Marcus Institute For Brain Health Impact Report

A Transformative Partnership in Pursuit of a Shared Vision

MARCUS INSTITUTE FOR BRAIN HEALTH

IMPACT REPORT FALL 2018

Executive Summary The Marcus Institute for Brain Health (MIBH) is building strength in its capacity to care for military Veteran patients. MIBH has built a strong and diverse referral network and we have already treated over 100 Veterans and family members. The MIBH Intensive Outpatient Program (IOP) has a significantly positive impact on patients, and our one month follow-up studies show that improvement is being sustained. In the past six months, we have ramped up our efforts with complementary/integrative therapies including mindfulness training, creative arts therapy and canine therapy all of which our patients report as important elements of the treatment program.

This report highlights our Colonels Row Veteran Patient Housing project, our successful relationship with Warrior Canine Connection (WCC) to involve patients in training service dogs for Veterans, and our exciting partnership with Boot Campaign as part of its Health and Wellness Pipeline. Our collaborative efforts are paying dividends and our advocacy work is promising.

We are working within our budget and again expect a year end carryover into the next calendar year. We remain focused on the long-term sustainability of the Marcus Institute for Brain Health by building revenues, increasing staff capacity, and locating space for the future.

In addition to the excellent clinical care our team provides, they have been very productive in scholarship and education, with a growing influence on the nation’s scientific and academic scene. Building on these accomplishments, MIBH is poised to disseminate its ‘lessons learned’ to collaborators across the country.

We are pleased to provide this progress report and we look forward to an enduring relationship, which has already begun to change the landscape of care for our deserving Veterans.

James P. Kelly, MD Executive Director Marcus Institute for Brain Health

1

2018 Budget Progress Report: Revenue and expense actuals through August, and projections for the remainder of the year, indicate we will end 2018 with a funds carry forward of approximately $400,000. We will fall short of the budgeted clinical revenue, which will be offset by significantly lower unreimbursed medical expenses for uninsured Veteran patients. The variance in Other Operating expenses is primarily due to unforeseen contract services related to patient care, and tenant improvements in clinical space.

MIBH P&L FY18 through 8/31/18* rev 9/14/2018 Existing Funds (FY17 carry forward)

Budget

Actual

Projected

Total

Budget Var

1/1/18-12/31/18 2018

1/1/18-8/31/18

9/1/18-12/31/18 2018

Actual+Proj

Bud+/-Act 2018

3,865,000

0

3,865,000

(1,500,000)

1,500,000

1,500,000

146,380

(814,164)

3,827,643

Revenue Marcus Foundation Gift

5,365,000

1,500,000

Colonels Row Bridge Fund Clinical Revenue Projections(1)

960,544

Evaluation/Diagnosis

473,305

Treatment (Intensive Outpatient Program)

487,239

103,380

43,000

30,525

30,525

30,525

(192,109)

(24,264)

(8,600)

(32,864)

159,245

6,133,435

5,444,116

64,925

5,509,041

(624,394)

2,868,171

1,708,835

950,000

2,658,835

209,336

803,088

473,353

250,000

723,353

79,735

3,671,259

2,182,188

1,200,000

3,382,188

289,071

Office Supplies/General Administration

50,000

55,830

25,000

80,830

(30,830)

Health and Wellness Center: Office Space

20,000

9,600

5,500

15,100

4,900

Health and Wellness Center/402: Clinic Space

161,880

122,565

83,250

205,815

(43,935)

Health and Wellness Center: Fitness and Training Facility

16,800

3,890

3,500

7,390

9,410

Outreach/Marketing/Publications

15,000

11,225

1,500

12,725

2,275

Executive Outreach/Travel

90,000

72,700

25,000

97,700

(7,700)

Other Operating(2)

73,000

153,450

49,143

202,593

(129,593)

0

500,000

500,000

(500,000)

Earnings CU Med Billing Services Fee/Dean's Tax (20%) Total Revenue

Expenditures PERSONNEL MIBH Salaries Benefits Total Personnel OPERATING

Colonels Row Bridge Fund Recruitment and Moving Expenses

15,000

18,500

5,000

23,500

(8,500)

Unreimbursed medical expenses for uninsured veteran patients

850,000

73,435

40,000

113,435

736,565

Total Operating

1,291,680

521,195

737,893

1,259,088

32,592

Total Expense (Direct)

4,962,939

2,703,383

1,937,893

4,641,276

321,663

496,294

293,845

193,789

464,128

32,166

5,459,233

2,997,228

2,131,682

5,105,404

353,830

674,202

2,446,888

Facilities & Administration Costs (Indirect) Total Expense (Direct/Indirect) Rev-Exps/Remaining Funds

403,637

*This budget has been modified from the original version due to the elimination of Dept Fees (10%), and a decrease in projected clinical revenue.

