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RESEARCH. D I S C OV E R I E S . BREAKTHROUGHS.

W I S TA R . O R G


WHERE TO FIND US

Wistar by the Numbers Our Mission

TOTAL EMPLOYEES (PAID)

289

The mission of The Wistar Institute is to marshal the talents of outstanding scientists through a highly enabled

LABS

32

culture of biomedical collaboration and innovation in order to solve some of the world’s most challenging and important problems in the fields of cancer, immunology and infectious diseases to

POSTDOCTORAL FELLOWS

58

produce groundbreaking advances in world health.

COUNTRIES REPRESENTED MORE THAN

(as of 2018)

20


History of Research & Discovery As an organization whose single mission is research and discovery, The Wistar Institute’s scientific trajectory must always be at the forefront, always pushing the boundaries of knowledge and pioneering new paths in innovation. This is the Wistar way of conducting science. Wistar is an international leader in biomedical science with special expertise in cancer and infectious disease research and vaccine discovery.

The Wistar Institute, the nation’s FIRST INDEPENDENT BIOMEDICAL RESEARCH INSTITUTE, was founded in 1892 and is the namesake of Caspar Wistar, M.D., a prominent Philadelphia physician.

Wistar’s independent status allows its scientists flexibility and FOSTERS A COMMUNITY OF COLLABORATION not often found in larger medical and academic institutions.

A NATIONAL CANCER INSTITUTE (NCI)-designated Cancer Center since 1972, Wistar recently received NCI’s highest rating of “Exceptional.”

The Wistar Institute is a global leader in VACCINE DEVELOPMENT.

Wistar’s high-impact science attracts major FUNDING FOR RESEARCH.


W I S TA R C A N C E R C E N T E R

Ahead of the Curve in Cancer Research The Wistar Institute Cancer Center’s pioneering work spans cancer genetics, the molecular and cellular events involved in cancer development and the role of the tumor microenvironment in cancer progression and metastasis.

Wistar’s transformative discoveries have led to advances in cancer prevention, diagnosis and treatment. Wistar scientists have identified genetic alterations that cause breast, brain, ovarian, lung, melanoma, and prostate cancers; developed a greater understanding of the complex genetic makeup of tumors; and devised antitumore strategies that may lead to the next generation of targeted therapies.

Our scientists are pinpointing how the human immune system can be trained to recognize and fight tumors, with the potential to DEVELOP IMMUNE THERAPIES FOR CANCER.

ACCOMPLISHMENTS

INVESTIGATING three-dimensional artificial skin models to advance understanding of melanoma biology. ELUCIDATING the role of key signaling pathways in melanoma.

DEVELOPING monoclonal antibody technology to evaluate pathways and proteins involved in tumor development. Monoclonal antibodies are the basis of a new generation of targeted therapeutics.

EXPOUNDING crucial mechanisms driving immunity against ovarian cancer.

IMPROVING cancer treatments and developing diagnostic tests for disease, including a blood test for lung cancer.

CREATING new drugs against cancers caused by Epstein-Barr virus.

HIGHLIGHTING the role of mitochondria in cancer progression and metastasis.


W I S TA R VA C C I N E C E N T E R

Saving Lives & Fighting Diseases The Wistar Institute’s half-century of achievement in vaccine development has saved countless lives in the U.S. and abroad. Our discoveries have led to the creation of vaccines that protect from widespread, debilitating and lifethreatening diseases.

ROTAVIRUS

RUBELLA

RABIES

A vaccine codeveloped by Wistar researchers is protecting children from a disease responsible for hundreds of thousands of cases of childhood illness and death worldwide.

Thanks to a Wistar vaccine, rubella, also known as German measles, no longer threatens the health of U.S. infants.

Wistar played an important role in the development of vaccines—one for humans, the other for animals in the wild—to prevent rabies infections, which are almost always fatal if left untreated.

Wistar scientists are now conducting vaccine research for infectious diseases including Ebola virus, Zika virus, Chikungunya, Marburg virus, MERS, influenza, hepatitis B, hepatitis C, HIV, HPV, and other emerging diseases. Wistar’s HIV laboratory conducts cutting edge virological and immune system-based research using laboratory models and clinical trials to identify different mechanisms of immunodeficiency, explore new ways to manage current HIV-1 therapies and understand the natural ability of our immune system to respond to HIV infection. Wistar is at the forefront in the development of DNA vaccine technology, which is the latest generation of vaccines with better immune responses and lower toxicity. Besides infectious diseases, DNA vaccines have applications as cancer immune therapies. Wistar researchers are developing a vaccine for the human papillomavirus (HPV), which is associated with different types of cancer, including cervical and head and neck cancers. They are also investigating new strategies to elicit better immune responses to vaccines targeting human tumor-associated antigens.


Education and training are central to The Wistar Institute’s mission, which includes encouraging young people to embrace careers in science. In the past decade alone, nearly 1,000 promising researchers were trained at Wistar, including predoctoral trainees, post-doctoral fellows, and visiting scientists.

Educating & Training the Next Generation of Scientists

Since 2000, Wistar’s awardwinning BIOMEDICAL TECHNICIAN TRAINING PROGRAM, conducted jointly with the Community College of Philadelphia, has been preparing students for new career opportunities as research assistants and technicians.

Our SUMMER FELLOWSHIP PROGRAM began in 1994 and offers students in the School District of Philadelphia the opportunity to become directly involved in biological research projects at the bench level.


Without Discoveries, There Are NO Cures.

The Wistar Institute is an equal opportunity/affirmative action employer. It is the policy of the Institute to provide equal employment opportunities to all individuals regardless of race, citizenship, ethnicity, color, creed, religion, marital status, national origin, ancestry, sex, age, veteran status, mental or physical disability (including HIV and AIDS), pregnancy, caregiver status, domestic or sexual violence victim status, sexual orientation, gender identity and expression, or on the basis of genetic information, or any other characteristic protected by federal, state, or local law, with respect to all terms and conditions of employment. TY OF UNIVERSI ANIA PENNSYLV

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