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Build No. 1

Science Port Holland JULY 2012

a magazine about creating Business / Science / Inspiration / Innovation



‘ Curiosity is the crux of innovation ’



Science Port Holland

“We need a transition in the energy sector, chemicals, agriculture, you name it. We need to go back to the basics in a number of ways.” “Know-how and talent have a strong magnetic function for even more know-how and talent.” “It’s not easy being God, you’re often faced with disappointments. When something occasionally works, however, being God feels good.” “An incubator for technical companies is definitely stimulating. A fresh look sometimes provides new insights. Also it’s a lively working environment.” …and so much more about developments in and around Science Port Holland in this issue of Let’s Build magazine.


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Helicopter view




by Science Port Holland managing director Willem Trommels. ‘This region has a unique combination of factors’

with former champion long track speed skating Ben van der Burg. ‘Curiosity is the crux of innovation’

of the actual developments between Rotterdam, Delft and Leiden. Let’s Build Science Port Holland


Five questions











Interview with Prof. Jan Rotmans PH.D. from DRIFT (Dutch Research Institute for Transitions). ‘We need fresh-viewers and cross-thinkers’

Photo spread of the beach animals from kinetic artist Theo Janssen. Creation, but with a twist

Interview with Director DSM Delft Frank Teeuwisse MSc. ‘Delft is a strong global brand. Use it!’

answered by entrepreneur Eline Mertens. From incubator to world leader

where there’s technology, there are gadgets. Ingenious ‘crystal balls’

with Prof. Bert Wolterbeek PH.D. (Technical University Delft) and Prof. Marion de Jong PH.D. (Erasmus University Medical Centre). New insights for cancer and heart diseases

with Jan van der Tempel PH.D. (founder and CEO of Ampelmann). ‘Boarding an offshore platform! A piece of cake?’

for professional IT-based water and climatological services and solutions Delft platform stimulates global innovation flow

about Science Port Holland


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Let’s Build Column

Realising a dream 4

Isn’t this a great time to work in this region? Especially now the strategy of the metropolitan regions is seen as the driving force that directs spatial and economic development.

We are presently well on our way to putting ourselves on the national and international map in terms of regional cooperation between educational establishments, the public sector and the corporate community. By combining expertise, finance and networks, we are developing a powerful presence at Science Port Holland (Delft – Rotterdam) in the very important fields of biobased economy, urban water management, energy and climate, and medical technology. Industrial biotechnology forms the basis for a biobased economy, which provides a sustainable solution as fossil fuels will inevitably run out. This region is amongst the world’s best in this area. With all the research and work carried out here in the field of urban water management, we are the world number one, alongside Singapore. The developments in medical technology also attract global attention, thanks to the combined technical expertise of the three universities of Leiden, Delft and Rotterdam and the two University Hospitals. In other words we have a large potential to be pioneers in these fields. Given the port and industrial complex of Rotterdam this region has a unique combination of factors seldom found anywhere in the world. An added advantage is that we have plenty of room for facilitating new industry here, whilst having the architectonic know-how required to develop attractive and inspiring campuses and science parks. Science Port Holland is therefore striving to make a good dream come true! Willem Trommels Managing Director Science Port Holland

Let’s Build a Coverstory


‘Curiosity is the crux of innovation’ Former long track speed skater Ben van deR Burg appreciates guts and a strong will

Let’s Build a Coverstory


Many people associate the word ‘innovation’ with new and exciting inventions, but innovation does not always require high-end technology. Think in terms of the upside-down ketchup bottle or a round rusk with a notch in it, to get it out the tin. Innovation is a broad concept - from paperclip to rocket. “It’s all about searching for solutions for the seemingly impossible.” He already did that back in his skating days, explains Ben van der Burg: “I used to lie in front of the television with a geometry setsquare to figure out the best angle to take a bend. How can I make the most of my technique? How do I skate most effectively? How to get a 100th of a second off my time? Those types of questions really kept me busy.” “I was mainly looking for process innovation. I was more conservative when it came to innovating equipment. Mind

you, one summer I went to Berlin with Ab Krook to test skates with ceramic tubes. They were a disaster. Ceramics scratches on the ice and for skaters that is the worst possible sound, because we associate it with having a burr on our edges.” Amazing change The speed skater – who was born in Schipluiden and won gold in the 1500 and 5000m during the Dutch National Distances Championships in 1990, gold at the National All-round Championships and silver medals in the World Cup and the World All-round Championships - is interested in product innovation rather than process innovation these days. “What used to be 20-80 is now 80-20. That’s quite a change in itself!”, he says smiling. He says he does not consider process innovation to be true innovation. Not that there’s anything wrong with it, because it can certainly make a differ-

ence. “My father used to grow Anthurium Lilies”, he says, “and he was always working on making his products better and more beautiful whilst using less energy. Difficult to achieve, but useful in every respect. I still think it’s a good example of why people should pay attention to process innovations.” Changing the world “Personally, I find changing the world more exciting than changing processes. It’s simply more interesting. If you work for the railways, for example, one of your main tasks is to make sure the trains run on time. If you fail, you need to ask yourself what can be done about it. I like that type of issue; finding solutions for problems that seem insurmountable at first. The crux of innovation is and always will be natural curiosity.” A very strong will and plenty of guts are also important if you want to get innovations off the ground. After all, the simple

Science Port Holland believes that vibrant communities foster the successful development of its innovation campuses. Therefore SPH is working together with the Clean Tech Delta and Medical Delta to create and strengthen the key elements of the innovation ecosystem.

