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National Institute of Science and Technology for Environmental Studies (INCT-EMA) Management committee Lauro Tatsuo Kubota (Coordinator) Yoshitaka Gushikem (Vice-Coordinator) Marília de Oliveira Fonseca Goulart Marina Franco Maggi Tavares Reinaldo Calixto de Campos Main researchers Alviclér Magalhães, Ana Valéria C. Simionato, Auro Atsushi Tanaka, Carla Beatriz G. Bottoli, César Ricardo Teixeira Tarley, Claudimir Lúcio do Lago, Dosil Pereira de Jesus, Eduardo C. da Rocha, Emanuel Carrilho, Érico Marlon de Moraes Flores, Fabio Augusto, Fábio Cesar Gozzo, Flávio Santos Damos, Jez Willian Batista Braga, José A. Fracassi da Silva, Lauro T. Kubota, Marcelo Martins de Sena, Marcello Garcia Trevisan, Marco Aurélio Zezzi Arruda, Marco Flores Ferrão, Marília de Oliveira F. Goulart, Marina Franco Maggi Tavares, Orlando Fatibello Filho, Pablo Alejandro Fiorito, Pedro de Magalhães Padilha, Reinaldo Calixto de Campos, Ricardo E. Santelli, Ronei Jesus Poppi, Rose Mary Z. G. Naal, Susana Ines C. de Torresi, Wendel Andrade Alves, Wendell K. Tomazelli Coltro, Yoshitaka Gushikem, Zeki Naal Main research topics Synthesis and characterization of nanostructured and/or polymer materials, as well as on their respective functionalizations with enzymes and biomimetic compounds on the surface of the electrode, in order to determine various analytes of clinical, environmental and pharmacological interest. Application of spectrofluorimetry coupled to second-order chemometric methods for the direct determinations of drugs in biological fluids. Analysis of pharmaceuticals compounds for imaging by NIR and Raman spectroscopy. Investigations of metallomic and proteomic trying to elucidate some diseases, effect of pollutant and transgenic plants with the use of different analytical tools. The speciation using different materials like molecularly imprinted polymer and other adsorbent materials. Summary of achievements and perspectives Several materials have been used successfully by INCTBio researchers, as a platform for the construction of amperometric, conductometric and optical sensors and biosensors. Some of them are carbon nanotubes, polymercoated carbon nanotubes, peptide nanotubes, titanate nanotubes, TiO2 nanocrystalline films, metal nanoparticles, thin nickel hydroxide films, mesoporous films of different materials, modified silica, and ceramic materials, among others. As a future perspective, a major challenge for the Bioanalytical Institute is the development of stable and highly selective electrochemical sensors, allowing the assembly of easy handling portable devices that will perform tests similar to “point-of-care“ tests. Another area of interest looks for the development of most stable possible sensors for in vivo applications. Two methods were developed for the direct determination of the antioxidant trans-resveratrol in human plasma and of the enantiomers of ibuprofen in plasma and urine. The perspective for this research topic is the application of these methods for the analysis of prohibited drugs in sports (doping). The use of 1H NMR spectroscopy and chemometric analysis proved an

effective strategy to differentiate healthy and bipolar patients as well as to distinguish bipolar patients under different treatments, using lithium or not; Identification of proteins with different expressions in transgenic and non-transgenic soybean samples; Fractionation of proteins from samples of plasma and muscle and liver tissue of Nile tilapia fish species. As a future perspective, the researchers intend to develop metalloproteomics studies to identify biomarkers of bipolar disorder in humans, genetic changes, toxicity of metal species and, mineral growth promoters in different organisms. Main publications 1. J. L. Costa, F. G. Tonin, L. A. Zanolli Filho, A. A. M. Chasin, M. F. M. Tavares, Electrophoresis, 30, 2238, (2009). 2. G. R. M. Duarte, C. W. Price, J. L. Littlewood, D. M. Haverstick, J. P. Ferrance, E. Carrilho, J. P. Landers, Analyst, 135, 531, (2010). 3. P. Valderrama, R. J. Poppi, Chemom. Intell. Lab. Syst., in press, doi: 10.1016/j.chemolab.2010.05.012. 4. C. D. Bernardes, R. J. Poppi, Marcelo M. Sena, Talanta, in press, doi:10.1016/j.talanta.2010.05.024 . 5. A. H. Iglesias, L. F. A. Santos, F. C. Gozzo. Anal. Chem. 82, 909, (2010). 6. A. Sussulini, A. Prado, D.A. Maretto, R.J. Poppi, L. Tasic., C.E.M Banzato, M.A.Z. Arruda. Anal. Chem. 81, 9755, (2009). Contacts Institute of Chemistry, Departament of Analytical Chemistry Cidade Universitária Zeferino Vaz s/n CEP: 13083-970 Caixa Postal: 6154 Campinas, SP Tel: (5519) 3521-3127 E-mail: inctbio@iqm.unicamp.br / kubota@iqm.unicamp.br http://www.inctbio.iqm.unicamp.br

CuHCNFe / Ppy mesoporous film used as redox mediator for glucose oxidase

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livroinct2010  

Carlos Alberto Aragão de Carvalho Filho Presidente do CNPq 1

livroinct2010  

Carlos Alberto Aragão de Carvalho Filho Presidente do CNPq 1

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