i n d u s try
the uk’s only free of charge medical aesthetics trade magazine
Goodbye Pigmentation Addressing the most visible signs of ageing with Jan Marini Skin Research
And the Aesthetic 2011 Nominees are… Awards the AwArds night for your industry
Find out who is in with a chance of scooping a coveted prize at the Aesthetic Awards as we announce the shortlisted nominees
in AssociAtion with cosmetic news
p l At i n u m
also inside this issue of cosmetic News I T t r e n d s | E m p l o y m e n t L a w H o t T o p i c s | A c c e n t V Sh a p e
cosmetic news expo 2012: The UK’S Largest Aesthetics Meeting | 29th & 30th april 2012 | www.cosmeticnewsuk.com
o c to ber
Cosmetic news t h e
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Welcome to the October issue of Cosmetic News. There has been a flurry of excitement in the Cosmetic News offices over the last few weeks as the entries for the inaugural Aesthetic Awards have come flying in. And what a response we have had! More than 4,500 people entered in a bid to win one of the coveted 25 awards being presented on the night – the best response Body Media has ever seen in its history of hosting awards. With so many high caliber entries hittling the nominees down to create the final shortlist has not been an easy task and I would like to congratulate all those who have made the grade and are now in with a chance of taking home a gong on the night. The Awards are being hosted at a glamorous James Bond themed night at Sopwell House in St Albans on December 1 and it is definitely going to be a night to remember, especially as it is the only event in the aesthetic calendar that celebrates the achievements of all those who work hard to make this industry what it is. Turn to pages 14-18 to find out if you have made the final shortlist and don’t forget to get people to vote for you by visiting www.cosmeticnewsuk.com. Voting closes on October 21. Good luck to all the nominees – we look forward to celebrating with you on the night!
the AwArds night for your industry
Awards 2011 in AssociAtion with cosmetic news
p l At i n u m
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October 04 EDITOR’S CHOICE The latest treatment from Syneron/Candela – Elevate with ePrime 06 INDUSTRY NEWS We round up the latest industry news 10 ON THE SCENE We report on the BACN AGM and IAAFA conference and charity ball 14 AESTHETIC AWARDS Find out who has been shortlisted for the Aesthetic Awards in Association with Cosmetic News, and how you can vote
Elevate with ePrime One treatment that has had everyone talking in recent months is the newest innovation from Syneron/Candela – the ePrime. Launched to the trade at the FACE conference in July, the Elevate with ePrime treatment was recently unveiled to the UK’s press at an exclusive event at the Haymarket Hotel in London, and has been hitting the headlines ever since. Touted as the new ‘45 minute non-surgical face-lift’, the treatment has gained popularity with the UK’s media because it is clinically proven to lift, tighten and volumise the skin from the deeper layers in just a single 45 minute treatment.
2 1 - 2 3 S P E C I A L F E AT U R E – MESOTHERAPY We take a look at mesotherapy and examine some of the best treatments and products on the market
The treatment was developed following eight years of extensive research and harnesses the deep delivery of bi-polar radio-frequency to the dermis to provide 37% of the result of a traditional face-lift procedure*, but at a fraction of the cost making it a safe and effective alternative to surgery without the downtime.
2 4 T R E AT M E N T S P OT L I G H T HB Health’s Leshem Aloni on the Accent VShape
When lotions and potions aren’t enough and a face-lift is too far a step, an Elevate with ePrime procedure is the perfect solution to address the
28 Q&A LPG’s Christian Gagniere on its latest campaign 3 1 I N N O VAT I O N S David Leahy on treating fungal toenails with 1064nm Nd:YAG lasers 34 CLINICAL STUDY We examine the results of a clinical study on a MultiIngredient Non-Hydroquinone Pigment and AntiAgeing Solution
early signs of ageing such as lack definition in the jaw line (jowls), sagging skin and deeper wrinkles around the mouth and cheek area. The treatment helps to smooth, tighten and contour skin with gradual, natural looking results, as opposed to the dramatic change that invasive surgery produces. Full results develop over the course of three months, so, rather than looking like you’ve had surgery, you’ll look fresher, younger and rejuvenated. Best of all, you can turn back the clock without rearranging your life for complex procedures or long recoveries. Downtime is so minimal that the following day you can apply your make-up and go about your usual routine. Sounds good to me!
40 PRODUCT NEWS We round up the latest product news 44 ABSTRACTS We round up the latest clinical studies 46 BEST PRACTICE Award winning lawyer Norman Rea on hot topics for clinics in employment law 49 BUSINESS FOCUS Ahmed Zubair on IT trends 5 2 D AT E S F O R T H E D I A RY Training course, conference and meeting dates 54 DIRECTORY Our guide to the manufacturers, suppliers and business services featured in this month’s issue
* Macrene Alexiades-Armenakas, MD, PhD, David Rosenberg, MD, Bradley Renton, PhD, Jeffrey Dover, MD, Kenneth Arndt, MD. Blinded, randomised quantitative grading comparison of minimally-invasive fractional radiofrequency and surgical face-lift for the treatment of skin laxity. Arch Dermatol, Vol 146 No. 4, April 2010
Meet the Cosmetic News team Charlotte Body Publisher 01268 754 897 firstname.lastname@example.org
Peter Johnson, Art Director 01268 754 897 email@example.com
Vicky Eldridge Editor 01268 754 897 M: 07940 083 677 firstname.lastname@example.org
Loraine Winter Designer 01268 754 897 email@example.com
Emilia Cops Associate Publisher 01268 754 897 firstname.lastname@example.org
Shauna Peters Production Assistant 01268 754 897 email@example.com
Hollie-Jane Dunwell Account Manager 01268 754 897 firstname.lastname@example.org DISCLAIMER The editor and the publishers do not necessarily agree with the views expressed by contributors and advertisers nor do they accept responsibility for any errors in the transmission of the subject matter in this publication. In all matters the editor’s decision is final.
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Q-Med sponsors inaugural Aesthetic Awards Q-Med will be the Platinum Sponsor of the inaugural Aesthetic Awards in association with Cosmetic News. The awards will be presented at a glamorous James Bond themed gala dinner at Sopwell House in St Albans on Thursday December 1 2011 and will be a chance to celebrate the achievements of everyone working within the arena of medical aesthetics. Q-Med is an industry leader in developing and commercialising products based on its
lighted that Q-Med has decided to be the Platinum Sponsor of the inaugural Aesthetic
patented NASHA™ technology. The company’s portfolio includes the market-leading
Awards. Q-Med is one of the most well-known names in the industry and Cosmetic
dermal filler Restylane® as well as Restylane Skincare. Over recent months Q-Med has
News is happy that they have decided to follow Galderma’s long standing tradition of
been acquired by Galderma, a major milestone in the aesthetic industry – bringing
supporting the UK’s aesthetics industry.”
together two very strong companies to creatie a powerful portfolio that meets the
The shortlisted finalists for the Aesthetic Awards have now been announced. Turn to
physicians’ and patients’ needs. Body Media publisher, Charlotte Body, said, “We are de-
pages 14-18 to find out who has made the cut and get voting!
GALDERMA TRAINS BACN MEMBERS IN AESTHETIC DERMATOLOGY Galderma (UK) Ltd is running a series of Study Days in aesthetic dermatology for the 11 regional groups of the British Association of Cosmetic Nurses (BACN). Frank Ward, Galderma’s key accounts manager, who is supervising the programme, explained that the company has a heritage of training in the field of dermatology and, given Galderma’s recent entry into the aesthetics market, is now replicating that expertise in this area too. “Our Study Days for the BACN are linking the two sectors and giving added value to members of the association”, he said. With their backgrounds as trained nurses and being registered by the Nursing and Midwifery Council (NMC), members of the BACN have joined the organisation as independent injectors of dermal fillers and botulinum toxin. By taking advantage of Galderma’s workshops they will learn how to diagnose and treat skin conditions such as acne, rosacea, eczema and psoriasis. Following two introductory BACN Study Days in the North West and South West – which have established a successful agenda - the next Galderma workshop will be in London in November at the Wellcome Trust in Euston. A series of events in 2012 will cover the rest of the UK. Details will be listed on the BACN website at www.cosmeticnurses.org. Non-BACN members wishing to find out how to become involved should call 01749 836 328.
New Training Room for SkinBrands Skin Brands has announced the opening of its new training room in Ealing Common, West London. This brand new venue encapsulates SkinBrands dedication to the service it provides and with a committed training team and an extensive programme already in place, clients will receive even more comprehensive support. Training is offered complimentary to all ongoing SkinBrands customers. Tracey Beesley, owner of SkinBrands, said, “We are passionate about the superb brands we distribute and are proud to do so. For us it was time to get our own venue that represented professionally and stylishly each of the brands but at the same time would allow our customers to get a feel for what we could potentially offer our customers in terms of marketing and support. Our customers and their needs are our priority. We believe training to be a quintessential part of our offering, and we want our customers to leave our training sessions, motivated, enthused and passionate about the brand(s) they offer their customers. Not only can the new venue be utilised as a showroom for all the brands in our portfolio but it allows our clients to send their staff to a comfortable training venue which offers them the best chance of learning outside of the clinic environment. In addition, our team of account managers can utilise the facility to present the products to their customers and offer them the highest levels of training. With Martine Jarman – account manager for the North - offering a mirrored training programme in the Manchester area we are working hard to meet our customer needs”.
UK website for Pastelli
Professional clothing brand Pastelli has launched a new UK based website www.pastelli.co.uk. The Italian based company has been manufacturing professional garments and uniforms for the medical, dental and beauty industries for decades, and is now distributed in the UK through Robert Eaglestone and Wigmore Medical. The garments are world-renowned for their quality and elegance and are currently sold to medical, dental,
Territory Managers – North & Scotland A fabulous opportunity awaits high calibre professionals to work with the UK’s leading cosmeceutical pharmacy specialist, Healthxchange Pharmacy
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Dr Dan Dhunna and Cindy Jackson appear on CBS’ Inside Edition USA Cosmetic doctor Dan Dhunna and cosmetic surgery record-holder Cindy Jackson have appeared on Inside Edition USA. The pair have been firm friends ever since filming for the BBC’s Weakest Link ‘Body Beautiful’ episode in September 2010. Dr Dhunna has since performed a number of procedures on Cindy who, at 56, is the Guinness World Record holder (confirmed in May 2011) for having had the most number of cosmetic surgery procedures. The TV crew came over to the UK to film Dr Dhunna demonstrating Photo by Celebrity Photographer James Nader www.jamesnader.co.uk live procedures including his ‘London Lift’. He said, “Cindy has had cheek implants and a lower lip and chin implant; the cheek area needed some support tissue rebuilding around the apple of the cheek and around the cheek implants, the lips required some slight asymmetry addressing and the volume required some boosting, and her neck and jaw line needed to look tighter and smoother” Cindy added, “Dan has a fantastic eye and perception of perfection as far as the face is concerned. Some of the ‘adjustments’ are subtle and other aestheticians may not go so far as to pick up on them and go to the lengths that he goes to really make a difference and give you a ‘wow factor’. He’s known as the Michelangelo of Botox®; I like to say he is the Da Vinci of dermal fillers.”
Journalists give Genuine Dermaroller™ Therapy ™ the thumbs up More than 90% of journalists who have tried Genuine Dermaroller™ Therapy™ would recommend the treatment to others, according to a survery carried out by AesthetiCare®. Publications surveyed included The Daily Mail, Prima and The Evening Standard. Journalists polled also commented that they saw Genuine Dermaroller™ Therapy ™ as a fantastic alternative to more invasive skin treatments and more than 70% stated that they found the procedure to be uncomfortable rather than painful. Many polled also felt that the treatment would be around for a very long time. AesthetiCare® manageing director Roger Bloxham said, “This interesting survey of top beauty journalists who really know their stuff, demonstrates what a valuable and now established treatment Genuine Dermaroller™ Therapy™ is and I would like to thank all the medical aesthetic practitioners through out the UK who have delivered this treatment and enabled thousands of their clients to receive the great benefits the journalists in this survey refer to. “Also I would like to thank them for maintaining the standards that we in the medical aesthetic community aspire to by using the highest quality Genuine Dermaroller™ German manufactured medical devices and spreading the message that this is a treatment that needs to be conducted in a medical aesthetic setting, this has enabled the reputation and therefore the benefits of this great treatment to be maintained in an environment which is otherwise currently unregulated in the UK”.
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SURGEON CALLS ON GOVERNMENT TO REINSTATE THE NATIONAL BREAST IMPLANT REGISTRY Midlands cosmetic surgeon Dalvi Humzah is calling on the Government to reinstate The National Breast Implant Registry (UKBIR). Following the recall of PIP implants by French medical authorities, Mr Humzah says it is essential the government adopts the mandatory registration of all implants by both private health consultants and NHS consultants. French company Poly Implant Perthese (PIP) is being investigated after authorities discovered PIP implants contained a non-approved silicone gel and had a high rupture rate leading to complications. The potentially dangerous implants are believed to have been used in up to 50,000 breast augmentation procedures in the UK. In the last six months alone, Mr Humzah has treated several patients with ruptured PIP implants. Most involved the removal of the implants, breast clean up and placing new implants in one single operation. “At the moment, there is no way of knowing for sure how many women have been given PIP implants. If the registry was reinstated, we could easily access this information to ensure patients affected are treated and made aware of such complications,” said Mr Humzah. Following its launch in 1993, The Department of Health decided to close the UKBIR in March 2006 claiming only a limited number of implanted women were willing to take part in the scheme. Mr Humzah continued, “Many problems associated with implants surface after several years. With no comprehensive record-keeping mechanism, necessary long-term information is unavailable. Ideally, we need a new registry that protects women’s privacy, yet enables the research we need to make sound, informed safety decisions. Just as importantly, it means women can be alerted quickly to any health threats that develop.”
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on the scene
BACN, AGM, Birmingham
We report on the annual International Academy of Advanced Facial Aesthetics (IAAFA) meeting and charity ball in London
The British Association of Cosmetic Nurses (BACN) held its second annual conference and AGM at the Conference Aston, Birmingham last month.
Last month the International Academy of
One of the hot topics
Advanced Facial Aesthetics held its annual
covered at the event
conference and charity ball in London. The
was the change in the
two-day event took place at the Royal Society of
way anti-ageing fillers
Medicine and kicked off on Friday September 2
are being administered using cannulas to minimise the risk of
with a welcome by the association’s president Dr
bruising and swelling.
Stephen Ritchie from Cutera chats to a customer on his stand
Bob Khanna. A packed programme of lectures and educational workshops then followed with The IAAFA charity ball was held at the Portman Radisson SAS Hotel
topics including everything from dentistry and plastic surgery to cosmetic injectables. The CPD accredited conference always attracts a high caliber of speakers with extensive experience in all areas of facial aesthetics, and this year is no different with the line up
JMSR exhibited at the show
including Dr Bob The Galderma girls along with Dr Beatriz Molina (second left) and Cosmetic News Hollie Dunwell (far right)
Khanna, on Total Facial Sculpting;
Manufacturers of several
Prof Piet Haers on Orthognathic Surgery Demystified; Mr Jonathan
leading dermal filler brands
Britto on the Anatomical Principles of Aesthetics; Dr Tapan Patel
are now advocating the use
on The Use of Lasers in Facial Aesthetics; Mr Raj Ragoowansi on
of cannulas over needles for
Patient Assessment Criteria for Optimising Aesthetic Outcomes;
IAAFA president Dr Bob Khanna and wife Sonia
The Galderma stand
certain treatments including
Dr Mark Devlin on Aesthetics v Deformity: Beauty and the Beast;
Q-Med, who gave a workshop
Dr Kimberley Taylor on Patient Consultation and Developing
on the use and benefits of
an Aesthetic Practice; Bobbi Anthony; Dr Chris Orr on Optimal
its patented range of pix’L®
Dental Aesthetics – Current Concepts and Eddie Hooker on Risk
microcannulas and Allergan,
Management in Aesthetic Practice. An exhibition also ran alongside
who sponsored several
speakers at the meeting, including including Dr Rodrigo The highlight of the event, as
Caceres and Dr Helga Van
always, was the Charity Ball
held at the Portman Radisson
Emma Davies, chair of the
SAS Hotel, which had an
British Association of Cosmetic Nurses (BACN) commented,
Arabian Nights theme this year. The glitzy event raised Cosmetic News’ Shauna Peters meets a snake at the Arabian Nights themed ball
“The introduction of the cannula is truly a technical revolution The Healthxchange team exhibited at the show
for professional injectors using facial fillers. Using cannulas
money for the Make-A-Wish Foundation, a charity that grants the
instead of needles takes practice but the BACN is fortunate
wishes of dying children.
that several companies behind this innovation are willing to train members both during our conference, and in workshops that will follow this event. Quite a few BACN members have already been working with cannulas for a while and the conference proved inspiring for many others.” Other topics covered ranged from botulinum toxin in the lower and upper face as well for migraines and hyperhidrosis; challenging lips; non-surgical nose correction and VAT. The meeting ended with the AGM and a closing speech by BACN chair Emma Davies.