‘Let’s pay attention to ridiculous ideas. Some have led to successful innovation’

fact that you have an innovative idea does not mean that you will receive support. Quite the contrary, he believes “In that sense, I love the story of the introduction of the Prius! Before it was marketed, a hybrid car was technically still impossible and nobody really wanted one. It is pretty obvious that most entrepreneurs would say ‘the business model is no good, I won’t touch it’. Logical enough, but Toyota went ahead anyway – against the flow. And I think that characterises a truly innovative company.” Own course He has two more examples to illustrate the need for innovators to set their own course and to believe in their ideas. When he first bought a mobile telephone with a built-in camera, he demonstrated the technical novelty to his friends and they thought it was ridiculous. They simply didn’t see the purpose. These days, a camera is a standard feature on a mobile. The police even has commer-

cials to encourage witnesses of crimes or accidents to use their mobile telephone to photograph such incidents. Van der Burg continues “Another nice example is the touchscreen. In 2006, Apple presented the iPod touch. Of course the device had been thoroughly tested beforehand and the tests showed that people did not like a touchscreen at all. Apple took no notice and continued anyway and we all know what happened next - iPhones and iPads are a fantastic success.” He is convinced that more could be done to stimulate innovation in the Netherlands. “We need more kids to go to the Technical University”, he says. “Parents also need to be aware of the importance of talented children studying the right subjects. My idea is forget the reasonable French or geography marks and pay attention to the subjects you’re really good at. Give children that opportunity.

You can turn a C into a C+ but never into an A, but you can turn a B or B+ into an A. We need people who are good at science or we’ll end up with even more economists and managers we don’t need.” Sticking your head above the parapet “All in all, innovative countries don’t exist but there are some innovative regions. We have Delft - Rotterdam and Eindhoven. Abroad, such regions include the Ruhr, the Po Valley, Shanghai, Singapore and above all Silicon Valley. We do our best here, but we’re not in the vanguard because our innovative culture can be improved. We tend to decapitate people when they put their heads above the parapet. That’s a crying shame when you are trying to achieve the seemingly impossible. A ‘don’t stand out’ mentality does not achieve progress. So I say Let’s pay attention to so called ridiculous ideas! Look what that did for Apple and Toyota…”


Let’s Build

Science Port Holland The concentration of educational establishments and knowledge-intensive companies in the Delft-Rotterdam region is increasingly facilitated through expansion of existing premises, new construction projects and merging of scattered locations. This process is further enhanced by the cooperation with Leiden in the Medical Delta. These pages give an idea of the main developments scheduled to take place from 2012 to 2013.

The Datacenter Group City: Delft Location: Technopolis Delft Completion: 15 Aug ‘12

Delft. The new office is an innovative sustainable development. When the building is finished, the main entrance of Deltares will be near tot the central roads of Technopolis Delft.

Dynamic Levees City: Delft Location: Technopolis Delft Completion: in the fall of 2012

Developed by cepezed projects as part of the Delft Engineering & Production building Applikon Biotechnology is a world leader in developing and supplying advanced bioreactor systems from laboratory scale to production scale. Applikon is an internationally operating company currently located in Schiedam. The headquarters as well as the R&D department will move to a new building at Technopolis.

dep-bio (Biotech multi-tenant building) City: Delft Location: Technopolis Delft, biotech campus


The Datacenter Group (TDCG) is developing a new datacenter in the Rotterdam-Delft region (together with Koninklijke BAM Groep). The unique cooling technology will make this company the most energy efficient datacenter of the Netherlands. TDCG is proving its technical leadership through application of this technology in a new center in one of the most technical and innovative regions of the Netherlands.

YES!Delft II City: Delft Location: Technopolis Delft Under development, completion date unknown Extension of the current incubator building ‘YES!Delft’ and the concept. This new construction project involves +/- 6,000 m2.

Deltares City: Delft Location: Technopolis Delft Completion: end of 2013 Deltares, world leader on research and development in the water sector, builds a new office on their plant. Deltares has decided to bring all their offices in Delft together at one location on Technopolis

Research institutes, private companies and local government are closely collaborating to realise a demonstration site for testing dynamic levees at Technopolis near the premises of the TU Delft and Deltares. Here innovative products can be tested on real scale and compared with other products.

