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University Of Rochester

April 18, 2014

Order of Events 12:30 p.m. SYMPOSIUM TALKS Engineering & Applied Sciences Gamble Room, Rush Rhees Library Natural Sciences & Mathematics Dewey 2-110E Humanities Welles-Brown Room, Rush Rhees Library Social Sciences Dewey 2-110 D 2:00 p.m. POSTER SESSION Hawkins-Carlson Room Rush Rhees Library 3:15 p.m. UNDERGRADUATE RESEARCH AWARDS VISUAL ART IN UNDERGRADUATE RESEARCH AWARDS SA PROFESSOR OF THE YEAR AWARDS Hawkins-Carlson Room Rush Rhees Library 3:55 p.m. CLOSING REMARKS Hawkins-Carlson Room Rush Rhees Library

Engineering and Applied Sciences Gamble Room, Rush Rhees Library 12:30 p.m. Jared Fialkoff ’15 Chemical Engineering Mentor: Dr. Lisa DeLouise “Gold Nanoparticle Sirna Delivery to Treat Allergic Contact Dermatitis”

12:50 p.m. Madeleine Reynolds Laitz ’16 Chemical Engineering Mentor: Professor Eldred Chimowitz “The Fate and Transport of Antibiotic Resistance Genes Near Agricultural Sites in California”

1:10 p.m. Pedro Vallejo-Ramirez ’16 Optical Engineering Mentor: Professor Wayne Knox “Measurement of Optical Scattering in Intra-Ocular Lenses” *Abstracts available in final pages

Natural Sciences and Mathematics Dewey 2-110E 12:30 p.m. Benjamin Goulet ’14 Ecology & Evolutionary Biology Mentor: Professor Daven Presgraves “The Genetics of Speciation Between Drosophila mauritiana and its Sibling Species”

12:50 p.m. Jennifer Newman ’14 Psychology Mentor: Dr. Braden Kuo, Harvard Medical School “Quality of Life in Irritable Bowel Syndrome Subtypes”

1:10 p.m. Claire Wyman ’14 Brain & Cognitive Sciences Mentor: Professor Thomas O’Connor “Physiological Stress Response and Infant Cognitive Development at 6- and 16-Months of Age” *Abstracts available in final pages

Humanities Welles-Brown Room, Rush Rhees Library 12:30 p.m. Daniel Gorman, Jr. ’14 History, Religion Mentor: Professor Margarita Guillory “Toward the Evening Star: The Rochester Origins of the Latter-day Saints”

12:50 p.m. David Markakis ’15 Music, Political Science Mentor: Professor Honey Meconi “An Alternative Reading of Baroque Musical Borrowing”

1:10 p.m. Cassidy Welter ’14 Religion, Political Science Mentor: Professor Margarita Guillory “The Effects of Urban Limitations on Food Rituals; A Study of Diaspora Populations of Orthodox Jews and Siva Devotee Hindus in New York City”

*Abstracts available in final pages

Social Sciences Dewey 2-110 D 12:30 p.m. Marissa Abbott ’14, Epidemiology and Shilpa Topudurti ’14, Molecular Genetics Mentor: Professor Amina Alio “Factors Impacting Decisions During Pregnancy in Hyderabad, India”

12:50 p.m. Katie Adams ’14 Psychology Mentor: Professor Harry Reis “A Study of Women's Experiences with Hooking-Up”

1:10 p.m. Jarrett Hannah ’14 Brain & Cognitive Sciences, Psychology Mentor: Dr. James Cantor “Investigating Resting State Networks in Pedohebephiles”

*Abstracts available in final pages

Poster Exhibition Participants ENGINEERING & APPLIED SCIENCES Eric Bigelow ’14: Brain & Cognitive Sciences, Computer Science Daniel Scarafoni ’14: Computer Science Alex Wilson ’15: Computer Science “Using an Imagistic Reasoning to Support Language Understanding” Zachary Perry ’15: Chemical Engineering “Rheological Study of Immunoglobulin M in the Analysis of Waldenstrom’s Macrglobulinema” Daniel Scarafoni ’14: Computer Science “Comparing Human and Automated Agents in a Coordinated Navigation Domain”

