Page 1

Prediction and Prevention of Drug Side Effects

THE CHEMICAL BIOLOGY OF NUCLEIC ACIDS EDITOR GÜNTER MAYER

S E RI E S

I N

M ET H O D S

O F

B I O C H E M I C A L

A N A LY S I S

INTRODUCTION TO

PROTEOMICS Principles and Applications

This second edition of a successful title bridging toxicology and environmental chemistry adopts a unique approach that ‘follows’ chemicals on a molecular level, from the environment through the different uptake mechanisms into the body, to the toxic effect. Along the way, this textbook explains the different routes of degradation and metabolism of the different classes of chemicals, linking general chemical properties to their toxicological equivalents. All the chapters have been thoroughly updated and the contents significantly expanded, including for example new chapters on pesticides, food chemicals and pharmaceuticals, as well as sections discussing endocrine disruptors and carcinogenicity assays.

Chemistry, Health, and Environment Olov Sterner Second, Completely Revised Edition

The text is aimed at a wide audience ranging from pharmacologists to environmental chemists and toxicologists.

Volume 45 Series Editors: R. Mannhold, H. Kubinyi, G. Folkers

Olov Sterner is Head of the Division of Organic Chemistry as well as of the Department of Chemistry at Lund University in Sweden. Originally an organic chemist he became interested in bioactive natural products and has conducted research aiming at the isolation, characterization, synthesis, and QSAR studies of secondary metabolites from plants and fungi. Professor Sterner has published more than 330 research papers, 20 conference papers, 120 conference abstracts and 20 patents.

Chemistry, Health, and Environment

nic chemistry from the PhD in 1995 from the egan his industrial career in chering in Berlin. In 2000 nsible for the establishment n Chemical Development. stry Department where he mistry I at Bayer Schering

W I L E Y

Aspartic Acid Proteases as Therapeutic Targets

Nuclear Receptors as Drug Targets

edicinal Chemistry at eceived his degree in ver where he graduated in ds an honorary y of Berlin. Subsequent to California at Berkeley, he ng in 1983, and took up his

Methods and Principles in Medicinal Chemistry

Edited by Arun K. Ghosh

Olov Sterner

ding pharmaceuound the world experience, this is emists, molecular pharmaceutical

39 Ottow · Weinmann (Eds.)

he most widely ated drugs derived ed their pivotal ardiovascular ng a new wave of lar targets. ring pharmaceutical ed drugs, this aspects of human ed receptors as eir application for

Biochemistry NAWIN C. MISHRA with a Foreword by the Nobel Laureate Professor Günter Blobel

BN 978-3-527-31872-8

www.wiley.com/wiley-blackwell

783527 318728

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RNA Biology An Introduction

Gunter Meister, University of Regensburg,

Germany

ISBN: 978-3-527-32278-7 | Paperback 400 pages | 2011 £55.00 / €59.00 / USD $85.00

RNA Biology An Introduction Gunter Meister

The first-ever advanced text on RNA biology captures all the excitement of this booming field. From ribozymes to RNA interference to RNomics — everything is competently explained and put into perspective.

Peroxidases and Catalases

Biochemistry, Biophysics, Biotechnology, and Physiology H. Brian Dunford, Univ. of Alberta, Edmonton,

SECOND EDITION

PEROXIDASES & CATALASES Biochemistry, Biophysics, Biotechnology, and Physiology

Canada

H. BRIAN DUNFORD

ISBN: 978-0-470-22476-2 | Cloth 459 pages | 2010 £100.00 / €125.00 / USD $195.00

With Invited Contributions

A vital reference for engineers and researchers, this book provides a summary of current research on peroxidase and catalase enzymes, along with detailed chapters on mammalian peroxidases, medical and physiological roles, as well as spectroscopic and theoretical techniques, enabling biochemists to understand the contributions made principally by physicists and physical/theoretical chemists. Heme peroxidases and catalases, as well as other peroxidases, like vanadium peroxidases and selenium peroxidase, are also discussed.

Ideas in Chemistry and Molecular Sciences

Where Chemistry Meets Life Bruno Pignataro, University of Palermo, Italy,

Editor

ISBN: 978-3-527-32541-2 | Cloth 358 pages | 2010 £85.00 / €99.00 / USD $145.00

Providing an account of the most recent results of research in life sciences in Europe based on a selection of leading young scientists participating in the 2008 European Young Chemists Award competition, the authors present state of the art research and the perspective or preview of future directions.