Delft Biotech Campus City: Delft Location: DSM and Technopolis Delft Industrial biotechnology works to

Developed by cepezed projects as part of the Delft Engineering & Production building

develop eco-friendly and renewable sources to replace scarce fossil fuels. Industrial biotechnology is embedded in the DNA of Delft. Innovations by the Technical University of Delft and DSM have resulted in Delft still enjoying worldwide acclaim as the home of industrial biotechnology. In order to maintain and extend Delft’s strong foothold, various projects are under development at DSM and the Technopolis Delft site.

Dep–bio offers space for small and medium-sized companies in the field of industrial biotechnology and green chemistry. The building will be a unique combination of modular production facilities, laboratories and offices, with spaces ranging from 50 sqm to 5,000 sqm. The ground floor will be partly reserved for shared facilities to serve SME’s companies by reducing large investments in standard laboratory equipment such as autoclaves and labware washers. The building is specially developed for medium and small businesses in the biotech sector. To stimulate interaction and innovation there are shared facilities available.

Applikon Biotechnology City: Delft Location: Technopolis Delft, biotech campus Completion: starts August 2012, completion date September 2013

dep-bio (Biotech multi-tenant building)

TNW (Faculty of Applied Sciences) City: Delft Location: Technopolis Delft, biotech campus Completion: Construction starting date autumn of 2013, expected completion 2015 The university of Delft had decided to

Erasmus MC City: Rotterdam Location: Hoboken Completion: Construction of the 2nd phase of the Eastern building and tower will be completed in March 2012. Part of the Eastern building, including the pharmacy, is expected to be operational by the end of 2012.

develop a new building to house the Biotechnology, Chemical Engineering and Bio-Nanoscience departments of the faculty of Applied Sciences at the Biotech campus of Technopolis Delft. The plan includes approximately 30,000 m2 total floor area, divided into laboratories, research areas, offices and facility areas.

the highest point is 9 metres. The physical stacking of private and public functions makes this a unique concept in the Netherlands.

The Concept House Prototype project City: Rotterdam Location: RDM Campus Completion: 1st Concept House in March 2012

DSM Delft City: Delft Location: Biotech campus, DSM location The Delft location is to be developed into a business park for industrial and R&D activities in the field of Biotechnology and Life Sciences. External parties will be attracted to settle at the location, in order to reap the benefits of open innovation, to create extra employment, and to reinforce the DSM image as a Life Sciences company. DSM developments include amongst others expansion of the pilot facility (the Bioprocess Pilot Facility) in collaboration with Purac and the TU Delft a new yeast dryer.

The Rooftop park will be built on top of 25,000 m2 (large-scale) shops and parking garage. The park will offer a great variety of greenery and three themed gardens: a playground garden, neighbourhood garden and Mediterranean garden with Orangery (catering establishment). The park will be 1 kilometre long, 80 metres wide (80,000 m2) and

The currently fragmented buildings will be transformed into a more compact unit. The dynamics, the design of the public spaces (squares, boulevards and avenues) will then become a natural component of the surrounding city.

Rooftop park City: Rotterdam Location: Merwe-Vierhavens Completion: the Bigshops section (interior and leisure shops) were completed in 2011. The park mid-2013

9 The purpose of the Concept House Village is to create a test situation for sustainable housing concepts. Various prototype houses will be developed, built and tested for the Dutch residential market, and will be dismantled after a number of years. This will simulate the complete life-cycle of the housing. It will be an international example of experimentation and innovation in the construction chain, and of sustainable urban development.

Let’s Build Value

We need freshviewers and crossthinkers!


In the Delft-Rotterdam region, Science Port Holland is active on the development of five innovation campuses that offer space and facilities throughout the complete innovation chain of R&D, experimentation, demonstration up to full-scale deployment.

According to transition expert Jan Rotmans, we find ourselves not in an era of change but rather in a change of era: socially, culturally, economically and even physically. With at least another ten years of crisis ahead of us (in terms of finance, energy, resources and climate), Europe, and therefore also the Netherlands, will need clever innovation in order to survive.

Transition is necessary

According to Prof. Jan Rotmans PH.D., transitions rely on systems of mutually reinforcing innovations Rotmans is convinced that “very few people are aware of the depth of the system change which is underway. It is irreversible and extremely drastic. Modern history has known few such turning points up to now. This time around however, the switch is more radical than ever before. In the coming 50 years society will undergo more change than in the past 500 years. That’s gigantic!” Switching to sustainability He sums up examples of the modernday transformational movement. Within Europe, power is increasingly shifting from the national parliaments to Brussels. Globally speaking, the power is shifting towards the Far East, so this means a different approach is required in Europe. The vacuum between governments and the market obliges us to consider more intelligent forms of organisation. Fuels and resources are drying up quickly, so we must switch to sustainable production methods - the bio economy. Continuous upscaling in the private sector results in increased bureaucracy. Young people, who are already less sensitive to traditional, hierarchic structures, do not feel at home there. This is one of the reasons why our country has around 2.5 million independent professionals. This urge for increased flexibility is supported by technological developments which strongly enhance our organisational capacity. Consumer strength has been slow to take advantage of such technologies, but this will change very quickly from now on. “All these aspects are interactive”, explains Rotmans. “That scares people, because it is chaotic. Populist politicians use this to their advantage by preaching traditional values. To no avail. There is no way to stop this transformative change or to ban it from our society. What we need to ask ourselves is how we can deal with it most effectively. To do so we need to think out of the box.”

