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The Endocannabinoid System: A Beginner’s Guide Learn more about the endocannabinoid system and how it affects your health. The endocannabinoid system is a biological system which plays many important roles in the human body. It is also responsible for the physical and psychological effects of cannabis. Scientists first discovered the system while trying to understand the effects of cannabis, and named it the endocannabinoid system for this reason. Endo stands for endogenous, which means originating within the body. Cannabinoid refers to the group of compounds that activate this system. The endocannabinoid system is a major target of medical research because of its widespread effects and therapeutic potential. While scientists have sorted out the basics of this fascinating system, much more remains to be uncovered.

What are Cannabinoids? Cannabinoids are the chemical messengers for the endocannabinoid system. While many different cannabinoids exist, they all fall under two categories: internal or external. Internal is known as endocannabinoids, these compounds are produced naturally by the human body. They interact with cannabinoid receptors to regulate basic functions including mood, memory, appetite, pain, sleep, and many more. External knows as the cannabinoids found in cannabis, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), are considered exogenous. When consumed, they also interact with cannabinoid receptors to produce physical and psychological effects in the body.

What are Cannabinoid Receptors? You may be wondering, what exactly are receptors? As their name suggests, receptors are message receivers. Messages come in the form of chemical messengers binding to the receptor. These messages produce a characteristic effect within the body. The endocannabinoid system has two receptors: CB1 and CB2. Each receptor responds to different cannabinoids, but some cannabinoids can interact with both. The distribution of CB1 and CB2 receptors within the body and brain explains why cannabinoids have certain effects. CB1 receptors are found throughout the body, but are mostly present in the brain and spinal cord. They are concentrated in brain regions associated with the behaviors they influence. For example, there are CB1 receptors in the hypothalamus, which is involved with appetite regulation, and the amygdala, which plays a role in memory and emotional processing. CB1 receptors are also found in nerve endings where they act to reduce sensations of pain. CB2 receptors tend to be found in the peripheral nervous system. They are especially concentrated in immune cells. When CB2 receptors are activated, they work to reduce inflammation. Inflammation is an immune response which is believed to play a role in many diseases and conditions.

With respect to the cannabinoids found in cannabis, researchers have found that THC binds to both CB1 and CB2 receptors, activating them just like an endocannabinoid. CBD does not bind directly to cannabinoid receptors. Instead, CBD works by inhibiting an enzyme called FAAH, which is responsible for the breakdown of anandamide — the most important endocannabinoid in the body. When FAAH is inhibited, it cannot break down anandamide at its normal rate. This leads to a buildup of anandamide in the brain.

What are Endocannabinoids? Endocannabinoids are cannabinoids produced naturally within the human body. 2AG and anandamide are the two major endocannabinoids that scientists know of. Anandamide was the first endocannabinoid to be identified by scientists. 2-AG is found at higher concentrations in the brain, while anandamide is found at higher concentrations in other areas of the body. Both are capable of binding to CB1 and CB2 receptors, but differ in their affinities for these receptors (i.e. how likely they are to bind to and activate each receptor). Endocannabinoids are “short-order� neurotransmitters. After being released, endocannabinoids are quickly broken down by enzymes.

The endocannabinoid system is involved with regulating many basic functions of the human body, including: Appetite Metabolism

Pain Sleep Mood Movement

Temperature Memory/Learning Immune function Inflammation Neural development Neuroprotection Cardiovascular

Digestion Reproduction Besides maintaining basic functions, the endocannabinoid system also acts in response to illness.

For example, tumor cells have been shown to express more cannabinoid receptors than healthy cells. Studies also show a rise in endocannabinoid levels in patients with various disorders, such as Parkinson’s disease, anxiety, chronic pain and arthritis. As a result, many scientists believe the overall function of the endocannabinoid system is to regulate homeostasis. Homeostasis is a key element in the biology of all living things. It is best described as the ability to maintain stable internal conditions that are necessary for survival. Disease is largely a result of a failure in achieving homeostasis. Thus, the endocannabinoid system’s role in maintaining homeostasis makes it a unique and promising target.