NATURAL SCIENCES & MATHEMATICS Naba Ali ’15: Neuroscience “Connectivity of Area 10 in Macaque Monkey” Alex Anderson ’16: Optical Engineering “Action Execution and Action Observation in the Motor and Premotor Cortex” Max Cheng ’15: Biochemistry, Music Joshua Cho ’16: Molecular Genetics “Sensitization of Human Prostate Cancer and Hepatocellular Carcinoma to Current Chemotherapies by AR-Degradation Enhancer ASC-J9®” Brigitta Gehl ’14: Molecular Genetics Siddhi Shah ’14: Biology “The Signaling Pathway of GPR56 and TG2 in Metastatic Melanoma”

Paige Haas ’16: Microbiology “Investigating the Intersection Between Heat Shock Response and Redox/Fyn/C-Cbl Signaling as a Therapeutic Target in Glioblastoma” Brittany Hopkins ’14: Neuroscience “Characterizing Microglia in the CX3CR1-GFP and Ya Transgenic Lines” Melissa Nogues ’15: Brain & Cognitive Sciences, Psychology “Numerical Distance Modulates Response Times in a Digit-Word Interference Task” Yanhan Ren ’16: Microbiology “Investigation of the Role of Fun30 Chromatin Remodeler in DNA Postreplication Repair and Heterochromatin Formation in Saccharomyces Cerevisiae” Julia Ross ’16: Linguistics “MitoNEET Expression and Oxidative Capacity” Patrick Schupp ’14: Microbiology “Discovery of Novel Arenavirus NP-Host Factor Interactions via the Yeast-Two Hybrid System” Raven Shah ’15: Biochemistry “Associations of Progtaglandin E2 (PGE2) and Cognitive Function in Breast Cancer Patients Receiving Chemotherapy” Michael Shteyn ’14: Neuroscience “TBD” Janice Zhao ’14: Biology “Role of Histone Methyltransferase EZH2 in TGF-ß-induced EpithelialMesenchymal Transition in Ovarian Cancer”

SOCIAL SCIENCES Alysha Alani ’15: Anthropology, Spanish “Blessing and Burden: Negotiating the Hemodialysis Experience” John Bernstein ’15: Brain & Cognitive Sciences, Psychology “The King-Devick Test as a Predictor of Long-Term Cognitive Effects Post-Concussion” Erin Bojanek ’14: Brain & Cognitive Sciences “Sensory Processing and School Functioning in Children with Autism” Natasha Chainani ’14: Microbiology “The Relationship Between Family Resources and the use of Alternative Treatments in Children with Autism Spectrum Disorders” Rebecca Goldberg ’16: Brain & Cognitive Sciences, Psychology Sean Oenick ’14: Neuroscience Anjalene Whittier ’14: Psychology “Hearing Treble? Perception of Speech in Noise and Musical Training” Rachel Kurtzman ’14: Health Policy “Exploring the Environmental Health Impact of E-Cigarettes” Grace Lisandrelli ’14: Brain & Cognitive Sciences, Psychology Jennifer Newman ’14: Psychology John Wilson ’15: Microbiology, Psychology “Hearing-in-Noise Perception Among Undergraduate Students Using Portable Media Devices” Lily Martyn ’14: Epidemiology “Psychosocial Risk Factors and Intention to use Tobacco: A Survey of Ladakhi Adolescents” Sydney Robinson ’14: Psychology “Dance-Based Advocacy Against Rape and Sexual Assault”

Katherine Thomas ’14: Brain & Cognitive Sciences, Psychology “Addressing Systemic Issues and Health of Women in Drug Treatment Court” Ruobing Wang ’14: Political Science “Taiwan and China: Economics Goes Political - Trade Treaty, Public Opinion and Cross-strait Relations” Anjalene Whittier ’14: Psychology “Motivation-Based Interventions for Reducing Disability Stigma: A Self-Determination Theory Approach” John Wilson ’15: Molecular Genetics, Psychology “Gender Differences in Mental and Physical Health Outcomes of Drug Treatment Court Participants”

Visual Art in Undergraduate Research Winner of the Deans’ Award for Art in Research: Molly Nemer ’17 Being Brynn “Fascinated with the various manifestations of synesthesia, a condition in which stimuli to one sense evokes a response from another, I chose Brynn's story to visualize one particular form.”

