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Department of

Awards Research and academic recognition for outstanding accomplishments Page 3-5

UCLA-Argentina International experience for our graduate students and faculty

Our Generous Donors Atsuko & Akira Fujimoto, Audree Fowler, and Roger Macomber

Sigman Lecture

Page 7

Page 8

Page 11

The 2009 Sigman Memorial Lecture recap and photos

Developing a New Prostate Cancer Drug By focusing on a key hormone receptor associated with prostate cancer, UCLA professor Michael E. Jung and coworkers, in collaboration with oncologist Charles L. Sawyers and his group at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City, have rationally designed a small molecule that provides the basis for a new prostate cancer treatment with a novel mechanism. Jung discussed the project at the American Chemical Society’s national meeting in Philadelphia last summer, explaining that there are three types of prostate cancer. Nonmetastatic prostate cancer is typically not very Mike Jung and Dong Won Yoo aggressive and often remains untreated. The second type — hormone-sensitive metastatic prostate cancer — is an aggressive cancer that responds to treatments that reduce male hormone levels, such as surgical castration and prescription of antiandrogens. Surgical castration and antiandrogens “make the tumor growth go down, at least for a time,” said Jung. “But after one to three years, about 60 percent of patients develop a third type of prostate cancer, which is also metastatic but can no longer be treated with antiandrogens.” This type is called hormone-refractory, castration-refractory or castration-resistant prostate cancer.

“MDV3100 reduced tumors to a third or fourth of their original sizes.” Jung and co-workers decided to pursue a medication against this third type of prostate cancer by targeting the androgen receptor, which Sawyers’ group had previously identied as a promising drug target. Their goal was to nd small organic molecules that bind to the androgen receptor and that exhibit potent receptor blocking ability (antagonism), as well as little or no tendency to activate the receptor (agonism). Synthetic and design efforts led to a lead compound, RD162, which had notable drug properties and retained potent androgen receptor antagonism in hormone-refractory cells. A trial in live mice with hormone-refractory prostate cancer showed that RD162 “knocked down the tumors,” Jung said. “We were hitting hormone-refractory cells.” The tests showed, surprisingly, that the agent was also effective against hormone-sensitive cells. (continued, p. 14)

Celebrating the Life of Sylvia Winstein (p. 14) (Saul and Sylvia Winstein pictured)

In This Issue

Page

Chair’s Message!............... 2 Awards"...........................3-5 Happenings".................... 6-7 Giving & Donors"............. 8-9 Seaborg Symposium"........ 10 Sigman Lecture"................ 11 Winstein Lecture".............. 12 Faculty Research"......... 13-14 In Memoriam".............. 14-15 Graduation"..................... 16

Spring 2009 Volume 29 - Number 2


UCLA Chemistry & Biochemistry - Spring 2009

Sheri Sangji, 1985-2009 This space is usually used to highlight the accomplishments of our faculty, staff, and students and to bring your attention to upcoming events in the department. Indeed, there are many such items to mention, which I will touch on later, but rst, I must discuss an event that overshadows any news about our accomplishments, that being the death of Sheharbano (Sheri) Sangji, a staff research associate in our department. Sheri’s death resulted from a tragic accident that occurred while she was carrying out her research duties in the Molecular Sciences Building on December 29, 2008. While Sheri was drawing an aliquot of t-butyl-lithium solution into a syringe, the plunger came out, allowing reagent to escape. This highly reactive compound ignites spontaneously in air, and as a result, Sheri’s gloves and sweatshirt caught re. Despite heroic efforts by the two co-workers with her that day, Sheri suffered second and third degree burns over 40 percent of her body. After an 18-day battle against infection and other complications resulting from the burns, Sheri died on January 16, 2009, at the Grossman Burn Center in Sherman Oaks. A memorial service held at the Islamic Center of Southern California on January 19 was attended by approximately 50 of Sheri’s colleagues from the department, as well as Dean Joseph Rudnick. Sheri was buried later that week in Toronto, where her parents reside. Sheri, 23 years old at the time of her death, graduated from Pomona College in 2008 with a degree in chemistry. As an undergraduate, she carried out research in the laboratory of Dan O’Leary, a graduate alumnus of our department who received his Ph.D. under the mentorship of Frank Anet. Sheri and Dan coauthored papers in the Journal of the American Chemical Society and Organic Letters. Some of her undergraduate research focused on the use of ring closing metathesis reaction in the synthesis of 310helical peptides. After several months working in industry as a synthetic chemist, Sheri decided that she preferred the intellectual stimulation of an academic lab and, in October 2008, joined our organic chemistry division to contribute to exciting research efforts in the synthesis of natural and designed compounds with potential to ght such human maladies as cancer and obesity. Sheri was a brilliant student who planned to enter law school in the fall.

Words are inadequate to describe the sadness we feel at losing such an intelligent and generous young woman. Our thoughts and prayers are with Sheri’s family and friends as they have been since this terrible accident occurred. In Sheri’s memory, we commit ourselves to!a thorough!review of safety!protocols and an immediate inspection of laboratories in the Molecular Sciences Building, as!well as other labs utilized by the Department of Chemistry and Biochemistry.! The department is deciding on the best way to memorialize Sheri, and your suggestions are welcome.

Honors and Events

As detailed on p. 3-4, a number of our faculty, including Jim Bowie, Paula Diaconescu, Xiangfeng Duan, David Eisenberg, Tom Mason, Joan Valentine, and Omar Yaghi, have received important extramural awards and honors since the last edition of the newsletter. In addition, one of our emeriti, Fred Hawthorne, was awarded the Priestley Medal, the highest honor conferred by the American Chemical Society. The department bestowed further honors of our own (also detailed on p. 5) upon our faculty, staff, and students at the 2008 Department Awards Ceremony, which took place on November 3, 2008. We were delighted to have UCLA alumni Ralph and Charlene Bauer, who are generous and loyal supporters of the department, in attendance at this ceremony. Ralph, who received his B.S. in chemistry from UCLA in 1952 and then went on to earn his Ph.D. in 1958 in our department working under the mentorship of Nobel laureate Don Cram, conferred the Ralph & Charlene Bauer Graduate Student Research Award upon Marisa Monreal. His presentation included an inspiring speech on the importance of his UCLA education in allowing him, as the son of immigrants, to achieve the American dream. Lastly, we would also like to invite everyone to the 2009 Department Graduation Ceremony, which will be held on Saturday, June 13, at 5 p.m. in the Court of Sciences.