The Endocannabinoid System in Medicine. Due to its widespread effects in the human body, the endocannabinoid system is believed to hold promise in treating many diseases and conditions. In recent years, scientists have been exploring various ways of targeting this system. Medical marijuana is one way of targeting the endocannabinoid system to treat various illnesses. Compounds in marijuana, including THC and CBD, are known to produce therapeutic effects by interacting with the endocannabinoids. However, this is not yet legal in every state or worldwide. An alternative has emerged on the market in the form of CBD Oil. CBD Oil is mostly made from Hemp and has a low amount of THC, therefore being non-psychoactive. In sum, the endocannabinoid system is truly a treasure trove for scientists and medical professionals. It is extremely complex, plays important roles in many vital processes, and holds promise as a treatment target for many debilitating conditions. The discovery of CBD and the Endo-Cannabinoid System, are two of the greatest health discoveries of the 21st century. This is because of the number of people and health conditions that are benefitting from CBD: everything from anxiety to migraines. CBD (CBD oil) is one of the main medicinal compounds in cannabis. It has so many benefits to both body and brain, that it can be hard to believe it at first.

CBD creates more stable moods, reduces inflammation (benefitting auto-immune conditions), lowers blood sugar (diabetics can take less insulin), and greatly benefits psoriasis and eczema. Yes, really! CBD benefits both body and brain, and is now being researched for its effects on cancer and tumors. CBD stands for "Cannabidiol". CBD does not make you high. The other main compound in cannabis is THC, "The high causer", which does make you high. CBD can be purchased with or without THC. CBD is not a drug. CBD helps restore homeostasis (balance) through its effects on our Endo- Cannabinoid System - which is a recent discovery. CBD oil has the following properties: 1. Anxiolytic - reduces anxiety 2. Anti-psychotic 3. Anti-inflammatory 4. Anti-oxidant - slows aging 5. Reduces pain 6. Lowers blood sugar 7. Neuro-protective 8. And may be cancer preventive

-Full Spectrum CBD vs Isolate- Which One is More Effective?

As the term suggests, full spectrum CBD comes with all the of the cannabinoids present in the plant. In hemp oil, this includes a long list of cannabis compounds, such as Cannabinol (CBN), Cannabicyclol (CBL), Tetrahydrocannabivarin (THCV) and Cannabichromevarinic Acid (CBCVA). It is crucial to point out that small amounts of THC can also be found in hemp. The government regulates concentration levels at 0.3 percent (dry weight) for “industrial hemp” products, resulting in very limited cerebral stimulation. When CBD is in isolate form, it is separated from other cannabis compounds in the source plant. It was previously believed that CBD isolates were more potent and concentrated than full spectrum CBD. This assertion was eventually debunked by a study from the Lautenberg Center for General Tumor Immunology in Jerusalem. In the 2015 study, researchers were able to prove that full spectrum CBD is capable of offering greater levels of relief, as higher doses were administered to mice. By comparison, the group that was given CBD isolate did not experience the same level of relief at higher doses. To better understand how these two CBD formulas differ, imagine being presented with two types of spaghetti sauce. In the first bowl, you’ll find a simple spaghetti sauce made out of pure tomatoes (CBD isolate). In the second bowl, you can find a more complex spaghetti sauce, containing roasted garlic and fragrant Italian herbs (full spectrum CBD). It’s clear that both bowls are holding spaghetti sauce – but the second recipe is more flavorful and interacts with one’s taste buds differently (also known as the “entourage effect”). Based on the comparison above, full spectrum hemp oil is more effective than CBD isolate, making it highly recommended for people interested in a holistic approach. Hemp oil is an extremely potent source of CBD (responsible for a large bulk of the oil’s cannabinoid profile).

-What is Hemp Oil Extract?

