Dr. Archana A Gupta, Dr. Supriya Kheur, Dr. Ravindra V. Badhe
AIM
Introduction
Scaffolds Characterization
• • • • •
Healing bone fractures and reconstructing bone defects a significant challenge Bone autograft and allograft – donor site morbidity Alternative methods for bone repair – Tissue engineered scaffolds Biocompatible, biodegradable with osteo-conductive & osteo-inductive properties The present study involves the use of Blank Chitosan Scaffolds
Potential of scaffolds to replace bone autografts and allografts
Vitamin D Scaffolds
Blank Chitosan Scaffolds
Differential Scanning Colorimetry Sustained release
Results
Evaluating scaffold efficacy for osteoconductive & osteoinductive properties
Fourier Transform Infrared Microscopy Biocompatible
Bone formation
X-Ray Diffraction ALP expression
Vitamin D Scaffolds
Scanning Electron Microscopy
Conclusion: 1. Scaffolds show sustained release of modulators. 2. Scaffolds are Biocompatible 3. Scaffolds help in Bone regeneration