The Hamilton Fraser Cosmetic Insurance Team
Mary-Kay Sheehy demonstrates on the Nordson stand
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the AwArds night for your industry
AAwards esthetic 2011 in AssociAtion with cosmetic news p l At i n u m gold
And the nominees are… It’s the event that everyone is talking about, but who is on their way to winning a coveted Aesthetic Award? We announce the shortlisted finalists
ver the past few weeks the entries have been flooding in for the inaugural Aesthetic Awards in Association with Cosmetic News. We have been astounded with the response from the industry, with more than 4,500 entries coming in – the most Body Media has ever seen in its history of hosting awards. With so many high caliber entries to sort through, picking the final shortlisted nominees has not been an easy task. Those who have been lucky enough to make the final cut will now be in with a chance of taking home a gong on the night. With a total of 25 categories, the awards have been designed to acknowledge those who have gone that extra mile over the last year. The Aesthetic Awards is the only event of its kind in the industry that gives both practitioners and suppliers a chance to celebrate their achievements with their friends and peers. The event is being sponsored by Q-Med (Platinum Sponsor) and Silderm (Gold Sponsor). Q-Med is an industry leader in developing and commercialising products based on patented NASHA™ technology. The company’s portfolio includes the market-leading dermal
filler Restylane®. Over recent months Q-Med has been acquired by Galderma, a major milestone in the aesthetic industry, bringing together two very strong companies and creating a powerful portfolio to meet the physicians’ and patients’ needs. Body Media publisher, Charlotte Body, said, “We are delighted that Q-Med has decided to be the Platinum Sponsor of the inaugural Aesthetic Awards. Q-Med is one of the most well-known names in the industry and Cosmetic News is happy that they have decided to follow Galderma’s long standing tradition of supporting the UK’s aesthetics industry.” The awards will be presented at a glamorous James Bond themed gala dinner at Sopwell House in St Albans on Thursday December 1 2011 and will be a chance to celebrate the achievements of everyone working within the arena of medical aesthetics. MyFaceMyBody’s Stephen Handisides will be hosting the event and announcing the winners. As well as a champagne reception, decadent three course meal and a free bar, guests will be left shaken and stirred by the entertainment, which will include a casino and live music. When it comes to putting on a night to remember, Nobody Does it Better!
The nominees are… I N D U S T RY AWA R D S S ales R epresentative of the Y ear This award is designed to acknowledge the hard work and services provided by sales reps working for manufacturers
and suppliers in the UK. The finalists in this category are those who received the most nominations from their customers.
L ifetime A chievement A ward
The winner will be decided by the number of votes they receive from their customers. To vote in this category please visit
This award will recognise the achievements of an
individual who has had a long and fruitful career in
T he nominees are :
the aesthetics industry. The recipient of this award has
L orraine mclaughlin , M er z J emma C oo k e , G alderma
• • •
P aula D ene , M er z J a z z D hariwal , R ioblush B everley P owell , S k in B rands
been selected by the Aesthetics Awards team from the nominations submitted and there will only be one winner who will be announced on the night.
S ervices to the I ndustry This category will award an individual who has gone above and beyond in their services to the industry. As with the lifetime achievement award, there will only be one winner in this category. We had so many fantastic nominations in this category that we have decided to create a shortlist and let people in the industry vote on who they think deserves to win. To vote in this category please visit www.cosmeticnewsuk.com.
T he nominees are : D r Patric k B owler
R on M yers
E mma D avies
Co-Founder and Fellow of the British
Ron Myers has more than 13 years
Emma Davies has been an aesthetic nurse since 1998, with her own clinic in Somerset.
Association of Cosmetic Doctors
experience in the pharmaceutical
With a special interest in sclerotherapy she established, in partnership with a vascular surgeon,
and Medical Director of Courthouse
industry in a variety of sales and
Veincare Training, to teach and promote best practice in the treatment of thread veins and
marketing, sales management and
went on to bring together cosmetic specialists with vascular specialists to learn from each other
Dr Patrick Bowler is pioneer of non-
business development roles working
and support continuing professional development, establishing The British Association of
surgical cosmetic treatments in the
for Smith Kline Beecham, Novartis, and
Sclerotherapists, now recognised by The Vascular Society and Venous Forum and represented
UK with 20 years experience. He has
Allergan Pharmaceuticals. Ron was
internationally. Passionate about this field and how nurses contribute to it, she has been an active
lectured extensively in Europe, the
involved in the launch of Botox® and M.D.
member of the RCN Aesthetic Nurses Forum Committee, and is proud of the achievements of
Middle East, the US and Australia and
Forté® glycolic peels into the UK market
this group. Whilst supported by the RCN the forum group was able to find a credible political
has had his research published in a
place in 1994. He set up a specialist
voice, all be a quiet one, and published several important documents that have informed practice
number of clinical journals. In 1993 he
consultancy service in 2002 with business
and been recognised and referenced by others establishing standards of practice. Although the
co-founded Cosmeceuticals Ltd and
partner Martyn Roe. Since then they
restructuring of The RCN and subsequent disbanding of the Forum was a huge disappointment,
in 1998 opened the first Court House
have been busy working on a variety of
Emma went on to become a founding member of the British Assocation of Cosmetic Nurses,
Clinic in Brentwood Essex. He is the
high profile projects in the aesthetics
of which she is chair. She hopes the association will provide a platform for excellence to be
co-founder and a Fellow of The British
industry, including the development of
celebrated and shared, to support and inspire us all and to give us a voice that will be heard.
Association of Cosmetic Doctors and
Wigmore Medical’s concept as a specialist
served as its chairman for the first seven
aesthetic distributor; the launch of the
years. Dr Bowler has researched and
Facial Aesthetic Conference and Exhibition
developed the effects of anti-oxidants
(F.A.C.E.) – now the UK’s largest non-surgical
on the skin culminating in the launch
medical aesthetic conference; business
of his own skincare range Vitage, in
development projects with individual
September 2004 and is frequently
medical aesthetic clinics and website design
quoted on skin and cosmetic problems
and development – including e-commerce
in the national papers and magazines
sites and the launch and management of
and regularly appears on national TV on
MediZen – a non-surgical medical aesthetic
news/current affairs shows including
clinic - in conjunction with Dr David
CNN and BBC Breakfast, Five News and
Eccleston. In addition Ron and Martyn
consumer programmes such as LK Today,
GMTV and UK Living. He was one of the
– launched in 2003, and now the largest
experts featured on the first two series
specialist aesthetic information website
of Channel 4 series 10 Years Younger and
in the UK, and winner of “Best Aesthetic
the Who’ll Age Worst on UKTV Style.
Patient Information Website” at the 2008 Aesthetic Medicine Awards.
E ddie H oo k er , Eddie Hooker has been involved in the insurance industry since 1985. He worked with many large insurers such as Legal & General prior to setting up his own brokerage, Hamilton Fraser Insurance, in 1995. Hamilton Fraser Insurance now employs over 115 staff out of their North London office. Eddie and Hamilton Fraser Insurance first started to insure cosmetic practitioners as early as 1996 when they became involved with nurses practicing in Collagen injections. Hamilton Fraser launched the UK’s first ‘aesthetics specific’ medical indemnity policy in 1998 and now insure over 2,500 individual practitioners and businesses within the sector, growing by over 100 new practitioners each and every month. By working closely with the sector’s leading practitioners and distributors, Eddie and his team have built up a detailed knowledge of the aesthetic market which has been highlighted in a recent customer survey finding that 95% of Hamilton Fraser’s customers were satisfied or more than satisfied with the service provided by the company. In 2005, Eddie and his team bid and were successful in securing one of only three government authorised tenancy deposit protection schemes, mydeposits.co.uk, and the scheme was launched in April 2007. To date mydeposits has protected in excess of 1,000,000 tenant rent deposits for more than 200,000 landlords country wide, increasing at a rate of over 20,000 new deposits each month. Eddie is keen to see and help bring about better standards of training within the aesthetics market and supports initiatives which raise standards overall.
the AwArds night for your industry
Awards 2011 in AssociAtion with cosmetic news p l At i n u m gold
R ising S tar
T he nominees are :
This award will be presented to an up and coming practitioner who may not
H ilary H aw k , C linica F iore
have the longevity of some of their colleagues but who has made an impact
L indsey M c E nroe , I nnercore C linics
in their field. The shortlisted finalists were selected based on the nominations
J ac k ie P artridge , D ermal C linics
D r R aina Zarb A dami , A esthetic V irtue
Best Clinic Chain
T he finalists are :
and their feedback as well as feedback from customers will determine the
• • •
Mystery shoppers will be sent to the clinics that have been shortlisted winner. If your clinic has been shortlisted then you can get your customers to vote for you by visiting www.cosmeticnewsuk.com.
C ourt H ouse C linics E F M edi - S pa R enew M edica
Best Clinic (four rooms or more)
Best Clinic (three rooms or less)
This award will be presented to the best
This award will be presented to the best
large clinic in the UK with four or more
T he finalists are :
treatment rooms. Mystery shoppers will be sent to the clinics that have been shortlisted and their feedback as
• • •
well as feedback from customers will determine the winner. If your clinic has been shortlisted then you can get your
Clinica Fiore, London The Cosmetic Skin Clinic, Buckinghamshire Dermal Clinic, Edinburgh Medizen, Birmingham Riverbanks, Bedfordshire
small clinic in the UK with three or less treatment rooms. Mystery shoppers will be sent to the clinics that have been shortlisted and their feedback as well as feedback from customers will been shortlisted then you can get your customers to vote for you by visiting
Absolute Aesthetics, Guildford CC Kat, Birmingham European Dermatology, London The Grampian Cosmetic Clinic, Aberdeenshire The Hadleigh Clinic, Essex Health + Aesthetics, Farnham The Medical Aesthetic Clinic, Winchester Temple Aesthetics, Aberdeen
determine the winner. If your clinic has
customers to vote for you by visiting
• • •
T he finalists are :
• • • •
Best Mobile Practitioner
Best Clinic Customer Service This award will be given to the clinic in the UK with the best customer service as judged by mystery shoppers.
This award will recognise the achievements of solo
The shortlisted finalists are:
practitioners. The shortlisted finalists have been chosen based on the number of nominations they received. Mystery shoppers will be sent to the practitioners who have been shortlisted and their feedback as well as feedback from customers will determine the winner. If you
The Cosmetic Skin Clinic, Buckinghamshire
Paul Banwell Cosmetic Surgery Clinic, Sussex
Best Customer Service by a Manufacturer/Supplier
have been shortlisted then you can get your customers to
This award will be given to the manufacturer/supplier
The nominees are:
vote for you by visiting www.cosmeticnewsuk.com.
with the best customer service as judged by their
customers. To vote for the manufacturer/supplier who
you think offers the best customer service visit
T he finalists are : • Monnica Berrange
• Frances Furlong
• Dr Susanne Farwer
• Wendy Demir
Association of the Year
Best Advertising Campaign by a Manufacturer/ Supplier
This award will be presented to the association that has gone above and beyond in 2011. There will only be one winner in this category. To vote for the association that you think deserves to win this award, please visit
This award will be given to the
manufacturer/supplier with the most
The nominees are:
memorable and effective UK advertising
This award is designed for any UK
This award will be given to the person
distributor of aesthetic products or
deemed to have given the best lecture
systems. To vote for the distributor who you think deserves to win visit www.cosmeticnewsuk.com.
at a UK conference or educational meeting in 2011. The shortlisted finalists were chosen based on the number of
The nominees are:
The finalists are:
Dr Tim Flynn
Dr Ravi Jain
Dr Bob Khanna
Dr Tracy Mountford
Dr Stefanie Williams
The British Association of Cosmetic Nurses
The Society of Cosmetic Physicians
Speaker of the Year
The British Association of Cosmetic Doctors
Distributor of the Year
nominations they received.
www.skinbrands.co.uk â€˘ 44 (0)560 314 1956
the AwArds night for your industry
Awards 2011 in AssociAtion with cosmetic news
p l At i n u m
Best Clinic Website
Clinic Receptionist of the Year
The most easy to navigate and informative clinic websites will be
This award will go the member of clinic front of house staff who has excelled
awarded in this category. Mystery shoppers will be asked to rate the
in 2011. The shortlisted finalists have been chosen based on the number of
websites on ease of use, information and style.
nominations they received. Mystery shoppers will be sent to the clinics that
The shortlisted finalists are:
have been shortlisted and their feedback as well as feedback from customers
will determine the winner. If you have been shortlisted then you can get your
Auroa Plastic Surgery and Aesthetic Centres – www.auroraclinics.co.uk
customers to vote for you by visiting www.cosmeticnewsuk.com.
CC Kat Aesthetic Clinic – www.cckat.com
The Cosmetic Skin Clinic – www.cosmeticskinclinic.com
Jo Andrews, Outline Skincare
Court House Clinics – www.courthouseclinics.com
Debbie Bower and Liz Kidd, Medizen
The Hadleigh Clinic – www.hadleighclinic.com
Debbie Keen, Cosmetic Skin Clinic
Riverbanks – www.riverbanksclinic.co.uk
Cathesha Williams, Court House Clinics
P R O D U C T / T R E AT M E N T AWA R D S Best Product Innovation
The most innovative new products on the market will be recognised in this category. To
Manufacturers/distributors of any new product launched in the UK market since the
vote for the product that you think is the most innovative visit www.cosmeticnewsuk.
beginning of 2011 can enter this category. To vote for the product that you think is the
most deserving winner visit www.cosmeticnewsuk.com .
The shortlisted products are:
The shortlisted products are:
Artiste Injection System (Nordson)
Artiste Injection System (Nordson)
Pix’L Micro Cannula (Q-Med)
Bocouture (Merz Aesthetics)
SkinCeuticals Pigment Regulator
Medik8 Blue Aox
SkinCeuticals Sheer Mineral Defense
Cosmeceutcial of the Year
This award will go to the best cosmeceutcial product range in the UK, as voted for by the readers of Cosmetic News. To vote winner visit www.cosmeticnewsuk.com. The shortlisted ranges are: Heliocare
Treatment of the Year (Face)
Consumer Choice Award for Best Treatment
This award will go to the best treatment in the UK as voted for by consumers via the MyFaceMyBody TV show and website. The winner will be announced on the night.
Treatment of the Year (Body)
Injectable Product of the Year
This award will go to the manufacturers/distributors of the
This award will go to the best product in the UK as voted for by consumers via MyFaceMyBody TV show and website. The winner will be announced on the night.
for the product range that you think is the most deserving
Consumer Choice Award for Best Product
Best Selling Retail Product
best injectable product available in the UK, as voted for by the readers of Cosmetic News. To vote for the product that you think is the most deserving winner visit www. cosmeticnewsuk.com. The finalists are: •
Equipment Brand of the Year
This award will be given to the
This award will be given to the
The finalists have been selected from the
The winner of this award will be the
manufacturer/supplier with the best
manufacturer/supplier with the
number of nominations they received from
manufacturer/supplier of what is deemed
treatment for the face, as voted for
best treatment for the body, as
clinics. Clinics will be able to vote for their
to be the best equipment brand by the
by the readers of Cosmetic News.
voted for by the readers of Cosmetic
top selling retail product in this category
readers of Cosmetic News. To vote for the
To vote for the treatment that you
News. To vote for the treatment
by visiting www.cosmeticnewsuk.com. The
brand that you think is the most deserving
think is the most deserving winner
that you think is the most deserving
winner visit www.cosmeticnewsuk.com.
visit www.cosmeticnewsuk.com. The
winner visit www.cosmeticnewsuk.
The finalists are:
com. The finalists are:
PRIORI Idebenone Peel
Obagi Vitamin C serum
SkinCeutcials Phloretin CF
Sound Surgical (VASER)
Soprano Pain Free
SkinMedica TNS Recovery
Hair Removal •
Image SKINCARE Vital C
Voting now open
In some of the categories the winners’ will be decided by the readers of Cosmetic News. Visit www.cosmeticnewsuk.com to cast your vote now! Voting closes on Friday October 21.
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NEEdlE POINT We take a look at mesotherapy treatments and techniques
When it comes to treatment options, not many procedures offer the variety of indications and methods of administration that mesotherapy does. The treatment can be used for both fat and cellulite reduction and to address skin ageing and can be performed using either manual syringes, specialised mesotherapy guns or via no-needle alternatives, which use an electrical current, rather than a needle, to push the products through the skin.
he concept of mesotherapy is that it is better to deliver medications directly to the area being treated than to ingest them through a tablet. Mesotherapy preparations usually comprise of a cocktail of vitamins, serums, medications or amino acids, which can be tailored for specific patients and indications.
For skin rejuvenation, the aim is to replace minerals, vitamins and amino acids that are found in lower levels in skin as we age. One of the main aims is to boost levels of hyaluronic acid in the skin. As the skin ages, levels of hyaluronic acid decrease, and it is claimed that injecting more hyaluronic acid into the dermal layers (just below the surface of the skin) helps to stimulate more collagen production, which, in turn, improves skin tone and helps to reduce fine lines and wrinkles. One of the most popular uses of mesotherapy in aesthetics is for the treatment of fat and cellulite. The fluid injected is a cocktail of vitamins and different medications designed to break down fat. The treatment is particularly good for dealing with cellulite but can also minimise fat on the stomach, thighs, chin and love handles. The ideal candidate for fat reduction treatment would be near or at their ideal body weight with small areas of stubborn, localised fat that cannot be shifted with diet and exercise.
