The University of Florida Health Cancer Center continues to provide exceptional care, engage in groundbreaking research and foster transdisciplinary collaborations to ensure that those residing within our 23‑county catchment area have access to world class cancer care. This catchment area profile provides a glimpse of the factors related to cancer health outcomes, both in terms of burdens or barriers, but it also identifies some of the assets and successes within. Our catchment area is distinguished by its large rural population and high rates of socioeconomic vulnerability, particularly among minority groups, as well as an aging population. The region is also characterized by high rates of smoking, obesity and late‑stage cancer diagnosis compared with the rest of Florida and the U.S. We hope this Catchment Area Profile and PORTRAIT is insightful and exhibits our efforts to assist you in the development or enhancement of your cancer‑related endeavors.