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Contents The Institute ……………………………………………2 2012 Annual Report …………….………………....4

Research Groups Roger Barker Parkinson’s and Huntingdon’s disease……….6 Kevin Chalut The Physical Biology of Pluripotency and Differentiation..…………………………………….……7 Robin Franklin Adult Neural Stem Cells and CNS Regeneration…………………………………...……....8 Michaela Frye Epithelial Stem Cell Homeostasis and Cancer……………………………………………………….9 Bertie Gottgens Transcriptional Regulation of Normal and Leukaemic Blood Stem Cells ……………….….10 Tony Green Haematopoiesis………………………………….…...11 Brian Hendrich Transcriptional Control of Stem Cell Fate………………………………..…...12 Brian Huntly Leukaemia Stem Cell Biology …………...….…13 Kim Jensen Epithelial Development, Maintenance and Regeneration……………………….………………….14 Thora Karadottir Neurotransmitter Signalling to CNS Progenitor Cells……………………………...……….15 Mark Kotter Neural stem cells, Cellular Reprogramming and Regenerative Medicine……….…….………16

Message from the Director Stem cells are remarkable cells that build, maintain and repair our bodies. In the laboratory they can be manipulated to reveal the mechanisms of human development and disease. Stem cells also hold the potential to be used in regenerative medicine and cell therapy to treat devastating conditions ranging from blindness, to multiple sclerosis, Parkinson’s disease and diabetes. The challenge in stem cell research is to elucidate the complex control processes that govern how stem cells function in order to take full command of their extraordinary capacities and harness them for medical benefit. Recognising

Cambridge Stem Cell Institute Brochure 2012  
Cambridge Stem Cell Institute Brochure 2012