Also available: Ideas in Chemistry and Molecular Sciences, Three-Volume Set Advances in Synthetic Chemistry Where Chemistry Meets Life Advances in Nanotechnology, Materials and Devices ISBN: 978-3-527-32875-8 | Cloth | 1272 pages | April 2010 £240.00 / €279.00 / USD $340.00

Instrumental Analysis of Intrinsically Disordered Proteins Assessing Structure and Conformation

W I L E Y

S E R I E S I N P R O T E I N A N D P E P T I D E V l a d i m i r N . U v e r s k y, S e r i e s E d i t o r

S C I E N C E

INSTRUMENTAL ANALYSIS OF INTRINSICALLY DISORDERED PROTEINS A ss e ss i n g S t r u c t u re a n d C o n f o r m a t i o n E D I T E D BY

V l a d i m i r N . U ve r s k y

AND

Sonia Longhi

Vladimir Uversky, Indiana University School of Medicine, USA; Sonia Longhi, AFMB, France

ISBN: 978-0-470-34341-8 | Cloth 760 pages | 2010 £100.50 / €125.00 / USD $149.95

This text offers the first systematic compilation of various techniques and methodologies used in the analysis of intrinsically disordered proteins (IDPs). Its coverage addresses one of the hottest yet least documented areas in protein biophysics today, summarizing recent achievements in the methods for structural characterization of intrinsically disordered proteins. Structural biology and protein degradation, along with a myriad of spectroscopic techniques that can be used to elucidate protein structure are also addressed. Part of the Wiley Series in Protein and Peptide Science.

Protein Misfolding Diseases Current and Emerging Principles and Therapies

Marina Ramirez-Alvarado, Jeffery W. Kelly, Christopher M. Dobson, Editors

Wiley Series in Protein and Peptide Science Vladimir N. Uversky, Series Editor

PROTEIN

MISFOLDING DISEASES CURRENT AND EMERGING PRINCIPLES AND THERAPIES

ISBN: 978-0-471-79928-3 | Cloth 1069 pages | 2010 £130.00 / €162.00 / USD $195.00

Edited by

MARINA RAMIREZ-ALVARADO JEFFERY W. KELLY CHRISTOPHER M. DOBSON

An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer’s, Parkinson’s, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease. Part of the Wiley Series in Protein and Peptide Science.

Calcium Binding Proteins Eugene Permyakov, Institute for Biological Instrumentation at the Russian Academy of Sciences; Robert H. Kretsinger, University of Virginia, USA ISBN: 978-0-470-52584-5 | Cloth 626 pages | 2010 £90.50 / €112.00 / USD $149.95

Chemical Binding Proteins explains the unique and highly diverse functions of calcium in biology with up-to-date information on all the major families of calcium binding proteins including their structural, physico-chemical and functional properties, as well as their evolution. An essential resource for professors and researchers in biophysics and biochemistry. Part of the Wiley Series in Protein and Peptide Science.

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The Chemical Biology of Nucleic Acids

THE CHEMICAL BIOLOGY OF NUCLEIC ACIDS EDITOR GÜNTER MAYER

Gunter Mayer, Strathclyde University

The Chemistry and Biology of Volatiles Andreas Herrmann, Firmenich SA, Editor ISBN: 978-0-470-77778-7 | Cloth 416 pages | 2010 £90.00 / €112.00 / USD $120.00

ISBN: 978-0-470-51974-5 | Cloth 478 pages | 2010 £110.00 / €139.00 / USD $170.00

THE CHEMISTRY AND BIOLOGY OF

VOLATILES ................................................................

Editor Andreas Herrmann

An essential guide to this important new set of tools. Probe the nature of biochemical molecules and systems as you focus on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include the synthesis and site-directed modifications of DNA and RNA, DNA-templated synthesis, antisense nucleic acids, and RNA interferences.

The Chemistry and Biology of Volatiles takes an interdisciplinary approach to volatile molecules. Review-style introductions to the main topics in volatile chemistry and biology are provided by international experts, building into a broad overview of this fascinating field. Of interest to students and researchers in organic and bioorganic chemistry, biochemistry, flavour and fragrance research, pest control, and atmospheric chemistry.