(1)100 veteran Pts/75% w/ TC coverage, 50 non-vet Pts/100% coverage, no self pay in this model (2) Tenant improvements (clinic/402), official functions, contract services, clinical supplies

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Colonels Row Housing Project When Veterans come to the MIBH from around the country, one of the challenges is where to house them while they are being evaluated and receiving treatment. We have explored many options, including renting transitional apartments and booking the Veterans into nearby hotels. Our stopgap solution has been to work with Boulder Crest Retreat, which arranges housing at nearby hotels. This near-term solution is less than ideal because of the relative isolation of a hotel room after a full day of difficult evaluation or treatment.

Our long-term solution is the renovation of a building located at the CU Anschutz Medical Campus less than one block from the MIBH. In 1921, Fitzsimons Army Medical Center had four residential duplexes built to house full colonels stationed at Fitzsimons. These classic buildings remain on campus and are owned by CU’s clinical partner, UCHealth. Over time, the buildings have fallen into various states of disrepair.

The MIBH is leasing one of these buildings from UCHealth and completely renovating the building. Our design will convert the 5,000-square-foot duplex into a single living space with 11 bedrooms and 8 and ½ bathrooms. Three bedrooms and 2 bathrooms will comply with the Americans with Disabilities Act. The space will feature a large community kitchen and dining area, along with a double living room that has a quiet side and an active side.

We have spent months ensuring feasibility, conducting design work, completing the legal work to secure the lease, and bidding the construction phase of the renovation. We plan to break ground on the project in October 2018, which will begin with asbestos and lead paint abatement. We are forecasting a project completion date in early 2019, with patients moving in no later than March 2019.

The total cost of this project is approximately $1.5 million, which the MIBH is covering using operating reserves while we work hard to build a coalition of external funders to backfill these expenditures. We are excited that the Colonels Row project is finally underway, creating new options for our patients and literally building our own future.

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MIBH Patients • Total patients treated The MIBH has treated a total of 78 patients since July 2017. That total includes 23 outside consults seen prior to November 1, 2017, when we began seeing cohorts of patients.

• Military/Veteran patients treated The MIBH has seen a total of 54 military patients since July 2017.

Military Patients Treated

July 1, 2017 - April 6, 2018 April 7, 2018 - August 31, 2018

• Military/Veteran family members treated 47 family members have been included in care as of August 31, 2018. Most of the family members are spouses or significant others, but the MIBH has also seen parents of the MIBH patient and children.

• Veteran patients referred to the MIBH and referring source 148 Veteran patients have been referred to the MIBH from a variety of sources and have been screened through the MIBH telephone intake process. The chart below shows, generally, the breakdown by referral source.

Patient Referral Source 9%

5% 16%

21% 8%

24%

17%

MIBH Partner

Providers

VSO

Media

Prior Patients

Other

Peers

4

National Impact MIBH patients come from across the United States to seek treatment. As the referral sources continue to diversify, so will the states that the MIBH serves.

MT WI WY

NY

MI

IA UT

CA

PA IL

CO

IN

OH VA NC

TN

AZ

SC GA TX

AK

5

LA FL

MD

Warrior Canine Connection Partnership It’s an 8-to-5 job for two dogs, Joseph and Eli. And for two years, they are in training at the CU Anschutz Medical Campus. At the end of their training, both service dogs will be adopted by military Veterans.

Today, they are learning the skills to become service dogs that can help Veterans with mobility issues, PTSD, traumatic brain injury (TBI) and more.

Recently, Warrior Canine Connection announced a formal partnership with the MIBH to provide an additional service to Veterans seeking care. “I go to all their meetings to understand treatment plans and figure out how training service dogs can fit into our patients’ therapy here,” said Ann Spader, a service dog training instructor for Warrior Canine Connection.

While Veterans undergo intensive treatment at the MIBH, many are able to train these new service dogs.

It fits into their treatment plan. For example, if a patient needs to spend more time in public, some of the training will take place in public. This helps patients with PTSD overcome some of their symptoms.

“When they are with us, patients focus on themselves 24/7, so training these dogs helps them take their minds off their treatment plans for a while,” said Spader.

This therapy is working and Veterans are feeling the benefits. While many of them are interested in getting a service dog, many decide they don’t need one following the program. The experience of training dogs often pushes them to the next level and decreases their need for a service dog.

Ultimately, the dogs they are training will go on to serve a Veteran, so it is a win in multiple ways.

The training sessions start with grooming to relax both the dog and the Veteran, and they both learn up to 90 different commands. This training teaches patients to be persistent to make sure the dog follows through. It also socializes them, helping both the dog and Veteran be successful. “These skills are particularly useful when dealing with PTSD,” said Spader. “It very clearly shows how this helps both Veterans and future service dogs.”