M E S OT H E R A PY T E C H N I Q U E S •
Traditional mesotherapy involves a series of very small (micro) injections into the area being treated. The treatment is done using a very fine hand-held needle or a ‘meso-gun’ and is virtually painless. The practitioner will inject measured amounts of different medications just under the skin. Puncturing the skin with micro-injections is also thought to induce new collagen production in the skin. For body treatments active ingredients that help to break down cellulite and localised trapped fat and improve circulation, lymphatic and venous drainage are used. The treatment takes around 30-45 minutes, depending on the size of the treated area. A course of up to eight treatments is usually required at one to two weekly intervals.
With no needle mesotherapy the cocktail of ingredients are applied directly onto the skin. An electrical current is then used to ‘push’ the ingredients through the skin. This treatment is virtually pain free and is ideal for people who don’t like needles. The procedure takes about half an hour and a course at weekly intervals is usually required to achieve the full effect. The side effects of the treatment are relatively minor so patients can return to their normal daily routine or work afterwards.
MESOTHERAPY PROdUCTS INNO-TdS® Mesotherapy Cellulite Programme (Medical Aesthetic Group)
Viora Infusion System (AZTEC Services)
INNOSEARCH has developed a new generation product line – INNO-TDS –
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uses mesotherapy techniques, which involves microinjections of conventional
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on the well-established science
TDS® Homeocel, homeopathic anti-cellulite treatment and INNO-TDS® Drainer,
of electroporation, Infusion™
Anti-cellulite and anti-retention treatment.
maximizes cell permeability
and absorption and enhances the overall appearance of the face and body. Designed for aesthetic professionals, Infusion™ offers the perfect, non-invasive solution to a wide variety of cosmetic conditions and significantly expands treatment options with such aesthetic mainstays as: • Anti ageing and wrinkle reduction • Collagen regeneration
Juvederm Hydrate (Allergan)
• Skin rehydration • Skin firming and toning
Juvéderm® HYDRATE is a un-crosslinked hyaluronic acid (HA) injectable
• Body sculpting and cellulite reduction
treatment comprising 13.5mg/g uncross-linked hyaluronic acid plus 0.9%
• Stretch mark reduction
mannitol. Although the treatment is classified as ‘skin revitilisation’ rather than mesotherapy, the techniques and principles behind the treatment are
virtually identical. The product has been clinically proven to deeply hydrate by
Ionwave™ increases skin
delivering hyaluronic acid (HA) into the skin through a series of tiny injections. As
permeability to allow the
well as containing HA, it also contains the anti-oxidant, mannitol and, together,
safe passage of natural
these allow the skin to regain its natural smoothness and reveal a healthy glow.
It is indicated for improving skin hydration and
Precisely crafted pulse
elasticity by multi-injection into the dermal/
waves temporarily open
epidermal junction and into the superficial
micro channels through
dermis to improve skin tone and reduce fine
the cell membrane to
lines and wrinkles. The addition of mannitol
bypass the stratum
leads to reduced free radical degradation of the
corneum layer without
hyaluronic acid to extend longevity.
puncturing the skin. Scientifically engineered
Mattioli Transderm System (Polaris)
to achieve the desired effect, the interplay between the Ionic solution and the Infusion™ device determines the penetration depth and ensures sufficient
Mattioli’s Transderm is a new non-invasive, stand-alone powered
permeability Each solution is a blend of special serums, proteins and healing
drug-delivery system utilising Dermoelectroporation® Technology,
agents and is precisely formulated for the specific application. The use of these
which is FDA cleared as a no-needle method of delivering active
unique Infusion™ solutions in conjunction with the Infusion™ system is highly
substances into the body for medical and cosmetic purposes.
recommended to attain optimal results.
Dermoelectroporation®, increases the skin’s permeability using the it’s water-based channels, which are opened by a controlled
mesoestetic (Wellness Trading)
current, delivered to the patient skin and allowing the substances
Wellness Trading has recently introduced two new CE marked mesotherapy
to absorbed to hypodermis and muscle membranes. The system
injection products from mesoestetic.
has been FDA approved for the “local administration of ionic drug
The mesoestetic mesohyal ™ range is designed for anti-ageing and skin
solutions into the body for medical purposes and can be used as an
rejuvenation and includes:
alternative to injections”. Dermoelectroporation allows the transdermal delivery of both micro- and macro
neck, chest and back of hands.
modifying the ionic drug solution pH, as with traditional iontophoresis, ensuring that the patient experiences no discomfort or irritation and both positive and
mesohyal ™ NCTC109, a revitalising solution that combines hyaluronic
negative ions are transdermally delivered. Dermoelectroporation also does
acid with an array of vitamins, amino acids, minerals and coenzymes
not require a pH compensation patch, driving gels, or pre-charged ions. Unlike
to repair and anti-oxidant action. This balanced formula is designed for
traditional iontophoresis, Dermoelectroporation does not have an electrolysis
stimulating biochemical processes and increasing cellular nourishment
reaction at the site of the electrodes. There is no degradation of the molecule
of connective tissue fibres to achieve integral revitalisation of skin lacking
being delivered.This means that both positive and negative ions of the drug are
in brightness, elasticity or firmness. Mesohyal NCTC 109 bio-revitalisation
delivered into the body - the drug is delivered as a whole.
mesohyal ™ HYALURONIC, a non-cross-linked hyaluronic acid solution with tratamientode, indicated for fine wrinkles and hydration of the face,
molecules (more than 800,000Dalton) safely into the body without the need of
cocktail produces an immediate repairing and anti-ageing action.
Other benefits of Dermoelectroporation are that it is non-invasive and there is no
Mesohyal HYALURONIC and NCTC 109 can be used in conjunction with other
trauma or bruising from an injection.
aesthetic injectables to enhance and prolong their effects.
Simildiet Face Antiageing (Medical Aesthetic Group) FACE ANTIAGEING is a sterile biological solution created for facial rejuvenation, hydration, toning and revitalisation.
It comprises nutritional, structural and metabolic elements essential for optimum skin regeneration and repair. The formulation, which includes vitamins, minerals, enzyme co-factors, hyaluronic acid and nucleic acid precursors. is presented as a single use sterile vial and contains the optimum proportions of each component required for skin cell metabolism. FACE ANTIAGEING can be used as a stand alone treatment or immediately following a glycolic acid mask or peel. The results will be enhanced and skin healing improved. It can be administered either using the intradermal technique with a needle or the meso electroporation transdermal system
Mesoscience by Skeyndor Mesoscience by Skeyndor is a virtual mesotherapy treatment that breaks through the resistant barriers in the skin, transporting the active ingredients to an unlocked cell, whilst lifting the skin at the same time. Mesoscience provides a patented four current system to ensure excellent results within the shortest period of time.
Specific treatment programmes include Line Filling of the face and neck area with hyaluronic acid, pigmentation reduction and melanin regulation via the use of concentrated vitamin C – Nikkol VCPtm, cellulite reduction and firming and toning treatments. The latest addition to the treatment range offered, Mesolift works on a system of Micro and Macro Lifting to sculpt, firm and lift
the facial skin. Pre-programmed chipped cards are provided with the Mesoscience, virtual mesotherapy device for ease of use guiding the therapists through the four stages of each treatment. Compared to injectable method’s the Mesoscience, virtual Mesotherapy device can treat much larger areas of application in one session and the use of Nano technology products guarantee deep penetration of active ingredients. For best results a course of weekly treatments are required and these should be followed by monthly maintenance treatments thereafter.
C R Y S TA L PEELING
Restylane Vital (Q-Med) Like Juvederm Hydrate, Restylane Vital is part of a new category of treatment, which bridges the gap between mesotherapy and dermal fillers. With numerous clinical studies proving its efficacy Restylane Vital can achieve impressive results on the improvement of skin quality, elasticity and smoothness, particularly on the hands, décolletage and face and has recently been used in the lips to give a subtle enhancement, achieved through hydration. Like its sister range of dermal fillers Restylane Vital uses Q-Med’s patented NASHA™ (Non-Animal Stabilised Hyaluronic Acid) technology. The Restylane Vital range of products provides deep dermal hydration, which restores hydrobalance, improves skin elasticity, structure and firmness. By increasing the skin’s moisture retention the skin becomes more resistant to dehydration and retains its turgor and structure.
Advanced Skin Technologies
GREAT VERSATILITY PROVEN EFFICACY RESULTS DRIVEN TREATMENTS HIGH RETURN ON INVESTMENT 5 YEAR WARRANTY AFFORDABLE QUALITY
Advanced Skin Technologies aesthetic mesotherapy product range is designed to be used alongside its Cryoderm System. Ultra sound acts as a delivery mechanism for the active ingredients, pushing product through the dermal layers of the skin without the use of a needle. In turn it will temporarily allow the cell membranes to become permeable allowing the cell to absorb the vital nutrients contained within each active ingredient. This technology allows the transdermal infusion of products designed and formulated to create a no needle version of mesotherapy. All of the company’s new mesotherapy product range uses liposomes as the delivery molecule. The advantage of this is the fact that, as the liposome is made up of the same material as the cell membrane, it will not be rejected, in fact the lipid bilayer can fuse with other bilayers such as the cell membrane, thus delivering the liposome contents e.g active
01903 768 380 email@example.com
of things to come… We speak to HB Health’s Leshem Aloni about the Accent VShape
ith so much competition in the beauty and aesthetics industry, it is paramount that your clinic is able to
ageing procedures, they want to look themself at their best, and I find
provide a treatment that makes you stand head and
the Accent VShape helps achieve these results.”
shoulders above your peers. ABC Lasers invests in
ensuring that its products are at the cutting edge of laser
How does the Accent Ultra VShape work?
technology and always one step ahead when it comes to aesthetic
The VShape works by utilising two operationally designed
trends and client demand. Famed for its Soprano XL machine,
UltraFace and UniFace modules. The UltraFace module uses
considered by industry insiders to be the ‘Rolls Royce’ of hair
ultrasound to contour and reduce fat from the face and neck,
removal, and with glowing reviews for its Accent XL treatment
and then two distinct ultrasonic modalities target tissue. The
in publications such as Glamour, Stylist and Metro, it seemed
‘hot mode’ uses compression waves to preheat the targeted areas
a natural step that ABC Lasers should embark on a brand new
and enhance the effectiveness of the cold mode. The ‘cold mode’
technology which focuses solely on retaining a natural aesthetic
uses shear waves to selectively damage fat cells and tissue with
results for the face and neck areas.
minimal damage to surrounding cells. The UniFace module uses radio-frequency energy to tighten the skin and improve
The brand new Accent Ultra VShape from ABC Lasers utilises the
collagen production, while increasing the lymphatic drainage and
strengths of the standard Accent XL technology, while introducing
eliminating the excess of fat safely and effectively.
two new ergonomically designed modules with ultrasound and radio-
The results display a gentle ‘lift and stretch’; firming and toning skin
frequency, which contour to the unique proportions of the face and
around the jaw, jowls, temples and neck without losing any of the volume
neck. This allows for a more thorough treatment, excellent results, and
of the face. In fact, the Accent VShape promotes collagen production so
above all, customer satisfaction. It is the brand new solution to the non
that areas, which are subject to sagging and volume loss, such as around
the cheeks and eyes, are plumper and restored, giving a natural aesthetic.
The VShape at HB Health
“From a therapist’s point of view, the machine is designed so that it
Clinic manager of Knightsbridge’s exclusive HB Health, Leshem
is fool proof”, adds Leshem. “The Accent Ultra VShape harnesses the
Leshem Aloni has
Aloni, describes working with the Accent Ultra VShape and why he
same touch screen technology that you find with all ABC Lasers. The
been with HB Health
thinks this unique machine is the shape of things to come. He says,
machine itself is very compact so doesn’t take up too much space in
since 2005. As the
“We bought the Accent Ultra this year and have been delighted
the treatment room. There’s nothing worse than having an eyesore of
clinic manager of HB
with the results it has given on areas such as the thighs, arms and
a machine in the room, so it’s great that the Accent Ultra VShape looks
tummy. It is a fantastic treatment for cellulite, stretch marks and
good and not out of place at all. The Accent Ultra VShape is the only
general body contouring, so when I heard they were introducing
device with a two-in-one technology so I have piece of mind that I am
objective is to
the VShape modules, I jumped at the chance to be one of the first to
able to offer something unique to my clients.”
maintain the clinic
have this in my clinic and invested in one three months ago.
on the highest
“The best thing about the Accent VShape is that it provides my clients
Room for improvement
with a really natural aesthetic result. Many clients are wising up to the
Not only does the Accent Ultra VShape allow for top up
with high quality and
fact that fillers and Botox® injections are not a ‘one size fits all’ solution
treatments, and therefore repeat business, it also provides scope for
excellent client service.
to ageing and, for those who are afraid of needles, this is the perfect
selling in other treatments and packages.
“I find I can always rely on ABC Lasers’ machines to help me sell in other treatments”, says Leshem. “Clients see the results we get with
“The Accent VShape provides an alternative to clients who do not
the Accent Ultra VShape and then ask if we do laser hair removal,
wish to go under the knife and the needle, yet are happy to invest in
and which other machines we use. Once they know that one ABC
the results and take anti-ageing seriously. These days, clients are more
Lasers machine can provide outstanding results, they trust that this
educated on the treatments available and are very headstrong when
will be the case with the next.
it comes to the results they want. Men and women no longer assign
“I find that the Accent Ultra VShape appointments are an ideal
to the ‘new you’ mantra that is so commonly associated with anti-
opportunity to talk about the Accent Re-Shape body contouring
and find that most clients are curious to see what results they
“What’s more, the Accent Ultra VShape not only allows us to sell in
can get from a variety of procedures. I have also found that since
other ABC treatments, but also treatments such as Dermaroller, cosmetic
purchasing my Accent Ultra at the start of the busy summer
acupuncture, mesotherapy, high performance skin peels and more. Not
months, I have been able to recover the cost of the machine, and
only have we been inundated with appointment bookings for the
I see the upgrade of the Accent VShape as a way of enhancing the
procedure and are recovering the cost of the machine, the Accent
range of treatments we offer.”
Ultra VShape has introduced a whole new demographic of clients. As the Accent Ultra VShape works all over the face, neck and
Who is suitable for the Accent VShape?
sensitive décolletage area, and there is no risk or any significant
While there is room for a whole range of anti-ageing procedures
side effects what so ever, which will naturally make clients less
and products, clients will find some to be more successful than
intimidated. “The sensation of the treatment is often associated
others. The Accent VShape offers a ‘refreshed’ rather than
with hot stone massage. This new clientele makes a real difference
‘remodelled’ appearance and is a great starting place for clients
to the clinic, not only financially, but also with our reputation,
looking to embark on a course of treatments.
service palate and performances. We have not yet advertised
The Accent VShape takes just 30 minutes so ideal for a lunchtime
this treatment, but have found that due to word of mouth, our
treatment, and the client can wear make-up as standard afterwards.
therapists are constantly fully booked.
Results can be seen after three to five treatments, but a full course
“After a very busy summer with both the Accent Ultra XL for
of five is suggested. These can be performed every seven to 12 days
‘beach body’ contouring and the Accent Ultra VShape for anti-
and the optimum results can be seen after about three months.
ageing, we are now moving into the party season where men and
Maintenance can be done every two to three months.
women alike are preparing for Christmas and the New Year. We find clients range from the professional woman who is rejecting
Building the business
injectables but looking for an alternative anti-ageing treatment, to
“I have five other beauty specialists on the same stretch of road as HB Health,
the woman who might normally be opting for a facelift, but has
so being able to provide an exclusive and high performing treatment gives
chosen the Accent Ultra VShape instead, to men from the City who
us the edge over competing businesses”, comments Leshem. “As the clinic
simply want to look refreshed after a lifestyle of late nights.
manager, it is up to me to invest in the newest technology and build the
“The Accent Ultra VShape is suitable for anyone looking for a non-
business so that we are always one step ahead. I find that having the latest
invasive and risk-free anti-ageing procedure, and perfect for beauty
technology converts into sales as patients are always interested in the newest
professionals looking to expand their services, further their reputation
treatments and are open minded when it comes to new treatments.
and ultimately, increase profits.” cosmeticnewsuk.com
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t h e u k ’ s o n ly free of charge aesthetics exhibition
Q&A - Christian Gagnière
We chat to LPG Systems marketing director Christian Gagnière
For LPG Systems this year was a year of innovation with the launch of the new Cellu M6® Integral and Cellu M6® Endermolab. 2011 not only turns a new page with the 25th anniversary of the brand but also unveils a totally new campaign making use of non-retouched images, a concept that is in complete harmony with LPG’s 100% natural approach and consumer’s expectations. Christian Gagnière, LPG Systems marketing director
Marseille, with about forty people ranging from 20
outlines the reasons they embarked on this ground
to 75 years of age. Without disclosing LPG’s identity
or involvement to the participants, we asked them about their views on beauty.
Cosmetic News: What is new about this campaign?