Introduction to Proteomics

Biochemical Pathways

Principles and Applications

W I L E Y

S E R I E S

I N

M E T H O D S

O F

B I O C H E M I C A L

A N A LY S I S

INTRODUCTION TO

PROTEOMICS Principles and Applications

Nawin C. Mishra, University of South Carolina; Foreword by Günter Blobel, Nobel

Gerhard Michal, Dietmar Schomburg,

Laureate Professor

ISBN: 978-0-471-75402-2 | Paperback 180 pages | 2010 £66.95 / €83.90 / USD $99.95

An Atlas of Biochemistry and Molecular Biology GBF Braunschweig, Germany

NAWIN C. MISHRA with a Foreword by the Nobel Laureate Professor Günter Blobel

A highly authoritative introduction to the promising and fast-advancing field of proteomics, examining the role proteomics play in the study of biological systems in general and disease in particular. It helps readers understand the structure, function, and interactions of proteins and how this knowledge is used for identifying diseases and developing new drugs. Nawin Mishra, a worldrenowned speaker and leader in proteomics studies, who has worked with the late Nobel Laureate E. L. Tatum when proteomics was in its infancy, offers an expert perspective on the entire field. Part of the Methods of Biochemical Analysis Series.

The Chemical Biology of DNA Damage Nicholas E. Geacintov, Suse Broyde;

both of New York University, USA, Editors

ISBN: 978-3-527-32295-4 | Cloth 471 pages | 2010 £120.00 / €139.00 / USD $185.00

A modern reference on a key topic in biochemical toxicology that reaches out into molecular biology, molecular medicine and environmental science. Covers basic concepts as well as the analysis and prediction of genotoxicty at the molecular level.

ISBN: 978-0-470-14684-2 | Cloth 384 pages | 2010 £83.50 / €105.00 / USD $125.00

Biochemical Pathways An Atlas of Biochemistry and Molecular Biology Gerhard Michal, Dietmar Schomburg

Covering a wide range of subject matter, including biochemistry, molecular and cell biology, medicine, chemistry, and allied health, Biochemical Pathways is a full-color, easy-to-use resource for students and professionals. This information-packed reference features a unique summary of biochemical pathways based on the wellknown Biochemical Pathways chart. Included is descriptive information about properties such as enzymes, chemicals, proteins, and DNA, all of which act together to create an elaborate chain that drives all biological functions. Completely updated, this new edition continues to play a valuable role in this important scientific field.

Biomimetic Organic Synthesis Erwan Poupon, University of Paris, France; Bastien Nay, Muséum National d’Histoire Naturelle, Paris, France, Editors

ISBN: 978-3-527-32580-1 | Cloth 1000 pages | 2011 £325.00 / €379.00 / USD $525.00

Biomimetic Organic Synthesis Erwan Poupon, Bastien Nay

Biomimetic Organic Synthesis, the first book covering the hot and rapidly developing biomimetic approach in modern synthetic chemistry, provides important key definitions and general concepts in a tutorial way. Unifying both synthetic and biosynthetic aspects this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.

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Introduction to Chemical Biology Paul J. Hergenrother, Amanda C. Nottbohm; both of University of Illinois, USA

ISBN: 978-0-470-99003-2 | Cloth 328 pages | 2011 £95.00 / €119.00 / USD $165.00

Introduction to Chemical Biology Paul J. Hergenrother, Amanda C. Nottbohm

Tackle the practical aspects of working in a chemical biology laboratory with this detailed introduction to the discipline. Gain insight into the tools and techniques of chemical biology as you examine more advanced topics such as target identification. Topics covered include: amino acids; protein structure; enzyme kinetics; transcription and translation; recombinant protein expression/purification; fluorescence microscopy and related techniques; facile chemical reactions for use as biomolecular probes; high-throughput screening; combinatorial biosysnthesis of natural products; activity based profiling; targeted therapeutics; proteomics; and more.

ISBN: 978-3-90639-034-5 | Cloth 300 pages | 2010 £45.00 / €49.90 / USD $75.00

Edited by

Bringing together current advances and in-depth reviews of bio-based industrial products and agricultural biotechnology, Biocatalysis and Molecular Engineering examines the recent energy and food crises and points out the importance of using bio-based products from renewable resources and agricultural biotechnology. Exploring the use of most modern tools, such as molecular engineering on plants, to solve these issues, as well as the methods employed, global experts show how development of the sustainable manufacturing industry is critical for the future wellness of our planet.