This formal partnership between Warrior Canine Connection and the MIBH is producing tangible benefits for Veterans – both treating patients and training service dogs.

6

Patient Breakdown • 58 patients have been treated through the diagnostic evaluation 58 patients have completed the diagnostic evaluation, of which 48 are Veterans, two are civilians and eight are elite athletes.

Diagnostic Evaluation Completed 10

20

30

40

50

60

Veterans Civilians Athletes

• 22 patients have been treated through the IOP 22 patients have completed the IOP. All have been Veterans with the exception of one athlete.

• 43 patients referred to supporting departments The MIBH has made a total of 43 referrals to other departments at the CU Anschutz Medical Campus.

The most frequent referrals are to Neuro-Ophthalmology, the Sleep Clinic and MRI Imaging. Having this kind of expertise available on campus is critical to the MIBH’s success in treating Veteran patients.

• Military/Veteran patients struggling with substance abuse Five Veteran patients reported issues with substance abuse, including one who was subject to court ordered monitoring during the IOP. Three have either completed the MIBH program or are in the process of completing the IOP. The others have been appropriately referred for follow-up substance abuse counseling or treatment with an offer to return after successful completion and appropriate.

• Military/Veteran patients who go through the CeDAR program One Veteran patient was referred to the CeDAR program for treatment in September 2018 and will begin the diagnostic evaluation upon completion of that program. Has since completed MIBH IOP. • Civilian patients treated The MIBH has treated a total of 16 civilian patients, including those seen on a consulting basis only.

• Elite athlete patients Eight athletes have completed the diagnostic evaluation, three have completed the IOP and one scheduled.

7

Marcus Institute for Brain Health Joins the Boot Campaign Health and Wellness Pipeline Boot Campaign’s health and wellness program is proud to announce a new partnership with the Marcus Institute for Brain Health at the CU Anschutz Medical Campus. As an official partner, the MIBH’s leading-edge care for traumatic brain injury as well as the physical, emotional and cognitive challenges that may go with it, is now available to participants in Boot Campaign’s health and wellness pipeline.

“Partnering with the MIBH is a huge win for Boot Campaign,” said Shelly Kirkland, Boot Campaign CEO. “We are excited to be working with a resource-focused facility that is committed to addressing the root causes of TBI symptoms from a multi-directional approach. We will also be collaborating with the MIBH to collect de-identified feedback and research findings to validate the protocols and improve future care.”

“Boot Campaign’s health and wellness program places the well-being of military Veterans at the center of its work,” said James Kelly, MD, executive director of the MIBH. “The MIBH is committed to the success of Veterans post-service, and we are humbled to be among the few programs selected by Boot Campaign to serve those who have served in the defense of our nation.”

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Metrics: As of August 31, 2018 Measure clinical improvement of Veteran patients The MIBH’s primary benchmark is the clinical improvement of its patients. The Patient Global Impression of Change, or “PGIC,” is a clinically validated measure to assess clinical improvement. With the PGIC, patients are asked to assess certain activities since beginning treatment and also asked to assess the degree of change they have experienced since beginning treatment.

Overall Quality of Life 7

PGIC Response

6 5 4 3 2 1 0 1

3

4

6

7

8

9

10 11 13 14 19 21 23 27 31 35 44 45 58 65 86

Upon Completion of Intensive Outpatient Program Since beginning treatment at this program, how would you describe the change (if any) in ACTIVITY LIMITATIONS, SYMPTOMS, EMOTIONS, and OVERALL QUALITY OF LIFE, related to your condition? Answers are on a scale of 1 (No change) to 7 (A great deal better).

This graph demonstrates that, of the 22 patients who have completed the intensive outpatient program, the vast majority reported their overall quality of life was substantially better. Only one patient reported no change.

9

“ Before coming to the Marcus Institute, I was in a very dark place.

Now after receiving care that works, the difference is night and day.

Coming to the Marcus Institute was undoubtedly the best and most comprehensive care I have ever received as a Veteran suffering from TBI and post-concussive syndrome. The Marcus Institute gave me a second chance; you will not find better care for TBI anywhere else.�

JAREK CARLSON Air Force Staff Sergeant

Degree of Change 7

PGIC Response

6 5 4 3 2 1 0 1

3

4

6

7

8

9

10 11 13 14 19 21 23 27 31 35 44 45 58 65 86

Upon Completion of Intensive Outpatient Program In a similar way, please circle the number below that matches your degree of change since beginning care at this program: Answers are on a scale of 1 (Much worse) to 7 (Much better).

With Degree of Change, all patients except one rated their degree of change as a 5, 6 or 7 indicating most felt they had improved to a high degree.

10

One month following completion of the Intensive Outpatient Program (IOP), patients were again asked to complete the “PGIC� to help determine if the changes experienced at the conclusion of the IOP are sustained over time. To date, only eight patients have completed this one-month follow-up. Notably, however, all patients report that their positive changes have been sustained after completion of the IOP, with some reporting continued improvement. This same assessment will occur at six months and one year following completion of the IOP.

