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OW HF Control

12W HF

WHAT SPARKS FORMATION OF ATHEROSCLEROTIC LESIONS? An Immune Angle on Vascular Inflammation T cell regulation, homeostasis, and apoptosis play critical roles in regulating cancer and autoimmune disease. Xiao-Feng Yang, MD, PhD, believes immune mechanisms also govern the early stages of vascular inflammation induced by metabolic stresses such as hyperlipidemia, hyperglycemia, hyperhomocysteinemia, uremia, and obesity. Using database mining and other novel tools, the team has discovered molecular events involving alternative splicing, micro-RNA suppression, immune regulatory cytokines, and caspase-1 activation.

ABOVE In an atherogenic mouse model, a high-fat (HF) diet produces atherosclerotic plaque in the aortic artery at 12 weeks. This gene-deficient model is speeding characterization of immune gene function in chronic inflammatory pathology.

IS PHOSPHOLEMMAN A POTENTIAL LEVER IN TREATING MULTIPLE DISEASES? A Gatekeeper of Ion Transport Phospholemman (PLM) is highly expressed in the heart. Joseph Y. Cheung, MD, PhD, and his research partners examine the overlapping and complex interactions between PLM and Na+-K+ ATPase, the Na+/Ca+ exchanger, and the L-type Ca2+ channel. Their novel genetic models have shed light on physiological roles for PLM in regulation of cardiac ABOVE Molecular interactions between

FXYD proteins such as phospholemman and sodium pump subunits determine the function and tissue specificity of these ion transport regulators.

contractility. In particular, this group has proposed that PLM preserves inotropy while reducing arrhythmia risks during stress. As these and other mechanisms are clarified, opportunities for novel rational therapies have emerged窶馬ot only in cardiac disease but also in neurological and renal diseases.

HEART | LUNG

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Profile for Temple Health

Temple University School of Medicine - Highlights of Basic and Clinical Research - 2014  

Temple University School of Medicine is pushing the boundaries of science to help reduce the devastating effects of heart and lung disease,...

Temple University School of Medicine - Highlights of Basic and Clinical Research - 2014  

Temple University School of Medicine is pushing the boundaries of science to help reduce the devastating effects of heart and lung disease,...