It emerged from these very enlightening discussions that women now identify with true beauty, that is to
Christian Gagnière: Our major innovation
say, the notion of natural beauty they associate with
“It emerged from these very enlightening discussions that women now identify with true beauty, that is to say, the notion of natural beauty they associate with the concept of wellbeing.”
in 2011 is a new ‘non-standard’ communication
the concept of wellbeing.
campaign, since we are one of the first companies
worldwide to implement an advertising campaign
We retained some very emotive words, for example:
based on non-retouched photos.
truth, lies, beauty, authentic, natural, wellbeing - which
Before the photo shoot, she had eight Cellu M6
we used for our campaign slogan ,“True beauty
sessions, certified by an affidavit drawn-up by a legal-
does not lie”. On this basis, we decided to conduct a
professional and with a contract stipulating that she
campaign with real, un-retouched photos. We therefore
had never had plastic surgery, cosmetic surgery or
chose a 39-year-old professional model who is a
Societal, under the leadership of the sociologist
mother of two children, a beautiful woman but by no
Christine Detrez. Four focus groups were organised
We then wished to collaborate with a female
CN: Can you explain your approach? CG: We first conducted a survey, called LPG in four major French cities: Lyon, Paris, Lille and
photographer, who would also adhere to our policy of not retouching the photos. Our choice was Kate Barry, daughter of actress and musician Jane Birkin and film composer John Barry. She is a renowned photographer whose work always strives for a natural and spontaneous look which was clearly appropriate for our campaign. The campaign is spread across two ads, one dedicated to the body, the other to the face and was published in French Elle, Marie Claire and Physiologies.
CN: In conclusion? CG: LPG is growing, and one phrase sums up this development well: “The beauty and anti-ageing routine”. More and more women now adopt LPG techniques as a beauty and anti-ageing routine, in the same way they use make-up or go to the hairdresser – hence our new line of communication!
25/07/11 16:07 1.indd 1
fo EW ra dv the an E ce lite d M ha P ir X l re a m se ov r, al
With the preferred partner of the aesthetic industry. Demand for skin, hair and body treatments in the aesthetic laser market is experiencing record growth. By 2012, the number of annual procedures being performed is expected to more than double.* That’s not just mere potential —it’s unprecedented opportunity. With Cynosure, you can make the most of it. Our multi-application laser workstations and comprehensive business support systems are designed to transform practices, as well as patients. Visit www.cynosureuk.com today to start transforming yours.
www.cynosureuk.com | firstname.lastname@example.org | +44 (0)1628 522252 Cynosure UK, The Old Barn Offices, Lower Mount Farm, Long Lane, Cookham, Berkshire, SL6 9EE *Source: InMedica Research 2008
Advanced anti-ageing UV protection
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Great skin feel formulations with advanced UV Photoimmunoprotection Technology
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David Leahy on fungal toenails â€“ a novel application for Nd:YAG lasers
Toe the point W
ith the more mainstream laser procedures
non-dermatophytes (usually candida) account for a smaller
becoming more competitive, and in some cases
percentage (10% to 20%) of toenail onychomycosis. The infection
less profitable, I am increasingly asked by laser
may occur in various patterns: fungal invasion of distal or lateral
users how they can use their 1064nm Nd:YAG
margins of the nail (distolateral subungual onychomycosis);
lasers in other clinical, and possibly more profitable,
direct effect from above or on top of the nail with a powdery,
applications. New applications for 1064nm are not launched that
white, patchy discoloration (superficial white onychomycosis); or
often by laser manufacturers, but one that has created quite some
infection beginning from the proximal location beneath the nail
attention is the use of these lasers to very successfully treat fungal
bed (proximal subungual onychomycosis).
toenail (and fingernail) infection.
David Leahy Anatomy of the Nail
David has spent 15 years as a pharmacologist, working
To have a better understanding of how onychomycosis affects the
primarily in dermatology,
Fungal toenail or onychomycosis, is a fungal infection of the toenails or
nail, a basic knowledge of the anatomy of the nail is helpful. The
before starting his own
fingernails. In some cases patients have both toenails and fingernails
nail, or nail unit, consists of the following parts:
company ABMEtech Ltd. The
infected simultaneously. Onychomycosis causes the infected nail to
The nail matrix (where the nail starts) is where nail cells multiply
company distributes Fotona
thicken, discolour, disfigure, and split. In its early stages, onychomycosis
and keratinize (harden and form into nail material) before being
Laser systems to the UK
appears to be only a cosmetic concern but without treatment, the
incorporated into the fingernail or toenail. Most of the matrix is not
market as well as various other
toenails can become so thick that they press against the inside of the
visible. The matrix starts under the skin 5mm below the nail fold (the
aesthetic surgical consumable
shoes, causing excessive pressure, irritation, and pain. The condition
area of the cuticle where the finger or toe skin meets the nail) and
components to healthcare
causes a great deal of psychological suffering as it prevents sufferers
covers the area called the lunula, or half moon (the white half moon-
professionals. The company has
from wearing any footwear that will expose their toes as they can
shaped area at the bottom of the nail).
now partnered with Med fx to
look disfigured, even when painted. Feet, however, can be covered by
The cuticle is a fold of modified skin where the finger or toe meets
provide accredited training for
shoes, but fingernail infection may cause even more psychological,
the nail. The cuticle acts to protect the matrix from infection.
social, or employment-related problems, as it can leave the fingers on
The nail plate is the nail itself.
the hands of the sufferer looking deformed and unclean.
The nail bed is the soft tissue underneath the nail, anchoring the nail plate. The nail plate protects the nail bed.
Half of all the nail disorders commonly seen are caused by onychomycosis, which is the most common nail disease in otherwise
Subtypes of Onychomycosis
healthy adults. Toenails are fair more likely to be infected than
Onychomycosis is divided into clinical subtypes based on the
fingernails, with the prevalence of onychomycosis in the UK adult
cause and progress of the infection.
population (20-55 years old) estimated at being between 2% to 18%, with prevalence increasing to 20% and 30% for those older than 60
Distal lateral subungual onychomycosis
years and 70 years respectively.
Distal lateral subungual onychomycosis (DLSO) is the most common form of onychomycosis. In DLSO, the fungus
Onychomycosis is caused by pathogenic fungal spores that
generally spreads from the skin and invades the underside of
have infected the nail. These fungal spores or dermatophytes,
the nail where the nail meets the nail bed. Inflammation in
are trichophyton rubrum and trichophyton mentagrophytes
these areas of the nail causes the symptoms of DLSO. In this
are the predominant pathogens in onychomycosis; but
form the nail plate is thick with a cloudy appearance cosmeticnewsuk.com
INNOVATIONS (opaque), the nail bed underneath the nail thickens and hardens (nail bed
Onychomycosis related to candidal (yeast) infection is slightly different from
hyperkeratosis), and the nail separates from the bed underneath (onycholysis).
onychomycosis related to other fungal infections. Candidal onychomycosis has
The nail can be discoloured and appear in a range from white to brown. The
edge of the nail becomes severely eroded.
lO nycholysis describes the nail separating from the nail bed. The separation is primarily
White superficial onychomycosis
lC hronic mucocutaneous disease (disease of mucous membrane and regular skin)
caused by yeast called candida. White superficial onychomycosis (WSO) is a rare infection caused by the fungi directly invading the surface of the nail plate and secondarily infecting the nail bed. WSO is usually confined to the toenails. Small white speckled
involves the nail plate (fingernail or toenail) and eventually the nail fold (the skin fold behind the cuticle, where the nail meets the finger or toe). lT otal dystrophic onychomycosis is not a distinct subtype of onychomycosis.
or powdery‐looking patches appear on the surface of the nail plate. The nail
Dystrophic onychomycosis is the term used to describe the most advanced form
becomes rough and crumbles easily.
of any of the above subtypes, and it involves the entire nail unit. Dystrophic onychomycosis may cause permanent scarring of the nail matrix.
Proximal subungual onychomycosis In proximal subungual onychomycosis (PSO), the least common subtype,
Symptoms of Onychomycosis
the fungi invade the cuticle (the skin around the nail) and the nail fold and
In general, onychomycosis does not cause any symptoms. People with onychomycosis
then penetrate the nail plate (fingernail or toenail). In PSO, an area of white
usually go to the doctor for cosmetic reasons, not because of physical pain or problems
spotting, streaking, or discoloration (leukonychia) develops near the nail fold
related to onychomycosis.
and may extend to deeper layers of the nail. The nail plate becomes white near
As the disease progresses, onychomycosis may interfere with standing, walking, and
the cuticle and remains normal at the end.
exercising. Paresthesia (a sensation of pricking, tingling, or creeping on the skin having no objective
cause and usually associated with injury or irritation of a nerve), pain, discomfort, and
Like DLSO, in endonyx onychomycosis (EO), the fungi reach the nail via
loss of agility (dexterity) may occur.
the skin. Instead of infecting the nail bed, however, the fungi immediately
Risk factors for onychomycosis include family history, advancing age, poor health,
invade the nail plate. In EO, the nail plate has a milky white discoloration,
trauma, living in a warm climate, participation in fitness activities, immunosuppression
but unlike DLSO, the nail does not separate from the bed (no onycholysis).
(can occur from HIV or certain drugs), bathing in communal showers (such as at a gym),
The area under the nail (subungual area) does not thicken or harden (no
and wearing shoes that cover the toes completely and don’t let in any airflow.
The effect of Nd:YAG laser on onychomycosis causing pathogens. There are various opinions as to how the 1064nm laser interacts with the pathogenic fungal spores to cause their destruction and subsequent healing of the nail. Microbiological and biochemical research is still being carried out by many companies manufacturing 1064nm laser systems in order to further evaluate the potent effect of laser in this application. Commonly accepted theories include the heat shock effect of the laser generating reactive oxygen species and denaturation of cellular proteins. that cause the destruction of the intracellular make-up of the spore.
Fig. 2: Trichophyton rubrum treated with
Fig. 6: Candida species treated with VSP
Fig. 1a: The above results to Dr Kozarev’s
VSP Nd:YAG laser: before a), 6 months
Nd:YAG laser : before a), 3 months after b)
initial study showing the efficacy of laser
after b) and 12 months after c)*
and 9 months after c)*
treatment (using the Fotona Spectro Nd:YAG laser) on onychomycosis, as
The procedure of treating a nail with
observed from mycological cultures
1064nm laser is simple and quick,
takenon three and six months and
and no noticeable side effects and complications have yet been reported.
clinically evaluated on 12 months.* Despite the ongoing research into
Fig. 3: Trichophyton mentagrophites
Nd:YAG laser therapy of onychomycosis
the actual process of fungal spore
Fig. 1b: The above diagram shows how
treated with VSP Nd:YAG laser : before a)
is safe and very efficient method for
destruction caused by laser, it is
the delivery of the laser beam in spiral
and 12 months after b)*
treating all types of onychomycosis
universally accepted that 1064nm has a
pattern on the nail plate surface (a),
caused by various fungal species. This
very significant effect to reduce fungal
Thermal images of toenail surface before
method is useful for the broadest range
burden within the nail and promote
(middle top), and after (middle lower)
of patients and is specially beneficial in
irradiation with VSP Nd:YAG laser Beam,
elderly, compromised and hepatopathic patients for which other alternative
yellow represents increased temperature. Temperature increase of the nail plate is
Fig. 5: Trichophyton rubrum treated
clearly visible. Measured temperature at
with VSP Nd:YAG laser: before a) and 12
the nail plate during the laser treatment
months after b)*
(right).* nail and promote healing.
treatments could present some risks. *Results courtesy of Dr Jasmina Kozarev of the Dr. Kozarev Dermatology Laser Clinic, Sremska Mitrovica, Serbia using a Fotona Spectro laser. The treatment was performed using a long pulse VSP 1064 nm Nd:YAG output with fluences in the range of 35 to 40 J/cm², a spot size of 4 mm diameter, and a pulse duration of 35 ms.
● 1064nm laser for treatment of Onychomycosis ● Versatile for multiple Podiatric Conditions ● Maximum ROI. No disposables or per-use fees ● Rapid Delivery. Reduces treatment time ● Light and Ergonomic handpiece ● Temperature Monitoring and real-time feedback
We examine the results of a study on a Multi-Ingredient NonHydroquinone Pigment and Anti-Ageing Solution ABSTRACT Introduction: Because of regulatory and safety concerns associated with hydroquinone, there is significant demand for a nonhydroquinone product to address the appearance of the two most visible signs of ageing - wrinkles and hyperpigmentation. The tested product, Enlighten MD uses a combination of nonhydroquinone ingredients including hexylresorcinol, alphaarbutin, dipotassium glycyrrhizate, kojic dipalmitate, licorice root extract and anti-oxidants plus retinol and salicylic acid. Combination approaches have often been shown to be more effective than single ingredient solutions and retinol is shown to improve both the appearance of wrinkles and the appearance of hyperpigmentation. This study was designed to evaluate the effectiveness of this high-concentration multiingredient non-hydroquinone solution. Methods: Twenty adult subjects with hyperpigmentation on the face were enrolled in an aggressive 12-week, open-label study. Approximately 50% of subjects exhibited hyperpigmentation from melasma, while the remainder were due to photodamage. Subjects applied the investigational product as part of a multi-product skincare regimen (The Skin Care Management System MD by Jan Marini Skin Research) with the investigational non-hydroquinone product introduced over a two-week acclimation period. Results were determined through live assessments conducted pre and post study by the principal investigating dermatologist and by the subjectsâ€™ self assessment. Assessments included Melasma Assessment Severity Index (MASI) scores, standardised photo-ageing assessment and quantified assessments of multiple skin aspects including overall skin quality, discoloration, acne, and erythema. At the final visit, subjects were also asked to rate their overall perception of improvement in multiple categories and overall satisfaction. Conclusion: The tested product generated significant improvement in the appearance of hyperpigmentation from both melasma and photo-damage. Improvement in photo-ageing and overall skin quality was also observed by both the principle investigating dermatologist and the study subjects. Subject and investigator satisfaction with the products was high and patient compliance was extremely high with no reported cases of irritation or transient complications. Enlighten MD, in conjunction with the Skin Care Management System MD, constitutes a highly effective non-hydroquinone solution to address the appearance of hyperpigmentation.
Hyperpigmentation and wrinkles are the two most significant signs of ageing. In fact, hyperpigmentation alone, even in the absence of wrinkles, is highly correlated with age and evenly coloured skin is perceived as younger, healthier, more vibrant and attractive (Matts, 2008). A product that can decrease the appearance of both wrinkles and hyperpigmentation is highly sought after by consumers as it can significantly reduce the perceived age of an individual. Hyperpigmentation affects people of all skin types and cultures and is primarily due to cumulative exposure to UV radiation. This cumulative damage results in areas of increased expression of melanin in the epidermis. The prevalence of solar lentigines vs melasma vs freckles varies across cultures but in all cases hyperpigmentation begins affecting large percentages of individuals in their mid to late 20â€™s and affects nearly 100% of all individuals by the age of 40-50. (Farage MA, 2010) (Schafer T, 2006) Tyrosinase, generated in the epidermis, is a major enabler of melanin production in the synthesis pathway. Inhibiting the expression of tyrosinase will decrease the potential for the body to produce excessive pigmentation. There are many known tyrosinase inhibitors but the most commonly known inhibitor is hydroquinone. Other topical agents such as hexylresorcinol also inhibit the synthesis of melanin by promoting the production of glutathione and inhibiting the production of DOPA to DOPAChrome. As melanin is generated in the epidermis, topical solutions are effective in altering the production and expression of hyperpigmentation. In the US, 4% (or greater) hydroquinone is the most frequently prescribed topical treatment for hyperpigmentation. Hydroquinone, however, has significant controversy and concern surrounding its use. In some people hydroquinone can cause ochronosis, a paradoxical increase in hyperpigmentation, which may not decrease after discontinuation (Westerhof W, 2005). Additionally there is some evidence linking hydroquinone to increased cancer risk (FDA, 2006) (Westerhof W, 2005) through the potential induction of endoreduplication and its potential role in genomic instability and subsequent carcinogenesis (Ji Z, 2009). As a result of these concerns, hydroquinone is banned in many countries around the world, including all the European Union and Japan. In response, research into alternatives for hydroquinone is rapidly growing. Many newer non-hydroquinone technologies combine several technologies to improve efficacy as combination technologies tend to be more effective than single technology solutions (Halder RM, 2004). Yet few, if any, products contain technologies that address multiple stages of the melanin production cycle, improve penetration, enhance results and provide additional anti-ageing benefits. The tested product contains significant concentrations of over seven different proven technologies including: hexylresorcinol, alpha-arbutin, dipotassium glycyrrhizate, kojic dipalmitate, licorice root extract, retinol, anti-oxidants and salicylic acid. This use of several proven technologies in a single product is intended to both increase the efficacy and response rate (compared to alternate, less concentrated, non-hydroquinone solutions) and improve the antiageing benefits of the product. This study investigates the efficacy of the cumulative product in each area.