Transition is necessary “The Port of Rotterdam, once the largest container port in the world, has dropped out of the top 10 worldwide list and is now at no. 11. The Far East and China in particular have taken over the top positions. The top 20 now lists sixteen Asian ports. We will never again come first in terms of mass and volume. We can however innovate! We can make Rotterdam a bio-port, for example. Sustainability needs to become the principal focus in all our activities.” “But what of open coal-fired power plants? That is back to the past and we just can’t go there anymore! We would deplete our resources to feed our industrial production. That’s no longer an option. Biotechnology already offers good solutions and we need to concentrate on them. We need a transition in all energy sectors, chemicals, agriculture, you name it. We need to go back to basics in a number of ways, design smaller cycles and keep re-using resources, like cradle to cradle.” Sustainability factory In order to promote such initiatives, including the project to render the Kuip football stadium in Rotterdam sustainable, Rotmans acquires funds in the market from companies active in the field of sustainability. He is very successful in this, resulting in opening a sustainability factory in Dordrecht this summer. Dordrecht? Yes, because Dordrecht is also part of the Rotterdam – Delft – Leiden knowledge axis, according to Rotmans. “In Shanghai, they see the province of Zuid-Holland as one big city, you know.”

in due time. The dynamics of change in Asia have direct consequences for us, but we’ve yet to react. We’ve ground to a halt, and legislation does not help either. If the Dutch present plans for a sustainable floating city in China, the Chinese want to get started without delay. Here they would start by saying ‘Yes, but...’ and present a pile of permit application forms, even if the concepts have been well thought out and developed. We need to move on, or we’ll miss the boat.”

‘In Shanghai, they see the province of Zuid-Holland as one big city, you know.’ Facilitation of innovation According to Rotmans, the development of Science Port Holland can substantially contribute to the essential knowledge concentration necessary to get new directional ideas off the ground. “Room for innovation releases forces which then need to be facilitated. I can only hope they (and that includes the government) will have the courage to allow the area to develop quasi-spontaneously. A little chaos would be nice…” DRIFT (Dutch Research Institute for Transitions) is a research institute aimed at sustainable transitions. We conduct scientific research into the dynamics of social transitions and the mechanisms they trigger or indeed obstruct, in the process of arriving at a sustainable society.

“We must no longer exploit the earth, but must cooperate with it instead,” he explains. Industry is holding up the process in order to profit from their earlier investments where possible. In the end however, they will have no choice. The petrochemical industry which now still dominates in Rotterdam and Antwerp will disappear

DRIFT is also called in to apply the transition know-how to social issues, in order to define, influence or initiate required innovations. DRIFT was founded at the end of 2004, as part of the Erasmus University of Rotterdam (EUR). In 2011, it became an independent research institute of the EUR, attached to the main faculty of Social Sciences.


Let’s Build Inspiration


‘It’s not easy to be God; you’re often faced with disappointments. The few times when something does work, being God feels great.’ In his book De Grote Fantast (The Great Pretender), kinetic artist Theo Janssen explains his role as a creator of

Creation, but with a twist

new species of animals without any delusions of grandeur, despite what the first two sentences might suggest. They are not created from proteins like all other life on earth, but from PVC pipes – they are the Animari aka the ‘beach animals’. They can walk; they generate energy from wind; they have a ‘stomach’ made from PET

bottles capable of storing air at extremely high pressures; they are equipped with fins or paddles, and they are truly evolving to make them increasingly capable of withstanding Mother Nature. Jansen studied physics at the TU Delft and has been working on various subspecies of the Animari for more than twenty years, including the

Animaris Ordis Parvus, Rhinocerus Parvus and Siamesis. He hopes that mimicking Creation will enable us to learn more about how nature really works because you are faced with the same types of problems. The founding father dreams that one day herds of beach animals will roam the beaches…

Checkout the ‘TED talk’ of Theo Jansen

Photo Loek van der Klis

Let’s Build Results

‘Delft is a strong global brand. Use it!’ The Director of DSM in Delft, Frank Teeuwisse MSc, states that cooperation and innovation are needed in a biotechnical race against the clock


Fossil fuels are running out, we all know that. It is becoming increasingly urgent to develop alternative production methods. With the DSM Biotechnology Centre in Delft, DSM is at the forefront of developments in the field of white biotechnology. The DSM site is open to new companies offering related activities. The traditional chemical industry mainly works with processes based on fossil fuels, but that is not sustainable. White biotechnology (industrial-scale manufacture of products using microorganisms) uses renewable sources and contributes to a more efficient use of natural resources. It ensures cleaner processes, less waste, lower energy consumption and therefore a cleaner environment and a healthier climate.