Overall Quality of Life 7

PGIC Response

6 5 4 3 2 1 0 1

3

4

6

7

10

13

Patient Record ID Discharge PGIC Response

1-Month Follow Up PGIC Response

Spencer Milo, Director of Veteran Programs, Communications and Strategic Development, accompanies MIBH alumni to the Georgia Aquarium for an immersion dive and meeting with Mr. Bernie Marcus.

11

45

Degree of Change 7

PGIC Response

6 5 4 3 2 1 0 1

3

4

6

7

10

13

45

Patient Record ID Discharge PGIC Response

1-Month Follow Up PGIC Response

“ After retiring from 21 years as an Army EOD Tech (Bomb Squad), I had multiple deployments, multiple concussions, TBI and post-traumatic symptoms. I had lost my purpose and my confidence, my emotional state was deteriorating and I had no good answers. I was quickly losing hope. A neurologist referred me to the MIBH and that all changed. I can’t begin to tell you how this amazing team of specialists changed the outlook for my future. I’m just one soldier of many that struggle with brain health, but my life will forever be changed and I can’t thank the team from the MIBH enough!”

RAYMOND WHITE Army First Sergeant

12

• Revenue from clinical reimbursement of civilian patients $0. The MIBH has not seen any non-athlete civilian patients since January 2018.

• Revenue from clinical reimbursement of elite athlete patients The MIBH has generated charges of $24,690 and has collected $6,740 from care for elite athlete patients. Note: a significant delay in clinical collections is standard.

• Revenue from clinical reimbursement of Veterans The MIBH has generated charges of $484,810 and has collected $96,640 from care for insured Veterans. Note: a significant delay in clinical collections is standard.

• Referrals to and from the Cohen Veterans Network Eight Veteran patients have been referred to the Cohen Veterans Network for follow-up. Additionally, the MIBH has referred 12 Veteran patients to Headstrong Project for continued treatment.

• Federally sponsored research applications and awards MIBH faculty and associated CU faculty have submitted seven applications for federally sponsored research projects. Total proposed budget for these awards is over $12 million. These are detailed in the Appendix. The federal research pipeline is a long process and, to date, the MIBH has been focused on its clinical treatment program while remaining mindful of the long-term positive impact that academic research will have on Veteran TBI care.

• Private foundation support awards MIBH faculty and associated CU faculty have submitted three applications for private foundation research funding. The total proposed budget for these awards is $500,000. These are detailed in the Appendix.

• Continuing medical education events or conferences MIBH faculty have published nine articles in peer reviewed journals. Additionally, multiple MIBH faculty presented 40 continuing education lectures at a variety of national and local forums. All the presentations are detailed in the Appendix. These publications and lectures help extend the reach and reputation of the MIBH as a national center of excellence in Veteran TBI care.

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PET/MR Scanner: The MIBH continues to work with the CU School of Medicine Department of Radiology to develop the capability for advanced clinical neuro-imaging scans at the CU School of Medicine’s new molecular imaging center. This new imaging center is a complex partnership involving the University of Colorado School of Medicine, UCHealth (CU’s primary clinical partner), the Fitzsimons Redevelopment Authority (which owns the land adjacent to the campus) and GE Healthcare.

The Fitzsimons Redevelopment Authority has broken ground for the new facility on its property.

UCHealth and GE Healthcare continue contract development for the ownership and operation of the cyclotron, which produces the “tracers” used to create advanced brain images. CU’s radiology and neuro-radiology faculty will provide the clinical expertise to run the facility.

The MIBH will monitor progress on center construction and equipment procurement.

PET MRI

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Collaboration: The MIBH continues to work with Veteran Service Organizations and others at the national, state and local levels. Some key examples include: • Active relationships with the Navy SEAL Foundation, The Green Beret Foundation, the Semper Fi Foundation and the Pararescue Foundation to help establish a referral pipeline to the MIBH • Leadership meetings with Team Red, White and Blue; the Psych Armor Institute; and The Mission Continues • Deepening the MIBH’s relationship with Boulder Crest Retreat; Spencer Milo attended BCR’s full PATHH program • Eight MIBH team members attended the DoD Warrior games at the U.S. Air Force Academy to cheer on MIBH alumni who were participating • Established relationships with both the Colorado Rockies and the Denver Broncos to provide recreational opportunities for MIBH patients, and involve players and alumni from both organizations in MIBH activities • Six MIBH alumni participated in the Georgia Aquarium’s Dive Immersion Program and met with Mr. Bernard Marcus • Hosted the George W. Bush Institute and former President George W. Bush’s Team 43 Continued Leadership Regional Engagement Series with a focus on health and wellbeing.