M ethods Twenty adult subjects aged 30-65 with
topical prescription tretinoin (0.05%) in addition to
period starting at week two.
hyperpigmentation on the face secondary to photo-
the tested configuration to determine effect and
Assessments included live review by the principal
ageing and melasma (n=12) were enrolled in an
tolerance as retinoids are a common component of
investigating dermatologist and patient self-assessment.
aggressive 12-week, open-label study. The study
hyperpigmentation therapies. Since there was little
Quantification of melasma was determined by physician
was designed to be only 12 weeks (vs. 24) to assess
to no sensitivity reported in either the prescription
assessment using Melasma Assessment Severity Index
the product’s ability to produce rapid changes in the
topical tretinoin group or the non-tretinoin group, the
(MASI) scores. Photo-ageing was assessed using a
appearance of hyperpigmentation. Subjects were
investigational product was modified to increase the
multi-factorial four-point scale developed by Dr. Macrene
enrolled in the study between the end of November
percentage of retinol. All other ingredients remained
Alexiades-Armenakas published in JDD Sept. 2006 for
2010 and beginning of February 2011. This timing
constant. The final six subjects used the modified
assessing photo-ageing pre and post non-ablative laser
was designed to eliminate the impact of summer sun
product with higher retinol concentration.
treatments. This scale was used in place of a standard
exposure and seasonal changes on appearance of
wrinkle score due to its increased granularity to measure
pigmentation over the course of the study.
Subjects followed a detailed protocol including a two-
changes in texture, erythema, elastosis and wrinkles.
To control all aspects of the test subject’s skincare routine,
week acclimation period to integrate Enlighten MD into
Improvement was further determined by the principal
subjects applied the investigational product as part of
the subject’s skincare routine. During the acclimation
investigator using a 10-point scale to assess overall skin
a layered skincare system (The Skin Care Management
period, the resurfacing step was applied AM only and
quality, overall hyperpigmentation, overall erythema and
System MD by Jan Marini Skin Research). This regimen
the test product was applied every other night during
consists of a total of six products applied in succession
week one and nightly during week two. From week
Statistical significance was determined by paired t-test.
including: a glycolic acid cleanser, a vitamin C serum, a
three through the end of the study all products (with the
Unless otherwise specified, statistical significance was
resurfacing gel, Enlighten MD, a hydrating anti-ageing
exception of the sunscreen) were applied AM and PM.
determined by comparing complete sets of pre and post
product and a broad spectrum sunscreen.
In the tretinoin arm, nightly application of prescription
treatment data. A p value of less than 0.05 was used to
Six of the initial 14 study participants applied a
tretinoin was integrated into the routine over a 3 week
R esults Compliance was extremely high with only one participant lost
Age distribution ranged as follows: six individuals between 30-39
to follow-up. Acclimation was minimal with no reported cases
years of age, seven individuals between 40-49 years of age, four
of skin irritation in either study arms. The final population to
between 50-59 years of age and two individuals over 60. Final data
complete the study consisted of nineteen female subjects. The
is separated into two categories, physician assessment and patient
only enrolled male subject was lost to follow-up at the final visit.
P hys i ci a n A sse ssme nt experiencing a reduction in photo-ageing, only 5% of which exhibited an increase in photo-ageing by the smallest possible score increment (• point). Results for standardised physician assessment scores are shown in Figure 1. Physician assessed improvement in overall pigmentation and sundamage was determined using a 10 point grading scale. Improvement in both overall pigmentation (p<0.001) and sun-damage (p<0.001) were statistically significant. Baseline and 3 month scores are shown in Figure 2. Significant Reduction in melasma was significant (p<0.01) with 75% of patients
improvements were also observed in skin quality (p=0.001),
with melasma (nine of 12) experiencing a reduction in MASI scores.
erythema (p=0.005) and acne (p=0.05). Physician assessment
The average MASI index score reduced by 27% over the three month
showed very consistent results with nearly all subjects. 17 of the 19
study period. Further, no subjects experienced a significant darkening
subjects (89%) experiencing measurable improvement in at least
or worsening of their melasma. Improvement in standardised photo-
one or more categories. 16 patients (84%) showed improvement in
ageing scores was also significant (p<0.001) with 74% of subjects
two or more categories.
3 Months cosmeticnewsuk.com
S u bj ec t S e lfA s ses s m e nt 100% of subjects reported improvement in their skin in at least two or more categories. Moderate to significant improvement was observed in six of eight categories including the key pigmentation categories of sun spots, melasma and luminosity. Mild to moderate improvement observed in the final two categories (Figure 3).
Quantitative assessments of skin quality taken pre and post study showed a significant reduction in dyschromia (p<0.001) and uneven skin tone (p<0.001) and a significant increase in skin elasticity (p<0.001) indicating a clearer more youthful complexion and improvement in overall skin quality (Figure 4).
Standardised photo-ageing improvement was significant (p<0.001) as was the change in scores denoting the overall quality of their skin (p<0.001) (Figure 5). Subject satisfaction was high with 89% of all participants indicating on the post study that they intended to purchase the products and would recommend them to a friend/family member.
Hyperpigmentation is one of the hallmarks of ageing skin. A
alone (Halder R.M., 2004). Typically, however, due to the
shown to reduce the production of melanin both the intra
product that effectively addresses both hyperpigmentation
irritation associated with both hydroquinone and tretinoin,
and extra-cellular space by interacting at multiple stages
and the many other facets of ageing skin offers significant
these combination products also require the use of a steroid
of the melanin production cycle. In-vivo, hexylresorcinol
consumer value. Available products that are designed
to decrease morbidity.
is shown to have equivalent lightening properties to
D is c us s ion
to decrease hyperpigmentation fall into two primary
hydroquinone at both four and eight weeks with â€˘ the
categories â€“ hydroquinone and non-hydroquinone
The tested product combines multiple non-hydroquinone
concentration (0.5% vs. 2%) and in vitro, interrupts
solutions. Hydroquinone, typically prescribed at 4%
technologies, each in concentrations proven to be
eumelanin formation more effectively than licorice root,
concentrations in the US, is highly effective and widely
comparable to hydroquinone, using retinol, salicylic
hydroquinone and kojic acid (Syntheon). The tested product
proven but irritation with use is common (Herndon JH Jr.,
acid and additional technologies designed to minimise
contains 2X the concentration used in these comparative
2006) resulting in frequent addition of steroids to minimise
inflammation and skin irritation. The key pigmentation
irritaiton (Davis EC, 2010). Further, concerns with the long-
technologies in the tested product include hexylresorcinol,
term safety use of hydroquinone have resulted in bans in
alpha-arbutin, licorice root extract, dipotassium
Topically, hexylresorcinol stimulates the production
many countries outside the US.
glycyrrhizate and kojic dipalmitate. salicylic acid and
of glutathione, which helps to decrease DNA damage
Many non-hydroquinone technologies have proven to be
retinol in the product increase cellular turnover and
secondary to oxidative stress and reduces the
effective tyrosinase inhibitors and improved results are
provide significant anti-ageing benefits in addition to
appearance of hyperpigmentation. Hexylresorcinol, and
often achieved through the use of multiple technologies
reducing the appearance of hyperpigmentation. They
the stimulated glutathione work on multiple pathways
in a single product. Unfortunately, most products available
also offer the potential to increase the penetration of the
as shown in Figure 6 (Syntheon). Further, it is extremely
today only include one or two technologies, thus limiting
aforementioned pigmentation technologies. Anti-oxidants
safe. It is listed as a safe for use as a food preservative in
efficacy. Studies have shown that the combination of
and anti-inflammatory agents in the product decrease the
the US and many foreign countries and is used in throat
tyrosinase inhibitors (hydroquinone) with retinoids
probability of skin irritation.
lozenges for its anesthetic and antiseptic properties to
(tretinoin 0.5%) is more effective than tyrosinase inhibitors
Hexylresorcinol, a key component in the tested product, is
Epionce® Targets Pigmentation Epionce® Melano Corrective System
Melano Corrective System
Using an innovative blend of botanical ingredients, the Melano Corrective system effectively reverses and prevents the appearance of unwanted pigmentation. This corrective system addresses each step in the abnormal pigmentation process without causing the irritation and redness caused by many other pigmentation products.
Clinically tested against the Obagi® Nu-Derm System for Pigmentation. Read the study at www.epionce.com/resourcekit.html
What makes MelanoLyte Tx unique? Fast, more complete clearing • Little to no irritation • Prolonged results • Less risk of recurrence • Clinical evidence •
Lightens Irregular Pigmentation
DR CARL THORNFELDT DISCUSSES THE SCIENCE BEHIND HIS SKINCARE LINE ‘If we could make the skin function at its optimum and stay in that optimum state, could we prevent all these diseases that develop as we mature?’ This was Dr Thornfeldt’s original hypothesis before creating his skincare line Epionce®. His objective was to create a range of products safe enough to use over the long term, suitable for all age groups, but that had multiple mechanisms of action to affect complex processes. Skin diseases and conditions all have multiple processes involved to produce what we see manifested visually in the skin. The result of his research and development is Epionce®.
How is Epionce different from other products? Carl Thornfeldt: Epionce® has been developed to modulate the underlying problems that create the visible disease or condition. In other words, not just help fix the symptoms of what the skin conditions are, but rather, to help treat the underlying effect. Epionce® helps to optimise the barrier function of the skin, and helps reverse and prevent chronic inflammation, which is destructive. Epionce Targets Pigmentation Carl Thornfeldt: The Melano Corrective System is comprised of two products that work synergistically to help the complicated process leading to visible hyperpigmentation. It is made up of a combination of herbal and algae extracts with multiple mechanisms of action that were previously evaluated in human skin in vivo trials. They are also able to deliver these active ingredients without destroying the stratum corneum barrier and activating inflammation response. The MelanoLyte Tx is for daily at-home use, that can be used year-round, and the MelanoLyte Pro is a very active mask for in-clinic application.
For more information about the Melano Corrective System and FREE training contact Episciences on 01245 227788 or email email@example.com
Figure 6 - Hexylresorcinol and and Melanin Production Cycle
DNA damage induced by H202
Competitive binding to Tyrosinase active site
Tyrosinase mediated path
DHI & DHIC
work together to increase the probability of
Interestingly, although the equivalent concentration of
tretinoin to the retinol in the test product is high, study
Retinoids provide significant anti-ageing
subjects did not indicate skin irritation or sensitivity
benefits by increasing skin thickness and
typically associated with high percent topical tretinoin.
increasing cellular turnover, promoting
The tested non-hydroquinone system is safe for
healthier skin. The standard prescribed
long-term use and, as with any pigmentation product,
retinoid is all-trans-retinoic acid, or
benefits will continuing with use. The subject shown
tretinoin, with concentrations typically
below (outside official study) used the tested system for
ranging from 0.025% to 0.1%. Results
10 months and shows significant reduction in melasma
from tretinoin are significant but irritation
on both cheeks.
and sensitivity is also high is as much as Peroxidase/H202 mediated path
Peroxidase/H202 mediated path
Interaction curve for parameter â€œLâ€?: treated zone vs control, difference M1/MO
82% of all subjects using 0.1% tretinoin experiencing at least moderate erythema and scaling more than once over a 10-month study period.
is approximately 10 times the equivalent concentration of
tested product (0.75%) is roughly equivalent to a 0.075%.
Co n cl us ion
all-trans-retinol and tretinoin, the retinol percentage in the
hyperpigmentation. In combination, these technologies
tretinoin. Based on these study data comparing topical
shown to provide effective reduction in the appearance of
a 1% all-trans-retinol is roughly equivalent to a 0.1%
the tested product, each of these technologies has been
Individually, and at concentrations less than those used in
all-trans-retinoic acid (Kurdlandsky SB, 1994). This means
necessary concentration of all-trans-retinol concentration
licorice root extract (glycyrrhiza glabra) responsible for
(Kligman LH, 2000). To achieve comparable results, the
compared to no changes (0 of 3) in the control group.
glycyrrhizate is a pure form of the compound in
of 6) subjects at concentrations of 0.3% and above as
Hydroquinone (Figure 7) (Pentapharm). Dipotassium
results at one month than kojic-acid, beta-arbutin and
orderliness and decreased melanin content in 100% (6
at concentrations of 0.15% with increased keratinocytes
Chinese descent, alpha-arbutin showed more significant
increased epidermal thickness, observed skin changes
in an 80 person skin-lightening study on individuals of
from the bearberry leaves. (Sugimotot K, 2003). Further,
2000). A histologic control comparison study observed
retinoic acid for multiple indications (Kligman LH,
much more strongly than classic beta-arbutin, derived
showing equivalent results to topically applied all-trans
a synthesised form of arbutin shown to inhibit tyrosinase
melanin production cycle (Zhu W, 2008). Alpha-arbutin is
skin, converting it to retinoic acid (tretinoin) with studies
2000). All trans-retinol undergoes a conversion in the
tyrosinase formation, thereby preventing initiation of the
and dipotassium glycyrrhizate all function to inhibit
tretinoin with less potential for irritation. (Kligman LH,
All-trans-retinol is an alternative to Alpha-arbutin, licorice root extract, Kojic Dipalmitate
Figure 7 - Alpha-Arbutin Lightening Effect
The high concentrations of multiple lightening technologies combined with high concentrations of retinoids and salicylic acid yielded significant improvement in the appearance of hyperpigmentation due to both Melasma and photo-damage. Additionally, significant improvement was observed by both the principle investigating dermatologist and subjects in photo-ageing and overall skin quality. Subject and investigator satisfaction was high, with extremely high subject compliance and zero reported cases of irritation or transient complications - even in the prescription topical tretinoin arm. The high rate of compliance significantly enhances the ability of the Skin Care Management System to deliver maximum results. Enlighten MD with the Skin Care Management System MD represents a highly effective non-tretinoin solution to address the appearance of hyperpigmentation and overall photo-ageing.
R eferences Davis EC, C. V. (2010). Postinflammatory Hyperpigmentation. J. Clin.
Kligman LH, G. E. (2000). Re-emergence of topical retinol in
Sugimotot K, N. T. (2003). Syntheses of Arbutin-a-glycosides and a
Aesthet. Dermatol , 3 (7), 20-31.
dermatology. J. of Dermatological Treatment , 11, 47-52.
Comparison of Their Inhibitory Effects with Those of a-Arbutin and
Farage MA, M. K. (2010). Textbook of Ageing Skin. Berlin: Springer.
Kurdlandsky SB, X. J. (1994). Biological Activity of Allt-trans Retinol
Arbutin on Human Tyrosinase. Chem. Pharm. Bull , 51 (7), 798-801.
FDA. (2006, August 29). Skin Bleaching Drug Products for Over-the-
Requires Metabolic Conversion to All-trans Retinoic Acid and is
Syntheon. (n.d.). Hexylresorcinol Data Sheet. The New Safe and Effective
Counter Human Use; Proposed Rule. Federal Register , 71 (167).
Mediated through Activation of Nuclear Retinoid Receptors in Juman
Skin Brightener with Protective Effects on the Skin , 14 (2) , 117-123.
Halder R.M., R. G. (2004, June-July). Topical Agents Used in the
Keratinocytes. Journal of Biologic Chemistry , 269 (52), 32821-32827.
Management of Hyperpigmentation. Skin Therapy Letter.com , 9 (6).
Matts, P. (2008). New Insights into Skin Appearance and Measurement.
Westerhof W, K. T. (2005). Hydroquinone and its analogues in
Herndon JH Jr., S. T. (2006). Efficacy of Tretinoin / Hydroquinone-Based
The Society for Investigative Dermatology , 13.
dermatology - a potential health risk. Journal of Cosmetic Dermatology
Skin Health System in the Treatment of Facial Photodamage. Cosmetic
Pentapharm. (n.d.). Alpha Arbutin Data Sheet. Alpha-Arbutin - the more
, 5 (2), 168-169.
Dermatology , 19 (4), 255-262.
effective, faster and safer approach to skin lightening. Pentapharm.
Zhu W, G. J. (2008). The use of Botanical Extracts as Topical Skin-
Ji Z, Z. L. (2009). The benzene metabolite, hydroquinone and etoposide
Schafer T, M. J. (2006). The Epidemiology of Nevi and Signs of Skin
Lightening Agents for the Improvement of Skin Pigmentation Disorders.
both induce endoreduplication in human lymphoblastoid TK6 cells.
Ageing in the Adult General Population: Results of the KORA-Survey
Journal of Investigative Dermatology Symposium Proceedings , 13,
Mutagenesis , 24 (4), 367-372.
2000. Journal of Investigative Dermatology , 126, 1490-1496.
Jan Marini Skin Research (JMSR) is known for creating breakthrough product solutions and dramatic technological advancements. Over the years, the company has established a portfolio of proprietary formulas that reflect itâ€™s on-going commitment to be the preeminent developer of skin care products that produce measurable clinical results. Backed by clinical studies and protocols, marketing support and striking branding, Jan Marini Skin Research products are only sold to professional, accredited outlets. As the exclusive distributor of JMSR, JMSR Europe Ltd will be conducting free seminars on the dates opposite. Join us for an opportunity to find out about the portfolio. Learn how leveraging the Skin Care Management System, and other key JMSR accelerator products, can increase your business success. Additionally, we will cover a broad range of relevant marketing and business concepts intended to positively impact your top and bottom line. A buffet lunch and refreshments are provided. For booking details please call 020 8868 4411.
