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AstraGinTM A Clinically Validated Natural Ingredient that Transports Significantly greater Amount of Nutrients from Blood Stream to Cells for Truly Improved Bioavailability

Presented by NuLiv Science January, 2010


AstraGinTM Makes more nutrients available to trillion cells for truly improved cellular nutrition and health •

AstraGinTM improves amino acids, glucose, vitamins absorption by 62%, 57%, and 50%.

AstraGinTM enhanced carbohydrate utilization and elevated cellular ATP level by 18%.

AstraGinTM’s Nutrients Absorption Model


What’s in AstraGinTM From highly purified enriched Notoginseng and Astragalus extracts using pharmaceutical grade extraction and processing technology


How AstraGinTM Works Through regulation and paralleled alteration on both the protein and mRNA expression levels of the nutrient transporter genes


Science Behind AstraGinTM In-house & 3rd parties In vitro, in vivo, and human studies


In Vitro

(Human intestinal Caco-2 cells)

Apical

Caco-2 cells, EM 4000x

Basal


In Vitro

(Human intestinal Caco-2 cells)

TM

AstraGinTM

100X

1X Con

10X

Relative SGLT1 protein levels

Relative fold

Relative fold

Relative level of SGLT1 mRNA


In Vitro

(Human intestinal Caco-2 cells) Relative folate transport protein levels

Con

TM

Con

AstraGinTM

100X

10X

1X

Relative fold

Relative fold

Relative level of folate transporter mRNA


In Vitro

Glucose and Folate absorption in Caco-2 cells Relative Glucose absorption (%) Control

AstraGinTM

100.00 High dose

141.27

Mid dose

164.16

Low dose

183.15 Relative folate absorption (%)

Control

100.00

AstraGinTM

150.00


In Vitro

Tryptophan and Arginine absorption in Caco-2 cells Relative tryptophan absorption (%) Control

AstraGinTM

100.00 High dose

142.48

Mid dose

133.47

Low dose

130.17 Relative arginine absorption (%)

Control

AstraGinTM

100.00 High dose

161.69

Mid dose

151.94

Low dose

136.97


In Vitro

(Human intestinal Caco-2 cells)

ATP level (%)

AstraGinTM enhanced carbohydrate utilization and elevated cellular ATP level by 18%


In Vivo AstraGinTM increased insulin sensitivity by 38% and decreased blood sugar level by 19% when compared to the control group TM

(min)

TM

(min)


Human Study

Glycogen (%)

AstraGinTM increased post exercise muscle glycogen level by 60% and improved recovery time and endurance threshold when compared to the control group 159.5 100

Placebo

AstraGinTM


Publication and Patent • T.C. Chang*, S.F. Huang, T.C. Yang, H.C. Lin, W.L. Chang *; The Effect of Ginsenosides on Glucose Uptake in Human Caco-2 Cells is Mediated through Altered Expression of Na+/coupled glucose transporter 1. J. Agric. Food Chem. (2007) • Taiwan patent (I271195) • Patent-pending (TW 095141624; US 20060292251, 20060293255; CN 200610090113.0, 200610090114.5)


Applications • • • • • • • •

General Health & Wellness Fitness & Energy Protein Products Sports Nutrition Body Building Digestive Health Multiple Vitamins & Minerals Pet Nutrition Thank you


An Overview of NuLiv Science's AstraGin