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Principles of Biochemistry

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4th Edition DONALD VOET, University of Pennsylvania, CHARLOTTE W. PRATT, Seattle, Washington, JUDITH G. VOET, Swarthmore College, USA

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Contents: PART I: INTRODUCTION: Introduction to the Chemistry of Life; Water; PART II: BIOMOLECULES: Nucleotides, Nucleic Acids, and Genetic Information; Amino Acids; Proteins: Primary Structure; Proteins: Three-Dimensional Structure; Protein Function: Myoglobin and Hemoglobin, Muscle Contraction, and Antibodies; Carbohydrates; Lipids and Biological Membranes; Membrane Transport; Enzyme Kinetics, Inhibition, and Control; Biochemical Signaling; PART IV: METABOLISM: 14 Introduction to Metabolism; Glucose Catabolism; Glycogen Metabolism and Gluconeogenesis; Citric Acid Cycle; Electron Transport and Oxidative Phosphorylation; Photosynthesis; Lipid Metabolism; Amino Acid Metabolism; Mammalian Fuel Metabolism: Integration and Regulation; PART V: GENE EXPRESSION AND REPLICATION: Nucleotide Metabolism; Nucleic Acid Structure; DNA Replication, Repair, and Recombination; Transcription and RNA Processing; Protein Synthesis; Regulation of Gene Expression. 978-1-1180-9244-6 • Paperback 1200 pages • April 2012 £49.99 / €60.00 Also available as an eBook, for Desktop, Laptop and iPad. 25% discount off the physical book price for students at: www.wiley.com/college/voet

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Principles of Biochemistry addresses the enormous advances in biochemistry, particularly in the areas of structural biology and bioinformatics by providing a solid biochemical foundation that is rooted in chemistry to prepare students for the scientific challenges of the future. While continuing in its tradition of presenting coverage that is clearly written, Principles of Biochemistry 4th Edition includes new pedagogy and enhanced visuals that provide a pathway for student learning. New to this edition: • Key Concepts provides the framework for true understanding by better defining important concepts • 280 NEW end of chapter problems • Each chapter also includes a new category of question entitled More to Explore which may ask students to extend the material they’ve learned or ask that they apply the chapter’s content to other topics • Process Diagrams: These illustrations highlight important concepts and integrate descriptive text into the figure, appealing to visual learners WileyPLUS, accompanied with Principles of Biochemistry, provides an innovative, research-based online environment for effective teaching and learning. • Complete online version of Principles of Biochemistry, 4th Edition • Interactive Exercises from the text allow students to manipulate them and answer questions based on their experiences. • Animated Figures from the text, illustrating concepts, techniques, and processes, are brought to life through brief animations • Interactive PowerPoints www.wileyplus.com

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Biochemistry 4th Edition DONALD VOET and JUDY VOET, University of Pennsylvania, USA

Biochemistry, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. The text incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge. As in past editions, the chemical basis of modern Biochemistry is presented in a thorough and uncompromising fashion. Don and Judy Voet are scholars and teachers who have dedicated their careers to their students and this text. The text includes a splendid art program of over 3000 figures presents both classical and contemporary concepts, experiments, and techniques. New to this edition: • New and updated protein and nucleic acid structures • New methods of protein structure prediction and design • Next generation DNA sequencing technologies

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“If you’re serious about biochemistry you need this book” *Review from Amazon

Also available as an eBook, for Desktop, Laptop and iPad. 25% discount off the physical book price for students at: www.wiley.com/college/voet

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Contents: PART 1: Introduction and Background: Life; Aqueous Solutions; Thermodynamic Principles: A Review. PART II: BIOMOLECULES: Amino Acids; Nucleic Acids, Gene Expression, and Recombinant DNA technology; Techniques of Protein and Nucleic Acid Purification; Covalent Structures of Proteins and Nucleic Acids; Three-Dimensional Structures of Proteins; Protein Folding, Dynamics, and Structural Evolution; Hemoglobin: Protein Function in Microcosm; Sugars and Polysaccharides; Lipids and Membranes. PART III: MECHANISMS OF ENZYME ACTION: Introduction to Enzymes; Rates of Enzymatic Reactions; Enzymatic Catalysis. PART IV: METABOLISM: Introduction to Metabolism; Glycolysis; Glycogen Metabolism; Signal Transduction; Transport Through Membranes; Citric Acid Cycle; Electron Transport and Oxidative Phosphorylation; Other Pathways of Carbohydrate Metabolism; Photosynthesis; Lipid Metabolism; Amino Acid Metabolism; Energy Metabolism: Integration and Organ Specializatiom; Nucleotide Metabolism. PART V: EXPRESSION AND TRANSMISSION OF GENETIC INFORMATION: Nucleic Acid Structures; DNA Replication, Repair, and Recombination; Transcription; Translation; Viruses: Paradigms for Cellular Function; Eukaryotic Gene Expression; Molecular Physiology. 978-0-470-57095-1 • 1408 pages November 2010 •£49.99 / €60.00