DSM aims to use more and more vegetable resources. It already does so in the yeast extraction and antibiotics factories in Delft, which are among the world’s largest. Nature is one big chemical factory and DSM’s production methods use it on a large scale. Biotechnology is sexy “When Van Marken founded the factory in Delft more than 140 years ago, he could never have dreamed that biotechnology would become so sexy”, laughs DSM Director Frank Teeuwisse. “What we’re doing in Delft is the future. And we’re so good at it, that we can compete with the developments in this field in Asia. In fact, there is much more biotechnological activity in this region than most people would imagine.” Teeuwisse would like to see companies and knowledge institutes working

together more closely. He recognises a great potential there, which has been used inadequately so far. He knows that Delft is a strong global brand name within universities, research centres and knowledge companies all over the world. DSM in Delft certainly contributes to that with its pilot factories for fermentation and processing, and with the DSM Biotechnology Centre. Companies with related activities are welcome to cooperate. At Technopolis Delft for example, start-up companies are encouraged to develop their possibilities. New opportunities This redevelopment of the DSM site into a high-quality business park for white biotechnology has been stimulated by regional initiatives in this field, such as Science Port Holland. The result is a strong synergy, which could make Delft the centre of this discipline in the Neth-

Together with partners from industry, universities and Dutch government, Science Port Holland actively promotes the biobased cluster on the international fora. Goal is to attract foreign companies to work together, strengthen our cluster and eventually (re)locate their business to the region.

Biotechnology is


erlands or even Europe. Another positive aspect is the increasingly strong relationship between DSM and the Technical University of Delft. Teeuwisse continues “Our top scientists enjoy working together with the University and a number of them are also part-time professors there. The fundamental research in the field of biotechnology that is carried out there is complimentary to what we do here. That offers wonderful opportunities - just like the development of Science Port Holland offers new chances for cooperation with relevant companies” Within the larger scale of Science Port Holland, a small local knowledge axis could be created from Technopolis Delft via the University to the DSM site. “University cities such as Leiden and Eindhoven have achieved successes and educational institutes, the corporate community and local government in Delft must follow suit and join forces

and recognise their common interests”, Teeuwisse emphasises. “We find ourselves on the eve of a development they started a while back. If we tackle this situation together, we can mobilise fantastic forces.”

15 Royal DSM NV is a global science-based company active in health, nutrition and materials. By connecting its

Selling themes “Know-how and talent act as a strong magnet for even more know-how and talent. Therefore, Science Port Holland needs to sell themes rather than square metres of the business park. I’m certain that biotechnology should be one such theme, which is beneficial for us too. DSM is pleased to cooperate with Science Port Holland on how we may assist and strengthen each other. The message is to quit individual thinking, to increase visibility and attraction, and to enhance each other in every respect!”

unique competences in Life Sciences and Materials Sciences DSM is driving economic prosperity, environmental progress and social advances to create sustainable value for all stakeholders. DSM believes that sharing ideas and know-how can open up new avenues to innovation. Real breakthroughs can only be achieved by those able to see beyond the boundaries of their own expertise, discipline or group. The company is realising the DSM Biotechnology Center on a part of the site in Delft.

Let’s Build Future

From incubator to world leader The ambitions of technostarter Windchallenge

Technostarters are the future. Especially if there are other starters to spar with over their ingenious ideas and business issues, when they are given opportunities and can rely on the know-how of experienced, commercial technicians. That’s what it’s all about at YES!Delft; incubator for technical companies. We put five questions to entrepreneur Eline Mertens …

1. What is the core business of Windchallenge? ‘Wind energy in built-up areas. Since 2009, we’ve been working at developing an innovative small wind turbine: the Yournergy. This wind turbine weighs 10 kg, has a rotor diameter of 1.7 meters and was designed for installation on roofs or masts. It will allow companies and private persons to partially meet their own energy requirements.’

2. Do you have any direct competition?


“No, we’re on virgin territory here. The crux is the wind load. Current turbines withstand the wind, but this produces enormous forces on the construction. The Yournergy can rotate the blades to ensure the turbine is not subjected to such forces. It’s a very complicated concept that is not likely to be copied any time soon.”

3. Do you think it will change the world? “There is certainly a great deal of interest and the future is looking rosy. We use top-quality synthetic materials and pay a great deal of attention to the price/ performance ratio. A product is only as good as its weakest link. That’s why we have really taken the time to conduct all

the necessary research. Up until January of this year, we concentrated solely on the product without allowing ourselves to be distracted by investors or the media.”

