CURO Symposium 2017 Book of Abstracts

Page 163

Abstracts and brain), organs, and intestines. N-glycans were obtained by enzymatic hydrolysis using PNGase F followed by MALDI-TOF and ESI-MS and bioinformatic analysis. Thus far, glycome analysis has revealed significant differences in the glycan composition and abundance of the control intestine as compared to the treated samples. There are also notable differences between the glycan composition in the intestine and carcass samples. Identification of the glycan structures is still in progress. These findings will aid in elucidating the physiological responses of organisms to chronic, low dose IR.

basement walls with the novel concrete mixture using Finite Element Analysis, and (3) constructing a full-scale basement wall to demonstrate the placeability of the novel concrete mixture. Nanocellulose Based Drug Loaded Micro/Nanoparticluate for Therapeutic and Drug Fate Analysis Betsi Micholas Dr. Jaya Sundaram, Chemical, Materials, and Biomedical Engineering, College of Engineering Nanoparticles provide massive advantages regarding controlled and targeted delivery with their potential to combine diagnosis and therapy, emerge as one of the major tools in nanomedicine. Curcumin has anti-cancerous and antiinflammatory benefits, specifically for the colon. The main issue with drug delivery to the colon is that the drug often degrades in the gastrointestinal tract before reaching the colon. Encapsulation of drug into bio-based polymer is a common practice in pharmaceutical industries. Nanocellulose is classified as a biopolymer and has unique properties allowing it to be a good candidate for site-specific drug delivery through nanoencapsulation. This project is proposed to make nanocellulose encapsulated curcumin nanoparticles to have site-specific controlled delivery at the colon. Cellulose nanocrystal (CNC) was dispersed in water and used to encapsulate curcumin. A measured amount of curcumin was dissolved in the required amount of ethanol, and added slowly to CNC solution by continuously stirring the mixture. Once the mixture was homogeneous, it aged for 24 hours and curcumin encapsulated CNC particles were separated using vacuum filtration. The filtered cake was dried at low temperature in a vacuum dryer and stored for further analysis. Analysis of curcumin-loaded nanoparticles follows surface morphology analysis, physicochemical analysis, bioavailability, biodegradability and in vitro release study using artificially simulated intestinal and stomach fluids. The specific aims are to have a controlled delivery of the drug in the intestinal fluid and to increase the bioavailability of curcumin. The developed nanoceullose encapsulated curcumin will improve the current drug delivery methods of colon cancer treatments.

Evaluation of Residential Basement Wall Concrete Mixtures for Water-Tightness and Reduction in Traditional Reinforcing Steel Jake Michael, CURO Research Assistant Dr. Stephan A Durham, Environmental, Civil, Agricultural, and Mechanical Engineering, College of Engineering The Atlanta housing market is expected to grow 7% in total households during the next five years. With this potential economic opportunity, it is advantageous to develop innovative methods of constructing more economical homes. Ready Mix USA is interested in evaluating concrete mixtures for basement walls that provide equivalent watertightness to that of current installation methods and have the potential to decrease the required area of temperature and shrinkage steel. The 2015 International Residential Code (IRC) requires foundation walls that retain earth and enclose interior spaces and floors below grade to be dampproofed. This study evaluated novel concrete mixtures for use in basement walls that satisfy the IRC without having to provide an exterior damproof/waterproof membrane and the novel mixture that utilized a permeability reducing admixture was found to reduce the seepage through concrete specimens. This study also examined the use of macrofibers and shrinkage reducing admixtures to potentially reduce the reinforcement required in the basement wall. This allows for a quicker and more economical installation of residential basement walls. The study was completed in three phases (1) establishing the property characteristics of novel concrete mixtures, (2) modeling and analyzing 158