62 -
나 종양크기 변화 최종일 결과를 보면 용매 대조군과 비교하여 – 투여군에 서 각각 투여군에서 각각 의 종양성장 억제 효과가 관찰 되었다 양성대조물질 투여군 에 서는 의 종양성장 억제 효과가 있었다 .
(day 23)
SAMPLE 1, 2, 3
2 g/kg
5.6%, 41.2%(p<0.001), 3.0%, SAMPLE 4 - 0.5, 1, 2 g/kg
38.9%(p<0.001)
2.7%, 4.0%,
.
55.9%(p<0.001)
(Doxorubicin.hcl)
.
종양크기 변화 및 최종일 종양무게 Group
Doses
(n=10)
(g/kg)
실험 대조군
0
3
Tumor volume(mm )
Tumor weight(mg)
0
7
9
11
14
16
18
21
23
(0903)
(0910)
(0912)
(0914)
(0917)
(0919)
(0921)
(0924)
(0926)
(0926)
0.0
43.6
67.4
100.8
145.9
194.0
266.4
402.3
646.7
2970.6
±
0.0
±
8.2
±
10.1
±
14.6
±
±
127.3
170.3
19.8
20.5
±
20.1
23
±
±
±
360.2
610.5
2707.6
34.7
63.2
608.4
(D.W) SAMPLE
2
1
0.0
±
0.0
42.0
±
7.0
2
2
SAMPLE
2
3
SAMPLE
0.5
4
1
2
Dox.hcl
2 mpk
0.0
±
0.0
0.0
±
0.0
0.0
±
0.0
0.0
±
0.0
0.0
±
0.0
0.0
±
0.0
±
9.2
87.5
±
±
±
14.3
20.0
31.8
238.7
±
37.6
±
±
65.3
65.9
±
354.5
3.6%
12.0%
13.1%
12.8%
12.2%
10.4%
10.5%
5.6%
8.9%
32.7
45.4
67.0
93.5
122.1
164.7
238.4
380.4
1758.7
†
SAMPLE
59.3
±
4.6
±
6.3
±
10.7
±
13.5
±
15.7
±
19.2
±
23.6
±
38.9
±
336.0
**
***
***
***
***
***
***
***
***
25.1%
32.7%
33.6%
35.9%
37.1%
38.2%
40.7%
41.2%
40.8%
39.6
59.9
89.3
129.5
175.2
244.6
369.5
627.3
2873.2
±
5.0
±
6.6
±
±
±
13.3
15.7
21.0
±
29.1
±
±
48.8
44.5
±
489.6
9.2%
11.1%
11.3%
11.3%
9.7%
8.2%
8.1%
3.0%
3.3%
42.4
64.0
98.1
140.0
187.0
255.3
386.0
629.5
2858.1
±
±
±
±
±
2.7%
5.1%
2.7%
4.1%
3.6%
40.8
60.2
88.6
128.5
173.7
±
5.4
6.5
7.3
±
7.4
10.7
15.6
±
±
±
11.3
18.3
19.2
23.6
±
±
±
4.2%
4.0%
2.7%
3.8%
241.9
366.7
621.1
2790.8
±
23.6
32.4
40.1
47.3
±
±
46.7
52.7
±
462.6
±
371.4
6.5%
10.7%
12.1%
11.9%
10.5%
9.2%
8.8%
4.0%
6.1%
33.6
49.0
69.7
97.6
126.1
166.3
246.6
394.9
1858.6
±
5.8
±
8.9
±
13.8
±
16.2
±
18.0
±
22.5
±
31.8
±
69.1
±
367.4
**
***
***
***
***
***
***
***
***
22.9%
27.3%
30.9%
33.1%
35.0%
37.6%
38.7%
38.9%
37.4%
28.6
39.5
58.0
76.1
98.1
128.7
186.3
285.1
1390.6
±
3.3
±
4.7
±
6.8
±
8.6
±
10.3
±
13.5
±
20.5
±
47.0
±
363.5
***
***
***
***
***
***
***
***
***
34.4%
41.4%
42.5%
47.8%
49.5%
51.7%
53.7%
55.9%
53.2%
Significant figures (t-TEST) : **p<0.01, ***p<0.001 (vs Vehicle Control),
†
:: IR(Inhibition Rate)