Heterocyclic Chemistry John A. Joule, The School of Chemistry, The University of Manchester; Keith Mills, Chemistry Consultant, Ware, Hertsfordshire

William L. Luyben and I-Lung Chien

ISBN: 978-1-4051-9365-8 | Cloth 718 pages | 2010 £120.00 / €149.00 / USD $195.00 ISBN: 978-1-4051-3300-5 | Paperback 640 pages | 2010 £39.95 / €49.90 / USD $59.95

This new title describes azeotropic systems in a comprehensive, readable form, with updates on recent developments in vapor-liquid and liquid-liquid-vapor equilibrium, simulation tools, and has specific examples covering the major processing options available. Methods for achieving optimum economic design and control structures, and demonstrations of tradeoffs between energy savings and controlability (product quality variability) are also presented.

Günther Ohloff

ISBN: 978-0-470-48759-4 | Cloth 490 pages | 2010 £90.50 / €112.00 / USD $135.00

Design and Control of Distillation Systems for Separating Azeotropes

ISBN: 978-0-470-44862-5 | Cloth 472 pages | 2010 £83.50 / €105.00 / USD $125.00

A Cultural History of Scents

Ching T. Hou, Editor, Jei-Fu Shaw

Fifth Edition

William L. Luyben, Lehigh University, USA; I-Lung Chien

Earthly Scents – Heavenly Pleasures

Biocatalysis and Biomolecular Engineering

CHING T. HOU JEI-FU SHAW

ISBN: 978-0-470-99004-9 | Paperback 328 pages | 2011 £37.50 / €46.90 / USD $65.00

Design and Control of Distillation Systems for Separating Azeotropes

Biocatalysis and Biomolecular Engineering

The new, fifth edition of Heterocyclic Chemistry continues to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes it a valuable reference for postgraduate-taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry.

The Biochemistry of Drug Metabolism Two-Volume Set

Earthly Scents – Heavenly Pleasures A Cultural History of Scents Günther Ohloff

Scented materials are an essential part of human culture. Author and expert on fragrances Gunther Ohloff guides readers through these scents and collects together the ingredients and recipes used in our world’s high cultures for the preparation of bewitching perfumes, ritual incenses, or soothing oils and ointments. From the ancient traditions of Mesopotamia to the perfumes of the present, from Europe to East Asia, this book presents a fascinating chapter in cultural history.

Bernard Testa, University of Lausanne, BEP, Switzerland; Stefanie D. Krämer, ETH Zurich, Switzerland ISBN: 978-3-90639-055-0 | Paperback 950 pages | 2010 £80.00 / €89.00 / USD $130.00

Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two volumes focus on the biochemistry, with an emphasis on xenobiotic-metabolizing enzymes, their reactions and regulations. The first volume covers principles, redox reactions, and hydrolyses, while the second is devoted to conjugations, consequences of metabolism, and influencing factors. The all-important issue of the consequences of drug and xenobiotic metabolism is also discussed. With a foreword by Prof Leslie Z. Benet, the renowned biopharmaceutical scientist.

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Approaches for Drug Discovery

Ernest Giralt, University of Barcelona; Mark Peczuh, University of Connecticut; Xavier Salvatella, University of Cambridge, Editors

Ernest Giralt, Mark Peczuh, Xavier Salvatella

ISBN: 978-0-470-05905-0 | Cloth 376 pages | 2011 £85.00 / €105.00 / USD $170.00

Amino Acids, Peptides and Proteins in Organic Chemistry C

losing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international „who‘s who“ in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides Volume 6: Peptide Natural Products and Amino Acid Chemistry Development

Clearly structured in three main sections, this second volume in the series begins with the synthesis and chemistry of modified amino acids. The second part deals with the catalysis of reactions by amino acids, while the final section is devoted to enzymes, including proteases as catalysts, semisynthetic enzymes, catalysis by peptide-based enzyme models, substrate and protein recognition, as well as mammalian and insect peptide hormones.

Edited by Andrew B. Hughes

Amino Acids, Peptides and Proteins in Organic Chemistry Volume 5 Analysis and Function of Amino Acids and Peptides

5

Amino Acids, Peptides and Proteins in Organic Chemistry

Protein Surface Recognition Approaches for Drug Discovery

Hughes (Ed.)

Protein Surface Recognition

Andrew B. Hughes, Department of Chemistry, Andrew Hughes is a reader and Head of the Department of Chemistry at La Trobe University, Melbourne, Australia. He obtained his degrees from the University of Western Australia, before taking up post-doctoral appointments at the University of Cambridge starting in 1989. After three years working with Professor Andrew Holmes, he joined Professor Steven Ley‘s group. While at Cambridge he was appointed the Shell Research Fellow at Robinson College. His interests lie in the general field of asymmetric synthesis and methodology, with a recent focus on amino acid chemistry.