Advocacy: • Provided tours of the MIBH to VA Deputy Secretary Thomas Bowman as well as Acting Secretary Robert Wilkie, now confirmed Secretary of the VA • Visit to the MIBH by Captain Mike Colston of the Office of the Assistant Secretary of Defense for Health Affairs • Work with Veteran Services Officers at the county level in Colorado to familiarize them with the MIBH’s program • May and September visits to Capitol Hill and VA headquarters in Washington, D.C., to advocate for MIBH and Veteran programs

15

Marcus Institute for Brain Health Team This organizational chart shows current staffing and organization including open positions that MIBH intends to fill by calendar year end. In addition to our full-time team members, we are building robust relationships across the university by incorporating part-time faculty and staff from other schools and departments.

Executive Director Director of Development

Director, Education

Education and Training Coordinator

Director, Special Projects

Director, Veterans Programs

Chief of Staff

Director, Finance and Administration

Senior Scientific Advisor

Chief Clinical Director

Director, Clinical Research

Business Administration Program Manager

Clinical Navigator/ Case Management Lead

Speech Language Pathologist

Speech Language Pathologist

Neuropsychologist/ Clinical Program Manager

Laboratory Manager

Clinical Coordinator

Case Manager

Social Worker

Psychologist

NeuroRadiologist

Professional Research Associate

Intake Coordinator

Case Manager

Physical Therapist

Physical Therapist

Clinical Pharmacist

Program Support Specialist

Art Therapist

Integrative Therapies

Neuro-Behavioral Fellow

Medical Assistant

Registered Nurse

Warrior Canine Connection

Licensed Practical Nurse/Medical Assistant

Information Technology

Open Position

MIBH Exclusive

Multiple Departments

16

“ I would like to express my admiration and appreciation for the MIBH team members.

Their expertise and professionalism are obvious, and the various injuries that I sustained during my combat deployments to Iraq have been noticeably improved thanks to their care.

Moreover, I have never in my life received greater care and concern from health care providers. It is through the team’s efforts that I have attained a measure of optimism and progress regarding my health that I have not had since before my first combat deployment in 2006.”

SEAN HANSEN Petty Officer First Class Navy

THANK YOU Because of The Marcus Foundation, the MIBH is helping Veteran patients build strength in their lives.

This is reflected in the Patient Global Impression of Change metrics shared in this report. The MIBH is also building strength in the capacity of its clinical team, and in the efficiency of its operational processes. We are working hard to increase both the breadth and depth of our collaborations to provide better resources to care for Veterans. Our advocacy work continues, in an effort to build a strong relationship with the VA. In short, we continue our hard work for this noble mission. Thank you for your vision and partnership.

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APPENDIX Scholarly and Research Dissemination Report October 2017 – June 2018 GRANT SUBMISSIONS Lisa A. Brenner, PhD • Title: Microbial Diversity, Inflammation, and Suicidal Behavior among Veterans with Moderate to Severe TBI o Primary Investigator: Lisa Brenner o Sponsor: American Federation of Suicide Prevention o Department: Physical Medicine & Rehabilitation o Total Grant Budget: $124,982.00 • Title: Integrating Military and Veteran Data to Prevent Suicide o Primary Investigator: Lisa Brenner o Sponsor: National Institute for Health o Department: Physical Medicine and Rehabilitation o Total Grant Budget: $1,737,810.00 • Title: Obesity, Cholesterol and Suicide o Primary Investigator: Teodor Postolache o Sponsor: National Institute for Health o Department: Physical Medicine and Rehabilitation o Total Grant Budget: $1,521,349.62 • Title: MVP Gamma Test Using MVP Data to Promote Suicide Prevention Among Those with TBI o Primary Investigator: Lisa Brenner o Sponsor: Clinical Science Research & Development – VA Research o Department: Physical Medicine and Rehabilitation o Total Grant Budget: $299,644.89 • Title: Biological Signature and Safety of an immunomodulatory Probiotic Intervention of Veterans with PTSD o Primary Investigator: Lisa Brenner o Sponsor: National Institute for Health o Department: Physical Medicine and Rehabilitation o Total Grant Budget: $2,173,040.00 • Title: Food Insecurity among Veterans with Psychological Distress: Developing a New Approach o Primary Investigator: Diana Brostow o Sponsor: Career Development Award o Department: Physical Medicine and Rehabilitation o Total Grant Budget: $357,650.00 • Title: Autoimmune Diagnostic for Gulf War Illness o Primary Investigator: John Repine o Sponsor: Department of Defense o Department: Physical Medicine and Rehabilitation, and Pulmonary Science & Critical Care o Total Grant Budget: $357,650.00 • Title: Prediction of Suicidal Behavior by Interactions between Immune-Driven Illness and Traumatic Brain Injury o Primary Investigator: Teodor Postolache