Applicants: Hillary Figler ’14: Microbiology, Psychology “Detection of Chromosomal Abnormalities in Acute Myeloid Leukemia Using New Technology” Brittany Hopkins ’14: Neuroscience “Microglia in the Brains of Two Transgenic” Chong Li ’14: Biochemistry “Staining of Serial Section from Ischemic and Diabetic Mouse Leg”

Undergraduate Research Awards 3:17 p.m. PROFESSOR STEVEN MANLY Introductory Remarks

3:20 p.m. DEAN JOANNA OLMSTED Presentation of the President’s Awards for Undergraduate Research

3:28 p.m. DEAN RICHARD FELDMAN Presentation of the Deans’ Awards for Undergraduate Research in Engineering & Applied Sciences, Humanities, Social Sciences, Natural Sciences & Mathematics, and Visual Art in Undergraduate Research

3:35 p.m. PROFESSOR STEVEN MANLY Presentation of the Professors’ Choice Awards for Undergraduate Research 3:40 p.m.

Students’ Association Professor of the Year Awards 3:55 p.m. DEAN RICHARD FELDMAN Closing Remarks

ABSTRACTS Marissa Abbott and Shilpa Topudurti “Factors Impacting Decisions During Pregnancy in Hyderabad, India” Maternal and child deaths constitute a significant burden of India’s health outcomes. It is estimated that India contributes to 25% of global maternal deaths, and despite efforts to improve maternal health, the maternal mortality ratio and infant mortality rate still remain high. Several studies have assessed the factors that contribute to maternal and infant mortality, however few studies have examined how cultural beliefs and perceptions of western biomedicine contribute towards the choice to seek prenatal care, an essential preventive care method. The goal of this study was to assess maternal behaviors surrounding pregnancy, and to examine barriers and facilitators to care in Hyderabad, India. In order to meet study objectives, a semi-structured qualitative interview was used to survey women of reproductive age (18-45). Women were recruited from residential communities or local schools. Demographic information, behaviors during pregnancy, and information on how women make their health care choices during pregnancy was collected. Results indicate that younger women in urban settings utilize prenatal care services and prefer hospital deliveries to home deliveries for safety reasons. Furthermore, tradition and family, specifically elder women, largely influence behaviors during pregnancy. The most evident barriers to compliance with prenatal supplements and frequency of visits to the doctor were proximity to “trusted” private hospitals and cost for care. Of the women utilizing prenatal care services, the general consensus was that women are not adequately informed of the risks and potential complications associated with pregnancy, indicating a gap in the information presented to patients. The results of this project provide insight into factors that impact decision-making during pregnancy in Hyderabad, India; the findings can be useful for further studies, as well as public health and health policy interventions within the region.

Katie Adams “A Study Of Women's Experiences With Hooking-Up” In the growing research on Hook-Up Culture, most attention has been given to the statistical gender differences in reported satisfaction by heterosexual individuals after hooking-up. This difference has been termed the "orgasm gap", which restricts satisfaction of hook-ups to strictly orgasm rates. This study seeks to examine satisfaction outside of orgasm rates; we, instead, focus on sexual satisfaction that is based on if the reason/desire for engaging in a hook-up (motivation for sex) was met, or not. Since people engage in sex for different reasons (i.e. to meet different needs), their motivation for hooking-up may influence their sexual satisfaction; in other words, how well they felt their reasoning for sex was met may determine how sexually satisfying they found the hook-up to be. The six motives for sexual behavior to be assessed are: enhancement, self-affirmation, coping, intimacy, partner approval, and peer approval. In conjunction with motivation, this study seeks to assess if there is a relationship between hook-up satisfaction and one's attachment style. Our hypotheses will be tested in a multi-part online study (an initial survey, followed by 5 weekly follow-ups) using the undergrad psych pool sample of between 250-300 participants. We are currently still in the data collection process through March 17th. We will analyze the data using regression to assess if hook up satisfaction is related to sexual motivations and attachment style. Jared Fialkoff “Gold Nanoparticle Sirna Delivery to Treat Allergic Contact Dermatitis” Delayed Type IV, T- Cell Mediated Hypersensitivity (CHS) is an immune response in skin to foreign antigens. This response is characterized by inflammation at the skin exposure site. Common examples include poison ivy and nickel containing jewelry. In order to observe this immune response one first needs to be sensitized. During the sensitization phase the, antigen complex is processed by skin resident dendritic cells (DCs) which are antigen presenting cells. They