La Trobe University, Victoria, Australia, Series Editor

Series ISBN: 978-3-527-32692-1 | Cloth 3600 Pages | 2011 £710.00 / €834.00 / USD $1125.00 Volume 5 of 6

www.wiley-vch.de

Used as a how-to or guidebook for the development of research programs, this book presents detailed treatment of the protein-protein interactions that are key players in human disease and biology and the potential for therapeutics derived from this new perspective. In addition, it covers the fundamental physical issues that surround protein-protein interactions that must be considered when designing ligands for protein surfaces. 39

Methods and Principles in Medicinal Chemistry

Ottow · Weinmann (Eds.)

N

uclear receptors are the site of action for some of the most widely used medications, namely oral contraceptives and related drugs derived from steroid hormones. Recent research has uncovered their pivotal role in a range of human diseases, including cancer, cardiovascular disorders, diabetes and metabolic syndrome, triggering a new wave of drug discovery efforts focused on this class of molecular targets. Edited by two experts working at one of the pioneering pharmaceutical companies and major global player in hormone-derived drugs, this handbook systematically treats the drug development aspects of human nuclear receptors, including such recently characterized receptors as PPAR, NR4A, and many others. Modern tools and their application for nuclear receptor research are also covered in detail. With its contributions from authors working at leading pharmaceutical companies and academic research institutions around the world providing examples and real-life data from their own experience, this is an invaluable reference for medicinal chemists, biochemists, molecular biologists, pharmacologists and those working in the pharmaceutical industry and academic institutions.

Edited by Arun K. Ghosh

Aspartic Acid Proteases as Therapeutic Targets Prediction and Prevention of Drug Side Effects

Arun K. Ghosh, Purdue University, West Lafayette, USA, Editor; Raimund Mannhold, University of Düsseldorf, Germany, Series Editor; Hugo Kubinyi, University of Heidelberg, Germany, Series Editor; Gerd Folkers, Swiss Institute of Technology (ETH), Zürich, Switzerland, Series Editor

Volume 45

Nuclear Receptors as Drug Targets

Hilmar Weinmann graduated in organic chemistry from the University of Tübingen and received his PhD in 1995 from the University of Hanover, Germany. He began his industrial career in the Process Research Department at Schering in Berlin. In 2000 he was appointed a group leader responsible for the establishment of novel automation technologies within Chemical Development. In 2003 he joined the Medicinal Chemistry Department where he is currently Director of Medicinal Chemistry I at Bayer Schering Pharma.

New Volumes Volume 3 – Building Blocks, Catalysis and Coupling Chemistry

Aspartic Acid Proteases as Therapeutic Targets Eckhard Ottow is currently Head of Medicinal Chemistry at Bayer Schering Pharma in Berlin. He received his degree in chemistry from the University of Hanover where he graduated in 1979 and his PhD in 1982. He also holds an honorary professorship at the Technical University of Berlin. Subsequent to a postdoctoral stay at the University of California at Berkeley, he began his professional career at Schering in 1983, and took up his present position in 2002.

Closing a gap in the literature, this practical book series draws on the expertise of the international ‘who’s who’ in amino acid research to provide a comprehensive discussion of the occurrence, uses and applications of amino acids, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures.

Series Editors: R. Mannhold, H. Kubinyi, G. Folkers

ISBN: 978-3-527-32102-5 | Cloth | 600 pages | 2011 £140.00 / €159.00 / USD $200.00

Volume 4 – Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis ISBN: 978-3-527-32103-2 | Cloth | 600 pages | 2011 £120.00 / €159.00 / USD $195.00

Volume 5 – Analysis and Function of Amino Acids and Peptides ISBN: 978-3-527-32104-9 | Cloth | 600 pages | 2011 £120.00 / €159.00 / USD $138.50

ISBN 978-3-527-31872-8

www.wiley-vch.de

Advanced Organic Chemistry

9 783527 318728

ISBN: 978-3-527-31811-7 | Cloth 640 pages | 2010 £140.00 / €159.00 / USD $200.00

Bradford P. Mundy, Colby College, Waterville, ME, USA

Edited by one of the most prominent protease drug developers in the pharmaceutical industry (who was personally responsible for the discovery of a breakthrough anti-AIDS drug), this ground-breaking practical reference provides professionals in industry, as well as students studying proteases and their function, with a description of the family of aspartic acid proteases from a drug developer’s perspective. Part of the Methods and Principles in Medicinal Chemistry Series.