Hemp oil extract is an oil derived from the stalks and seeds of the industrial hemp plant. This oil can be used for a variety of purposes and can be consumed as a wellness supplement, either alone or paired with other ingredients. Common Hemp Misconceptions There are some common misconceptions when it comes to hemp, especially due to the relation to its psychoactive cousin. -Does CBD get you high? Absolutely not. In order to be legally considered hemp, the hemp plant must contain less than 0.3% THC. THC, or tetrahydrocannabinol, is the psychoactive chemical compound found in cannabis. The 0.3% amount of THC is negligible and cannot produce a high. In fact, CBD is known to counteract the psychoactive properties of THC. Hemp extract is not the same as what you’d find in the grocery store. You can buy hemp seeds and hemp seed oil in stores, but it is not the same as hemp oil extract. Oil extracted from the seeds of the hemp plant is extremely nutritious but does not contain phytocannabinoids, which are a part of a diverse class of chemical compounds. Hemp oil extract contains many phytocannabinoids including cannabidiol (CBD), which is being studied extensively for its beneficial properties. Hemp seed oil does not contain CBD (Do Not be fooled). Properly sourced hemp oil can be sold in all 50 U.S. states and many other Countries. To be considered hemp, the cannabis plant must have less than 0.3% THC.

What does hemp taste like? We’ve heard hemp described as good and bad tasting. The honest truth is…it depends on your personal preferences, just like any other food. If you don’t like earthy flavors, we suggest using a flavored product. Hemp oil extract is a high-CBD, low-THC product that does not have psychoactive properties. CBD and THC are both phytocannabinoids found in the cannabis plant; it can sometimes be confusing to differentiate the two. The following infographic gives a better look at the differences between THC and CBD, as well as the differences between hemp and marijuana

Most Asked Questions While we are not doctors nor allowed to make medical claims, many of our customers turns to us for questions, concerns and comfort. We can only share our experience and guide you to follow your doctor, pharmacist or physicians advice.

Legal Disclaimer: These statements have NOT been evaluated by the Food and Drug Administration. These products are NOT intended to diagnose, treat, cure or prevent any disease. The Food and Drug Administration (FDA) considers non-THC based hemp products to be “food based� and therefore LEGAL without a medical marijuana license. 1. Can I still take my medication? Serious drug interactions have not been seen with Cannabidiol (CBD) in combination with any other drug. However, CBD and other plant cannabinoids can potentially interact with many pharmaceuticals by inhibiting the activity of cytochrome P450, a family of liver enzymes. This is like the "Grapefruit Affect", we recommend that you consult with your doctor or physician. 2. How long is it going to take to work? There are a wide range of factors which contribute towards how long the CBD Oil is going to take to work. Method of consumption, quality of oil, serving size, and the severity of symptoms is main influences. it does also tend to vary from person to person. Therefore, you can never be sure of how long it is going to take to produce the effect in you. The only way with which you can get to know it for sure is via experiment. 3. How long does a bottle last? Our Bottles are 30ml/1oz, they contain 50 servings. Now that being said, 1 serving is .6ml a full dropper which is 10mg (500mg). Since you will start at a very low dose and slowly increase on weekly basis. The first bottle will last you longer than others. Again, this depends on what your "sweet spot" serving will be. On average a bottle can last 1 to 3 months.

4. What is the best way to take/use CBD Oil?

-The drops SUBLINGUALLY are by far the most concentrated form of CBD because you are getting in sublingually (under the tongue). There’s a 98% absorption rate with the oil drops because the CBD gets absorbed right into the bloodstream. Many suggests maximizing the effects of the oil, to keep it under tongue a few minutes to get maximal absorption. -TOPICALLY: Whether it is rubbed on achy muscles in oil or pain rub, CBD is known to help your body from inside out and from outside to inside while applied on skin. We have seen some improvement with applying 1-2 drops on skin for things such as eczema, acne, skin tags, dropping in ear and much more!! When people are in pain and they have a natural solution, they experiment and this one thing I love about our oil is that we can use it in multiple ways! -DIFFUSING: Essential oil lovers are excited to try their favorite oil with 5-6 drops of our Peppermint or natural flavor CBD oil added to their favorite diffuser.. I personally add 23 drops of Lavender and 5-6 of our HempWorx Peppermint oil and it lasts for days and smells refreshingly good! Great to help sleep or during winter cold seasons or just the refreshing scent during the day.