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Textbook of Biochemistry with Clinical Correlations 7th Edition THOMAS M. DEVLIN, Drexel University School of Medicine , USA

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Contents: PART I: STRUCTURE OF MACROMOLECULES: Eukaryotic Cell Structure; DNA and RNA: Composition and Structure; Proteins I: Composition and Structure; PART II: TRANSMISSION OF INFORMATION: DNA Replication, Recombination, and Repair; RNA: Transcription and RNA Processing; Protein Synthesis: Translation and Posttranslational Modifications; Recombinant DNA and Biotechnology; Regulation of Gene Expression; PART III: FUNCTIONS OF PROTEINS: Proteins II: StructureFunction Relationships in Protein Families; Enzymes: Classification, Kinetics, and Control; The Cytochromes P450 and Nitric Oxide Synthases; Biological Membranes: Structure, Receptors, and Solute Transport Fundamentals of Signal Transduction; PART IV: METABOLIC PATHWAYS AND THEIR CONTROL: Bioenergetics, Mitochondria, and Oxidative Metabolism; Carbohydrate Metabolism I: Major Metabolic Pathways and Their Control; Carbohydrate Metabolism II: Special Pathways and Glycoconjugates; Lipid Metabolism I: Synthesis, Storage, and Utilization of Fatty Acids and Triacylglycerols; Lipid Metabolism II: Pathways of Metabolism of Special Lipids; Amino Acid and Heme Metabolism; Purine and Pyrimidine Nucleotide Metabolism; Metabolic Interrelationships; Biochemistry of Hormones; PART V: PHYSIOLOGICAL PROCESSES: Molecular Cell Biology; Cell Cycle, Programmed Cell Death and Cancer; Digestion and Absorption of Basic Nutritional Constituents; Vitamins and Minerals: Requirements and Function; Macronutrients: Metabolic Effects and Health Implications; Appendix: Review of Organic Chemistry Glossary; Index.

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This text presents a clear and precise discussion of the biochemistry of eukaryotic cells, particularly those of mammalian tissues, relates biochemical events at a cellular level to the subsequent physiological processes in the whole animal, and cites examples of abnormal biochemical processes in human disease.  The organization and content are tied together to provide students with the complete picture of biochemistry and how it relates to human diseases. Each chapter has been updated with latest information and correlations. Features: • Contains multiple choice questions at the end of each chapter to test knowledge of the topic  • Includes a concise appendix reviewing important organic chemistry concepts • Includes a glossary of important terms • Contains detailed, full-color illustrations that clearly explain the associated concepts • Contains pertinent biochemical abbrevations and normal clinical laboratory values for blood and urine 978-0-470-28173-4 • January 2010 Hardcover • 1240pp • £49.99 / €60.00 Also available as an eBook, for Desktop, Laptop and iPad. 25% discount off the physical book price for students at: www.wiley.com/college/devlin

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Functional Biochemistry in Health and Disease ERIC NEWSHOLME, Retired from University of Oxford and ANTHONY LEECH, Gresham’s School, UK

This textbook provides a clear and straightforward account of the biochemistry that is necessary to understand the physiological functions of tissues or organs essential to the life of human beings. Focusing on the dynamic aspects of biochemistry and its application to the basic functions of the body, the book bridges the gap between biochemistry and medical practice. By linking biochemistry, medical education and clinical practice this book will prove invaluable to students in medical and health sciences, biomedical science and human biology taking an introductory biochemistry course. In addition it will appeal to biochemistry and biology students interested in clinical applications of biochemistry. Features: • Focuses on medically relevant aspects of biochemistry written from a physiological rather than a chemical perspective • Clear presentation that minimises the use of jargon • Each chapter contains boxes on related topics, relevant diagrams and a brief glossary • Coverage includes athletic performance, apoptosis and the immune system • Key historical developments are included to show how modern biochemistry has evolved