The enormous cost incurred when a candidate drug fails in a clinical

trial because of poor pharmacological parameters or severe side effects makes it imperative to screen for “safe” drugs in the very early stages of drug development. Various biochemical and other in vitro assays are thus used in conjunction with the analysis of physicochemical properties of the potential drug molecules, enabling an informed selection of drug development candidates before they enter clinical trials. By addressing both drug efficiency and drug safety, this modern practical reference shows how each individual aspect figures in shaping the key decisions on which the entire drug development process hinges. The result is a complete toolbox for assessing the risk/benefit ratio for any novel compound, using both in vitro and in silico methods. Following a brief introduction to the necessities of filtering and risk assessment, the two equally important aspects of pharmacological (ADME) and safety (toxicity) profiling are covered in separate parts. The whole of the fourth and final part is devoted to organ-specific toxicity assays for the liver, heart, kidney and blood, as well as profiling for autoimmune reactions. Invaluable know-how for every medicinal chemist and drug developer.

Chemokine Receptors as Drug Targets Prediction and Prevention of Drug Side Effects

Hit and Lead Profiling

Laszlo Urban is global head of Preclinical Safety Profiling at the Novartis Institutes for Biomedical Research (NIBR), Cambridge, MA, and previously was the Deputy Head of the Novartis Institute for Medical Sciences in London, UK. He received his MD and PhD in neurophysiology/neuropharmacology in Hungary, and was visiting professor at Duke University between 1987-1989. He joined the Sandoz Institute for Medical Research, London, in 1990, where he was head of pharmacology. Dr. Urban has published over 130 scientific articles, book chapters and patents and has served on the editorial board of several journals, while also serving as President of the European Neuropeptide Club, between 1999 and 2001.

Methods and Principles in Medicinal Chemistry

Edited by Martine J. Smit, Sergio A. Lira and Rob Leurs

Vol. I

Martine J. Smit, Free University of Amsterdam, The Netherlands, Editor; Sergio A. Lira, Mount Sinai School of Medicine, New York, USA, Editor; Rob Leurs, Free University of Amsterdam, The Netherlands, Editor; Raimund Mannhold, University of Düsseldorf, Germany, Series Editor; Hugo Kubinyi, University of Heidelberg, Germany, Series Editor; Gerd Folkers, Swiss Institute of Technology (ETH), Zürich, Switzerland, Series Editor Bernard Faller is currently director in the Metabolism and Pharmacokinetics department at NIBR, Basel, Switzerland. He graduated as a biochemist from the University of Strasbourg, France, where he obtained his PhD in 1991. He then started at Ciba-Geigy as a post-doctoral fellow, becoming head of laboratory in 1995. In 1999 he moved to central technologies and established the foundations of the Novartis biopharmaceutical profiling group that addresses early ADME properties in drug discovery, and two years later became technology program head for physicochemical profiling in the Preclinical Compound Profiling Unit. In 2007 Dr. Faller was named “Hero of Chemistry” by the ACS for the discovery of Exjade , the first orally-active iron chelator for the treatment of transfusional iron overload.

43

Faller · Urban

Chemokine Receptors as Drug Targets

Volume 46 Series Editors: R. Mannhold, H. Kubinyi, G. Folkers

ISBN: 978-0-470-40472-0 | Cloth 850 pages | 2011 £66.95 / €83.90 / USD $99.95

This easy-to-use, single volume textbook includes broad coverage of all topics relevant to the subject, including the structure, reactivity, and synthesis of organic compounds. With useful reviews of fundamental concepts in relevant appendices and examples that clearly illustrate general concepts, the text is supplemented with a solutions manual for adopting professors as well as additional content on the web for students such as downloadable files and helpful study flash cards.

Auf Fischzug nach deutschen Titeln

?

ISBN 978-3-527-32331-9

www.wiley-vch.de

9 783527 323319

ISBN: 978-3-527-32118-6 | Cloth 384 pages | 2010 £130.00 / €139.00 / USD $195.00

Written by a team of authors from academia and several large pharma companies, this first book on the topic systematically surveys drug development efforts based on chemokine signaling for HIV/AIDS, cancer, neural and autoimmune disorders. Part of the Methods and Principles in Medicinal Chemistry Series.

