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Oral Fluid Drug Testing: A Simple Solution for a Complex World Guest Speaker:

Ben Agee

Oral Fluid Scientist, Keystone Laboratory

Moderator:

Kendra McCardle

Business Relationship Director for Wolfe, Inc.


ORAL FLUID DRUG TESTING: A SIMPLE SOLUTION FOR A COMPLEX WORLD

“Never underestimate the power of a simple tool.” - Craig Bruce


“WOLFE WORDS” Adulterated – made impure by adding extraneous, improper, or inferior ingredients Neat Sample – a sample obtained by expectorating (spitting) rather than through a medium such as a pad or buffer

Metabolite – a product of metabolic action

Substituted – any sample not produced by the donor


Sample Collection is the Key

Not all samples are equal (even the best drug test is only as good as the specimen)

A “neat� oral fluid sample is the best method of collection for the highest percentage of drug recovery. -SAMHSA Proposed Revisions to Mandatory Guidelines for Federal Workplace Drug Testing Programs

No pads No buffers No diluents


Less non-productive time for donors and collectors

Ideal for onsite collecting

Totally observable

No donor privacy concerns

Less set-up time

Dual gender observations

No “shy bladder� issues


Saves time and productivity

Reduces the likelihood of possible adulteration/substitution

If the donor does not have to leave the facility Ideal for post-accident testing, pre-employment testing, random testing and reasonable suspicion testing

Only a 5 step collection process


Premium Oral Fluid Collector

Fast, easy and convenient sample collection


Minimal setup time

No “shy bladder”

Dual gender observation


75,400 websites have advice on beating urine-based screening - Google

Dilute

Substituted

Adulterated


Oral fluid drug testing can detect current drug use. The window of detection in oral fluid drug testing is 12-24 hours.

Oral Fluid is great for: For Cause

Post Accident

Random Tests

Return to Duty

PreEmployment


Marijuana is the most commonly used illicit drug

Δ9THC

• is the primary compound and psychoactive ingredient in marijuana • (parent) is the most prevalent marijuana compound in saliva • becomes very sticky when warm and tends to cling to porous surfaces • is the most difficult drug to recover in oral fluid testing


Inadequate Recovery Δ9-THC in Collection Devices “The recovery of Δ9-THC from devices with absorbing components is a problem. The recovery of Δ9-THC is not as good as that of other analytes due to the absorption of Δ9 THC to the plastic and the absorptive compounds of the device.” *Langel, K., C. Engblom, et al. (2008). "Drug testing in oral fluidevaluation of sample collection devices." Journal of Analytical Toxicology 32(6): 393-401.


Premium Oral Fluid Collector

* Unaltered sample for maximum recovery * No pads, no buffers and no diluents to affect sample integrity * Glass is a better collection container vs. plastic for THC recovery and screening accuracy * Sample collection is fast and easy


Equally important is a device with a sample volume indicator -SAMHSA Proposed Revisions To Mandatory Guidelines for Federal Workplace Drug Testing Programs

No objective way to measure sample volume

Without an Indicator Collected sample volume can vary from 18-83%

Large variations are problematic to get quantitative results for drug recovery


Premium Oral Fluid Collector

� Accurate sample volumes are necessary to ensure accurate results � Easy to read fill line ensures sufficient sample volume � Decreases rejections for insufficient quantity


� Δ9-THC � Cocaine � Opiates � PCP � Amphetamine � Methamphetamine � MDMA (Ecstasy)


Oral Fluid Trends ďż˝ Oral fluid specimens

3500000

accounted for only 5%

3000000

of collected samples 2500000

in 2009 ďż˝ We project that by

2000000

2016 approximately 1500000

20% (over 20 million) of all

1000000

collected specimens

500000

will be oral fluid 0 2003

2004

2005

2006

2007

2008

2009

Reproduced from A Five Year Analysis of Oral Fluid Drug Testing Results from a MRO Data Source, 2003-2007; Walsh, J.M., et al., 2008 Society of Forensic Toxicology National Meeting and data collected from the field in 9/09. Data is conservative and only shows one MRO source. 2009 data point from personal communication with J.M.Walsh.

samples


Calculating Savings for Higher Positive Rates � 75%+ of drug users have jobs

� There are between 10 million and 12 million drug users in the workplace � It is estimated businesses lose between $129 billion and $180 billion per year due to productivity losses to drug use � Drug users are 33% less productive than their co-workers, and on average cost their employers between $7,000 and $15,000 annually U.S. Department of Labor, Occupational Safety & Health Administration website; Safety and Health Topics, Workplace Substance Abuse.


� Easy to collect � Difficult to adulterate �Better indicator of recent drug use


Featured Presenter Ben Agee Oral Fluid Scientist, Keystone Laboratory

Ben is the resident Oral Fluid scientist for Keystone Laboratory in Asheville, NC. He graduated from Western Carolina University with a degree in Biology.

Contact Ben directly at 1.800.230.2991 or at BennettA@WolfeInc.com


Wolfe, Inc 1.800.230.2991 BizRelations@Wolfeinc.com www.WolfeInc.com

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