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Contents: Preface; Abbreviations; I INTRODUCTION: The Structural and Biochemical Hierarchy of a Cell and a Human; II ESSENTIAL TOPICS IN DYNAMIC BIOCHEMISTRY; Energy: In the Body, Tissues and Biochemical Processes; Enzymes: Activities, Properties, Regulation and Physiology; Transport into the Body: The Gastrointestinal Tract, Digestion and Absorption; Transport into the Cell: Particles, Molecules and Ions; III ESSENTIAL METABOLISM: Carbohydrate Metabolism; Fat Metabolism; Amino Acid and Protein Metabolism; Oxidation of Fuels and ATP Generation: Physiological and Clinical Importance; Metabolism of Ammonia and Nucleic Acids; Synthesis of Fatty Acids, Triacylglycerol, Phospholipids and Fatty Messengers: The Roles of Polyunsaturated Fatty Acids; Hormones: From Action in the Cell to Function in the Body; IV ESSENTIAL PROCESSES OF LIFE: Physical Activity: In Non-Athletes, Athletes and Patients; Mental Activity and Mental Illness; Nutrition: Biochemistry, Physiology and Pathology; Starvation: Metabolic Changes, Survival and Death; Defence Against Pathogens: Barriers, Enzymes and the Immune System; Survival after Trauma: Metabolic Changes and Response of the Immune System; Sexual Reproduction; Growth and Death of Cells and Humans: The Cell Cycle, Apoptosis and Necrosis; V SERIOUS DISEASES. Cancer: Genes, Cachexia and Death; Atherosclerosis, Hypertension and Heart Attack; Index. 978-0-471-93165-2 • Paperback 560 pages • 2010 • £39.95 / €48.00

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Biochemistry for Sport and Exercise Metabolism DONALD MACLAREN and JAMES MORTON, Liverpool John Moores University, UK

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Contents: One: Basic Muscle Physiology and Energetics; Energy sources for muscular activity; Skeletal muscle structure and function; Biochemical concepts; Two: Fundamentals of Sport and Exercise Biochemistry; Proteins; Carbohydrates; Lipids; Three: Metabolic Regulation in Sport and Exercise; Principles of metabolic regulation; High-intensity exercise; Endurance exercise; Highintensity intermittent exercise; References and suggested readings; Index 978-0-470-09185-2 • Paperback 264 pages • December 2011 £29.95 / €36.00

How do our muscles produce energy for exercise and what are the underlying biochemical principles involved? These are questions that students need to be able to answer when studying for a number of sport related degrees. This can prove to be a difficult task for those with a relatively limited scientific background. Biochemistry for Sport and Exercise Metabolism addresses this problem by placing the primary emphasis on sport, and describing the relevant biochemistry within this context. Biochemistry for Sport and Exercise Metabolism will prove invaluable to students across a range of sportrelated courses, who need to get to grips with how exercise mode, intensity, duration, training status and nutritional status can all affect the regulation of energy producing pathways and, more important, apply this understanding to develop training and nutrition programmes to maximise athletic performance. Features: • A clearly written, well presented introduction to the biochemistry of muscle metabolism • Focuses on sport to describe the relevant biochemistry within this context • In full colour throughout, it includes numerous illustrations, together with learning objectives and key points to reinforce learning

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Essential Physiological Biochemistry An Organ-Based Approach STEPHEN REED, University of Westminster, UK

This text provides a fresh, accessible introduction to human metabolism that shows how the physiological actions of selected organs can be explained by their particular biochemical processes.  Focusing on metabolic integration, rather than pathways, this book opens with three introductory chapters that explore the principles of metabolism and its control before moving onto ‘themed’ chapters that investigate liver, communication systems (endocrine and neurological), blood and vascular system, muscle and adipose tissue and renal biochemistry.  Targeted at non-biochemistry majors who need to get to grips with key biochemical concepts and ideas, this textbook is an essential guide for all undergraduate biomedical science, sports science, nutrition and other allied health students. 

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Contents: Preface; Introduction to metabolism; Dynamic and quantitative aspects of metabolism: bioenergetics and enzyme kinetics; Principles of metabolic control: enzymes, substrates, inhibitors and genes; Biochemistry of intercellular communication; metabolic integration and coordination; Biochemistry of the blood and the vascular system; Biochemistry of the liver; Biochemistry of muscle; Biochemistry of the kidneys; Biochemistry of connective tissue: bone and adipose; Appendix 1 Answers to problems; Appendix 2 Table of important metabolic pathways; Index. 978-0-470-02636-6 • Paperback 342 pages • November 2009 £29.95 / €36.00

Features: • Assumes only a basic understanding of chemistry • Chapters are arranged specifically to enable students to grasp key concepts and to aid understanding • Some chapters include Case Notes, illustrating key aspects of metabolism in cells, tissues and organs