o Sponsor: National Institute for Health o Department: Physical Medicine and Rehabilitation o Total Grant Budget: $2,500,000 Chris M. Filley, MD • Title: TBN o Primary Investigator: Brianne Bettcher o Sponsor: National Institute on Aging o Department: Neurosurgery o Total Grant Budget: $3,572,014 Jeffrey R. Hebert PhD • Title: Human Sensorimotor Adaptation to Altered Environments with Applications for Vestibular Rehabilitation: Predicting Individual Differences, Enhancing Adaptability, and Personalized Training Programs o Primary Investigator: Torin Clark o Sponsor: Boettcher Foundation Webb-Waring Biomedical Research Grant o Department: Physical Medicine & Rehabilitation o Total Grant Budget: $61,015 PUBLICATIONS Bahraini N.H., Hostetter T.A., Forster J.E., Schneider A.L., Brenner L.A. (2018). A Rasch Analysis of the Neurobehavioral Symptom Inventory in a national cohort of Operation Eduring and Iraqi Freedom veterams with mild traumatic brain injury. Pyschologial Assessment, 30(8), 1013-1027 DOI: 10.1037/pas0000555.

Betthauser L.M., Brenner L.A., Cole W., Scher A.I., Schwab K., Irvins B.J. (2018). A Clinical Evidence-Based Approach to Examine the Effects of mTBI and PTSD Symptoms on ANAM Performance in Recently Deployed Active Duty Soldiers: Results From the Warrior Strong Study. Journal of Heat Trauma Rehabilitation, 33 (92), 91-100 DOI: 10.1097/HTR.0000000000000376.

Broussard, J. I., Acion, L., De Jesus-Cortes, H., Yin, T., Britt, J. K., Arciniegas, D.B., . . . Jorge, R. (2018). Repeated mild traumatic brain injury produces neuroinflammation, anxiety-like behaviour and impaired spatial memory in mice. Brain Inj, 32(1), 113-122. doi:10.1080/026990 52.2017.1380228 Filley C.M., Kelly J.P. (2018). White Matter and Cognition in Traumatic Brain Injury. Journal of Alzheimer’s Disease, Pre-press, 1-18 DOI: 10.3233/JAD-180287.

Filley, C. M., McConnell, B. V., & Anderson, C. A. (2017).

The Expanding Prominence of Toxic Leukoencephalopathy. J Neuropsychiatry Clin Neurosci, 29(4), 308-318. doi:10.1176/appi. neuropsych.17010006.

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Filley, C.M. (2017). The History of Subcortical Cognitive Impairment.

Brenner, L.A., Betthauser, L.M., Kreisel, C. (2018, February).

Fronteirs of Neurology and Neuroscience.

Strength and Awareness in Action: an Intervention for Post-Acute TBI Headaches (SAA-TBI). 2018 Rehabilitation Psychology Conference,

Hebert, J. R., Forster, J. E., Stearns-Yoder, K. A., Penzenik, M. E., &

Dallas, TX.

Brenner, L. A. (2018). Persistent Symptoms and Objectively Measured Balance Performance Among OEF/OIF Veterans With Remote

Brenner, L.A., Stearns-Yoder, K.A., (2018, February). The

Mild Traumatic Brain Injury. J Head Trauma Rehabil. doi:10.1097/

Interaction between Brain, Gut, and Microbiome and Implications

htr.0000000000000385.

Regarding Recovery Post Brain Injury. 2018 Rehabilitation Psychology Conference, Dallas, TX.

Manago M.M., Hebert J.R., Kittelson J., Schenkman M. (2018).

Feasibility of a Targeted Strengthening Program to Improve Gait in

Brenner, L.A., Forster, J.E. Stearns-Yoder, K.A., Laker, S. Bahraini,

People with Multiple Sclerosis: A Brief Report. International journal of

N.H. Dise-Lewis, J.E. (2018, February). The Natural History of

Rehabilitation Research, DOI: 10.1097/MRR.0000000000000306.

Post-Concussive Recovery among High School Athletes. 2018 Rehabilitation Psychology Conference, Dallas, TX.

Manago M.M., Hebert J.R., Kittelson J., Schenkman M. (2018).

Contributions of Ankle, Knee, Hip, and Trunk Muscle Function to Gait

Brenner, L.A. (2017, October). The Brain, Gut, & Microbiome:

Performance in People With Multiple Sclerosis: A Cross-Sectional

Implications Regarding Short and Long-Term Recovery Post-Brain

Analysis. Physical Therapy, 98 (7), 595-604 DOI: 10.1093/ptj/pzy048.

Injury. Presentation at the Brain Injury Alliance of Colorado Conference, Denver, CO.

PRESENTATIONS Akram, F., Fuchs,D., Daue, M., Mijar, G., Ryan, K., Brenner, L.A., . . .