JMSR Europe Ltd. www.janmarini.co.uk firstname.lastname@example.org
Seminar Dates 4th October 2011 EDINBURGH Radisson Blu 10-11th October 2011 MANCHESTER Lowry Hotel 26th October 2011 DUBLIN The Burlington Hotel 8th November 2011 LONDON Royal Society of Medicine 29th November 2011 MANCHESTER Lowry Hotel
Product News New FDA clearance for SOPRANO Alma lasers, distributed in the UK and Ireland by ABC Lasers, has received a new FDA clearance indication for the Soprano Xli Blue laser for treatment of all skin types including black skin types and sun tanned skin.
JMSR launches Skincare Management System boxes Following its recent launch of Age Intervention Enlighten Plus and Enlighten MD, Jan Marini Skin Research (JMSR) has announced the arrival of six new full sized Skin Care Management System boxes incorporating either of these products and an extra cleanser. This means each of these new Skin Care Management System boxes will contain seven full sized products for under £300. Both Age Intervention Enlighten Plus and Enlighten MD are pigmentation solutions comprising high concentrations of both retinol and multiple proven non-hydroquinone based tyrosinase inhibitors. Both products use the original and popular Age Intervention Enlighten as a base and then enhance it by introducing additional tyrosinase inhibitors and increasing the concentrations of select key ingredients. The result is a significantly more concentrated product with a 50% increase in the concentration of brightening technologies.
Syneron/Candela launches CO2RE Syneron/Candela has unveiled its latest innovation in fractional CO2 skin resurfacing – the CO2RE. Featuring four treatment modes, CO2RE can be used to rejuvenate the skin in a single treatment and may be used for spot or full face/neck/ decolletage and body treatments. Traditional CO2 laser treatments came with risks, pain and weeks of downtime due to the removal of all the epidermis, but because CO2RE is able to remove a much smaller percentage of the skin, part of the epidermis remains intact, resulting in far less downtime, pain and a reduced risk of post inflammatory hyper-pigmentation, sensitivity and infection. Boasting the fastest CO2 scanning technology in the industry, C02RE delivers spot treatments in a matter of minutes. Adding to its uniqueness, CO2RE’s FUSION MODE allows doctors to treat both the upper and deeper skin layers simultaneously with complete precision. This provides improvement of the skins surface texture and the stimulation of healthy collagen deep in the dermis. Co2RE offers multiple treatment options for skin resurfacing, wrinkles and scar reduction. Offering surface, middle and deep dermal layer treatments to suit the individual’s needs and results. 40
This breakthrough modification in the Soprano Xli SHR (IN-MOTION) Pain Free Hair Removal technology, will now, uniquely and exclusively open the door for Soprano offering clinics, to offer Laser Hair Removal all year round even to those clients who are sun tanned (although fake tans are still prohibited). This recent FDA approval is a result of very extensive clinical research and publication of several peer reviewed studies which provide an overwhelming evidence as to the long term efficacy (at six and 18 months post a six sessions course), presenting an impressive safety record of 0% adverse skin respond of any kind.
SkinMedica launches CalmPlex SkinMedica has introduced the first and only skincare product to contain a patented ingredient clinically proven to reduce visible redness – Redness Relief CalmPlex. A recent discovery made by the team at SkinMedica® saw that Prostaglandin E2 was the major contributing factor for visible redness. CalmPlex is designed specifically to diminish PGE2, which will consequently dramatically even skin tone. SkinMedica also discovered that this was the main cause for most types of visible redness, including sun exposure, extreme temperatures, blushing, menopause, rosacea, acne, infection and cosmetic procedures. Decreasing levels of PGE2 with CalmPlex will prevent the vasodilatory effect, which is the primary cause of redness in post-menopausal women. It will also prevent UV-induced inflammation as well as the reduction of melanin distribution. Further research by SkinMedica additionally shows dramatic prevention of hyperpigmentation. Key ingredients include 4-Ethoxybenzaldehyde, a patented ingredient with proven clinical safety in humans, that suppresses the release of PGE2; Niacinamide, which improves barrier function whilst reducing sebum production and Squalene and Jojoba Oil, which improve barrier function with moisturisation as well as controlling release of inflammatory cytokines.
Inspira Med Ltd to distribute Red + MRS Fine Titanium Derma Roller Inspira Med Ltd will be distributing the Red + MRS Fine Titanium Derma Roller in the UK. The comprehensive range includes rollers for both in-clinic and at-home use. The device comes in a number of sizes: 0.20 mm-0.30mm for home use and 0.50mm-3.00mm for professional use. All rollers are delivered in individual sealed sterile envelopes and plastic cases.
Six new Skin Care Management Systems featuring Enlighten Plus or Enlighten MD.
Skin Care Management System Plus and Skin Care Management System MD are preconfigured to specifically meet the significant market need to address pigmentation. All systems, featuring seven full sized products are competitively positioned with suggested Retail Prices at under £300. The Skin Care Management System (SCMS) was named “The Best Skin-Care System Sold in a Doctor’s Office” in the 2010-2011 New Beauty Awards and was judged to “Really transform skin into a glowing, youthful complexion.” SCMS Plus and MD combine this award winning system with a dedicated, advanced, non-hydroquinone formulation lightening product (Enlighten Plus or Enlighten MD) and a gentle cleanser. Enlighten Plus Skin Care Management Systems Normal/Combination PLUS: BioGlycolic Cleanser, AI Gentle Cleanser, C-Esta Serum, Bioclear Serum, TGF Cream, Enlighten PLUS, Spf 30 Tube. Catalogue Number: SCMS05 Dry PLUS: BioGlycolic Cleanser, AI Gentle Cleanser, C-Esta Serum, Bioclear Cream, AI Cream, Enlighten PLUS, Spf 30 Tube. Catalogue Number: SCMS06 Oily PLUS: BioGlycolic Oily Cleanser, AI Gentle Cleanser, C-Esta Oil Control, Bioclear Serum, TGF Serum, Enlighten PLUS, Spf 30 Tube. Catalogue Number: SCMS07
Enlighten MD Skin Care Management Systems (for Doctors and nurse prescribers only) Dry MD: BioGlycolic Cleanser, AI Gentle Cleanser, C-Esta Serum, Bioclear Cream, AI Cream, Enlighten MD, Spf 30 Tube. Catalogue Number: SCMS08 Normal/Combination MD: BioGioglycolic Cleanser, AI Gentle Cleanser, C-Esta Serum, Bioclear Serum, TGF Cream, Enlighten MD, Spf 30 Tube. Catalogue Number: SCMS09 Oily MD: BioGlycolic Oily Cleanser, AI Gentle Cleanser, C-Esta Oil Control, Bioclear Serum, TGF Serum, Enlighten MD, Spf 30 Tube. Catalogue number SCMS10
All products to be sold by consultation only, not to be sold on the internet. Supply: Approx 2 months
JMSR Europe Ltd. www.janmarini.co.uk email@example.com 020 8868 4411
Product News CE Mark Approval for TissuGlu® Surgical Adhesive Cohera Medical has received CE Mark approval for its lead product, TissuGlu® Surgical Adhesive, allowing the product to be sold in the European Union. TissuGlu is an internal surgical adhesive for large flap surgeries, such as abdominoplasties, that helps reduce fluid accumulation and the need for postsurgical drains. Its unique chemical composition is resorbable, non-toxic, forms a strong bond between tissue layers and allows for natural healing, which ultimately may provide the patient with a quicker return to normal activity. “TissuGlu Surgical Adhesive provides an innovative approach to the way plastic surgeons address wound drainage challenges and helps plastic surgeons improve the overall care of their patients,” said Dr Peter Rubin, Chief, Division of Plastic and Reconstructive Surgery at the University of Pittsburgh Medical Center. “Surgeons will be eager to apply this product to their procedures, which we believe will ultimately save them time and money through the reduction of post-surgical complications and additional OR time.”
“Achieving the CE Mark on our TissuGlu Surgical Adhesive represents a significant milestone and achievement by all of the employees of Cohera Medical,” said Chad A. Coberly, Vice President of Clinical, Regulatory and Legal Affairs for Cohera Medical. “The certification signifies that we have met the rigorous clinical, quality, and performance requirements of the EU authorities and demonstrates the commitment we have to our future customers, partners, and investors.”
Intraceuticals Rejuvenate Range now Paraben-Free Intraceuticals has now released a new paraben-free Rejuvenate product range. Intraceuticals’ Rejuvenate range is designed for intense rehydration of the skin, and is used in conjunction with its proprietary 3-Step Hyaluronic Layering, the underpinning philosophy behind the entire Intraceuticals product range. At Step 1 of the process, Rejuvenate Daily Serum revives the skin from within. The serum’s low molecular weight makes it the perfect vehicle for a deep delivery of carefully selected anti-ageing actives and nutrients to the skin. Rejuvenate Hydration Gel is applied as Step 2 to replenish the skin and provide an invisible barrier against moisture loss. Rich in Hyaluronic Acid, vitamin C and vitamin E, the lightweight gel works synergistically with Rejuvenate Daily Serum to smooth fine lines and wrinkles, allowing osmotic hydration to continue. As the third step Rejuvenate Moisture Binding Cream combats surface dehydration to nourish, moisturise and defend the skin. The active ingredients of the Daily Serum and Hydration Gel are locked into the skin by the Moisture Binding Cream, while adding anti-oxidants and wheat germ for continuous hydration and restoration of the skin’s natural pH balance.
Medik8® betaGel targets acne Medik8® has developed a new product to target acne. Medik8® betaGel™ is a 24 hour, professional strength protection gel for use on individual blemishes or larger problem areas day or night. The lightweight formula contains a fusion of spot fighting actives that can be applied invisibly underneath or over make-up. The deep cleansing action and antiredness properties that alleviate the unwanted redness associated with acne and spot breakouts are what make Medik8® betaGel™ the ideal product for all skin types. Unlike typical anti-acne treatments which induce dryness, betaGel™ keeps the targeted area hydrated and supple reducing the discomfort normally experienced when spots are inflamed or sore. Key ingredients include: Azelaic Acid, Salicylic Acid and Niacinamide.
BOTOX TO BE USED TO TREAT INCONTINENCE The go-ahead has been given in Europe for Botox® to be used for treating certain patients with urinary incontinence in adults with neurogenic detrusor overactivity (NDO), opening up a potentially new market for its maker Allergan. The Irish Medicines Board has given a positive recommendation for Botox® to treat patients with overactive bladder problems caused by multiple sclerosis and spinal cord injury. This is an important step towards securing national licences in the 14 European countries involved in the Mutual Recognition Procedure and marks a key milestone in bringing this innovative treatment to patients suffering from urinary incontinence due to NDO. The positive opinion is specific for Botox® and is based on Allergan’s successful global phase III programme. Targeted injections of Botox® into the bladder muscle have been shown to reduce the involuntary contractions and increase bladder capacity. In turn, this reduces the number of urinary leaking episodes and may even stop leaking altogether in some patients.
Discover The Light
Advanced Skin Lightening Fast, Safe and Gentle Skin Appearance Improvement Syneron’s elure product line is an Advanced Skin Lightening Technology, based on the proprietary enzyme Melanozyme™ - our patented version of the naturally occurring enzyme lignin peroxidase. elure is the ﬁrst clinically demonstrated skin lightening product to temporarily reduce the appearance of melanin in the skin to reveal a visibly more radiant and more even skin tone. The elure™ Promise • Unique scientiﬁc discovery • Proven faster, safer, more visible results • Revolutionary patented formula • Melanozyme – a safe, naturally occurring enzyme • Hydroquinone free, dermatologist tested, clinically proven • Healthier, brighter, younger looking skin s i lv e r sponsor
cosmetic news xpo 2012 E
29th - 30th april 2012 | business design centre, islington, london w w w. c o s m e t i c n e w s u k . c o m
t h e u k ’ s o n ly free of charge aesthetics exhibition
Before China Clinical Trial
After (Day 28)
After (Day 28) Courtesy: Tess Mauricio, M.D.
s i lv e r sponsor
cosmetic news xpo 2012 E
t h e u k ’ s o n ly free of charge aesthetics exhibition
Coming soon to the UK! Sold exclusively through physicians. www.elureskin.com, firstname.lastname@example.org, www.facebook.com/elureskin © 2010 . All rights reserved. Syneron, the Syneron Logo, and elure are trademarks of Syneron Medical Ltd. and may be registered in certain jurisdictions. PB74971EN
We summarise some of the most recent studies you may have missed Title:
severe complication of vascular necrosis and
There was no significant difference in the
medicine, and rejuvenation in 2010: the role of
detect impending necrosis after injection of a
degree of reduction in non-inflammatory lesions
adipose-derived stem cells
dermal filler, especially with hyaluronic acid fillers.
between the two peels. There was no significant
Authors: Beeson W, Woods E, Agha R Published: Facial Plast Surg. 2011
Materials and Methods: Case report
reduction in the number of inflammatory lesions.
of a patient who was followed for six months
Both peels were generally very well tolerated.
from time of injection of hyaluronic acid filler to
Conclusion: This study suggests that
complete healing of wound.
lipohydroxyacid peels can be beneficial to subjects with comedonal acne.
Tissue engineering, regenerative
Results: Complete wound healing was
Facial rejuvenation is rapidly evolving sector
achieved with early recognition and institution of
in the field of facial aesthetics. There is a wide
variety of dermal fillers and many more are in
Conclusion: Early recognition of vascular
development. Over the past few years, the study
necrosis with specific protocol for treatment after
of adult-derived stem cells has become a very
injection necrosis with hyaluronic acid fillers
Authors : Yingcong Zhou, Ajay K Banga Published: Journal of Cosmetic
active area of research.
improves the outcome of wound healing.
Dermatology Volume 10, Issue 3, pages 179–184,
Enhanced delivery of cosmeceuticals
Adult stem cells are an attractive option for volume restoration and facial rejuvenation. Adult
stem cells are isolated from adipose tissue-
chemical peel containing a lipophilic hydroxy acid
Background: Microdermabrasion (MDA)
adipose derived stem cells and have mesodermal,
derivative of salicylic acid with a salicylic acid peel
is one of the top five nonsurgical cosmetic
ectodermal, and endodermal potentials.
in subjects with comedonal acne
procedures performed. It is a well-established
Adipose-derived stem cells could conceivably
Authors: Annie Levesque, Iltefat Hamzavi,
technology with widespread applications in the
be an alternative to pluripotent embryonic stem
Sophie Seite, André Rougier, Robert Bissonnette
cells and could play a critical role in the rapidly
Published: Journal of Cosmetic Dermatology
Aims: To investigate the effects of MDA on skin
expanding fields of tissue engineering and
Volume 10, Issue 3, pages 174–178, September
and delivery of cosmeceuticals.
Randomised trial comparing a
Methods: The alternation of skin structure post-MDA was examined by histological
This article reviews the history of soft tissue augmentation using adipose tissue grafting and
Background: Lipohydroxyacid is a
sectioning and transepidermal water loss
the advent of using adipose-derived stem cells.
lipophilic derivative of salicylic acid with
measurements. The effect of MDA treatment
The state-of-the-art stem cell isolation technique
on skin permeation profiles of hydrophilic and
as well as anticipated future therapeutic
Objectives: To compare lipohydroxyacid
lipophilic molecules was investigated by laser
indications are also addressed.
and salicylic acid peels in subjects with
scanning confocal microscopy and in vitro
Methods: In this split face, randomised
Results: Confocal images indicated
hyaluronic acid filler: case report and review of
study, 20 subjects with comedonal acne received
different absorption profiles and permeation
lipohydroxyacid peels on one side of the face,
depths for hydrophilic and lipophilic molecules.
Authors: Kassir R, Kolluru A, Kassir M Published: J Cosmet Dermatol. 2011
while the other side was treated with salicylic acid
Microdermabrasion enhanced the transdermal
peels. A total of six peels at two-week intervals
delivery of nicotinamide, the model hydrophilic
were performed. Efficacy was evaluated by
compound employed. On the other hand,
counting non-inflammatory and inflammatory
permeation of retinol, the model lipophilic
Background: Use of dermal fillers for soft
lesions and by performing a global change
compound, did not improve after treatment
tissue augmentation has become an integral part
in acne assessment. Safety was assessed by
with MDA. When treated with 20 passes, the skin
of aesthetic practices. Dermal fillers temporarily
evaluating adverse events, global tolerance, and
recovered from MDA induced changes in four
remove the appearance of rhytids and reduce
the presence of erythema, scaling, and dryness.
the depth of skin folds. Even with the most
Results: There was a statistically significant
Conclusion: Permeation of cosmeceuticals
experienced of injectors, adverse effects can and
decrease of 55.6% and 48.5% from baseline to
into skin was found to be affected by their
do occur ranging from mild bruising to severe
Day 98 in the mean number of non-inflammatory
lipophilicity. Application of skincare products
lesions for the sides treated with lipohydroxyacid
post-MDA therapy may be promising to improve
Aims: Physicians should be able to treat the
and salicylic acid peels, respectively (P < 0.001).
their dermal uptake.