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Essential Biochemistry for Medicine Mitchell Fry, University of Leeds, UK

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Received a highly commended award at the BMA Medical Book Awards Ceremony in 2011 BMA - British Medical Association

Contents: Preface; Nutritional requirements; Metabolism and energy; Regulating body weight; Digestion and absorption; Synthesis, mobilisation and transport of lipids and lipoproteins; Theliver; Alcohol metabolism and cirrhosis; Protein structures; Enzymes and diagnosis; The kidney; Haemostasis; Bone metabolism and calcium homeostasis; Intracellular signalling; Inflammation; The immune response; Mitochondrial dysfunction; Nerve and muscle systems; The cytoskeleton; Genes and medicine; Antibacterial drug resistance; Index. 978-0-470-74327-0 • Paperback 326 pages • October 2010 £21.50 / €25.80

Essential Biochemistry for Medicine is not intended to be an exhaustive, comprehensive reference; rather a concise, accessible guide that will help first year students, from a wide spectrum of backgrounds, gain a good basic understanding of the biochemistry behind common medical disorders. It integrates biochemistry with clinical applications and the understanding of the etiology of diseases, their diagnosis and treatment. Each chapter includes a concise and simple introduction to the relevant biochemistry and terminology to reinforce what biomedical students have covered, orientate them and encourage them to consider the medical context; whilst at the same time outlining the biochemistry in a simple, “must know” format, for medical students before directing them to the all important clinical considerations. Features: • A fully integrated approach to give students a basic understanding of the biochemistry behind common medical disorders • Concise, accessible and well-written with numerous clear illustrations in full colour throughout • Uses ‘FOCUS’ sections to expand on certain areas such as diabetes, HIV and obesity • Includes links and quick references for those wanting a broader knowledge of each topic

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Essential Biochemistry 2nd Edition CHARLOTTE W. PRATT, Seattle, Washington, KATHLEEN CORNELY, Providence College, USA

Essential Biochemistry describes the chemical basis of life by placing information about molecules in the appropriate biological context. Selective in its coverage, it emphasizes the topics that accurately reflect the current scope of the field. The material in this book, as well as the depth of coverage, has been chosen to reflect the following goals: • To understand the major themes of biochemistry • To apply biochemical knowledge in solving problems and evaluating related topics, and to appreciate the challenges and approaches of modern biochemistry

To further achieve these goals, the authors created more focused chapters and added a separate chapter on carbohydrate chemistry.

WileyPLUS, accompanied with Essential Biochemistry, provides an innovative, researchbased online environment for effective teaching and learning.

Contents: Part One: Molecular Structure and Function: The Chemical Basis of Life; Aqueous Chemistry; From Genes to Proteins; Protein Structure; Protein Function; How Enzymes Work; Enzyme Kinetics and Inhibition; Lipids and Membranes; Membrane Transport; Signaling; Carbohydrates; Part Two: Metabolic Reactions: Overview of Metabolism and Free Energy; Glucose Metabolism; The Citric Acid Cycle; Oxidative Phosphorylation; Photosynthesis; Lipid Metabolism; Nitrogen Metabolism; Regulation of Mammalian Fuel Metabolism; Part Three: Management of Genetic Information: DNA Replication and Repair; Transcription and RNA; Protein Synthesis; Glossary; Solutions; Index. 978-0-470-50477-2 • August 2010 Hardcover • 704 pages • £48.99 / €58.50

• Complete online version of Essential Biochemistry, 2nd Edition • Interactive Exercises from the text allow students to manipulate them and answer questions based on their experiences. • Animated Figures from the text, illustrating concepts, techniques, and processes, are brought to life through brief animations • Interactive PowerPoints www.wileyplus.com

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Also available as an eBook, for Desktop, Laptop and iPad. 25% discount off the physical book price for students at: www.wiley.com/college/pratt

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Pain-Free Biochemistry An Essential Guide for the Health Sciences PAUL ENGEL, University College Dublin, Ireland

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“It’s not every day that one picks up a textbook that can claim to occupy a unique niche, given the multitude of scientific textbooks that are vying for a medical readership. However, with the recent publication of ‘PainFree Biochemistry: An Essential Guide for the Health Sciences’, which is specifically aimed at students of medicine and nursing, one could be left wondering just why nobody thought of this sooner.” – Irish Medical Times, 2010

Accessible, enjoyable to read and packed with a wealth of clinical examples from heart disease to cancer and blood clotting to antibiotics, this essential textbook reveals how biochemistry is fundamental to clinical practice and everyday life. 978-0-470-06046-9 Paperback • 344 pages 2009 • £27.50 / €33.00