4. Is it stimulating to be part of an incubator for technical companies? “Definitely, and probably even more so for recently graduated entrepreneurs. We already have some commercial experience and therefore required less feedback in that field. However, we do attend workshops and master classes on a regular basis and we make very grateful use of the coach that was offered via YES!Delft. A fresh look provides new insights at times. It’s also a lively and professional working environment.”

5. Where do you plan to be in five years time? “In the global top 3 of companies in the field of wind energy in built-up areas. If the Yournergy passes all the tests we plan to subject it to, this wind turbine can be marketed full on from early 2013. We will start with the commercial market, possibly followed by the private market. After that we will take it one step at a time. We have plenty of plans for development.”

Let’s Build Gadgets

Ingenious ‘crystal balls’

Where there’s technology, there are gadgets. Ingenious products which are fun for consumers or companies and which help to innovate markets. A successful gadget shows the direction in which a market is developing. A few outstanding examples from incubators YES!Delft and DNAMO Rotterdam…

Flux It is not a magician’s illusion or magic trick, but a prize winning concept by entrepreneur Flux: the Flux Chair. Simply fold what looks like a giant envelop of sustainable material into a design chair. Following the full-sized adult chair, Flux has now introduced a version for children. The Flux Junior. Easy to fold, easy to store away and also very sustainable. Very much a product of our times.

YUNO van Yummm! Concepts

Xpozer The latest form of wall decoration: a very clearly defined photo enlarged on thin plastic photo film with a unique tensioning system. Tensioning and changing the photos is child’s play, and the look is ultra-modern. The Xpozer tensioning system combines style with functionality. With an Xpozer PRO photographer, the optimum experience is guaranteed. Now also available via HEMA.

It’s time for healthy sweets! FreakyFruits (fruit sweets) and WackoWaves (vegetable crisps) are the healthy YUNO sweets and snacks products The basic ingredients are fruit, vegetables, protein and fibre. Less fat, less sugar, less calories but more nutritional value. YUNO is a trendsetter in healthy sweets. Available from Albert Heijn and several other supermarket chains.


deLight deLight extends our human imagination via augmented reality. Using mARk software, a 3D model, product or idea can be visualised in future situations. The applications are unlimited: from the design of a living room to understanding technical products. Car manufacturer BMW recognised the potential and has used the software to optimise the quality of the entertainment system in their cars.

NewCompliance The frequency of opening operating theatre doors is an important process indicator for the number of post-operative wound infections. The wireless ComSens OK (OT) door counter system registers, analyses and reports the number of door movements. This renders the hygiene and air quality controllable at all times. Patient safety through innovation.

Let’s Build Results

3 binding creates new insights and treatment for cancer and heart diseases

3BINDING realises strong cooperation between Rotterdam, Delft and Leiden. Founders Prof. Bert Wolterbeek Ph.D. and Prof. Marion de Jong Ph.D. talk about their success


The healthcare sector awaits the introduction of a number of innovations planned for 2014. Within the cluster Medical Delta, scientists, doctors and industry join forces to improve the diagnosis and treatment for oncology and cardiology patients worldwide. The 3BINDING project is quite unique in bringing these fields together. Bert Wolterbeek, sector head of Radiation and Isotopes for Health at the Technical University of Delft, explains how 3BINDING (a project for innovating nuclear diagnostics and therapy in healthcare) makes a difference. “Normally”, he says, “we all tend to work towards improvements within our own disciplines. The advantage of our approach is that the equipment developer learns what the doctor really wants. With everyone talking to everyone within this project, horizontally across the disciplines, we have been able to achieve better and efficient targets, and consequently more results.” Simultaneous breakthroughs The project is on the brink of achieving breakthroughs with improved radioac-

tive chemical tracers (radionuclides) that stick to cancer cells, inflammations, infarction tissue or other abnormalities of interest. They can then be seen outside the body with new imaging equipment that was also developed within this project. This equipment uses a popular combined detection method called PET/ SPECT and 3BINDING achieved an volumetric improvement factor in resolution of 25,000. Due to its complexity, a project like this can only by accomplished through a joint effort of leading global experts in their fields - and they are present within the Medical Delta. The researchers from the universities, medical centres and companies need to find solutions for many difficulties at the same time. For instance, not all tumour cells connect to the detection molecules in the same way, and during the production of the detection radionuclides unusable radionuclides also appear. When they are used in the body they need to become attached to the tumour and they may not get lost along the way. There is indeed a long list of issues and criteria.

Therapeutic treatment At the Nuclear Medicine Department of the Erasmus University MC in Rotterdam, a team carries out pre-clinical and clinical research into the possibilities of detection and where possible destruction of tumours. Marion de Jong explains: “We studied the properties of tumour cells and started with the so-called neuroendocrine tumours. We attack them with radioactive peptides (small proteins) via an injection into the bloodstream, so that the peptides can adhere to receptors (the antennae as it were) on the tumour cells. Here in Rotterdam, we successfully used the PET/SPECT machine, developed by Freek Beekman from Delft, to visualise tumours in test animals, for example.” “Once we had sorted the imaging side of things, including in patients at the clinic, we conducted a study to discover whether this principle could be used to develop a therapy for treating neuroendocrine tumours. The tumour cells are blasted from the inside out as it were, using radioactive particles. By now, we are treating eight patients a week with this method.”