On January 23, Dean Rudnick and I sent a letter to the campus community discussing Sheri’s tragic death that included the following comments:

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UCLA Chemistry & Biochemistry - Spring 2009

2009 Priestley Medal Award

Richard C. Tolman Medal Joan S. Valentine, professor of biochemistry, has won this year’s Richard C. Tolman Medal in recognition of her outstanding contributions to chemistry. The Medal is awarded each year by the Southern California Section of the American Chemical Society. The Tolman Medal was presented to Professor Valentine at the Southern California Section of the ACS award dinner in May, held at the UCLA Faculty Center.

M. Frederick Hawthorne, B.S.’49 (Pomona), Ph.D.’53 (Cram), Professor Emeritus from UCLA since 2006, received the 2009 Priestley Medal at the American M. Frederick Hawthorne Chemical Society March meeting. The Priestley Medal, University of Missouri, Columbia recognizing distinguished Director of the International Institute of Nano and Molecular service to the eld of Medicine chemistry, is the highest UCLA Chemistry & Biochemistry honor the ACS can bestow. Professor Emeritus Fred, who returned to UCLA in 1969 as professor of inorganic chemistry, is best known for his work in boron chemistry, including the synthesis of the icosahedral ion B12H122-. He is now director of the International Institute of Nano and Molecular Medicine at the University of Missouri, Columbia.

American Physical Society Thomas G. Mason has been elected as a fellow of the American Physical Society, through the Division of Condensed Matter Physics, “for pioneering the approach of microrheology of complex uids based on the thermal diffusion of probe colloids.”

Jim Bowie Honored by AAAS James U. Bowie, professor of biochemistry, has been elected a Fellow of the American Association for the Advancement of Science for his role in devising techniques to determine protein structure. Jim was one of only three UCLA Faculty to receive this honor in 2008. The AAAS fellows were honored at the AAAS annual Meeting in Chicago on February 14, 2009.

Sloan Research Fellowship

Professional Development Award

The Alfred P. Sloan Foundation has awarded Paula Diaconescu, assistant professor of inorganic chemistry, with a 2009 Sloan Research Fellowship. The fellowships are awarded to “exceptional young researchers” based on their “outstanding promise of making fundamental contributions to new knowledge.” Her research involves the design and synthesis of complexes with specic geometric and electronic properties.

Laurence Lavelle and Eric Scerri have been awarded UCLA Professional Development Awards. Laurence Lavelle will use the award for curriculum development during the 2008-2009 academic year. Eric Scerri’s award will be used to fund his attendance at a science education meeting in Cartagena, Columbia, where he will be organizing a symposium on the periodic table and its applications in science and science teaching.

Dickson Award and Royal Society of Chemistry

Charles M. Knobler

Joan S. Valentine

Charles M. Knobler, Professor Emeritus of physical chemistry, was selected as one of six UCLA emeriti for the 2009 Dickson Emeritus Professor Award, given for outstanding performance in scholarship, teaching, and service after retirement. He was also elected as a fellow of the Royal Society of Chemistry in January 2009.

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SPRING 2009 NEWSLETTER FACULTY, STAFF & CONTRIBUTORS

Editorial Board Miguel Garcia-Garibay, Heather Maynard, Al Courey

Direction & Design Stephen S. Naczinski

Editing & Production Jin Lee, Tami Fertig

College Policy & Relations Development: Steve Ramirez, Erica Marentes; Silvia Busch

Contributors Steven Clarke, David Eisenberg, Robin Garrell, Ken Houk, Mike Jung, Laurence Lavelle, Charles Knobler, Eric Scerri, Robert Scott, Todd Yeates, Cynthia Allen, Lissett Bastidas, Mandy Bell, Judith Forman, David Imai, Penny Jennings, Shamar Jones, Bo Tendis, Carolee Winstein UCLA Department of Chemistry & Biochemistry 607 Charles E. Young Drive East Los Angeles, California 90095-1569


UCLA Chemistry & Biochemistry - Spring 2009

Harvey International Prize in Human Health

David S. Eisenberg

Professor David Eisenberg received the 2008 Harvey International Prize in Human Health in March at the Technion in Haifa, Israel. This award was set up by Leo M. Harvey, an immigrant businessman who settled in the Los Angeles area in 1910 to work as a tool maker with the Hot Point Electric Company.!In 1914, he started his own shop with two workers, called the Harvey Machine Company, in downtown Los Angeles.!By 1920, the company had more than 300 employees, and eventually morphed into Harvey Aluminum Company. In different years, the Harvey Prize is awarded in various elds. Previous awardees include Claude Shannon, Seymour Benzer, Freeman Dyson, Paul Lauterbur, Sidney Brenner, Pierre-Gilles de Gennes, Benoit Mandelbrot, Mikhail Gorbachev, Harry Gray, and Wolfgang Baumeister.

ACS Award and Miller Research Professorship Omar Yaghi is the recipient of the 2009 ACS Award in the Chemistry of Materials. The ACS proudly recognizes his contributions to the development of the eld of research in polymer and materials science. He has also been awarded a 2009 Visiting Miller Research Professorship, a program designed to bring scientists to the UC Berkeley campus for collaborative research interactions.

NIH New Innovator Award Xiangfeng Duan, assistant professor of inorganic chemistry,!was awarded with the 2008 National Institutes of Health (NIH) New Innovator Award. This program, which is in its second year of existence, supports high-impact research by young investigators. Xiangfeng’s award is to support his studies into the development of minimally invasive neural nanoprobes to monitor and manipulate neural activity.

Alumna Honored for Contributions to Biotechnology Katherine Kantardjieff, Ph.D.’88 (Eisenberg), has been honored with the Andreoli Faculty Service Award, the highest honor for faculty given by the California State University Program for Education in Research and Biology. Dr. Kantardjieff is currently a professor of physical chemistry at Cal State Fullerton.

Charles and Sue Young Graduate and Undergraduate Student Awards Katherine A. Kantardjieff Benny Ng, graduate student in Sarah Tolbert’s lab, and Kevin Roy, one of four undergraduate departmental scholars and a member of Guillaume Chanfreau’s lab, were awarded with the Charles E. and Sue K. Young Graduate and Undergraduate Student Award (respectively), at the College Awards Dinner on April 27, 2009. The award is given once a year to three graduate students and four undergraduate students “for exemplary academic achievement, research, and university citizenship.”

First Annual Audree Fowler Fellowship The rst awards for the Audree Fowler (B.S.’56, Ph.D.’63 in Biochemistry) Fellowship were presented in October 2008 at the UCLA Molecular Biology Institute (MBI) Lake Arrowhead Retreat. Neil King (Todd Yeates Group) and Nathan Joh (Jim Bowie Group) were awarded with the fellowships. The Audree V. Fowler Graduate Fellowship in Protein Science serves as a tting testament to Fowler’s commitment and dedication to her research and to UCLA.

