2005 Van Andel Research Institute Scientific Report

External Collaborators Eric Arnoys and John Ubels, Calvin College, Grand Rapids, Michigan Stephan Baldus, University of Cologne, Germany Lonson Barr, Marcos Dantus, and Matti Koeppel, Michigan State University, East Lansing Nadia Harbeck, Ludwig-Maximilians-Universität, Munich, Germany Christine Hughes and O. Orit Rosen, Harvard University, Cambridge, Massachusetts Sylvia Kachalsky, Linkagene, Lod, Israel Iafa Keydar, Tel Aviv University, Israel Stephen Krawetz, Wayne State University, Detroit, Michigan Ernst Lengyel, University of Chicago, Illinois Maria Roberts, National Cancer Institute, Frederick, Maryland Rulong Shen, Ohio State University, Columbus Ilan Tsarfaty, Tel Aviv University, Israel Recent Publications Kort, E.J., M.R. Moore, E.A. Hudson, B. Leeser, G.M. Yeruhalmi, R. Leibowitz-Amit, G. Tsarfaty, I. Tsarfaty, S. Moshkovitz, and J.H. Resau. In press. Use of organ explant and cell culture. In Mechanisms of Carcinogenesis, Hans Kaiser, ed. Dordrecht, The Netherlands: Kluwer Academic.

Lengyel, Ernst, Dieter Prechtel, James H. Resau, Katja Gauger, Anita Welk, Kristina Lindemann, Georgia Salanti, Thomas Richter, Beatrice Knudsen, George F. Vande Woude, and Nadia Harbeck.

2005. c-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu. International Journal of Cancer 113(4): 678–682.

Rozenblatt-Rosen, Orit, Christina M. Hughes, Suraj J. Nannepaga, Kalai Selvi Shanmugam, Terry D. Copeland, Tad Guszczynski, James H. Resau, and Matthew Meyerson. 2005. The parafibromin tumor suppressor protein is part of a human Paf1 complex. Molecular and Cellular Biology 25(2): 612–620.

Seals, Darren F., Eduardo F. Azucena, Jr., Ian Pass, Lia Tesfay, Rebecca Gordon, Melissa Woodrow, James H. Resau, and Sara A. Courtneidge. 2005. The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells. Cancer Cell 7(2): 155–165.

Akervall, Jan, Xiang Guo, Chao-Nan Qian, Jacqueline Schoumans, Brandon Leeser, Eric Kort, Andrew Cole, James Resau, Carol Bradford, Thomas Carey, Johan Wennerberg, Harald Anderson, Jan Tennvall, and Bin T. Teh. 2004. Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients.

Clinical Cancer Research 10(24): 8204–8213.

Birchenall-Roberts, Maria C., Tao Fu, Ok-sun Bang, Michael Dambach, James H. Resau, Cari L. Sadowski, Daniel C. Bertolette, Ho-Jae Lee, Seong-Jin Kim, and Francis W. Ruscetti. 2004.

Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. Journal of Biological Chemistry 279(24): 25605–25613.

Holmen, Sheri L., Troy A. Giambernardi, Cassandra R. Zylstra, Bree D. Buckner-Berghuis, James H. Resau, J. Fred Hess, Vaida Glatt, Mary L. Bouxsein, Minrong Ai, Matthew L. Warman, and Bart O. Williams. 2004. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. Journal of Bone and Mineral Research 19(12): 2033–2040.

Tan, Min-Han, Carl Morrison, Pengfei Wang, Ximing Yang, Carola J. Haven, Chun Zhang, Ping Zhao, Maria S. Tretiakova, Eeva Korpi-Hyovalti, John R. Burgess, Khee Chee Soo, Wei-Keat Cheah, Brian Cao, James Resau, Hans Morreau, and Bin Tean Teh. 2004. Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroid carcinoma. Clinical Cancer Research 10(19): 6629–663 40