Medical Delta is a successful cooperation with triple helix parties from Delft, Rotterdam and Leiden. In close cooperation with the Leiden Bioscience Park, West Holland Foreign Investment Agency and the Rotterdam Investment Agency, Science Port Holland contributes by developing and implementing a joint marketing and acquisition strategy.

‘This project can provide a very wide range of spin offs.’ Other tumours as well The next step will be to detect other types of tumours, to make them visible and then to destroy them. For prostate and breast cancer, the Delft-based radionuclides allow labelling of newly developed peptides, which means these types of tumours can be rendered visible and then treated. The imaging technology is already applied pre-clinically and clinically for these types of cancer. The scientists haven’t reached the therapeutic stage yet, but research is already underway to achieve that. Wolterbeek comments “We are able to detect the fatty cells that are deposited in the arteries in cases of atherosclerosis (a condition in which an artery wall thickens as a result of the accumulation of fatty materials such as cholesterol) at an early stage, and to treat them. That is the speciality of the University of Leiden. The 3BINDING project also includes the detection of infarction tissue and the possibility of making it functional again. The best thing about this type of research is that you are faced with issues that were initially outside your scope of attention

- Can we use the coupling of tracers and isotopes in MRI scans in the future? Can the methods developed be deployed for researching chemotherapy? And further down the line, is there any chance of cooperating with civil engineers to distil a method for visualising concrete rot? This project could provide an enormous range of spin-offs.”

CT and MRI are standard imaging techniques for anatomical scanning of brains, the heart, sites of inflammation, tumours etc. PET and/or SPECTimaging of the distribution of

Joint undertaking According to Wolterbeek and De Jong, regional cooperation such as the Medical Delta (Health science & technology) and initiatives such as Science Port Holland stimulate these types of projects. “They promote joint enterprise. It is also beneficial for participating commercial companies as they will continue to develop and market the obtained compounds and instrumentation.”

radioactive targeted molecules permits the visualization of brains, heart, tumours and other tissues of interest in a functional way: the physiological status quo (the functioning) of the tissue can be judged. 3BINDING focuses on the development of new and better targeted molecules, and new radionuclides of higher specific activity and of selected chemical and radiation properties, specifically developed for cardiologic and oncologic disorders. Furthermore, 3BINDING focuses on innovation in imaging instrumentation, by the development of a fused SPECT/ PET imaging approach.


All aboard!

Let’s Build Results

Boarding an offshore platform! A piece of cake? Founder Jan van der Tempel PH.D. on the rapid application of the Ampelmann by the offshore industry


Only a few years ago, it was still a risky business to get from a ship onto an

The maiden task for the first operational Ampelmann was to dismantle a gas plat-

The devices are manufactured in a factory at the Research Design & Manufacturing

offshore platform. Since 2008, it is as simple as crossing the road thanks to a device with an ingenious hydraulic frame mounted to ships to compensate for the swell of the sea - the Ampelmann.

form. A year later, in 2009, the device was used for the construction of an offshore platform. Since then business has boomed and by March of this year, nine Ampelmanns were operational and number 13 was completed in May. Van der Tempel expects to see twenty of his creations deployed at sea by the end of this year. “There is great demand for them”, he says. “At the end of February this year, the 100,000th transfer was made from an Ampelmann to a platform. It offers so many advantages for our clients.”

Campus in Rotterdam (RDM Campus). According to Van der Tempel that was a logical choice, because his company needs two things - open water and clever people. There is ample open water in Rotterdam, and Delft provides plenty of good graduates with the expertise his company requires. “However, we are also taking on people who already have experience in this sector.”

Ampelmann? Yes! The device used by platform personnel to board from ships once had a codename derived from the little red or green illuminated figure in traffic lights on pedestrian crossings in Berlin. Jan van der Tempel, founder and owner of Ampelmann BV explains. “In 2002, I was at a conference in the German capital, where I saw a construction intended to help people board wind turbines at sea. I didn’t like the design. I was sure I could do better. While talking about the idea over a beer in the evening, I decided it would be sensible to protect my secret idea with a codename. And I still use it now; but as the company name.” Flying start At that time, Van der Tempel worked at the TU Delft and he initiated the research required to build a prototype. It was an ideal environment for such an initiative because the cooperation between Delft University and companies such as Shell and Smit soon resulted in funding. In 2005, tests using scale models proved that Van der Tempel’s design was physically feasible. The government stepped in with further financing, which came from natural gas revenue amongst other sources. Three years later, the inventor of the Ampelmann was able to continue as an independent commercial enterprise. “A flying start, it couldn’t have been better.”