UCLA Mortar Board Awards Joe Rangel Nathan Joh (left) presented with the Fowler Fellowship by Reid Johnson

Joe Rangel, a machinist for UCLA Chemistry & Biochemistry Department, was awarded by the Agathai Chapter of the Mortar Board at UCLA, with the Tip of the Hat Award. The Award recognizes Joe’s hard work and dedication to working for UCLA.

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UCLA Chemistry & Biochemistry - Spring 2009

Chemistry & Biochemistry Departmental Awards Ceremony

Undergraduate Awards Stone Prize for Excellence in General Chemistry Tadeh Vartanian

November 3, 2008

Graduate Awards

Excellence in First Year Academics and Research

Charlene and Ralph Bauer

Tadashi Kawashima William Morris Kyle Quasdorf Lufeng Zou

Excellence in Teaching Steevens Alconcel Eric Broderick Robyn Hodgkins Meghan Johnson Gert Kiss Yuen Lau Laura Schelhas Mitsuharu Suzuki Aimee Terauchi Courtney Thomas Joann Um Oscar Villalta

Excellence in Research Ralph & Charlene Bauer Award Marisa Monreal George Gregory Award William Glover Majeti-Alapati Fellowship Amy Hayden

Mike Jung presenting Steven Kim with the Hanson-Dow Award

John M. Jordan Memorial Award Shakir Sayani Ernest F. Hare, Jr., Memorial Scholarship Henry Tran John Stauffer Fellowship Sarah Angelos

Faculty Awards Hanson-Dow Award (For Excellence in Teaching) Steven Kim

Herbert Newby McCoy Awards (For Contribution to Scientiďƒžc Discovery in Chemistry & Biochemistry)

Tim Deming Saeed Khan Thomas Mason

Award recipients Meghan Johnson and Courtney Thomas

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UCLA Chemistry & Biochemistry - Spring 2009

TV Spot: Fighting Air Pollution

Clean energy could save our planet. And when it arrives, Omar Yaghi will be one of the scientists who make it possible. Yaghi, UCLA professor of inorganic chemistry, is the creator of Metal Organic Frameworks, or MOFs, a kind of crystalline sponge that can store amazing quantities of natural gas, hydrogen or CO2 in very small spaces. He’s also the inventor of “reticular chemistry,” or the stitching together of molecules into extended structures. Yaghi explains, “If we were just to take the automobiles now using natural gas, like the buses in L.A. or sedans in Italy or taxis in Southeast Asia, if you stuff the tank with MOF, you can drive twice as long or twice as far.” Yaghi was featured presenting these ideas on the “Here. Now. UCLA” commercials currently running on TV.

Chemist to Head UCLA Faculty Senate

The Yaghi ad is currently airing on TV stations, and also at www.spotlight.ucla.edu/here-now-stories/omar-yaghi/.

Robin Garrell, professor of organic chemistry, has been elected Chair of the Faculty Senate for the 2009-2010 academic year. !Professor Garrell is a spectroscopist and surface scientist who has worked with Professor Joe Loo to make major advances in the development of microuidic devices for mass spectrometric analysis.!She was recently the Chair of the Faculty Executive Committee of the UCLA College. !

JACS of All Trades This past January, Professor Miguel Garcia-Garibay took on a great responsibility: He became an associate editor for the Journal of the American Chemical Society (JACS), the highest-ranking chemistry journal in the world. The weekly publication, which was established by the ACS in 1879, receives upwards of 10,000 submissions every year. Each manuscript is assigned to one of 22 associate editors, who must decide the fate of the paper based on peer review and their own expertise. Only about a third of all submissions — the ones reporting the most cutting-edge research with the broadest appeal — get published in the journal. The job requires a tremendous amount of dedication — Miguel spends several hours a day reading through manuscripts — but it’s all very rewarding. Every day, he says, he is “exposed to groundbreaking science as it is happening.” Almost as thrilling? Being selected for the highly regarded position by editor-in-chief Peter Stang. “Associate editors should be among the leaders in their discipline and be recognized as such by the scientic community,” says Miguel. “I feel honored to be chosen.”

Table Talk

The chemistry department has long been dependent on UCLA’s Court of Sciences lecture halls, otherwise known as CS76, CS50 and CS24. After many decades of heavy use, these halls are now undergoing major renovations. The department, for its part, has contributed new periodic tables. Many years before UCLA Facilities put the Court of Sciences on their renovation list, several of the department faculty members wanted to update the periodic table in the agship Kenneth N. Trueblood Lecture Hall (CS50). It wasn’t until 2005, however, that Laurence Lavelle was asked to take on the “periodic table project,” which required signicant customization since the wall space available did not match the width-to-height ratio of available periodic tables. More importantly, the font sizes, thickness, and spacing had to be The new periodic table on display customized to maximize viewing in these large lecture halls. during a lecture by Laurence Lavelle The previous periodic tables stopped at element 105, making them severely outdated, and, perhaps most importantly, missing element 106, Seaborgium (Sg), named in honor of the Nobel laureate Glenn Seaborg, who was a chemistry major undergraduate at UCLA. It is now present for a new generation of UCLA undergraduates to see. After hundreds of hours of work, Laurence showed an early version to approximately 20 faculty members in 2007. Several versions and a year later, it was ready for nal printing. The department appreciates Laurence’s volunteering to design these informative and colorful periodic tables, and overseeing their installation. In addition, many thanks to Steve Hardinger for overseeing the lecture hall renovations, and to Gigi Marr and the many helpful people involved at UCLA Facilities.

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UCLA Chemistry & Biochemistry - Spring 2009

Exciting International Experience for Graduate Students and Faculty

In March, graduate students and faculty of the UCLA Department of Chemistry & Biochemistry headed down to South America to participate in the U.S.-Argentina Workshop on Nanomaterials. The meeting from March 15-17, 2009 was a stimulating forum for U.S. and Argentinean faculty, industrial, and student researchers to come together and share top-notch science in the general area of nanomaterials. The setting was in the beautiful Patagonia mountain region of Argentina in the Amancay Hotel in Bariloche. In an exciting turn of events, the workshop was selected as the The U.S.-Argentina Workshop Group rst Bilateral Cooperation on Nanotechnology by the respective countries. As a result, Mr. James Perez of the U.S. Embassy in Buenos Aires and Dr. Chris Cannizzaro of the U.S. State Department were both in attendance. On July 10, 2008, a Joint Statement on Increasing Cooperation in Nanotechnology was signed by U.S. Assistant Secretary of State Tom Shannon and Argentina’s Minister for Science, Technology and Productive Innovation, Lino Barañao. Both countries have existing scientic programs and are committed to promote this cooperation on nanotechnology through interactions in the frame of joint projects. Concomitant with the workshop, several UCLA faculty participated in bilateral roundtable discussions and helped identify steps to promote and further nanotechnology cooperation between the two countries. A school was also held for the Chris Kolodziej, Eric Schopf, Heather Maynard and Alison Oostendorp students, with lectures on bionanotechnology and discourses on the cultures of the respective countries. UCLA Associate Professor Heather Maynard rst proposed the idea for the workshop as part of her National Science Foundation (NSF) Career Award. She and Assistant Jeff Zink, Meghan Johnson and Professor Lia Pietrasanta of the Universidad de Buenos Aires co-organized the event. Miguel Garcia-Garibay Funding from the U.S. was provided by the NSF through the International Center for Materials Research (ICMR) and the California NanoSystems Institute (CNSI). Maynard said, “We had hoped that this workshop would lead to the proliferation of tangible goals for joint research at the frontier of chemistry and materials science and strengthen cooperation and networking between the two countries. The workshop met and far exceeded our expectations.”

