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Epithelial Tissues Epithellia are the tissues that line body cavities and surfaces and are separated from the adjacent connective tissue by a basement membrane. The mediate diverse functions, including secretion, absorption, transcellular transport and protection from environmental assaults. Epithelial function is perturbed in a large number of conditions, such as psoriasis, emphysema and certain types of blindness. It is estimated that epithelial cancers account for 90% of human tumours. Theme Leader: Principal Investigators: Affiliate Investigators: Associate Investigators:

Frye Jensen, Rawlins, Simons, Ventura Philpott, Watson Jones, Stingl, Winton

Cardiovascular Stem cell research has great potential for improving understanding and treatment of cardiovascular disease. Cellbased therapies are currently limited by lack of knowledge about human stem cell differentiation and about the extent and kinetics of integration and survival of transplanted tissues. However, the progeny obtained by in vitro differentiation of pluripotent stem cells can provide unprecedented cellular systems for understanding fundamental cardiovascular disease mechanisms, for drug discovery and testing. The developing programme will explore the interface between stem cells and cardiovascular medicine with a focus on iPS cells as human cardiovascular disease models and the prospects for early mesodermal progenitors in regenerative approaches. Theme Leader: Affiliate Investigators:

Pedersen. Sinha

Institute Mission To explore and define the properties of stem cells in order to establish their true medical potential. Our overall aims are:

 To make fundamental discoveries that provide new insights into stem cell function and potency;

 To understand the role of stem and progenitor cells in disease and thereby to improve diagnosis and treatment

 To harness the capacity of endogenous stem and progenitor cells for repair and regeneration;

 To exploit stem cells as tools for studying the molecular

pathogenesis of human diseases and discovery of therapeutic agents;

 To nurture future generations of stem cell scientists and clinical investigators in an intellectually invigorating mix of basic and translational research.

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The Centre for Stem Cell Research (CSCR) and the Laboratory for Regenerative Medicine (LRM) presently constitute twin bases for stem cell research in the School of Biological Sciences and the School of Clinical Medicine respectively. Stem cell groups are also housed in the Cambridge Institute for Medical Research (CIMR), Gurdon Institute, Centre for Brain Repair (CBR) and other Departments. This distribution reflects the intellectual diversity of the Cambridge stem cell community and the breadth of institutional support. The coalescence of basic stem cell research and translational medicine is key to development of clinical applications and therefore the University has invested in the establishment of the Stem Cell Institute. The following facilities support the research:

 Advanced Vector Design and       

Recombineering Bioinformatics Flow Cytometry Histology Imaging Next Generation Sequencing Libraries Tissue Culture Cambridge Biomedical Research Centre (BRC) hIPSCs Core Facility

Cambridge Stem Cell Institute Brochure 2012  
Cambridge Stem Cell Institute Brochure 2012