-VAPING also has a high adsorption %, both are very effective. It's a personal preference. Before vaping the oil make sure you have a vape that can take the thickness of cbd oil, offers a low wattage option and won’t burn the oil. With HempWorx oil we don’t currently have a vape line just yet but many users enjoys the almost instant fast relief with shorter effects that vaping does. Great for acute anxiety and pain. -BELLY BUTTON (Pechoti) Application Ok this one may sound weird but research it if you’re curious... From one of our happy customers in our testimonial group: Yes, it's called the Pechoti delivery. When a fetus is in vitro, they get all their nutrition from their mother via the umbilical cord. A gland at their end of the umbilical cord, the Pechoti gland, is responsible for distributing the nutrients to the developing baby. After birth, the Pechoti remains. In Western cultures, it is ignored. However, in many cultures, e.g. India, the Pechoti is a common method for delivering medication, especially when there's a stomach virus or something wrong with the absorption in the intestinal tract due to liver or kidney disease. The Pechoti has 72,000+ nerves running through it, and has the capacity to reach nearly every part of the body. ...... I was interested in this because I have heard of some who couldn't take the oil orally because of taste or whatever. I decided to try it the next few days in my belly button just for grins. I must say that while it takes a little longer to get into my system, the effects had lasted a lot longer than taking orally. Just FYI for anyone who doesn't like the taste or who wants another way to use. I also didn't use near as much product.

OTHER CBD OIL INFUSED PRODUCTS: -Massage Relief pain rub on painful, inflamed or affected area, or apply our Renew and Revive face creams morning or night. A little goes a long way so apply a small amount on tip of finger and massage the cream widely until it is absorbed. Most have reported to have relief within minutes of using this topical pain rub and it is perfect for the healers, physical therapist and salons. Many therapies now include CBD treatments and the results are amazing!! Our face creams have improved skin complexion, reduce wrinkles and acne and leaves young radiant feeling skin. Timeframe of 3-6 months is approximately how long one of these bottles would last depending how much you use or if you share with family.

5. How Much CBD Oil Should I Take? (Serving) It's best to start low and work your way up gradually. Research has shown that small doses of cannabinoids from can signal the body to make more endocannabinoids and build more cannabinoid receptors. Slowly increasing to a maximum amount, then breaking for a couple of days, then cutting the dose in half over a certain interval of time, repeating until the lower dose is reached, and then maintaining at the lower dose. While this may not work for some more chronic issues, it does work for many. While we are using lower doses of cbd oil, our body is making more endocannabinoids and more CB receptors so we will be more sensitive to it and our bodies will respond better and heal faster. 6. What is CO2 extraction? What's the difference in between

subcritical and supercritical CO2 extractions? CO2 extraction is an extraction procedure that uses pressurized co2 to extract phytolchemicals (such as CBD, CBG, or terpenes, flavonoids, etc.) from a plant. CO2 at specific temperatures and pressures acts like a solvent, without the threats of really being one. It is the most expensive extraction method, and is commonly considered the most reliable and safest plant extraction technique in the world. Lots of hemp and CBD companies boast about their supercritical CO2 extractions, however that's actually just one (and perhaps an inferior) approach of using a CO2 extraction machine. There are also subcritical CO2 extractions, and ‘mid-critical', a basic range between subcritical and supercritical. Subcritical (low temperature, low pressure) CO2 extractions take more time and produce smaller sized yields than super- critical, however they retain the important oils, terpenes, and other sensitive chemicals within the plant. Supercritical, on the other hand, is a high pressure and heat procedure that harms most terpenes and heat sensitive chemicals, but can extract much bigger molecules such as lipids (omega 3 and 6), chlorophyll, and waxes. A genuinely full-spectrum CO2 extract consists of very first performing a subcritical extraction, separating the drawn out oil, and after that drawing out the very same plant material using supercritical pressure, then homogenizing both oil extracts into one. In the vital oil industry, an extract used this specific process is described as a CO2 Total. 7. Are hemp derived cannabinoids such as CBD as great as CBD from

cannabis? The short response is yes. CBD is CBD, whether from marijuana or hemp. The majority of the time hemp would be far more preferable for anything besides THC. Marijuana is usually extremely high in THC (provides individuals the high) but typically very low in other non- psychoactive cannabinoids (like CBD, CBC, CBG). Nowadays in the USA, lots of farmers are growing industrial hemp flowers that are just as beautiful, odorproducing, and terpene rich as the very best marijuana pressures, such as our partnered farmers in Kentucky.