The New Organic Division! This is the new Organic Division at the steps of Royce Hall. ! Along with the “veterans,” there is the new Cram Chair, Patrick Harran, and two newly tenured professors, Heather Maynard and Ohyun Kwon, and a new assistant professor, Neil Garg.

Top Row (Left to Right): Neil Garg, Craig Merlic,Yves Rubin, Tim Deming; Bottom Row (Left to Right): Heather Maynard, Patrick Harran, Mike Jung, Miguel Garcia-Garibay, Ohyun Kwon, Robin Garrell, and Ken Houk.

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UCLA Chemistry & Biochemistry - Spring 2009

Roger Macomber Dr. Roger S. Macomber has arranged to provide an unrestricted bequest of $100,000 to the department. When the department receives these generous discretionary funds, the chair will use the new resources to address the greatest needs and highest priorities, such as support for outstanding students or innovative research. Dr. Macomber received his B.S. in chemistry from UCLA and then, in 1968, became the youngest person, at age 23, to Roger S. Macomber, an avid earn a chemistry Ph.D. here. cyclist, during a competition (This record has since been (circa 1995) broken.) After graduation, he spent most of his career as a professor of chemistry at the University of Cincinnati and later at Pepperdine University, and authored numerous books, monographs, and scientic articles. He stated recently, “I really owe a debt of gratitude to the Chemistry & Biochemistry Department. My education launched me into a wonderful career of 30 years as a professor, and I always remember my marvelous days at UCLA.” We are grateful to Dr. Macomber for his generous support of the Department of Chemistry & Biochemistry.

Fujimotos Endow the Roberts A. Smith Graduate Student Award The Department of Chemistry & Biochemistry is pleased to announce that alumna Atsuko Fujimoto and Akira & Atsuko Fujimoto her husband, Akira Fujimoto, have created the Roberts A. Smith Graduate Student Award for the Study of Biochemistry with a generous endowment of $50,000. Dr. Fujimoto earned a Ph.D. in chemistry in the department in 1963 and then an MD from the Geffen School of Medicine in 1969. She said, “My studies at UCLA would not have been possible without the nancial support I received from the Department of Chemistry & Biochemistry. It is my turn to help young, aspiring students.” She chose to honor Professor Emeritus Smith because, she said, “his constant encouragement and

assurance helped me advance toward the degree.” Professor Smith has been a pioneer in the study of phosphorus-nitrogen bonds in proteins and the mechanisms of antiviral agents and methionine and folic acid metabolism in normal and malignant cells. Dr. Fujimoto currently is chief of the Genetics Division at Los Angeles County/ USC Medical Center. Her husband, a 1960 graduate of UCLA’s Anderson School, is Roberts Smith president of Jastam USA Inc., an importer of electrical and electronic equipment and parts. In addition to this gift, the couple are regular supporters of the department, the Chemistry Advisory Council Fund, the Glenn T. Seaborg Medal Dinner, and the Seaborg Endowment. Atsuko Fujimoto (center) in 1963 We thank the Fujimotos for their commitment and at UCLA Graduation generosity.

Biochemistry Division Raises Funds in Honor of Distinguished Faculty Emeriti It is hard to imagine a chemistry department without biochemists, but a generation ago, biochemistry was not taken seriously by most chemists. However, at UCLA, a few insightful pioneers within our department — Dan Atkinson, Paul Boyer, Richard Dickerson, Roberts Smith, Verne Shumaker and Charlie West — persevered and assembled what is now considered one of the top biochemistry divisions in the world. These revolutionary professors helped create a new eld, and in the process, two became members of the National Academy of Sciences, one built a major pharmaceutical company, and one brought a Nobel Prize to UCLA. All made major discoveries and all enhanced the lives of their colleagues and students. To honor their contributions, we are raising discretionary biochemistry research funds in their honor. Our long-term goal is to establish chairs in each of their names. We are proud to honor their important contributions to science, teaching and the department through these fundraising efforts and invite you to join us by donating to the “Biochemistry Discretionary Fund in Honor of Emeriti Faculty” (Biochem Dsct/Emeriti Fac #618870) using the envelope included in the newsletter. Additionally, if you would like information about funding a chair in honor of a specic professor, please contact Steve Ramirez, director of development for the Physical Sciences Division, at (310) 794-9045.

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UCLA Chemistry & Biochemistry - Spring 2009

SEABORGIUM (Over $999)

Allergan Inc. Amgen Inc. Bristol-Myers Squibb Cannon Survivor’s Trust Carter, Robert & Mae Chen, Tei-Fu & Oi-Lin Clark, Andrew J. Crawford, Thomas C. Creek, Jefferson & Jane Eli Lilly and Company Fujimoto, Atsuko & Akira Gabriel, Philip & Ronald Gelbart, Nina R. & William Goh, Ma C. J. Inami, Harry & Kay International Technologies, Inc. Knobler, Charles & Carolyn Lau, Ronald Moore, Stephen & Darcie Morimoto, Bruce & Joy Muscular Dystrophy Association of America Nagumo, Mark & Dote, Janis Saisho, Kenji & Gloria Sekera, Michael & Sharon Strathearn, Gary & Olga The Albert Parvin Foundation The Clorox Company The Rathmann Family Foundation The Sheldon Lewis Fund The Raymond & Dorothy Wilson Trust Tsay, Jim & Barbara Wiredja, Heru & Waty

PLATINUM ($500 - $999)

Bermingham-McDonogh, Olivia M. Gresser, Michael & Hannelore Jung, Chu Wah & Victoria Kivelson, Margaret G. Kollmeyer, Willy & Barbara Murashige, Kate A. Scott, Robert & Elizabeth Siebert, Eleanor & Raymond Sitler, Susan & David Smith, Roberts & Adela Stavros, Kimiko & Harry Sweet, Jack Timberlake, William & Karen Tsai, Shih-Wa

GOLD ($250 - $499)

Berman, Rod S. Caballero, Ross & Rochelle Clarke, Catherine F. & Steven Fellows, Bruce & Sylvia Garrell, Robin L. Gin, Carolyn Handa, Paul Holzer, Margaret E.