Brenner, L.A. (2017, October). Mental Health and the Microbiome

Postolache, T.T (May, 2018). Association of Plasma Nitrite Levels with

of the Build Environment. Presentation at the Microbiome of the Built

Metabolic Syndrome and Its Components in the Old Order Amish.

Environment Symposium, Washington, DC.

Presentation at the Society of Psychiatry’s 2018 Annual Meeting, New York, NY.

Brenner, L.A., & Lowry, C. A. (2017, December). The microbiome and mental health. Presentation at the CU Boulder Neuroscience Seminar

Anderson, C.A. (December 2017). Confabulation. Presentation at the

Series, Boulder, CO.

Colorado Mental Health Institute Grand Rounds, Pueblo, Colorado.

Brenner, L.A. (June, 2018). Suicide & Traumatic Brain Injury: Anderson, C.A. (December 2017). Neurodegenerative Disease.

Understanding the Relationship between suicide and Traumatic Brain

Presentation at the University of Colorado School of Medicine: M2

Injury. Presentation at Injury Control Research Center for Suicide and

Neuroscience Lecture, Aurora, CO.

Prevention Webinar Series: The Intersection of Suicide and Suicide Prevention with Other Injuries.

Anderson, C.A. (December 2017). Neurodegenerative Disease: New Concepts. Presentation at the Colorado Mental Health Institute Grand

Brenner, L.A. (May, 2018). A Holistic Approach to Brain Injury Care.

Rounds, Pueblo, Colorado.

Presentation at the 5th Annual Brain Institute, Anchorage, AK.

Anderson, C.A. (December 2017). The Neurology of Confabulation.

Brenner, L.A. (May, 2018). Two Promising Evidence-Based

Presentation at the University of Colorado Behavioral Neurology &

Interventions for Suicide Prevention among Veterans with TBI.

Neuropsychiatry Conference, Denver, CO.

Presentation at the 5th Annual Brain Institute, Anchorage, AK.

Arciniegas, D.B. (2017, October). Disorders of Mood and Affect after

Brenner, L.A. (May, 2018). Unique Physical and Mental Health

TBI: A Neuropsychiatric Perspective. Presentation at the Brain Injury

Exposures among Veterans and the Potential Promise of Probiotic

Alliance of Colorado Conference, Denver, CO.

Interventions. Presentation at the Florida State University Integrated Clinical Neuroscience Colloquium, Tallahassee, FL.

Bateman, J., Rubinstein, D., Filley, C.M. (2018, March). Volumetric Analysis of Mild Traumatic Brain Injury (mTBI) Using NeuroQuantÂŽ.

Brenner, L.A., Betthauser, L.M., Adams, R. S., Hostetter, T., Scher,

29th Annual Meeting of the American Neuropsychiatric Association,

A.I., Schwab, K. (June, 2018). Lifetime History of TBI among Active

Boston, MA

Duty Soldiers. Presentation at the 4th Federal Interagency Conference on Traumatic Brain Injury, Washington, D.C.

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Brenner, L.A., Hosington, A.J., Stearns-Yoder, K.A., Hoffmire,

Hartford, M., Kelly, J., Milo, C.S. (2018, January). Wounded Warrior

C., Heinze, J.D., Stamper, C.E., Postolache, T.T., Lowry, C.A. (June,

Project Brief. Wounded Warrior Project, Aurora, CO.

2018). Characterization of Skin, Oral, and Gut Microbiome among a cohort of U.S. Military Veterans. Presentation to the American Society

Hartford, M.W., Kelly, J.P. (March, 2018) MIBH and Las Vegas

for Microbiology, Atlanta, GA.

Recovery Center Brief. Presentation at the Las Vegas Recovery Center Brief, Aurora, CO.

Brenner, L.A., Stearns-Yoder, K. A., Hosington, A.J.; Postolache, T.T.; Lowry, C. A. (June, 2018). Biological Signature of an

Hartford, M.W., Kelly, J.P., Milo, S. (March, 2018) Marcus Brain

Immunomodulatory Probiotic Intervention for Veterans with mild TBI

Health Report. Presentation to the Colorado State Legislature, Denver,

and PTSD. Presentation at the 4th Federal Interagency Conference on

CO.

Traumatic Brain Injury, Washington, D.C. Hartford, M.W., Kelly, J.P., Wilkerson, D., Pelver, W., Hardin, K.T. Brenner, L.A., Stearns-Yoder, K.A., Stamper, C.E.; Heinze, J.D.;

(March, 2018) Marcus Institute for Brain Health Tour. Presentation to

Hoffmire, C., . . . Lowry, C.A. (June, 2018). Veteran Microbiome

the Cohen Veteran Network, and Psych Armor, Aurora, CO.

and Application for those with TBI and Co-Occurring Mental Health Conditions. Presentation at the 4th Federal Interagency Conference

Hartford, M.W., (March, 2018) MIBH. Presentation at the VA VISN

on Traumatic Brain Injury, Washington, D.C.

