Bulletin Daily Paper 10-12-14

Page 30

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Vitamin D May Influence Disease Activity in Multiple Sclerosis

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Ellen M. Mowry, MD, and her colleagues studied 469 MS patients over five years. The patients had their blood levels of vitamin D measured at the beginning of the study, and they underwent periodic magnetic resonance imaging (MRI) scans to measure disease activity.

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People with lower vitamin D levels had more brain lesions and were more likely to have active MS. In the disease, the immune system attacks the myelin sheath that surrounds nerves.

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Reference: Mowry BM, Wauhant B, McCunoch CB, m al Vitamin D elatue pndicte new hndn magnetic nscnsnce imagiag activity in multiple eeieosie.dnasi ofNntndegy, 2012;72:234-240.

Rcfermcel Gorhsm BD, Gsrlend CP, Burgi AA, et at Lower ~ ecrum 25-hydroxyviaaain D conceananon is aamciatad with highcr risk of insulineetuirmg diaheter a nectcdease eonuoi ctudyDiuhemrogia2012i55l32243227.

compared with those who had levels of 17 ng/mL or less.

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People with vitamin D blood levels of 17 ng/mL or less — a serious deficiency — were 3.5 times more likely to develop type-1 diabetes. Similarly, those with blood levels between 17 and 23 ng/mL were twice as likely to develop type-1 diabetes. People in the study with blood levels of vitamin D above 40 ng/ mL had a 70 percent lower risk of developing type-1 diabetes,

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For each 10 ng/mL increase in vitamin D, people were 15 percent less likely to have new brain lesions, as well as a one-third lower risk of spots indicating an active disease process. In addition, each 10 ng/mL increase in vitamin D was associated with less disability.

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The subjects were compared with similar healthy subjects of the same sexy who had blood draws within the same time frame, were the same age, and had been in the military for the same length of time.

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Edward D. Gorham, PhD, of the Naval Health Research Center, San Diego, California, and his colleagues studied 1,000 military personnel whose blood was drawn between 2002 and 2008, and who later developed type-1 diabetes.

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In type-l, or insulin-dependent, diabetes, the body's immune system attacks and destroys the insulin-producing beta cells of thepancreas. Low vitamin D may be a predisposing factor.

In anew study,researchers at Johns Hopkins University, Baltimore, and the University of California, San Francisco, have found that patients' vitamin D levels are related to disease activity.

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Low Vitamin D May Be Factor in the Risk of Type-1 Diabetes

Studies have suggested that the risk of multiple sclerosis (MS) increases in populations living farther from the equatormeaning less year-round sun exposure and lower blood levels of vitamin D.

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