Houk, Kendall N. Ieng, Maly & Castro, Sheryll Katz, Marion & Howard Keller, Walter G. Kim, June Y. Lin, Yung-Ya Lo, Frederick & Chan, Polly Marsi, Marianne & Lewis Marvin, Dean & Lee McMahon, Robert & Angela Mitchell, Dennis K. Nasi, Kourosh Reisler, Emil & Hanna Russell, Arlene A. Schwartz, Richard S. Smith, Judith L. West, Charles & Carol Williams, Michael G. Williamson, Arthur G.

Margerum, Suzanne & Lawrence Martinson, Harold & Sara Mason, Thomas G. Maverick, Emily & Andrew Maynard, Heather D. & Bass, A.S. Millar, Michelle D. Menon, Neeta Miyada, Don & Setsuko Mork, H. Craig & Linda Murai, James & Doris Nakagawa, Yumi Ogawa, Yasushi Ohara, Pamela C. Okita, Richard T. Pham, Hoa B. Pinto, Joseph D. & Linda Ravetto, Jeffrey J. Reyes Jr., Reynaldo Roberts, John & Edith Rosman, Edwin & Anida Rowen, Scott & Rana Russell, Christopher T. Schwartz, Kenneth E. Singler, Robert & Judith Spielmann, Peter H. Spring, Denise J. Steelink, Cornelius I. Steichen, Dale & Sandy Strouse, Charles & Jane The Greiner Family Trust Tsai, Mark Valencia, Maria Vera Sanchez, Raul Venerable II, Grant D. Weisman, Gary & Donna Yokobata, Kathy E. Yokokawa, Hiroshi P. Zehnder, Dean & Biddle, Andrea Ziegler, Stanley & Frances

SILVER ($100 - $249)!

Amponsah, David Babajanian, Masis Barnes, Larry & Sandra Berengian, Anderee R. Biale, John & Elena Bingham, Carleton D. Birely, John H. Bise, Ryan T. Bishara, Anne-Marie & Ishak Block, Thomas E. Bloomeld, Jordan & Doris Bocarsly, Andrew B. Bogy Pringle, Rebecca L. Boyd, Steven A. Brady, John F. Brinkerhoff, Ana L. Cappiello, Camille & Doug Chang, Evelyn & Ching-J. Chapman, Susan P. Clement, Noriko Diaconescu, Paula L. Eisenberg, David & Lucy Fachini II, Roger & Wendy Felker, Peter & Patti Fung-Tomc, Joan C. Gabrielian, Sylva & Leon Georgiadis, Taxiarchis M. Goyne, Thomas & Cheryl Gralla, Edith & Jay Greer, Alexander & Edyta Grifn, T. Scott Hanson, John & Lois Harran, Patrick Hays, Auda K. Ho, Siew P. & Lam, Patrick Hoel, Elvin & Donna Huang, Tung-Shiuh Jergenson, Dale & Phyllis Jiang, De-En Kaesz, Herbert & Joan Kaner, Richard & Sara Koehler, Carla Krane, Sonja & Abramo, Graham Kwan, Janice & Reginald Kwon, Ohyun Leitereg, Theodore & Marianne Louie, Jeffrey & Corry

COPPER ($1 -$99)!

Abelt, Chris, & Mooring, Anne Aglipay, Ralph J. A. Alconcel, Steevens N. S. Blumstein, Nancy A. Bouchard, Louis Boyer, Paul & Lyda Buckner, Clay E. Cappiello, Stephanie L Carter, Ann W. Castillo, Romeo & Julie Chang, Shang-Poa Y. Chauhan, Sonam Chen, Eric Clubb, Robert Cohlberg, Jeffrey A. Delphey, Craig E. Dreyfuss, Beth W. Falk Sr., Carl & Florence Fricke, Oscar & Julie Garcia-Garibay, Miguel & Beatriz Garcia, Jose & Maria Gelfand, Cheryl A. Gillan, Edward G.

Glick, Betty J. Goodman, Leon & Marilyn Goto, Joy J. Graves, Sara M. Grover, Gregory Gunaydin, Hakan Guo, Feng Hanin, Israel Harn, Lucy C. Hayes, Richard A. Hellberg, Lars H. Hodgkins, Robyn E. Hoffenberg, Howard Hui, Zhe Hurley, James F. Hwang, Maggie & Rong Jung, Michael E. Kabehie, Sanaz Kaganove, Steven N. Kelly-Quintos, Casie A. Kim, Jennie J. Kim, Soo Hong Law Ofce of Howard L. Hoffenberg Lay, Anna Lee, Dennis H. Lee, Kinbo J. Lin, Yushiu Lowe III, John A. Ly, Dean & Julie Ly, Leslie MacDonald, David J. MacPhail, Richard A. Martin, Lenore M. Mehta, Uchita Mg, Kyaw Kyaw Muranaka, Neil J. Neuhauser, Daniel & Rachel Ngo, Chilan Nguyen, Cara N. Nguyen, Dung T. Nguyen, Lam T. Oldham, Susan B. Osborne, Ursula Ota, Irene M. Palais, Robert Patel, Krina M. Pickwoad, Richard Piersol, Christopher Quan, Norman & Brenda Roberts, Andrew G. Rodriguez, Marc A. Shen, Dong-Ming Sinclair, James & Sara The Leitereg Living Trust Tolbert, Sarah Trinh Pharm.D., Catherine Valdez, Nikkole Gaile B. Villa, Reymundo A. Wade, Charles & Betty Weakliem, Paul & Cheryl Weiss, Shimon Whiteker, Roy & Jean Whitelegge, Julian P. Wilking, James & Connie Wilson, Samuel Wu, Chin-Hua Xie, Gui D. Yu, Kuen W.