More effective and less expensive It is more effective and less expensive than previous methods. The Ampelmann compensates for the swell of the sea while people transfer from the ship to the platform or vice versa over a gangplank, and that means they can work for a much longer period of the year. “The weather has to be pretty bad to stop them now”, says Van der Tempel. “Furthermore, the ratio of working hours versus travelling time in a day has also been improved considerably by the Ampelmann. In the past, a great deal of time was wasted getting on and off drilling platforms via small boats or unwieldy constructions, and they were much more dependent on the vagaries of the weather. Economically speaking, this solution is very profitable and that has been recognised. Offshore is a traditionally conservative sector, but the Ampelmann has been received with open arms.”

Own personnel go along Ampelmann BV currently employs around a hundred people. They work in the offices in Delft, the factory in Rotterdam and on the water. Clients prefer to hire an Ampelmann rather than buy their own. Van der Tempel believes strongly in the importance of safety and effective use, and therefore the rental price includes operation by specially trained in-house personnel. So boarding an offshore platform is a piece of cake!

The Ampelmann system exists since 2008. The company has been established as a spin-off of the Delft University of Technology. This is one of the most innovative and leading technical universities in the world. Despite the young age of the company, the Ampelmann system already has operated in several jobs all over the world. The system effortlessly endured the harsh North Sea, but also coped with tough conditions in the seas surrounding Australia and Trinidad & Tobago. The system has 95% reliability during the entire year. This means that only 5% of the time, the system is unable to operate because of too high waves, storms or other severe adverse weather conditions.


‘A flying start, it couldn’t have been better’ A vibrant start-up community is essential for creating breakthrough innovations. The incubators on the innovation campuses, like Dnamo, YES!Delft and ErasmusMC Incubator, play an important role as breeding ground for over 100 hightech start-ups in the last five years.

Let’s Build Digital Delta

Delft platform stimulates global innovation flow


Sea levels are rising and ground levels are sinking, temperatures are on the up and so is the volume of rainfall. These are threatening developments which call for innovative solutions, sustainable cooperation and sharing of knowledge. The Digital Delta IT platform provides support by lowering thresholds for innovative companies in the water sector.

The corporate and public sectors are investing jointly in the platform initiated by TU Delft. This will give a strong impulse to economic growth, innovation and reinforcement of the Dutch water sector. It will help us realise and safeguard access to clean and fresh water in safe and liveable deltas of our world. Global position Climate change is a threat not only to the safety of the Netherlands but also to our competitive strength in the global economy. This platform reinforces our competitive position. The great know-how of the Dutch water sector puts it in an excellent international position to make such a platform a success. The globally increasing demand for water-related IT services is a natural follow-up.

Global online marketplace The Digital Delta is a global online marketplace for professional IT-based water and climatological services and solutions. Validated data, information, software and data processing facilities can be offered commercially or freely, within an open or secure environment. This allows companies and developers to focus on their core business and to give added value in combination with fellow companies and developers. The Digital Delta offers providers and clients of water management services a transparent and user-friendly entrance to the latest solutions. The bundling and online access to validated data and applications can considerably reduce purchasing and development costs. The innovation process is accelerated, allowing for quicker tackling of water and climate problems.

Science Port Holland is a regional development corporation founded in 2008 by three shareholders: the City of Delft, the City of Rotterdam and the Technical University of Delft. Its ambition is to offer technology companies an optimal investment climate, based on knowledge and open innovation, leading towards high impact technological breakthroughs and tangible solutions. The organisation is developing five innovation campuses and is actively working on strengthening the innovation infrastructure in the region. Science Port Holland focuses on the Biobased economy, Energy & Climate, Urban Water Management and Medical Technology. More information on

Colophon Editors

Digital Delta helps starters Disdrometrics is a spin-off from the TU Delft. This company develops and implements costefficient and robust rain meter systems. Disdrometers (drop sensors) register the acoustic impact and relate it to the drop size. Dangerous situations can arise during extreme rainfall, such as flooding of tunnels. By installing disdrometers near the tunnel and combining the data flows with a hydrological model for the specific tunnel, an alarm signal can be sent to the traffic control service before traffic problems occur. The Digital Delta provides techno-starters with data, removing the need for them to establish their own information chain and therefore allowing them to focus on their expertise.

Malou Spruit – Science Port Holland NV Chris van Voorden – Science Port Holland NV Job Nijs – Science Port Holland NV Roel Kamerling – Medical Delta Hetty van der Lecq – Technopolis Delft Annet van der Elst – Technopolis Delft Kim Meulenbroeks – Science Port Holland NV Allard de Wolf – Port of Rotterdam

Concept and Design Wijnand de Vries – Walvis & Mosmans

Text Hans Dalmeijer, Maxim Dalmeijer – De TekstGroep

Photography Mieke Meesen


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Let's Build Science Port Holland – issue 1  

A magazine about creating business, science, inspiration, innovation.

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