Extensive necrosis after injection of
BEST PRACTICE - Social media
in employment law Award winning lawyer Norman Rea, consultant at Sydney Mitchell Solicitors, begins a series of interesting legal articles for our readers and, in this article, explores the phenom ena of Social Media sites and their usage in the workplace and beyond.
Social Networking Media – Do you have some twits on Twitter ? The world and how we communicate has changed in the last few years. A lot of us (me included) have profiles on sites such as Facebook, Twitter, LinkedIn, Google+ and MySpace. We all like to share our stories with our friends, followers
Social Media Policy
and fans and we like to listen and comment on what they
On any view it would be extremely wise to have a usage
have to say. More importantly, people trust what we say
policy in place which is clearly understood by all staff and
which sets out unequivocal guidelines of what is or is not acceptable usage within the employment arena.
The widespread availability and use of social media and networking applications brings opportunities to understand
Generally, contracts of employment or staff handbooks
and engage and communicate with our clients and
do not deal with this relatively new issue or are vague
customers in new ways. Used correctly they are an effective
and not coherent which, ultimately, makes it difficult to
take disciplinary action or to defend employee claims.
However, it is important that, as an employer, you are able
to use this technology and service effectively and flexibly to
Discrimination can occur at every stage of the employment
the benefit, as opposed to the detriment, of your business.
relationship, i.e. during recruitment, during the contractual
The main problem has been employee’s increasing use
relationship and post termination when providing
of personal blogs in situations where there is a blurring
of the relationship between the employee’s work and personal lives.
Note also that employers can be vicariously liable for any acts of discrimination carried out by their employees. If,
Some employers have, quite rightly, embraced the
for example, an employee makes a comment on Facebook
technology and use it for knowledge sharing, positive
about another employee which amounts to harassment ; an
publicity and product information. Others however have
Employment Tribunal may very well hold that the comment
fallen foul of the various legal obligations and traps which
was made “during the course of employment” or indeed
Norman is an award winning
are ready to ensnare the unwary.
may draw inferences from such evidence even if it was not done during working hours.
employment lawyer and experienced tribunal advocate.
He has written many articles for
It is important to be aware of the legal issues and risks
the legal and national press.
posed by the use of social networking.
Employers face a potential minefield if they use social networking sites to vet and gather further information
He is a member of the Employment Lawyers
Employees have the right to freedom of expression and
on candidates in the recruitment process. Social media
Association and Birmingham Law
a right to privacy. Therefore any action an employer
often contains details about sex, race, religion, etc and if
Society’s Education & Training
takes must bear these rights in mind and balance it
a candidate is rejected on the basis of such information
with their overriding objective, i.e. to protect their
gathered, a discrimination claim is possible.
Case Law Examples
The following case law examples provide a useful
Recently, an Employment Tribunal decided that a pub
The dividing line between what employees do in their
demonstration of how Employment Tribunals have
manager had been fairly dismissed for gross misconduct
own time and what they do in the workplace can be
dealt with the problematic area of social networking
having made inappropriate comments on Facebook
a thin one, particularly when the use of social media is
and how employers are sometimes too quick to
about her customers in breach of the employer’s e-mail
involved. It is particularly interesting that a chain e-mail,
and Internet policy. The “conversation” on Facebook took
with the imperative to pass it on, was considered to take
place whilst she was at work. It did not matter that she
the e-mail sent from an employee’s home computer to
thought that her privacy setting meant that only close
another employee’s home computer, out of the realms
Two sisters were held to have been unfairly dismissed
friends could see her entries. In fact a wider audience
of private life.
following their excessive use of the Internet. The
was able to view her Facebook page including relatives of
employer’s Internet usage policy which permitted access
the customers in question!
The key point was not that the employee intended for
outside “core working times” was held to be unclear.
the material to be passed on, but that he had no control Case 4
over whether it would be.
More recently, an Employment Tribunal has found that an
Two employees were held to have been unfairly
employee was dismissed fairly when he sent an offensive
This decision has alarming implications for employees
dismissed after they were sacked for allegedly bringing
e-mail from his home computer to a colleague’s home
who might heedlessly send on a chain e-mail outside
the supermarket Somerfield into disrepute. The Claimant
computer. No privacy attached to the email since it was a
work, only to find their employment jeopardised as a
had posted a video on YouTube showing two of his
chain e-mail asking recipients to pass it on.
colleagues hitting each other with plastic bags. The Tribunal did not accept that there was sufficient grounds
This case highlights the tension that can exist between
for dismissal – it was influenced by the fact that there
the employer’s right to protect its reputation and
were only 8 hits on the video clip and no provable loss
arguments about the employees privacy when
caused to the employer.
employees use social media outside work.
There are also data protection implications if a prospective employer consults
including clients or
online social media to gather additional information about a candidate.
customers, which may be sensitive information
The ‘Genie’ is out of the bottle – Control it!
which could affect the core
It is perhaps now clear that the massive growth in popularity of social media
of the business.
sites is creating issues as well as opportunities in the workplace. In my direct experience employers have a differing range of attitudes to the
Policies and Procedures
strategic importance of social media contribution to their culture and business
Some employers do not allow access to social media during business
and, consequently, a corresponding range of responses.
hours whereas others impose no limits and indeed positively
Some will ban it and others will actively encourage it.
handbook to ensure that they specifically address the issues.
Blogs and similar media presentations provide a unique opportunity to get a
Ensure disciplinary policies make specific reference to the use of social media
positive image of a business into the public domain.
and outline precise guidelines and penalties for breach of clearly laid out
External networking with other professionals may lead to business
I urge you to review your employment contracts and/or staff
opportunities and indeed do so.
Social Media Policy The risks
If you already have one in place revisit it and ensure that it is not vague or
Discrimination. As stated above anti discrimination laws can hold employers
capable of misinterpretation. This will make it difficult to defend potential
vicariously liable for discrimination by their employees. Tribunals apply a
very wide test to what is “acting in the course of employment”.
Your policy should clearly set out what is expected of employees, how they should conduct themselves whilst using social media and the penalties for
Employers are exposed to the danger that employees may post confidential
information online. Embarrassing, business information is
It is important to remember that nothing is ever private on these sites
suddenly thrust into the public eye.
Clearly, social media is here to stay and, if used competently and sensibly, it can actively promote your business. However you must decide your particular strategy for dealing with your employee’s use of such sites and the standard of behaviour expected of them. It is then important that policies and contracts
Some social media sites
of employment reflect the same in order to demonstrate a clear and consistent
create a whole host of
fresh problems for the employer owing to the fact that they encourage publication of a list of an employee’s business contacts,
The ‘Golden’ Rule It is important to remember that nothing is ever private on these sites. Basically, if you wouldn’t like your Granny to read it – don’t post it! Forthcoming article on Bribery Act in next issue. cosmeticnewsuk.com
Why do you need an App for your business? Technology has greatly influenced our society and lifestyles over the last decade. Businesses have also adapted to the ever-changing technology. We all remember the dawn of websites when the businesses were faced with the dilemma of having a website or not- eventually it turned out websites became essential for the businesses. Nowadays, every business needs a website and the ones which have not got a website, find themselves having less visibility than the others. Websites became part of the business brand identity and a quintessential tool in their promotions. The story for having a website for your business is going to repeat itself, just this time with an App. Yes a phone App.
o why should businesses have an App? The foremost thing to consider is that there’s an all-time increase in smart phone users – which now includes millions of users from different walks of life, age groups, social and demographic backgrounds. There is a whole generation of users who are now more tech savvy and use their smart phones in everyday activities
e.g. booking tickets, social interactions, cinema viewings, grocery ordering, reviewing and rating services, using maps and finding directions etc. This all leads to a great opportunity for your business to become accessible to the mass audience, where you can market your products proactively to your existing customers as well as attracting new customers. Secondly, in the Google and Groupon age, brand loyalty is diminishing, people are going for the better deals, so there is a great need for customer touch points to maintain a constant and positive engagement with customers. Smart phone Apps offer a host of facilities to achieve better relationships with your customers. For instance, a
notification facility can help you to be in touch with your customers more frequently,
Ahmed Zubair is head of operations
and due to automation available, it can be done conveniently without hassle. You can
with Welltime Ltd, a technology
send birthday, seasonal, and Christmas greetings to them automatically, along with
company looking into the future with
your offers that can be broadcasted straight to your customer’s phones. This can be
modern business solutions such as
done very cost effectively, usually without any charge -unlike the SMS messageing
iPhone Apps, PatientConnections - a
for marketing interactions where you have to pay for each text message. All this
customer retention solution – and
leads to strengthening your brand and increasing your market share. Apps also
online booking systems.
have the visibility to reach the customers wherever they are, due to the portableand
The pervasive and constant connection to each other, and the world at large, through anytime, anywhere, any device, availability of information, means that the phrase ‘out of sight, out of mind’ applies more than ever
are re-directed to the relevant place to download the App. Spend some time in carefully thinking how your customers would search for it, what words would they use to find your business. You can use different key words (called meta tags) to make your App more ‘findable’. You can use Google keywords and social media (such as Facebook, Twitter, Google+ etc.) to promote your App and of course word of mouth always helps in raising the awareness for your App.
personal nature of mobiles. And most of the messages
Finally your business should consider developing an App as a
sent to the phones get read as compared to other forms of
strategic investment, rather than an expense, because just like
communications. The marketing done via smart phones is
your website, your app is likely to generate you revenues. As a
highly measurable and can provide valuable insights into
business you would be well advised to check the availability of
choices, preferences and interests of your customers, allowing
your business name on the App Store and the App market and
you to serve them better and in accordance with their wishes.
get an App out there as soon as possible, even a basic one, in order to register and safeguard the App name reflecting your
While you are designing an app for your business you should
business. Since there can only be one app with a particular
keep in mind that the apps should have a value for your
name, if another business registers the name you cannot get it
customers, e.g. they should be able to get in touch with you
(like the early days of websites, once a .com or .co.uk domain for
more easily, book their appointments through their app, find
your business name is gone, its gone, and it becomes a problem
directions to your business etc. As an added advantage for
since by trying to choose an alternative name, the rest of your
the customers, you can provide the functionality where they
marketing would be out of sync and inconsistent with your app
can receive special offers or get notification when you upload
name- which people are most likely to search for on the App
new blog, videos or services. All these aspects should help you
store and the Internet).
to open a new channel for your business to connect to your customers through your app. It should effectively be a further
We are living in exciting times. The pervasive and constant
extension of your brand and should integrate with your
connection to each other, and the world at large, through
current website with the same look and feel.
anytime, anywhere, any device, availability of information, means that the phrase ‘out of sight, out of mind’ applies more
So if you have got the iPhone App developed and launched it
than ever. If you are out of your customer’s thoughts, you
on the App store or the App market, the next pivotal question
may be losing grounds to the competitor who is trying their
is how to market it. Marketing your app is pretty much the
best to get in front of your customers, at the very least, with
same as marketing any new product or service for your
the fast changing information constantly presented to the
business. You should include your App’s information on every
customers, it would be helpful for you to occasionally pop
touch point you have with your customers, e.g. your website
up in front of them – with your special offers- to keep the
should display the App button from where your customers
relationship going strong.
REMOTE CONSULTATIONS • Remote consultations by phone or video call 9am-9pm 7 days/week • UK wide Doctor Visiting Service
• Remote Dermatology Service available
• Botox® Training for Nurses £400 Full Day
• Discounted Aesthetic Products and Insurance
• Free UK and European Advanced Training
• On-line Ordering, Patient Records, Invoices, Training Videos etc
• Annual conference Saturday 24th September, Manchester • For more info on v300 visit realnurseprescriber.com
Dates for the Diary
We round up upcoming events, training courses and meetings
bioptica Laser Safety Consultants Bioptica: Laser Core of Knowledge course given at YOUR clinic on a date that suits YOU. Visit www.bioptica.co.uk for more information or call 07766 591 085.
1 Cosmetology Botox® Vistabel® Foundation, Birmingham, www.cosmetologyuk.com 2 Cosmetology Dermal Fillers Foundation, Birmingham, www.cosmetologyuk.com 2 Foundation Botox® and Dermal Fillers, Birmingham www.sallydurant.com 2 Wigmore Medical Training, Introduction to Skincare and Chemical Peels, London, email@example.com 3 Wigmore Medical Training, Camouflage, London, firstname.lastname@example.org 3 Aesthetic Academy + Dermal Filler Basic Course, Leeds, Yorkshire, www.aestheticstraining.co.uk 3-5 LCS Academy BTEC Medical Laser/IPL Part 1 (Pt 2: 21-22 Nov), www.lcsacademy.co.uk 4 Aesthetic Academy + Botulinum Toxin Basic Course, Leeds, Yorkshire, www.aestheticstraining.co.uk 4 Wigmore Medical Training, Sculptra Training Day One (day two six weeks later), London, email@example.com 4-5 SkinCeuticals Training, Cheshire, www.SkinBrands.co.uk 4-5 Medik8 Training, London, www.SkinBrands.co.uk 6 Dr Bob Khanna Training Institute, Dermal Fillers – Advanced, www.drbobkhanna.com 7 Wigmore Medical Training, CPR, London, firstname.lastname@example.org 7 Dr Bob Khanna Training Institute, Oral Facial Course, www.drbobkhanna.com 8 Wigmore Medical Training, Microsclerotherapy and Facial
NOVEMBER 1-2 Medik8 Training, London, www.SkinBrands.co.uk 6 Cosmetology Advanced Facial Aesthetics, Glasgow, www.cosmetologyuk.com 7-8 Sterex Advanced Electrolysis, www.sterex.com 8-9 SkinCeuticals Training, Cheshire, www.SkinBrands.co.uk 9 Wigmore Medical Training, Introduction to Skincare and Chemical Peels, London, email@example.com 9 Dr Bob Khanna Training Institute, Botulinum Toxin - Beginners, www.drbobkhanna.com 10 Dr Bob Khanna Training Institute, Botulinum Toxin - Advanced, www.drbobkhanna.com 10 Wigmore Medical Training, Introduction to Boutlinum Toxin Type A, London, firstname.lastname@example.org 11 Dr Bob Khanna Training Institute, Dermal Fillers – Beginners, www.drbobkhanna.com 11 Wigmore Medical Training, Introduction to Dermal Fillers, London, training@ wigmoremedical.com 12 Dermis Deep Microsclerotherapy Course, Birmingham, www.dermisdeep.com 12 Cosmetic Courses Foundation Botulinum Toxin and Dermal Fillers, www.cosmeticcourses.co.uk 12 Wigmore Medical Training, Microsclerotherapy and Facial