These gifts were received from June 1, 2008 to February 15, 2009. - 9-


UCLA Chemistry & Biochemistry - Spring 2009

Seaborg Symposium & Medal Presentation

was held on November 1, 2008, in CNSI Auditorium and the Covel Commons. Joan S. Valentine, the 2008 Seaborg Medalist, is a biological inorganic chemist and biochemist. She has been a faculty member of the UCLA Department of Chemistry & Biochemistry since 1980. She is also currently the editor-in-chief of Accounts of Chemical Research. Harold Martinson, Xiangfeng Duan, Joan Valentine, Yi Lu, and Edith Gralla

Scott Waugh, Bill Gelbart, Al Courey, and Lyda and Paul Boyer

David and Lucy Eisenberg and Harry B. Gray

Joan Valentine displaying the Glenn T. Seaborg Medal

Joan Valentine and Judith Smith

Photos by William Short

will be presented to Mostafa A. El-Sayed, UCLA Chemistry & Biochemistry Professor Emeritus, Georgia Tech Julius Brown Chair and Regents Professor, and Director, Laser Dynamics Laboratory. The symposium and medal dinner will be held on November 14, 2009. The theme of the symposium will be “Advanced Materials and Nano-Technology.� In addition to Professor El-Sayed, speakers will include Professors A. Paul Alvisatos (Lawrence Berkeley National Laboratory at UC Berkeley), Professor Paul Barbara (Director of the Center for Nano & Molecular Science and Technology at University of Texas, Austin), Professor Zhong Lin Wang (Director of the Center for Nanostructure Characterization, Georgia Tech), and Professor Ahmed Zewail (Arthur Amos Noyes Lab of Chemical Physics, CalTech). For information on the Seaborg events, please contact Cynthia Allen at callen@chem.ucla.edu or phone (310) 267-5123.

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UCLA Chemistry & Biochemistry - Spring 2009

2009 David S. Sigman Memorial Lecture

with those of David Sigman. Prof. Stubbe is a member of the National Academy of Sciences and was the recent recipient of the National Academy of Sciences Award in Chemistry. The David S. Sigman Memorial Fund, established in 2002, honors individuals for their signicant contributions to chemical biology. David Sigman was a faculty member in Chemistry and Biochemistry, and in the Department of Biological Chemistry in the UCLA School of Medicine. His discovery of chemical nucleases stands as an important contribution to the eld of enzymology. Born in New York City in 1939, he graduated magna cum laude from Oberlin College in 1960 with his B.S. in chemistry. Prof. Sigman received his Ph.D. in 1965 from Harvard. After postdoctoral work, he served briey as an instructor at Harvard before joining the UCLA faculty in 1968. His research bridged the elds of organic chemistry, biochemistry, and molecular biology. As one of the founding members of the UCLA Molecular Biology Institute, he served as its associate director from 1994-2001. David Sigman died in 2001 at the age of 62. Contributions to help assure the future of the lecture series can be made by sending your donation in the enclosed donation envelope. (Please write “Sigman” on the envelope.)

On January 22, 2009, JoAnne Stubbe, Novartis Professor of Chemistry and Professor of Biology at the Massachusetts Institute of Technology, was honored as the Seventh Annual David S. Sigman Memorial Lecturer at UCLA. She Marian Sigman, Sebeeha Merchant presented a talk titled and JoAnne Stubbe “Ironing Out Ribonucleotide Reductase.” Her talk was followed by a reception and poster session highlighting the work of UCLA graduate students and postdoctoral fellows in the eld of chemical biology, in particular this year the research being conducted by graduate student trainees from the Chemistry-Biology Interface Training Program. JoAnne Stubbe received her undergraduate education in chemistry at the University of Pennsylvania and carried out her Ph.D. studies in chemistry at the University of California, Berkeley. She did a brief postdoc in chemistry at UCLA with Jules Rebek, where she worked on the total synthesis of LSD starting from tryptophan. Her rst job was in the Chemistry Department at Williams College, focused on undergraduate education. She soon realized that she wanted to carry out research with graduate students, and took a leave of absence from Williams to work with Robert Abeles at Brandeis University, where she fell in love with enzymes and became fascinated with how they work. She moved from Brandeis to Yale University Medical School in the Department of Pharmacology, then to the University of Wisconsin in Madison in Biochemistry. In 1987 she moved to her current position at MIT. Prof. Stubbe’s lab unraveled the complex JoAnne Stubbe and Howard Chang free radical mechanism (Eisenberg Lab) of ribonucleotide reduction catalyzed by ribonucleotide reductases and the importance of stable and transient protein and nucleotide free radicals in catalysis. She also worked on the mechanism of free radical mediated degradation of DNA by the antitumor antibiotic bleomycins, where her interests extensively overlapped

Chemistry-Biology Interface Training Program: Sigman Lecture Poster Session The Chemistry-Biology Interface Training Program is an NIHand UCLA-supported program to train graduate students in a variety of chemical and biological programs using state-of-the-art chemical techniques to solve problems in biology. Trainees are supported for three years and participate in a variety of activities including an internship in another laboratory.! The program was started by David Sigman in 1994.! He was succeeded as director by Joan Valentine and then by Ken Houk.! Fifteen trainees presented posters on their research at this year’s Sigman Symposium.

Sam Hasson (Koehler Lab) and Ken Houk

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UCLA Chemistry & Biochemistry - Spring 2009

Sixth Annual Winstein Lecture The Organic Division hosted the Sixth Annual Winstein Lecture on March 12, 2009. The Saul Winstein Lecture has become an annual UCLA event, sponsored by the Winstein family and UCLA through the Winstein Chair. Saul Winstein was the greatest physical organic chemist of his generation. The lecture pays tribute to his achievements by honoring outstanding physical organic chemists, Herb Kaesz, Maurice Brookhart many who have and Miguel Garcia-Garibay strong ties to UCLA. This year, Maurice Brookhart from the University of North Carolina - Chapel Hill was the Winstein Lecturer. Brookhart’s lecture was titled, “Catalytic Transformations Based on CarbonHydrogen Bond Activation Reactions of Late Transition Metal Complexes.” Saul Winstein was an undergraduate at UCLA, receiving his degree in 1934. After his Ph.D. at Caltech, NRC postdoc at Harvard and one year as instructor at IIT, he returned to UCLA as an instructor in 1941. During his 28-year career at UCLA, he created many of the concepts that guide our understanding of reactions in solution. Members of the Winstein family continue to be major supporters of activities in our department, and we were thankful that Sylvia Winstein was able to attended the reception held before the lecture in the Winstein Commons. Professor Brookhart attended Johns Hopkins University in Baltimore where he received an A.B. degree in chemistry in 1964. He carried out his doctoral work in physical organic chemistry at UCLA under the direction of Saul Winstein. After nishing his Ph.D. degree in 1968, he spent six months as a National Science Foundation postdoctoral fellow at UCLA with Winstein and Frank Anet, followed by a year of study at Southampton University as a NATO postdoctoral fellow. Brookhart joined the University of North Carolina faculty in 1969 and is currently the William R. Kenan, Jr. Professor of Chemistry. Brookhart served as associate editor of Organometallics (1990-96), received the 1992 American Chemical Society (ACS) Award in Organometallic Chemistry, the 1994 ACS Cope Scholar Award, and the 2003 ACS Award in Polymer Chemistry. He was elected to the American Academy of Arts and Sciences

Ken Houk, Maurice Brookhart, J.D. Roberts and Mike Jung

in 1996, the National Academy of Sciences in 2001, and received the North Carolina Award in Science in 2008. The lecture was preceded by a reception in the Winstein Commons, and after the lecture in the CNSI auditorium, there was a reception for Professor Brookhart and all those attending the lecture. Contributions to help assure the future of the lecture series can be made by sending your donation in the enclosed donation envelope. (Please write “Winstein” on the envelope.)