uptake and process the antigen and then travel to the lymph nodes where they present the antigen naïve T- cells. There, cytokines are secreted, leading to clonal proliferation of the newly formed memory T-helper cells. During re-exposure memory T-helper cells that are present in skin immediately recognize the antigen and this triggers the release of proinflammatory cytokines such as IL-1, TNF-a, and IL-6, which induce an immune response (itch, redness, swelling) to this foreign antigen. Current methods for treating CHS include application corticosteroid skin creams, topical immunomodulators, phototherapy and in extreme cases immunosuppressive agents. These drugs generally act on the immune system in a systemic fashion and have diverse effects that maybe harmful. The goal of this project is to design and develop a targeted therapeutic approach based on topical a gold nanoparticle (AuNP) siRNA drug delivery system to remedy the bodies’ response by specifically silencing the production of proinflammatory cytokines in skin, which in turn would reduce the CHS response. Daniel Gorman, Jr. “Toward The Evening Star: The Rochester Origins Of The Latter-Day Saints” Given the academy’s turn toward cultural history, scholars of religion should study the portrayal of Mormonism in the media and the ways in which Mormons have used media to present their own story. After all, Mormon and non-Mormon (i.e., often anti-Mormon) writings differ sharply in their treatment of Joseph Smith Jr. and the origins of the Church of Jesus Christ of Latter-day Saints. This division in terms of tone and historical detail is apparent from the earliest primary source materials onward. The result of this dichotomy – hagiography versus polemic – is that most primary sources about Joseph Smith feature strong biases either for or against the authenticity of his religious message. With the primary source record so contentious, it is difficult to draw firm conclusions about the historical Joseph Smith. Still, it is clear that the Mormons rapidly created an idealized origin narrative for themselves in response to negative criticism, and this idealized narrative extends into present-day church teachings. The LDS story also suggests the need for religions to finesse their origin stories in order to make them

more appealing to potential converts. These conclusions are drawn from a two-part historical analysis. First, I construct a historical narrative outlining Mormonism’s origins in the greater Rochester area, with considerable attention paid to the depositions collected in Mormonism Unvailed and ninety-five newspaper articles (mostly from upstate New York) published in the 1820s and 1830s. Second, I consider the portrayal of the LDS Church’s Rochester origins in Smith’s memoirs, LDS religious education manuals, films, and the Palmyra, N.Y. historical sites. Benjamin Goulet “The Genetics of Speciation Between Drosophila mauritiana and its Sibling Species” Determining how one species splits into two reproductively isolated species is one of the major challenges of evolutionary biology. Two species may evolve incompatible courtship signals, resulting in prezygotic isolation, or incompatible genetic interactions, resulting in postzygotic isolation – the intrinsic sterility or lethality of species hybrids. The evolution of these reproductive barriers has resulted in the enormous diversity of life on earth. Here, we describe a genetic incompatibility that causes postzygotic isolation between three Drosophila species that diverged ~240,000 years ago. The hybrid lethal on the X (hlx) allele of Drosophila mauritiana is incompatible with the Suppressor of hlx [Su(hlx)] alleles of its two sibling species, D. simulans and D. sechellia. Hybrid males carrying hlxmau in a Su(hlx)sibling genetic background die during development. The hlx locus maps to the repetitive pericentromeric heterochromatin, making it difficult to precisely map. However, we are testing the hypothesis that hlx corresponds to the ribosomal DNA (rDNA) locus, the only known functional element in this region. We show that escaper hybrid males with the otherwise inviable genotype display a phenotypic syndrome similar to bobbed mutations of D. melanogaster, including developmental delay, smaller body size, and shorter, thinner bristles. In D. melanogaster, bobbed alleles are partial deletions of the rDNA locus. Taking advantage of variable, rDNA-specific retrotransposon insertions, we demonstrate a perfect association between a bobbed-like phenotype