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Preface; SECTION 1 Foundations: Why biochemistry? Remarkableness of life; Chemistry I The basic structure of substances: atoms, molecules, elements and compounds; Chemistry II Atomic structure, valency and bonding; Chemistry III Protons, acids, bases, concentration and the pH scale; Shape, molecular recognition and proteins: an example; Proteins: molecular necklaces. Chemical transformations in the living organism: metabolism; Reactions, catalysts and enzymes.vi CONTENTS; Specificity, saturation and active sites; Structure of metabolism: anabolism and catabolism; Chemistry IV Equilibrium; Catabolism: degradation vs energy metabolism; Chemistry V Oxidation and reduction; Oxidation and reduction in metabolism; SECTION 2 Catabolism; Chemistry VI Aldehydes, ketones and sugars; Carbohydrates: sugars and polysaccharides in metabolism; Glucose inside the body; Breakdown of sugar: glycolysis; Aerobic oxidation of pyruvate: Krebs cycle; Respiratory chain, oxidative phosphorylation and overall ATP yields; Mobilising the carbohydrate store: glycogenolysis; Chemistry VII Alcohols, esters, glycerol, fatty acids and triglycerides; Chemistry VIII Hydrophobic, hydrophilic and amphiphilic; Phospholipids and membranes; Chemistry IX Saturated and unsaturated; Fats as an energy source; Fats: digestion, transport, storage and mobilisation; Fats: oxidation of fatty acids; Ketone bodies in health and disease; Dietary fat: essential fatty acids; Protein and amino acid breakdown; Shedding excess amino groups: urea cycle. SECTION 3 Anabolism and Control: Is anabolism just catabolism backwards? Making new glucose: gluconeogenesis; Fatty acid biosynthesis; Providing reducing power: NADPH and the pentose phosphate pathway; Chemistry X Isotopes; Red cells and white cells: defence against reactive oxygen and reactive oxygen as defence! ; The need for metabolic control; Relationship of fats and carbohydrates: use by different tissues; SECTION 4 Genes and Protein Synthesis: The idea of genes; The chemistry of genes: DNA and the double helix; The genetic code and mRNA; Protein synthesis, ribosomes and tRNA; Genetic differences and diseases; Genetic variability: drug metabolism and disease susceptibility; Mutation, radiation and ageing; Switching genes on and off: development, tissue specificity, adaptation and tolerance; DNA and protein synthesis as targets: chemotherapy, antibiotics, etc; SECTION 5 Physiological Systems and Clinical Issues: Hormones and second messengers; Switching enzymes on and off: coarse and fine control; Insulin, glucagon and adrenaline; Diabetes; Steroid hormones and receptors: fertility control, pregnancy testing, etc; Pituitary hormones and feedback loops; Thyroid hormones; Adrenal cortex; Prostaglandins and inflammation: aspirin; Membrane transport; Nerve and muscle; 52 pH homeostasis; Diagnostic markers: biochemical tests; Blood, bleeding and clotting; SECTION 6 Appendices; Glossary; MCQ answers. Index.

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of related interest...

Introduction to General, Organic, and Biochemistry

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10th Edition MORRIS HEIN, Mount San Antonio College, SCOTT PATTISON, Ball State University, SUSAN ARENA, University of Illinois, Urbana-Champaign, LEO R. BEST, Mount San Antonio College

Includes improved explanations, updated materials, cutting-edge developments, emerging technologies, and revisions to the popular Chemistry in Action sections. While the authors have revised and updated sections on inorganic and organic chemistry throughout the text, they particularly focused on incorporating many of the recent developments in biochemistry. Learn more and view online resources at: www.wiley.com/college/hein Also available as an eBook, for Desktop, Laptop and iPad. 25% discount off the physical book price for students at: www.wiley.com/college/hein

978-0-470-59880-1 • March 2011 Hardcover • 1184 pages Price on Request

Basic Bioscience Laboratory Techniques A Pocket Guide

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PHILIP BONNER and ALAN HARGREAVES

This unique, practical, pocket-sized guide and reference provides every first year bioscience student with all they need to know to prepare reagents correctly and perform fundamental laboratory techniques. It also helps them to analyse their data and present their findings, in addition to directing the reader, via a comprehensive list of references, to relevant further reading. All of the core bioscience laboratory techniques are covered. Learn more at www.wiley.com/college/bonner 978-0-470-74309-6 • 216pp • March 2011 • Pbk • £16.99 / €20.40

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