...die finden Sie unter: www.wiley-vch.de/home/chemie www.wiley-vch.de/lbk/chemiebio www.wiley-vch.de/lbk/physik

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Classics in Total Synthesis III K. C. Nicolaou, Jason S. Chen; both of The Scripps Research Institute, La Jolla, USA ISBN: 978-3-527-32958-8 | Cloth 650 pages | 2011 £110.00 / €129.00 / USD $160.00

Classics in Total Synthesis III K. C. Nicolaou, Jason S. Chen

Understanding Bioanalytical Chemistry

Principles and Applications Victor Gault, Neville McClenaghan;

both of School of Biomedical Sciences, University of Ulster, UK

ISBN: 978-3-527-32957-1 | Paperback 650 pages | 2011 £70.00 / €79.00 / USD $99.95

ISBN: 978-0-470-02906-0 | Cloth 304 pages | 2009 £90.00 / €112.00 / $169.00

Using his didactically skillful approach, K.C. Nicolaou compiles and contrasts the important synthetic methods that lead to a complex molecule with valuable properties. All the key steps of the synthetic pathway are explained, with major developments highlighted in blue boxes.

ISBN: 978-0-470-02907-7 | Paperback 304 pages | 2009 £29.95 / €36.90 / USD $69.95

Carbon-Centered Free Radicals and Radical Cations

Structure, Reactivity, and Dynamics

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:8I9FE$:<EK<I<; =I<<I8;@:8CJ 8E; I8;@:8C :8K@FEJ JKIL:KLI<#I<8:K@M@KP# 8E; ;PE8D@:J

Malcolm D. E. Forbes, Editor

Malcolm D. Forbes, Editor

Wiley Series of Reactive Intermediates in Chemistry and Biology.

Ke-Li Han, Guang-Jiu Zhao; both of the Dalian Institute of Chemical Physics ISBN: 978-0-470-66677-7 | Cloth 1072 pages | 2011 £245.00 / €365.00 / USD $395.00

Hydrogen Bonding and Transfer in the Excited State Ke-Li Han, Guang-Jiu Zhao

Hydrogen Bonding and Transfer in the Excited State is an essential overview of this increasingly important field of study. Both the experimental and theoretical investigations on the excited-state hydrogen bonding structures and dynamics of many organic and biological chromophores are discussed, along with the influences of the excited-state hydrogen bonding on various photophysical processes and photochemical reactions. Experimental and theoretical studies on the nature and control of excited-state hydrogen transfer in various systems are also explored.

Chemistry, Health, and Environment Olov Sterner Second, Completely Revised Edition

Second, Completely Revised Edition

The text is aimed at a wide audience ranging from pharmacologists to environmental chemists and toxicologists.

Olov Sterner, Lund University, Sweden

Olov Sterner is Head of the Division of Organic Chemistry as well as of the Department of Chemistry at Lund University in Sweden. Originally an organic chemist he became interested in bioactive natural products and has conducted research aiming at the isolation, characterization, synthesis, and QSAR studies of secondary metabolites from plants and fungi. Professor Sterner has published more than 330 research papers, 20 conference papers, 120 conference abstracts and 20 patents.

ISBN: 978-3-527-32582-5 | Cloth 413 pages | April 2010 £70.00 / €79.90 / USD $124.95

Chemistry, Health, and Environment

The only comprehensive review to cover carbon-centered radical intermediates and their role(s) in chemistry and biochemistry, this book provides detailed explanations of the role of these intermediates in organic reactions and detailed discussions of their versatility with respect to functional groups. Chapters address a broad range of topics, including synthesis and stereochemistry, structure and mechanism, spectroscopy and dynamics, free radicals in donoracceptor chemistry, and polymers.

This second edition of a successful title bridging toxicology and environmental chemistry adopts a unique approach that ‘follows’ chemicals on a molecular level, from the environment through the different uptake mechanisms into the body, to the toxic effect. Along the way, this textbook explains the different routes of degradation and metabolism of the different classes of chemicals, linking general chemical properties to their toxicological equivalents. All the chapters have been thoroughly updated and the contents significantly expanded, including for example new chapters on pesticides, food chemicals and pharmaceuticals, as well as sections discussing endocrine disruptors and carcinogenicity assays.