Telangiectasia, London, email@example.com 10 Aesthetic Academy + Dermal Filler Basic Course, Scotland, www.aestheticstraining.co.uk 11 Aesthetic Academy + Botulinum Toxin Basic Course, Scotland, www.aestheticstraining.co.uk 13 Aesthetic Academy + Dermal Filler Basic Course, Newport, Wales, www.aestheticstraining.co.uk 13 Dr Bob Khanna Training Institute, Peel Course, www.drbobkhanna.com 13 Wigmore Medical Training, Introduction to Boutlinum Toxin Type A, London, firstname.lastname@example.org 14 Aesthetic Academy + Botulinum Toxin Basic Course, Newport, Wales, www.aestheticstraining.co.uk 14 Wigmore Medical Training, Introduction to Dermal Fillers, London, email@example.com 15 Foundation Botox® and Dermal Fillers www.aesthetox.co.uk 15 Cosmetic Courses Botulinum Toxin and Dermal Filler Course, www.cosmeticcourses.co.uk 15 Dermis Deep Superficial and Medium Chemical Peels, Manchester, www.dermisdeep.com 15 Cosmetology Botox® Vistabel® Foundation, Manchester, www.cosmetologyuk.com 16 Cosmetology Dermal Fillers Foundation, Manchester, www.cosmetologyuk.com 18 Medik8 Training, Cheshire, www.SkinBrands.co.uk 19 SkinMedica Training, Cheshire, www.SkinBrands.co.uk 19 Aesthetic Academy + Dermal Filler Basic Course, Manchester, www.aestheticstraining.co.uk 19 Aesthetic Academy + Dermal Filler Basic Course, Windsor, Berkshire, www.aestheticstraining.co.uk 19-20 Sterex Advanced Cosmetic Procedures, London, www.sterex.com 20 Aesthetic Academy + Botulinum Toxin Basic Course,
Telangiectasia, London, training@ wigmoremedical.com 12 Cosmetology Botox® Vistabel® Foundation, London, www. cosmetologyuk.com 13 Cosmetology Dermal Fillers Foundation, London, www.cosmetologyuk.com 13 Foundation Botox® and Dermal Fillers Birmingham, www.aesthetox.com 15 Laser/IPL Core of Knowledge Training, www.lasersafe.co.uk 15 Medik8 Training, Cheshire, www.SkinBrands.co.uk 16 SkinMedica Training, Cheshire, www.SkinBrands.co.uk 18 Wigmore Medical Training, CPR, London, firstname.lastname@example.org 19 Dermis Deep Botox® Course, Manchester, www.dermisdeep.com 19 Dermis Deep Dermal Filler Course, Manchester, www.dermisdeep.com 19 Cosmetology Botox® Vistabel® Foundation, Birmingham, www.cosmetologyuk.com 20 Cosmetology Dermal Fillers Foundation, Birmingham, www. cosmetologyuk.com 21-22 LCS Academy BTEC Medical Laser/ IPL Part 2, www.lcsacademy.co.uk 21-22 Sterex Advanced Cosmetic Procedures, Birmingham, www.sterex.com 23 Wigmore Medical Training, Medik8 DermalRoller, London, training@
Manchester, www.aestheticstraining.co.uk 20 Aesthetic Academy + Botulinum Toxin Basic Course, Windsor, Berkshire, www.aestheticstraining.co.uk 22 Dermis Deep Botox® Course, Central London, www.dermisdeep.com 22 Dermis Deep Dermal Filler Course, Central London, www.dermisdeep.com 24 Wigmore Medical Training, GloMinerals, London, email@example.com 24 Dr Bob Khanna Training Institute, Botulinum Toxin Beginners, www.drbobkhanna.com 25 Dr Bob Khanna Training Institute, Botulinum Toxin Advanced, www.drbobkhanna.com 25 Wigmore Medical Training, Introduction to Skincare and Chemical Peels, London, firstname.lastname@example.org 25-26 SkinCeuticals Training, London, www.SkinBrands.co.uk 26 Dr Bob Khanna Training Institute, Dermal Fillers – Beginners, www.drbobkhanna.com 26 Wigmore Medical Training, Medik8 DermalRoller, London, email@example.com 29 Foundation Botox® and Dermal Fillers - Birmingham, www.aesthetox.co.uk 29 - Masterclass Botox® and Dermal Fillers - Manchester, www.aesthetox.co.uk 29 Dermis Deep Botox® Course, Glasgow, www.dermisdeep.com 29 Dermis Deep Dermal Filler Course, Glasgow, www.dermisdeep.com 29 Cosmetology Botox® Vistabel® Foundation, Glasgow, www.cosmetologyuk.com 30 Cosmetology Dermal Fillers Foundation, Glasgow, www.cosmetologyuk.com
wigmoremedical.com 24 Wigmore Medical Training, Advanced Toxins and Fillers, London, training@ wigmoremedical.com 24-26 Microsclerotherapy for thread veins of the leg, www.theclinicalexchange. com/courses 25 Foundation Botox® and Dermal Fillers Birmingham, www.aesthetox.com 26 Dermis Deep Botox® Course, Belfast, www.dermisdeep.com 26 Dermis Deep Dermal Filler Course, Belfast, www.dermisdeep.com 26 Wigmore Medical Training, Microsclerotherapy and Facial Telangiectasia, London, firstname.lastname@example.org 26 Cosmetology Botox® Vistabel® Foundation, Manchester, www.cosmetologyuk.com 27 Cosmetology Dermal Fillers Foundation, Manchester, www.cosmetologyuk.com 28-29 SkinCeuticals Training, London, www.SkinBrands.co.uk 29 Wigmore Medical Training, Introduction to Skincare and Chemical Peels, London, email@example.com
DECEMBER 1 The Aesthetic Awards in Association with Cosmetic News, Sopwell House, St Albans, www.cosmeticnewsuk.com 1-2 SkinCeuticals Training, Cheshire, www. SkinBrands.co.uk
3 Dermis Deep Advanced Botox® Course, Central London, www.dermisdeep.com 3 Dermis Deep Superficial and Medium Chemical Peels, Manchester, www.dermisdeep.com 3 Cosmetic Courses Foundation Botulinum Toxin and Dermal Fillers, www.cosmeticcourses.co.uk 3 Cosmetology Botox® Vistabel® Foundation, Glasgow, www.cosmetologyuk.com 4 Cosmetology Dermal Fillers Foundation, Glasgow, www.cosmetologyuk.com 5 Medik8 Training, Cheshire, www.SkinBrands.co.uk 5 Dr Bob Khanna Training Institute, Botulinum Toxin - Beginners, www.drbobkhanna.com 6 Dr Bob Khanna Training Institute, Botulinum Toxin - Advanced, www.drbobkhanna.com 6 SkinMedica Training, Cheshire, www.SkinBrands.co.uk 6-7 Medik8 Training, London, www.SkinBrands.co.uk 7 Dr Bob Khanna Training Institute, Dermal Fillers – Beginners, www.drbobkhanna.com 9 Wigmore Medical Training, CPR, London, firstname.lastname@example.org 10 Foundation Botox® and Dermal Fillers, Birmingham, www.aesthetox.com 10 Meeting of the Society of Cosmetic Physicians & Surgeons (SCPS), London, www.scps-uk.org
tur Monday 24th october cour ed se £225s Advanced Skin Science Monday 31st october Consultative Analysis and Advanced Skin Assessment Monday 14th noveMber The Causes Development and Management of Acne Monday 21st noveMber The Ageing Process and Regenerative Treatments Monday 28th noveMber Nutrition and the Skin All courses take place at enclosed solutions training centre, Ealing, London. iNCl VA T
leading the way in electroporation skin treatment
Full details oF all course agendas are available on our website
• On going support and protocols for electroporation needle free meso therapy • Treating Acne, Rosacea, Pigmentation, Ageing and scars • Electroporation is the only way to penetrate micro and macro molecules Methods Absorption Ability to be absorbed 1. Mesoporation/ 1mm - 10cm 99% by depth of 1cm Electroporation 2. Microneedle therapy 0.3 - 1.5 mm 65% by depth of 6 cm
10 - 25%
10 - 25%
Limitation Possible some slight pain Some discomfort and pain during treatment, after treatment skin is bruised Unable to deliver micromolecule medication Able to deliver ionisable medication molecules only.
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BOCOUTURE does not require a cold chain. ®
Transport and storage does not require refrigeration prior to reconstitution.
Unopened BOCOUTURE® vials can be stored at controlled room temperature ( 25°C) for up to 3 years.
Botulinum toxin type A free from complexing proteins
BOCOUTURE® 50 Abbreviated Prescribing Information Please refer to the Summary of Product Characteristics (SmPC) before prescribing. Presentation 50 LD50 units of Botulinum toxin type A (150 kD), free from complexing proteins as a powder for solution for injection. Indications Temporary improvement in the appearance of moderate to severe vertical lines between the eyebrows seen at frown (glabellar frown lines) in adults under 65 years of age when the severity of these lines has an important psychological impact for the patient. Dosage and administration Unit doses recommended for BOCOUTURE are not interchangeable with those for other preparations of Botulinum toxin. Reconstitution with 0.9% sodium chloride unpreserved for intramuscular injection (50 units/1.25 ml). Standard dosing is 20 units; 0.1 ml (4 units) injected into each of the 5 injection sites: 2 injections in each corrugator muscle and 1x procerus muscle. May be increased to up to 30 units. Use a thin sterile needle (e.g. 30 gauge). Intervals between treatments at least 3 months. Not recommended for use in patients over 65 years or under 18 years of age. Use immediately after reconstitution. Superior and medial alignment of the needle should be maintained during the injection. Injections near the levator palpebrae superioris and into the cranial portion of the orbicularis oculi should be avoided. Injections into the corrugator muscle should be done in the medial portion of the muscle, and in the central portion of the muscle belly. Contraindications Hypersensitivity to Botulinum neurotoxin type A or to any of the excipients. Generalised disorders of muscle activity (e.g. myasthenia gravis, Lambert-Eaton syndrome). Presence of infection or inflammation at the proposed injection site. Special warnings and precautions BOCOUTURE should only be used for one patient for one session. Should not be injected into a blood vessel. Patients may experience exaggerated muscle weakness. Not recommended for patients with a history of dysphagia and aspiration. Seek immediate medical care if swallowing, speech or respiratory disorders arise. Adrenaline and other medical aids for treating anaphylaxis should be available. Caution if bleeding disorders of any type occur. Caution in patients receiving anticoagulant therapy or taking other substances in anticoagulant doses. Caution in patients suffering from amyotrophic lateral sclerosis or other diseases which result in peripheral neuromuscular dysfunction. Caution in targeted muscles which display pronounced weakness or atrophy. Too frequent or too high dosing of Botulinum toxin type A may increase the risk of antibodies forming. Should not be used during pregnancy unless clearly necessary. Use during lactation cannot be recommended. Has a minor or moderate influence on the ability to drive and use machines. Interactions No interaction studies have been performed. Theoretically Botulinum neurotoxin may be potentiated by aminoglycoside antibiotics or other medicinal products that interfere with neuromuscular transmission e.g. tubocurarine-type muscle relaxants. Concomitant use with aminoglycosides or spectinomycin requires special care. Peripheral muscle relaxants should be used with caution. 4-aminoquinolines may reduce the effect. Undesirable effects Usually, undesirable effects are observed within the first week after treatment and are temporary in nature. Localised muscle weakness, blepharoptosis,
localised pain, tenderness, itching, swelling and/or haematoma can occur in conjunction with the injection. Temporary vasovagal reactions associated with pre-injection anxiety, such as syncope, circulatory problems, nausea or tinnitus, may occur. Frequency defined as follows: very common (≥ 1/10); common (≥ 1/100, < 1/10); uncommon (≥ 1/1000, < 1/100); rare (≥ 1/10,000, < 1/1000); very rare (< 1/10,000). Infections and infestations; Uncommon: bronchitis, nasopharyngitis, influenza infection. Psychiatric disorders; Uncommon: depression, insomnia Nervous system disorders; Common: headache. Uncommon: facial paresis (brow ptosis), vasovagal syncope, paraesthesia, dizziness. Eye disorders; Uncommon: eyelid oedema, eyelid ptosis, blurred vision, eye disorder, blepharitis, eye pain. Ear and Labyrinth disorders; Uncommon: tinnitus. Gastrointestinal disorders; Uncommon: nausea, dry mouth. Skin and subcutaneous tissue disorders; Uncommon: pruritus, skin nodule, photosensitivity, dry skin. Musculoskeletal and connective tissue disorders; Common: muscle disorders (elevation of eyebrow), sensation of heaviness; Uncommon: muscle twitching, muscle cramps. General disorders and administration site conditions Uncommon: injection site reactions (bruising, pruritis), tenderness, Influenza like illness, fatigue (tiredness). General; In rare cases, localised allergic reactions; such as swelling, oedema, erythema, pruritus or rash, have been reported after treating vertical lines between the eyebrows (glabellar frown lines) and other indications. Overdose Increased doses of Botulinum neurotoxin type A may result in pronounced neuromuscular paralysis distant from the injection site. Symptoms of overdose are not immediately apparent post-injection and may include general weakness, ptosis, diplopia, speech difficulties, paralysis of the respiratory muscles and swallowing difficulties which may result in an aspiration pneumonia. BOCOUTURE may only be used by physicians with suitable qualifications and proven experience in the application of Botulinum toxin. Prescriber should consult the SmPC for full information regarding side effects. Legal Category: POM. Basic NHS Price 50 U/vial £72.00 Product Licence Number: PL 29978/0002 Marketing Authorisation Holder: Merz Pharmaceuticals GmbH, Eckenheimer Landstraße 100, 60318 Frankfurt/Main, Germany. Date of revision of text: June 2010. Full prescribing information and further information is available from Merz Pharma UK Ltd., 260 Centennial Park, Elstree Hill South, Elstree, Hertfordshire WD6 3SR. Tel: +44 (0) 333 200 4143 Adverse events should be reported. Reporting forms and information can be found at www.yellowcard.gov.uk. Adverse events should also be reported to Merz Pharma UK Ltd at the address above or by email to email@example.com or on +44 (0) 333 200 4143. 1047/BOC/JAN/2011/JH. Date of preparation: Jan 2011. BOCOUTURE® is a registered trademark of Merz Pharma GmbH & Co, KGaA.
onfidence is... Her happiness. Your expertise. Our experience. Vistabel® is licensed for the treatment of moderate to severe glabellar lines Delivers lasting patient satisfaction, time after time1,2 Trusted with over 1 million cosmetic procedures across Europe3* The world’s first and most studied botulinum toxin4†
Satisfaction that shows
Vistabel® (botulinum toxin type A) Abbreviated Prescribing Information Presentation: Botulinum toxin type A (from clostridium botulinum), 50 Allergan Units/vial. Indications: Temporary improvement in the appearance of moderate to severe vertical lines between the eyebrows seen at frown, in adults <65 years, when the severity of these lines has an important psychological impact for the patient. Dosage and Administration: See Summary of Product Characteristics for full information. Do not inject into blood vessels. Doses of botulinum toxin are not interchangeable between products. Not recommended for patients <18 or >65 years. Use for one patient treatment only during a single session. Reconstitute vial with 1.25ml of 0.9% preservative free sodium chloride for injection (4U/0.1ml). The recommended injection volume per muscle site is 0.1ml (4U). Five injection sites: 2 in each corrugator muscle and 1 in the procerus muscle: total dose 20U. Contra-indications: Known hypersensitivity to any constituent. Myasthenia gravis, Eaton Lambert syndrome. Infection at proposed injection sites. Pregnancy or lactation. Warnings/Precautions: Use for one patient treatment only during a single session. Relevant anatomy and changes due to prior surgical procedures must be understood prior to administration. Product contains less than 1mmol sodium (23mg) per dose. Do not exceed recommended dosages and frequency of administration. Epinephrine (adrenaline) or any other anti-anaphylactic measures should be available. Very rare reports of adverse reactions possibly related to spread of toxin distant from site of injection. Therapeutic doses may cause exaggerated muscle weakness. Caution in patients with history of dysphagia and aspiration. Patients or caregivers should seek immediate medical care if swallowing, speech or respiratory disorders arise. Too frequent or excessive dosing can result in risk of antibody formation, which may lead to treatment failure. Caution in the presence of inflammation at the proposed injection site(s) or when excessive muscle weakness or atrophy is present. Caution when used in patients with amyotrophic lateral sclerosis or with peripheral neuromuscular disorders. Effects of administering different botulinum toxin stereotypes simultaneously, or within several months of each other, is unknown and may cause exacerbation of excessive neuromuscular weakness. Interactions: Theoretically, effect may be potentiated by aminoglycoside antibiotics or other drugs that interfere with neuromuscular transmission. Adverse Effects: See Summary of Product Characteristics for full information on side effects. Based on controlled clinical trial data, the proportion of patients that would be expected to experience an adverse reaction after treatment is 23.5% (placebo: 19.2%). These adverse reactions may be related to treatment, injection technique or both. In general, reactions occur within the first few days following injection and are transient and of mild to moderate severity. Pain/burning/stinging, oedema and/or bruising may be associated with the injection. Frequency By Indication: Defined as follows: Very Common (≥1/10), Common (≥1/100, <1/10), Uncommon (≥1/1,000, <1/100), Rare (≥1/10,000, <1/1,000), Very Rare (<1/10,000). Infections and infestations. Uncommon: Infection.
Psychiatric disorders. Uncommon: Anxiety. Nervous system disorders. Common: Headache. Uncommon: Paresthesia, dizziness. Eye disorders. Common: Eyelid ptosis. Uncommon: Blepharitis, eye pain, visual disturbance. Gastrointestinal disorders. Uncommon: Nausea, oral dryness. Skin and subcutaneous tissue disorders. Common: Erythema, Uncommon: Skin tightness, oedema (face, eyelid, periorbital), photosensitivity reaction, pruritus, dry skin. Musculoskeletal and connective tissue disorders. Common: Localised muscle weakness, Uncommon: Muscle twitching. General disorders and administration site conditions. Common: Face pain, Uncommon: Flu syndrome, asthenia, fever. The following have been reported rarely for glabellar lines and other indications: rash, urticaria, pruritus, erythema multiforme, psoriasiform eruption, anaphylactic reaction (angiodema, bronchospasm), alopecia, madarosis, tinnitus and hypoacousia. Adverse reactions possibly related to spread of toxin distant from injection site have been reported very rarely (muscle weakness, dysphagia, or aspiration pneumonia which can be fatal). Price: £85.00 per vial. Marketing Authorization Number: PL 05179/0010 Marketing Authorization Holder: Allergan Pharmaceuticals (Ireland) Ltd., Westport, Co. Mayo, Ireland. Legal Category: POM. Date of preparation: December 2008.
Adverse events should be reported. Reporting forms and information can be found at www.yellowcard.gov.uk Adverse events should also be reported to Allergan Ltd. UK_Medinfo@allergan.com or 01628 494026 References: 1. Stotland MA et al. Plast Reconstr Surg, 2007;120:1386-1393. 2. Carruthers A et al. Journal of Clinical Research, 2004;7:1-20. 3. Allergan Data on File (DoF) VIS/003/DEC 2010. 4. Allergan Data on File (DoF) VIS/005/MAR 2011. *Given in 5 key EU countries since VISTABEL® launch. Data taken from UK, France, Spain, Italy and Germany. Global figures. Launched in 1989 in the U.S. Search strategy conducted using; Medline, Embase, Embal, Biosis, SciSearc, Pascal, HCAPlus, IPA. Search applied to Allergan, Ipsen & Merz botulinum toxin type A presentations (cosmetic indication).
Date of search: February 2011.
UK/0101/2011 Date of Preparation: March 2011
Published on Nov 18, 2011
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