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National Institute of Science and Technology of Investigation in Immunology (iii-INCT) Management committee Jorge Kalil (Coordenador) Manoel Barral-Neto (Vice-coordenador) Mario Palma Ana Maria Moro Esper G. Kallas Luiz Vicente Rizzo Main researchers Aldina Maria Prado Barral, Aluisio Augusto C. Segurado, Amélia Maria Ribeiro de Jesus, Amilcar Tanuri, Ana Maria Caetano de Faria, Ana Maria Camargo, Ana Maria Moro, Andrea Maranhão, Anna Carla Goldberg, Claudia Ida Brodskyn, David Saitovitch, Edecio Cunha-Neto, Ester Sabino, Esper G. Kallas, Fábio F M Castro, Francisco Inácio P.M. Bastos, Guilherme Loureiro Werneck, J. Gustavo P. Amarante-Mendes, Jorge Kalil, Luisa Karla de Paula Arruda, Luiz Carlos de Sá Rocha, Luiz Vicente Rizzo, Luiza Guglielmi Guilherme, Manoel Barral Neto, Marcelo M Brigido, Maria Regina Alves Cardoso, Mario Palma, Osmar Malaspina, Pedro Giavina Bianchi, Pedro Michaluart Junior, Roque Pacheco de Almeida, Sandro José de Souza, Verônica Coelho Main research topics It is well established today that several diseases of previously unknown etiology are due to dysfunctions of the immune system, either by excessive or inadequate inflammatory responses. The Institute for Investigation in Immunology (iii) is precisely focused on this issue. Our areas of interest (autoimmune diseases, immunodeficiencies and HIV/ AIDS, leishmaniasis, transplants, cancer and allergies) pertain to health problems that affect millions of people in Brazil and all throughout the world. Besides its socio-economic relevance, these diseases are relevant biological models since their study allow the advancement of knowledge of pathophysiologic mechanisms and, therefore, leading to the design of therapeutic strategies based on disease pathogenesis. Summary of achievements and perspectives The core research areas at iii regard some of the most important topics in medical immunology. In autoimmunity we will advance the development of our candidate vaccine to prevent S. pyogenes infection and Rheumatic Fever with the first phase I and II clinical trials. We will also study and try novel immunomodulatory approaches to Crohn’s disease. Several studies are planned -and some already underway- to study HIV pathogenesis and the development of AIDS. We will also study adjuvant therapy and conduct a phase I clinical trial of the first candidate AIDS vaccine developed in Brazil, which is already patented, in addition to test other products in primates. In primary Immunodeficiencies, we will extend the genetic studies, improving their diagnosis and treatment of patients, and test a new adjuvant therapy for hypogammaglobulinemia. We will conduct two clinical studies on prevention and treatment of visceral leishmaniasis. In the area of transplants, we will study the mechanisms involved in graft rejection to detect new targets of intervention. We will also test an

immunobiological drug developed by us to treat acute graft rejection. In the area of câncer and immunotherapy we will conduct clinical trials with two new products. In the area of allergy, we will study potential new allergens for diagnosis and treatment and develop recombinant allergens to be used in those two areas. Main publications L. Guilherme, J Kalil. Rheumatic Fever and Rheumatic Heart Disease: Cellular Mechanisms Leading Autoimmune Reactivity and Disease. J Clin. Immunol., 2009 Clarêncio, J, Oliveira, CI de, Favali, C,Medina, O, Caldas, A, Costa, J, Costa, D, Brodskyn, CI, Barral, A, Barral-Netto, M. Could the lower frequency of CD8+CD18+CD34RO+ lymphocytes be biomarkers of human VL? . International Immunology, v.21, p.137-144, 2009. Victora GD, Socorro-Silva A, Volsi EC, Abdallah K, Lima FD, Smith RB, Moyses RA, Zárate-Bladés CR, Michaluart P, Silva CL, Kalil J, Coelho V. Immune response to vaccination with DNA-Hsp65 in a phase I clinical trial with head and neck cancer patients. Cancer Gene Ther. 2009 Jul;16(7):598-608 Bento, Cleonice AM, Hygino, Joana, Andrade, Regis M, Saramago, Carmen SM, Silva, Renato G, Silva, Agostinho AL, Linhares, Ulisses C, Brindeiro, Rodrigo, Tanuri, Amilcar, Rosenzwajg, Michelle, Klatzmann, David, Andrade, Arnaldo FB, Tanuri, Amílcar. IL-10-secreting T cells from HIV-infected pregnant women downregulate HIV-1 replication: effect enhanced by antiretroviral treatment. AIDS (London).,v.23,p.9-18, 2009. Agondi RC, Barros MT, Rizzo LV, Kalil J, Giavina-Bianchi P. Allergic asthma in patients with common variable immunodeficiency. Allergy. 2009 Oct 15 Alvarez, M. S, LR; Pineda, MA, González, MP, Entringer, PF, Oliveira, C. I, Nascimento, IP, Souza, AP, Corvo, L, Bonay,P , Brodskyn, C. I, BarralL,A, BARRAL-NETTO,M. Searching Genes Encoding Leishmania Antigens for Diagnosis. Scholarly Research Exchange pp. 173039, 2009. Contacts Laboratório de Imunologia - Instituto do Coração Av. Dr. Enéas de Carvalho Aguiar, 44, bloco II, 9º andar Cerqueira César – São Paulo (SP) CEP 05403-900 Website: www.iii.org.br E-mail: comunicacao@iii.org.br

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livroinct2010  

Carlos Alberto Aragão de Carvalho Filho Presidente do CNPq 1

livroinct2010  

Carlos Alberto Aragão de Carvalho Filho Presidente do CNPq 1

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