Olov Sterner

Chemistry, Health and Environment

ISBN: 978-0-470-39009-2 | Cloth 370 pages | 2010 £83.50 / €105.00 / USD $125.00

Hydrogen Bonding and Transfer in the Excited State

A novel teaching and learning resource for tutors and students of first year undergraduate chemistry, this textbook describes basic principles, terminology and core technologies, which include modern experimental techniques and equipment used to analyze important biomolecules in diagnostic, industrial and research laboratory settings. Clearly written and user-friendly, it also provides an introduction to advanced technologies used in the emerging fields of genomics, peptidomics/proteomics and metabolomics.

www.wiley.com/wiley-blackwell

This second edition explains the relationship between chemical properties of environmental compounds and their metabolism and toxicological effects in man on a molecular level. A must-have for toxicologists, environmental chemists, pharmacologists and organic chemists.

Encyclopedia of Marine Natural Products Three-Volume Set Jean-Michel Kornprobst ISBN: 978-3-527-32703-4 | Cloth 1680 pages | April 2010 £510.00 / €599.00 / USD 810.00

This exhaustive listing of almost all marine natural products known to date adopts a unique approach in its classification of the compounds by biological species. It also provides background information on the respective species, based on the biological classification of the organisms from which these compounds are derived. The treatise covers more than 8,700 formula, 14,000 references, and 650 websites on almost 1700 pages.

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Drug Disposition and Pharmacokinetics

Drug Disposition and Pharmacokinetics from Principles to Applications

From Principles to Applications

Essential Biochemistry for Medicine Mitchell Fry, University of Leeds, UK

Stephen H. Curry Robin Whelpton

Stephen H. Curry, University of Rochester; Robin Whelpton, Queen Mary University, London, UK

ISBN: 978-0-470-68446-7 | Cloth 392 pages | October 2010 £45.00 / €55.90 / USD $79.95

Written by two experienced authors with a proven track record in research, teaching and industry, this new titles provides a vigorous, balanced account of the processes underlying drug disposition and the practical uses of pharmacokinetic derivations. The text is generously illustrated with examples, tables and figures throughout and a dedicated website with additional illustrations, further equations and numerous worked examples is available.

Functional Biochemistry in Health and Disease Eric Newsholme, University of Oxford, UK; Tony Leech, Gresham’s School, Norfolk, UK ISBN: 978-0-471-98820-5 | Cloth 560 pages | 2010 £95.00 / €119.00 / USD $190.00 ISBN: 978-0-471-93165-2 | Paperback 560 pages | 2010 £37.50 / €46.90 / USD $75.00

This book provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings. Focusing on the dynamic aspects of biochemistry and its application to the basic functions of the body, this text bridges the gap between biochemistry and medical practice.

Essential Biochemistry for Medicine Mitchell Fry

ISBN: 978-0-470-74328-7 | Cloth 328 pages | 2010 £60.00 / €73.90 / USD $109.95 ISBN: 978-0-470-74327-0 | Paperback 328 pages | 2010 £19.99 / €24.90 / USD $39.95

This text is a concise, accessible guide that will help first year students gain a good basic understanding of the biochemistry behind common medical disorders. It integrates biochemistry with clinical applications and the understanding of the etiology of diseases, their diagnosis and treatment. Each chapter includes a concise and simple introduction to the relevant biochemistry and terminology to reinforce what biomedical students have covered, orientate them and encourage them to consider the medical context; whilst at the same time outlining the biochemistry in a simple, ‘must know’ format, for medical students before directing them to the all important clinical considerations.

Encyclopedia of Industrial Biotechnology

Bioprocess, Bioseparation, and Cell Technology Seven-Volume Set Michael C. Flickinger, North Carolina State

VOLUME 3

ENCYCLOPEDIA OF

INDUSTRIAL BIOTECHNOLOGY

BIOPROCESS, BIOSEPARATION, AND CELL TECHNOLOGY

University, Raleigh, USA, Editor

MICHAEL C. FLICKINGER, editor

ISBN: 978-0-471-79930-6 | Cloth 5248 pages | 2010 £1633.00 / €2300.00 / USD $2800.00

Combining Wiley’s acclaimed Encyclopedia of Bioprocess Technology and the Encyclopedia of Cell Technology to create a single resource and gateway to the many areas of industrial biotechnology, the new Encyclopedia of Industrial Biotechnology has been revised, updated and greatly expanded to cover important areas of pharmaceutical and biologics bioprocess technology. Its A-to-Z organization, coupled with its extensive index, makes it easy for readers to find the articles they need and discover the current state of the technology.

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