STEM CELL : A REGENERATIVE THERAPEUTIC ABSTRACT BACKGROUND:
Stem cells set out to be a more adept and competent regenerative medicinal elucidation. RATIONALE: There is a large cleft between the advancing present day evolutionary expansion in the field of exploration and the populace because of the lesser cognizance of the research’s significant applications reaching out to people in an efficacious manner. Thus bridging this gap is truly rational. STRATEGY: With a view to extend and reach across with a more feasible and humanly perspective is to vivaciously exhibit the contemporary breakthrough together with its momentous utilizations. RESULTS: Stem cells promise out to be a veracious regenerative medicament given that it being utilized to its absolute potential surpassing all of the budgetary impediments with an enduring remedy. CONCLUSIONS: The utmost essence of stem cells cure explored should outstretch to one and all at an unchallenging and an attainable charge with There are certain cells a perennial restoration.
within the organs which are able to internally repair the damage caused to these organs.This INTERNAL RESTORATION COMPLEX BEING THE STEM CELLS.
WHAT ARE THESE STEM CELLS ? These are SPECIAL CELLS of human body that are UNSPECIALIZED with an ability of SELF RENEWAL and also accompanied by its potency to DIFFERENTIATE INTO ANY CELL of that particular organism with its potency decreasing for every step of its further specialization.
FROM WHERE DO WE PROCURE STEM CELLS ?
Oligopotent Multipotent
Somatic /Adult / Tissue Stem cells
Pleuripotent Totipotent
Unipotent
Haematopoietic Stem cells
Mesenchymal Stem cells
Unipotent STEM CELL
Neural Stem cells
Bone marrow derived mesenchymal Stem cells
Adipose derived mesenchymal Stem cells
Umbilical cord derived mesenchymal Stem cells
Induced Pleuripotent Stem cells (iPSC) By Reprogramming STEM CELL
Embryonic Blastocyst Stem cells
OSTEOARTICUALR DISEASES
TYPE I DIABETES
Bone mineralization was found mainly being accelerated with the scaffolds being overlayed with AFSCs. Further authentication in the bone thickness was prooved by micro-CT (Murphy,& Atala, 2013).
MSCs cultured under ably defined conditions found being able to differentiate to cells capable of secreting insulin(Oh et al., 2004).
Osteoblasts
AUTOIMMUNE DISEASES AFSCs showed to have a lasting potential of its hematopoietic repopulation in vivo with transplant trials and its able restorative uses for managing immune and blood diseases (Ditadi et al., 2009).
Researches do show a direct corelation between food and proliferative growth of stem cells thus marking the importance of consuming nutrious food.
Urine derived stem cells
NEURAL REGENERATION In certain degenerative brain diseases namely Alzheimer, Parkinson, recent researches recommend AFSCs to play an important role in its treatment(Murphy,& Atala, 2013).
LIVER DISEASES
Insulin producing cells
Neurons
Stem cell remedy being an effectual course of action in some fulminant hepatic failure, when MSCs derive hepatocytes being transplanted to a liver failure immunodeficient mice, hepatocytes repopulation was noted(Kuo et al., 2008).
LUNG DISEASE INFLAMMATORY BOWEL DISEASES Immune cells
Stem cell remedy as a medication for patients with Crohn disease,being effectual in lowering signs of the disease without any carryover (Murphy,& Atala, 2013). Intes
tinal
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Human amnion epithelial cells(hAECs) have been noticable for the use of treating cystic fibrosis patients with the cells expressing cystic fibrosis transmembrane conductance regulatory lung specific protein(Murphy,& Atala, 2013).
Lung cells
RENAL DISEASE
CARDIOVASCULAR DISEASES Establishing Amniotic fluid stem cells (AFSCs) therapeutic potential serving as a Mesenchymal stem cell(MSCs) for severe heart attack(Bollini et al., 2011).
Stem
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A mouse model with a injured tubules showed a positive association of injected AFSCs to repopulation of tubular epithelial kidney cells with reduction in apoptosis of these cells(Murphy,& Atala, 2013).
Cardiomyocytes
REFERENCES: ·Bollini S, Cheung KK, Riegler J, Dong X, Smart N, Ghionzoli M, et al. Amniotic fluid stem cells are cardioprotective following acute myocardial infarction. Stem Cell Dev 2011;20:1985-94. ·Ditadi A, de Coppi P, Picone O, Gautreau L, Smati R, Six E, et al. Human and murine amniotic fluid c-Kit+ Lin− cells display hematopoietic activity. Blood 2009;113:3953-60. ·Kuo TK, Hung SP, Chuang CH, Chen CT, Shih YRV, Fang SCY, et al. Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem 2008;134:2111-21. cells. Gastroenterology ·Murphy SV, Atala A. Amniotic fluid and placental membranes: unexpected sources of highly multipotent cells. Semin Reprod Med 2013;31:62-8. ·Oh SH, Muzzonigro TM, Bae SH, LaPlante JM, Hatch HM, Petersen BE. Adult bone marrow-derived cells transdifferentiating into insulin-producing cells for the treatment of type I diabetes. Lab. Invest., 2004. 84(5): p. 607-617.
By: Samhitha S