R E S E A R C H IN FOCUS 12 YOUR UNIVERSITY | 2022/2023
Flagship Research Institutes Flagship Research Institutes: The key issues facing humanity are embedded within complex systems that cross the boundaries of academic disciplines. Our four research flagships, the Energy Institute, the Healthy Lifespan Institute, the Neuroscience Institute and the Institute for Sustainable Food, each focus on an era-defining challenge to change the world for the better. Find out more: sheffield.ac.uk/research/flagship-institutes
HEALTHY LIFESPAN INSTITUTE
Uncovering the link between heart disease and dementia The pioneering research that discovers how one disease is causing another.
he Healthy Lifespan Institute is investigating how age-related health conditions are connected and group together. Many diseases share the same root cause, so discovering the cause of multiple diseases, and how to treat it, can delay and prevent the onset of multimorbidity. New pioneering research by Dr Osman Shabir, a member of the Healthy Lifespan Institute and the Neuroscience Institute, has demonstrated that heart disease can directly cause brain dysfunction which can lead to dementia, and treble a key Alzheimer’s protein, much earlier than previously thought. The research has found that heart disease causes the breakdown of a key brain function which links brain activity and blood flow, meaning the brain gets less blood for the same amount of activity.