Directors Meeting, Washington, D.C.

Brenner, L.A., Stearns-Yoder, K.A., Johnston-Brooks, C., Hardin,

Hartford, M.W., Kelly, J.P., Milo, S., Wilkerson, D. (April, 2018)

K.T., Filley, C.M., Kelly, J.P. (June, 2018). Marcus Institute for Brain

MIBH Brief. Presentation to the VA Deputy Secretary, Aurora, CO.

Health: Selecting and Sharing Outcomes to Promote Evidence-Based Treatments. Presentation at the 4th Federal Interagency Conference

Hartford, M.W., Milo, S. (April 2018). MIBH Brief. Presentation at

on Traumatic Brain Injury, Washington, D.C.

Colorado VSOs, Westminister, CO.

Browb, G.K., Brenner, L.A., Ghahramanlou-Holloway, M., Green, K.,

Hartford, M.W., Kelly, J.P., Milo, S., Wilkerson, D. (May, 2018)

Stanley, B. (April, 2018). Reducing Suicide Risk Among Veterans and

MIBH Brief. Presentation to the Acting VA Secretary, Aurora, CO.

Military Service Members In Acute Care Settings. Panel participation at the American Association of Suicidology Conference, Washington,

Hartford, M.W. (June, 2018) MIBH Brief. Presentation to the Health

D.C.

Resources and Services Administration, Aurora, CO.

Bryan, C., Franklin, K., Brenner, L.A. (May, 2018). Innovative Practice

Hebert, J.R., (2018, February). Fatigue & Mild Traumatic Brain Injury

in Suicide Prevention. Panel participation at the Association of

- addressing the perpetual elephant in the room, a rehabilitation

Veterans Affairs Psychology Leadership Conference, San Antonio, TX.

perspective. University of Colorado School of Medicine: Department of Neurology Monthly Behavioral Neurology & Neuropsychiatry

Filley, C.M. (May, 2018). Journal Club. Presentation at the University

Conference, Aurora, CO.

of Colorado School of Medicine Anschutz Medical Campus, Denver, CO.

Hoffmire, C., Monteith, L., Park, C., Brenner, L.A., Hoff, R. (April, 2018). Military Discharge Type and Suicide Ideation among OIF/OED/

Hardin, K.Y. & Sanchez,D (2018, January). Colorado D1 female

OND Veterans. Presentation at the 51st Annual Conference of the

soccer players’ perspectives on reduced exposure: A tale of

American Association of Suicidology, Washington, D.C.

subcultures. 2018 Brain Injury Summit: A Meeting of the Minds, Vail, CO

Johnston-Brooks, C. (2018, March). Persistent PostConcussive Symptoms in Mild Traumatic Brain Injury: The Role

Hardin, K. Y. (2017, November). Concussion and Speech-Language

of Neuropsychology. University of Colorado School of Medicine:

Pathology: The State of the State. Presentation at the Academy of

Department of Neurology Monthly Behavioral Neurology &

Neurologic Communication Disorders and Sciences, Los Angeles, CA.

Neuropsychiatry Conference, Aurora, CO.

Hardin, K. Y. (2017, November). Concussion and the SLP: A

McCarthy, M.S., Hoffmire, C., Nazem, S., Brenner, L.A. (June,

Symposium on Current Research, Clinical Limitations, & Future

2018). Difference in Veteran Versus Civilian Sleep Patterns. Poster at

Directions. Presentation at the American Speech-Language Hearing

the Meeting of the American Academy of Sleep Medicine and Sleep

Association Conference, Los Angeles, CA.

Research Society (SLEEP), Baltimore, MD.

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Milo, C.S. (2017, October-December). Marcus Institute for Brain Health. Multiple presentations to various Military and Veteran Outreach Programs.

Milo, C.S., Hartford, M., Filley, C.M., Kelly, J.P. (2017, October).

Marcus Institute for Brain Health. Presentation at the GRECC, MIRECC, COIN Grand Rounds, Aurora, CO. Taub, E., Morris, D.M., Brenner, L.A. (June, 2018). RCT of CI Therapy vs a Meditation/Exercise Intervention (LEFT) for Improving Arm Function and PTSD after TBI: The BRAVE Project. Presentation at the 4th Federal Interagency Conference on Traumatic Brain Injury, Washington, D.C. Wadhawan, A., Daue, M., Brenner, L.A., Lowry, C., Dagdag A., …

Postolache, T.T. (May, 2018). Toxoplasma Gondii-oocyst Seropositivity and Depression in the Older Amish. Presentation at the Society of Biological Psychiatry’s 2018 Annual Meet ing, New York, NY.

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