Andrea J. Liu Presents Kivelson Lecture The seventh Kivelson Lecture was given on March 2, 2009, by Andrea J. Liu, Edmund J. and Louise W. Kahn Professor in the Natural Sciences in the department of physics and astronomy at the University of Pennsylvania. Liu, Andrea J. Liu whose eld is theoretical condensed matter physics, spoke on “Jamming and the Glass Transition”, work that she started during her 10 years in the physical chemistry faculty at UCLA. Liu received her Ph.D. from Cornell in 1989, and, after several years as a postdoc rst at Exxon and then at UC Santa Barbara, joined our department in 1994, leaving for Penn — to our great regret — in 2004. (continued, top of p. 13) Andrea Liu and Juli Feigon

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UCLA Chemistry & Biochemistry - Spring 2009

Initial funding for the Kivelson Lectures was established in 2002, to honor Daniel who, though several years past his retirement, was still as active as ever pursuing his creative and exciting researches in the area of liquid state dynamics and the theory of the glass transition. The idea was to bring friends and collaborators of Daniel’s to the department on an annual basis who he would be particularly eager to see and from whose expertise his colleagues in the department could regularly benet. Unfortunately, Daniel became seriously Sabeeha Merchant and Margaret ill just months before the rst lecture (January Kivelson at the Kivelson Reception 6, 2003), and was unable to attend; he passed away weeks later, on January 23, 2003. Next year’s (2010) Kivelson Lecturer will be Tom Keyes, professor of theoretical and computational biochemistry at Boston University, Ph.D’71 (Kivelson). We are already looking forward to his visit! Contributions to help assure the future of the lecture series can be made by sending your donation in the enclosed donation envelope. (Please write “Kivelson” on the envelope)

Unraveling the Mysteries of Chemical Reactivity Ken Houk, distinguished professor of chemistry at UCLA, is already known for developing theoretical models to understand what controls reactivity and selectivity. His frontier molecular orbital theory of cycloaddition regioselectivity has been in general use for more than 30 years. Now his research group has developed a more Lai Xu, Amy Hayden, Ken Houk, Franziska Shoenebeck complete model, the and Elizabeth Krenske distortion/interaction model, to account for differences in reactivity of different types of 1,3-dipoles, a useful class of reactants. First developed with former graduate student Daniel Ess, the distortion/ interaction model has been extended to a number of other cycloaddition reactions by current co-workers Lai Xu, Amy Hayden, Franziska Schoenebeck, and Elizabeth Krenske (pictured), who have applied this to explain reactivity of many 1,3-dipolar systems. Dr. Schoenebeck and former Houk group members Yeimy Garcia and Claude Legault have also shown how this model explains regioselectivity of palladium-catalyzed cross-coupling reactions. The work has been published in a series of papers in the Journal of the American Chemical Society.

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Breathing Life Into An Old Idea A new paper in JACS by Stephen Kent at the University of Chicago, highlighted in an accompanying C&E News article, is breathing new life into an old idea. About 13 years ago a graduate student in the Yeates laboratory, Stephanie Wukovitz, provided a mathematical answer to a longstanding puzzle concerning why proteins tend to crystallize in just a few strongly favored kinds of symmetric arrangements. The mathematical analysis further predicted that proteins would be much easier to crystallize if they could be prepared synthetically in both enantiomeric hands. The difculty has been in synthesizing racemic mixtures of proteins of reasonably interesting size. In the last decade, Kent has been pushing that eld forward by developing novel synthetic methods. His recent work shows that, in multiple cases, small proteins that had resisted crystallization by other approaches can be crystallized from synthetic racemic mixtures, as had been predicted. Those successes suggest that racemic crystallization might eventually become a routine strategy for overcoming the difcult challenges of protein crystallization.

A crystal containing biological (cyan) and non-biological (yellow) enantiomers of a protein molecule


UCLA Chemistry & Biochemistry - Spring 2009

Cancer Drug (continued from p. 1) The chemists licensed their patents to San Francisco-based Medivation. “They didn’t take RD162,” he said. “They took another compound, an analog of RD162. They called it MDV3100, and that is the compound they decided to move forward” into pharmacokinetics, toxicology and animals tests. Medivation’s animal trials showed that MDV3100 reduced tumors to a third or fourth of their original sizes. Jung himself doesn’t understand why the drug acts as effectively as it does. “The mechanism we have says it should be cytotoxic, but instead appears to be apoptotic,” he said. “All it’s supposed to be doing is stop binding to the androgen receptor. But there’s something else going on, and we’re studying the system like crazy to nd out.” Human trials of MDV3100 began in July 2007. “In October 2007, there was a Prostate Cancer Foundation meeting, and eight or 10 people I never met asked me for samples of MDV3100,” Jung said. “Word was sneaking out that it was looking good.” In an ongoing 90-patient Phase I and II clinical trial of MDV3100, early results suggest encouraging antitumor activity. If results continue to be positive, Medivation says it will seek Food & Drug Administration approval for a Phase III trial. (It’s worth noting that another androgen receptor blocker called BMS-641988, developed by oncology chemist Mark E. Salvati’s group, is also in clinical trials for hormone-refractory metastatic prostate cancer.) While Taxotere and Novantrone are already approved medications for treatment of hormone-refractory prostate cancer, they are not androgen-receptor antagonists. “They have marginal benet, signicant toxicity, and work by killing cells nonspecically,” says Sawyers. “MDV3100 is novel because it has minimal side effects,” and it is targeted at the condition that specically drives hormone-refractory metastatic prostate cancer: increased levels of androgen receptor. Notably, funding for Jung’s research on prostate cancer drug candidates didn't come from the National Institutes of Health, but from the Prostate Cancer Foundation founded by Michael Milken. “Milken was treated for prostate cancer and has since remained cancerfree,” said Jung. “He decided to raise money for prostate cancer research. Without him, we wouldn't have had the money for this project, so Michael Milken is to be thanked for this.”

