i nghor mone f unc t i oni ngofbody .Thes ear ei nnumer abl ec ompoundsr el eas edf r om i ndus t r i es ,dai l yc hor es , pes t i c i des . Thes ec ompoundsgetnotonl yaddedt onat ur al r es er voi r sduet oant hr opol ogi c al ac t i vi t y andal s os howt endenc yt obui l dupi nt hef oodc hai nl eadi ngt obi omagnic at i ons .
Endoc r i nedi s r upt orc ompoundsper c ol at ei nt owat erbodi es ,s omeoft hes ear el i pophi l i c , whi c hwhenc ons umedbyani mall eadst obi oac c umul at i onandevent ual l yt ohumansal s o. Thes ear emanymeansbywhi c hEndoc r i nedi s r upt orc ompoundent er si nt oourbody . Nor mal l y Endoc r i nedi s r upt orc ompounds per s i s t si nenvi r onmenti nt r ac eamount s ,mos toft hes e c ompoundsar ehet er ogeneousands t r uc t ur al l ydi s s i mi l ar . St r uc t ur aldi ver s i t y&oc c ur r enc ei n t r ac eamount spos esc hal l engef oranal yt i c al det ec t i on, whi c hr equi r es ophi s t i c at eddevi c esl i k e ELI SA,HPL CorGC/MSt odet ec tt hei rpr es enc e.Butast hes edevi c ear enothandynori ti s c heap,as s es s mentoft hes ec ompoundsi nr ur alpl ac esbec omesdi ffic ul twheni tc omest o qual i t yofdr i nki ngwat er .Henc et hi spr es entc onc eptofbi os ens orwi l lc i r c umventandmak e anal y s i ss i mpl e, c heap&c os teffec t i ve.
DESI GI NGOFABI OSENOR: PROTOTYPE: Sel ec t i ngs ui t abl eads or bentmat er i al ads or pt i onofant i body Des i gnamonoc l onal ant i body( Pr i mar yant i body) Sui t abl ehapt enf orEDCsi ss el ec t ed Fi g: Effec tofEDConc el l al t er i ngnor mal phys i ol ogy
SOLUTI ON:Bi os ens or swi l lbet heeas i erand effic i entdet ec t i on met hod wi t hi mmens e ac c ur ac y . Theabi l i t yt odet ec tver ymi nut eamount soft het ar gets ubs t anc e( EDCs ) , c ont i nuous moni t or i ng,l ow c os t ,ar et hek eyf eat ur esofbi os ens ort ec hnol ogy .Keyi ndevel opmentof Bi os ens ori st hati r r es pec t i veofnat ur eofEDCi tbi ndst or ec ept or sf oundont hes ur f ac eoft he c el l , f r equent l yus edr ec ept or sar eGPERorERal phar ec ept or s . Thi smec hani s mi sex pl oi t edf or c r eat i ngabi os ens or , t her ec ept oranal oguei sc r eat edaspr i mar yant i bodyandi mmobi l i z edon t os uppor t , whenEDCbi ndt or ec ept oranal ogue, c ompl exgener at esc hemi c al ener gy , whi c hi s c onver t edt oel ec t r i c alener gybyt r ans duc er , ampl ierr ec or dsi nt ens ieds i gnal . Her ehapt en c onj ugat esc anbeus edt odet ec tt r ac eamount soft hec ompounds&det ec ti nwat ers ampl es .
Sec ondar yant i body , whi c hbi ndst oc ompl ex( Pr i mar yAbEDC/hapt en)i s us edOpt i onal Compl exgener at esc hemi c al ener gy , whi c hi sc onver t edt oel ec t r i c al ener gyby t r ans duc er , ampl ierr ec or dsi nt ens ieds i gnal as as hl i ght .
BI OSENSORFOREDC
CONCL USI ON Paper bas eds ens or sr epr es entanemer gi ngappr oac hwi t happl i c at i onsr angi ng f r om di s eas edi agnos t i c s ,anddet ec t i onofenvi r onment alagent st omoni t or i ng f or ens i cs ampl es .Thes ear ei nex pens i veandpor t abl edevi c es ,duet ot hei rl ow f abr i c at i onc os t ,t heyar enotonl yus ef uli nf ul l yequi ppedl abor at or i esbutal s oi n r es our c el i mi t ed s et t i ngsand aus t er e envi r onment s .The paper bas ed devi c es pr es entvar i ousadvant agesbec aus et hey ( i )ar es i mpl eandus er f r i endl y;( i i )ar eequi pment f r ee( l i mi t i ngener gyex pens es bec aus epumpsorext er nal appar at usar enotr equi r edf ordr i vi ngt he ui d ow) ; ( i i i ) ar epor t abl e; ( i v)ar eeas yt odi s pos eof ; ( v)r equi r eonl ys mal l vol umesofanal yt es( i n t hemi c r ol i t err ange) ; and( vi )havet heabi l i t yt odet ec tmul t i pl eanal yt esatt hes ame t i me( mul t i pl ex edanal y s i s ) .
S r i Dha r ma s t ha l aMa nj una t hes hwa r aCol l ege( Aut onomous ) Uj i r e574240
-PRARTHANAJ