Theme 2 â€“ Force Balancing
Theme two draws inspiration from the balanced use of fundamental physical forces down to the nanoscale, such as electrostatics and effects arising from geometrical confinement. One of the projects in this theme is the design and synthesis of chaperonin-inspired materials for enzyme immobilisation.
In nature, enzymes catalyse the reactions necessary for life. When cells undergo stress, like high temperature, they create multi-protein complexes, called chaperonins, to protect and stabilise enzymes. In order to use enzymes in pharmaceutical manufacturing, we design enzyme support materials based on these chaperonins. Both the nano-confinement and the electrostatic forces that are the basis for stabilisation of enzymes in the cavity of chaperonins are implemented in the nanoporous, non-biological materials we synthesise. This leads to increased activity and stability of the immobilised enzymes by force balancing in the nanopores.
GaudĂâ€™s Sagrada Familia Church in Barcelona is a great example of force balancing organic architecture.
CENTRE FOR NATURE INSPIRED ENGINEERING
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