Sylvia Winstein On Friday, March 27, the Department lost a great friend and benefactor, Sylvia Levin Winstein, aged 93. Sylvia came to UCLA as an undergraduate in psychology nearly 80 years ago and, except for a brief respite, never left. It was at UCLA that she met Saul Winstein, an undergraduate chemistry major, who after receiving his master’s degree in 1935, went on to Caltech for his doctoral studies. He and Sylvia were married in 1937, and they returned to UCLA in 1941, when Saul accepted a Sylvia Winstein presenting the position as instructor. With Saul’s untimely death in 1969, Winstein Scholarship (circa 1970) Sylvia Winstein Sylvia’s ties to the department and the university became even (circa 1950) stronger. She was instrumental in establishing the Winstein Chair in Organic Chemistry and the Winstein Awards given annually to graduate students, until recently presenting the awards at the departmental graduation ceremonies. She served for many years on the Chemistry Advisory Council. Her commitments to UCLA extended beyond our department and include her work with Aesculapians, the School of Medicine support group, Design for Sharing, which brings elementary and high-school students to campus for concerts, and the Grunwald Center for Graphic Arts. In 1980 she took over the management of the annual Emeriti Arts and Crafts exhibit, which ourished and is now named in her honor. Despite suffering a debilitating stroke several years ago, she continued to participate in departmental activities; just two weeks before her death she had been present for the annual Winstein Lecture. In 2002 Sylvia donated her Westwood house to the university as a gift annuity. This permitted her to continue to live in the house and to receive some retirement income. Now, when UCLA receives the house, the proceeds from its sale will add substantially to the funds supporting the Saul Winstein Chair and the Winstein fellowships. The gift will also be used to establish a Sylvia Winstein Fund Carolee and Sylvia Winstein at to benet the UCLA Emeriti Association’s art programs. the 2006 Graduation Ceremony

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UCLA Chemistry & Biochemistry - Spring 2009

Robert Bau

Mark S. Delaney

B.S.’64 (U. of Hong Kong), Ph.D.’68 (Kaesz), professor of chemistry at the University of Southern California, died December 28, 2008, aged 67. After a year as a postdoc at Harvard, he joined the USC faculty in 1969. Bau was a distinguished researcher in the eld of x-ray and neutron diffraction crystallography and was president of the American Crystallographic Association in 2006.

B.S.’75 (Cal State Fullerton), Ph.D.’80 (Hawthorne), associate professor of chemistry, McNeese State University, Louisiana, died April 4, 2008, aged 55. Delaney worked seven years at Dow Chemical (1980-87) before joining the faculty at McNeese in 1987. Although he considered himself an organometallic chemist, most of the projects he investigated had some connection to polymer chemistry. His most recent research interests included anionic and cationic polymerizations, halatopolymers, gas permeability through polymer membranes, and thermal characterization of polymers.

Hans Frederick Bauer B.S.’56, Ph.D.’62 (Drinkard), died February 6, 2009, aged 76. Before returning to UCLA for graduate work, he served for the Navy, in the Pacic. After receiving his Ph.D., Bauer had an extensive research career including working with Occidental Petroleum and with the Department of Energy.

Loraine Geissman

development and applications of polypyridyl complexes of ruthenium, osmium, and rhenium. Most recently, in collaboration with workers at the Pacic Northwest Regional Laboratory, Sullivan reported new highly oxidizing excited states of rhenium and technetium.

Sheharbano (Sheri) Sangji B.S.’08 (Pamona), a research assistant in the Patrick Harran laboratory, died January 10, 2009, aged 23, as a result of injuries sustained in a laboratory re. She had been at UCLA only three months and intended to start law school in the fall. (See also the Chair’s message on p.2)

Sami Talhouk

Lecturer in chemistry from 1979 to 1988, died September 2, 2008, aged 81. Dr. Talhouk, a Druse in Lebanon, obtained his undergraduate degree from the American University of Beirut. Coming to Stanley J. Cristol Jay C. Kochi the United States in 1952, he obtained his B.S.’37 (Northwestern), Ph.D.’43 B.S.’49, Ph.D.’52 (Iowa State), M.S. from Southern Methodist University (Young), Joseph Sewell Professor of died August 9, 2008, aged 81. and a Ph.D. in physical chemistry from Chemistry at the University of Kochi was Welch Professor of Ohio State University. Talhouk returned to Colorado, died January 23, 2008, Chemistry at the University of Lebanon to lecture at the Lebanese aged 91. One of the rst doctoral Houston and had a distinguished University’s Faculty of Science, but, when students in chemistry at UCLA, he did career in organic chemistry. He received the the Lebanese civil war forced closure of research with Bill Young on the James Flack Norris Award in physical that university, he returned to the United stereochemistry of iodide-ion-promoted organic chemistry from the American States, teaching rst at Penn State, and then elimination of dibromides. After Chemical Society 1981 and was elected to at UCLA. His last teaching position was in postdoctoral work with Roger Adams at the the National Academy of Sciences in 1982. the Department of Chemistry at California University of Illinois, he joined the faculty Before joining the Department of State University Northridge. at Colorado in 1946, retiring in 1986. Chemistry at UH in 1984, Kochi worked as Cristol contributed to many areas of Irving D. Webb an instructor at Harvard, a chemist at the physical organic chemistry, including Shell Development Company, a faculty M.A.’42, Ph.D.’44 (Young), died solvolysis reactions, free-radical chemistry, member at Case University, and Earl March 26, 2008, aged 87. After small-ring chemistry, and polycyclic Blough Professor of Chemistry at Indiana serving in the Navy during World chemistry. He was elected to the National War II, he worked as a research University. Academy of Sciences in 1972 and in the chemist with DuPont. In the early same year received the James Flack Norris B(rian) Patrick Sullivan 1950’s he accepted a position with Unocal, Award in physical organic chemistry. In B.S.’71 (UC Irvine), M.S.’86 spending the rest of his career there, rst in 1994, the University of Colorado renamed (UCLA), Ph.D.’89 (North Yorba Linda, California, and later in Los its chemistry and biochemistry building Carolina, Chapel Hill), professor Angeles. He retired in 1980. after Cristol. of chemistry, University of Wyoming, died August 10, 2008, aged 58. His eld was inorganic photochemistry, specializing in the Widow of Professor Theodore Geissman, died February 28, 2008, aged 93.

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UCLA Chemistry & Biochemistry - Spring 2009

Join Us at the 2009 Commencement Ceremony Saturday, June 13, 2009 at 5 p.m. the Court of Sciences

2009 Graduation The UCLA Chemistry & Biochemistry Department would like to invite everyone to join us in celebrating the achievements of our new graduates. It’s a wonderful opportunity to reconnect with our faculty and your fellow Bruins! We hope to see you there!

UCLA-DEPARTMENT OF CHEMISTRY & BIOCHEMISTRY

607 Charles E. Young Drive East Los Angeles, California 90095-1569

Now More Than Ever Help Keep Us Great! During these challenging economic times, your generous gifts mean more to us than ever and helps ensure that the department remains at the forefront of scientic advancement.

Call Steve Ramirez Director of Development (310) 794-9045

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UCLA Chemistry Spring 2009 Newsletter