8.Drug Testing… Will this show up positive on a test? HempWorx products utilize a Full Spectrum CBD which may contain trace amounts of naturally occurring THC. We are below the Federal Legal Limit and have less than 0.3% THC by dry weight. Even though in most cases our CBD products are NOT detectable on a urine or saliva test, we recommend that you check with your Employer or whom it may concern before taking our products. There is a slight possibility even though in most cases CBD products are NOT detectable on a urine or saliva test, that a positive/ false positive may occur. Same thing can happen using pharmaceuticals. It is recommended that you check with your Employer or whom it may concern before taking our products.

9. What to look for when shopping for CBD products? -Less is more!! Less ingredients is always better and at HempWorx we are proud to say our product surpasses many other cbd products out there due to these reasons. -Hemp crops that are grown free of chemical fertilizers, herbicides and pesticides, as the quality starts with the hemp plants. -Make sure that it’s tested multiple times from the time it’s harvested to manufactured, to ensure accuracy in potency and to check for possible contaminants, heavy metals, mold, as well as Cannabinoid content. -How is it extracted? This is a big question and many companies use cheap extraction methods that contain harsh solvents and that is why asking for 3rd party lab results is really important. A CO2 extraction method is a much healthier choice than other potential solvents and is “generally regarded as safe” by the FDA. -Are the products non GMO?, made ORGANIC?, grown and made in US? What raw material are they using? 10. Can my pet use CBD oil? Pet owners have used it for a variety of health issues and behavioral problems. Known reasons for CBD OIL use, cancer pain, arthritis, muscle spasms, seizures, CBD can stimulate the appetite and speed up recovery. CBD does all this be stimulating the endocannabinoid system. Hemp derived CBD is not psychoactive and won’t make an animal high. It has no unpleasant side effects, hemp products containing less than 0.

11. Can I experience side effects? When you first start using CBD OIL, it can in some individuals create a cleansing effect to the body. This can also be known as HerxHeimer Reaction. This reaction is the release of endotoxins after a large quantity of bacteria, fungal, or parasitic organisms die. During a Herx, the amount of endotoxins released outweighs the bodies detoxification capabilities thus some may produce in some “fever, chills, rigor, hypotension, headache, tachycardia, hyperventilation, vasodilation, muscle pain. This can last a few days up to 2 weeks. A good way to aid your body in removal of the endotoxins is sweat, water, and vitamin C. Make sure to drink close to a gallon of water a day to help flush out toxins. You can feel bad for several days and do numbers on your emotions and mental progress. Keep in mind though it is only temporary and having your body go through this cleansing process is a sign that the CBD OIL is doing its job. After this process, it is a pleasant surprise. Your energy will improve, your pain will start to go away, and your overall sense of well-being will be greatly improved. 12. Why Choose HEMPWORX? -

Full Spectrum (CBD, CBC, CBN, CBG) Uses Co2 extraction method Doesn’t use fillers 100% Organic / Non GMO Third party tested Certificate of Analysis provided Hemp farms are USA grown in Kentucky We have topicals, CBD oil 500mg, 750mg and a 250mg for Dogs and Cats & dog treats

Thank you for reading this eBook that was created by MDC HEMPWORX BOSSES members

Please get back to the person who shared this book with you, visit their site to keep learning more on CBD oil and our amazing products. We strongly suggest reading the FAQ ( on our site as many more great questions are answered there. The information provided within this eBook is for general informational purposes only. While we try to keep the information up-to-date and correct, there are no representations or warranties, express or implied, about the completeness, accuracy, reliability, suitability or availability with respect to the information, products, services, or related graphics contained in this eBook for any purpose. Any use of this information is at your own risk. This eBook contains information that is intended to help the readers be better informed consumers of health care. It is presented as general advice on health care. Always consult your doctor for your individual needs. HempWorx affiliates wrote this, while some company facts are shared this is not company documents and some info are only views and research of our affiliates. We put together the most asked questions we got to make it easier for everyone. Hope you enjoyed đ&#x;˜Š December 2017

Beginners Guide to CBD Oil  

Learning the basics of CBD Oil, its application, benefits and effects

Beginners Guide to CBD Oil  

Learning the basics of CBD Oil, its application, benefits and effects