in escaper hybrid males and the presence of a D. mauritiana rDNA locus in a non-mauritiana genetic background. The appearance of a bobbedlike phenotype in escapers of hybrid lethality suggests that the D. mauritiana rDNA is under-expressed in the genetic background of either sister species. The regulation of rDNA expression has therefore diverged between these species. In on-going work, we will use qPCR to assay rDNA expression in hybrids, identify the Su(hlx) gene, and determine the population genetic forces involved in the evolution of this interspecific genetic incompatibility. Jarrett Hannah “Investigating Resting State Networks In Pedohebephiles� Pedophiles are often described in the media as sexual offenders against children, however, pedophiles are men with an exclusive or inclusive attraction to children, regardless of attempts at molestation. Many studies have used functional magnetic resonance imaging to explore the task driven brain functioning of pedophiles, but the present is the first to utilize resting state fMRI. Our lab hypothesized that the pedophile group (sexual offenders against children) will display significant differences in default mode network connectivity in absence of a task, when compared to nonsexual offenders (criminal controls) and nonpedophilic nonoffenders (healthy controls), because similar findings have been detected in studies of other mental health disorders (ie depression). Our major discovery was that the pedophile group showed significantly decreased connectivity between the dorsolateral prefrontal cortex and the bilateral hypothalamus, as well as Brodmann area 25. Phallometric pedophilia index measures, which were derived from assessments of increased penile blood volume due to exposure to nude pictures of children, were correlated to these disconnections. This suggests that pedophillic interests may stem from a disconnection, between the frontal lobe and other areas, which causes a dysregulation of functioning: normal attraction functioning to an abnormal erotic stimulus.

Madeleine Reynolds Laitz “The Fate And Transport Of Antibiotic Resistance Genes Near Agricultural Sites In California” After doing preliminary studies, experiments, and a presentation on the fate, transport, and treatment of antibiotic resistance genes in agricultural areas of California, Dr. Jennifer Jay’s lab received funding for a largescale project in the same vein. Six excursions were made over the summer to nearby feed lots, both large cattle CAFOs and small organic farms, where samples were taken at or near the ranch using a biosampler, as well as upwind and downwind of the site using three satellite filters. Once the air samples were returned to the lab, the process of purification began. For each of the six sites tested, each sample underwent three rounds of purification. High throughput followed these rounds, a process in which the samples’ resistance to antibiotics was tested. DNA extraction and PCR were utilized as a way of accruing information about the specific genes involved in resistance and pathways of resistance – the protein used to impede the antibiotic’s effect on bacteria. The results will hopefully show a relationship of increased antibiotic resistance at the CAFO sites, as well as decreased or no antibiotic resistance at the organic sites. It is anticipated that this research will contribute to an overall body of work used to make a case for regulation of the administration of antibiotics. David Markakis “An Alternative Reading Of Baroque Musical Borrowing” Composers of the so-called Baroque era in music (c. 1600-1750) often use previously existing musical material in composing a new piece, a practice we now refer to as “borrowing” or “quotation.” Though some contemporary musicians and philosophers take issue with borrowing, it is not until the late 1700s and early 1800s (the start of the “Classical era” of Western Music) that quotation becomes equated with plagiarism. The philosophical shift that also informed the codification of intellectual property law is often linked to these accusatory attitudes. However, one must consider the impetus behind the philosophical shift itself. While musicologists — beginning in the late twentieth century — have

corrected the derision that G. F. Handel and other composers received for their borrowing, they have not identified much practical reason for the philosophical rejection of borrowing. I propose that these changes were informed by a decrease in printing costs, which reshaped the marketability aspect of music for many composers. In other words, cheaper printing allows composers and other idea-owners to disseminate their works with greater ease, which results in undermining “borrowing,” as borrowing paid homage to fellow composers and improved one’s own credibility. Jennifer Newman “Quality Of Life In Irritable Bowel Syndrome Subtypes” Irritable bowel syndrome (IBS) is a commonly diagnosed condition characterized by abdominal pain and altered bowel habits in the absence of an organic cause. This condition has been demonstrated to have adverse effects on patients’ quality of life (QOL). Concomitant diagnoses of other functional gastrointestinal diseases (FGID) are seen in patients with IBS. Specific research tools, such as the Rome III Functional Bowel Disorders questionnaire and the Patient Assessment of Gastrointestinal Symptom Severity Index (PAGI-SYM), are used to measure the severity of functional bowel disorders and upper gastrointestinal symptoms, respectively. We correlated IBS symptom scores to upper GI tract symptom scores to determine the relationship between the severity of IBS to the severity of other upper gastrointestinal disorders, as well as elucidate the impact that the symptoms had on overall quality of life. In the IBS-Diarrhea (IBS-D) subtype, severity of IBS-QOL correlated moderately well to severity of generalized abdominal symptoms, specifically bloating. These results have important clinical implications since the data suggests that targeted therapy to combat bloating in patients with IBS-D may significantly improve their overall quality of life.

Pedro Vallejo-Ramirez “Measurement of Optical Scattering in Intra-Ocular Lenses” Intra-ocular lenses (IOLs) are implemented to surgically replace cataract-affected lenses in human eyeballs. Glistenings are fluid-filled micro vacuoles that form within certain IOLs through time when the IOL is immersed in an aqueous environment. These vacuoles cause scattering within the IOLs, therefore causing a gradual reappearance of scattering. The present study focused on measuring and characterizing the scattering pattern from these IOLs using a custom built scatterometer with a very high dynamic range. The objective is to understand the scattering properties of the vacuoles and determine if this can severely affect visual performance. Cassidy Welter “The Effects Of Urban Limitations On Food Rituals: A Study Of Diaspora Populations Of Orthodox Jews And Siva Devotee Hindus In New York City” The Siva devotee Hindus and Orthodox Jews of New York City, NY in conjunction with the respective practitioners of Rochester, NY have been forced to alter their traditional beliefs and ritual practices of India and Israel in response to changing immigrant environments, limitations on physical and sacred space, as well as the limited availability of traditional goods and services in the United States of American for diaspora populations. Food rituals are exemplary for understanding how urban spaces limit religious traditions in the Jewish and Hindu context. When making the shift from traditional religious landscapes to the urban metropolises of the United States, religious minority groups are forced to alter their traditions in respect to the majority culture, available products, as well as spatial limitations for practice, worship, and religious experiences. The findings of this study will have greater implications for the comparative study of religions, especially in the field of American religious studies.

Claire Wyman “Physiological Stress Response And Infant Cognitive Development At 6And 16-Months Of Age� Conclusive evidence has been found in adults that exposure to stress, and the stress-induced glucocorticoid cortisol, can reversibly decrease certain aspects of memory. Although the evidence is limited, research suggests that salivary cortisol measured in early childhood is related to cognitive development. This project tested the hypothesis that physiological stress reactivity will be associated with cognitive and language development in infants at 6 and 16 months of age, as part of a prospective longitudinal study. The Bayley Scales of Infant Development (BSID) was used to assess cognitive and language development of the infants. Salivary cortisol levels in response to a stressor were measured to analyze stress reactivity (n=210). The BSID scores were stable from 6 to 16 months, but the cortisol reactivity was not stable over time. No significant relationship was found between the BSID scores and cortisol reactivity at 6 or 16 months, or over time. The findings reflect how unstable and still developing the stress response system is at this point in infancy.

University of Rochester Office of Undergraduate Research Dewey Hall 4209-B Rochester, NY 14627 (585) 276-5306

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