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Essential  Organic  Functional  Multi-­‐Nutrient  Supplement     from  Antarctica  &  New  Zealand   with  High  Biological  Value     ENHANCED  

Made in Barcelona


INDEX

>  KRILLIUM  PLUS  ®  IN  THE  MEDIA          

     

 

                               

               p.  3    

>  INSTITUTIONAL  &  MEDICAL  PRESENTATION  TO  THE  PUBLIC    

     

               p.  5  

> KRILLIUM  PLUS  ®  WITH  IMAGES                  

       

     

               p.  7  

> KRILLIUM  PLUS  ®  WITH  TEXT                                        

     

               p.  16  

-­‐ KRILLIUM  PLUS  ®    -­‐    at  a  glance  

               p.  16  

-­‐ PRODUCT  PRESENTATION  

                   p.  18  

-­‐ POSOLOGY  

                   p.  19  

> DETAILED  NUTRITIONAL  INFORMATION    

                                   p.  19  

-­‐ FUNCTIONAL  NUTRIENT  DESCRIPTION  

               p.  19  

-­‐ ORGANIC  NUTRIENT  DESCRIPTION  

               p.  19  

-­‐ KRILLIUM  PLUS  ®    -­‐  ORGANIC  FUNCTIONAL  MULTI-­‐NUTRIENT  SUPPLEMENT                  p.  20

-­‐ WHITE  CAPSULES  ENHANCED  POWDER  CONCENTRATE      

 (NEW  ZEALAND´s  GREEN-­‐LIPPED  MUSSEL  -­‐  PERNA  CANALICULUS)  

                 p.  22  

AMINO ACIDS  PROFILE    

                 p.  23  

FATTY ACIDS  PROFILE    

                 p.  29  

MINERAL PROFILE  

                 p.  30  

REINFORCED FORMULA  FOR  ENHANCED  SYNERGIES    

                 p.  31  

-­‐ WHAT  IS  KRILL  

-­‐ RED  OIL  PEARLS  OF  ANTARCTIC  KRILL  NUTRITIONAL  INFORMATION  

               p.  35  

-­‐ PROFILE  LIST  OF  ANTARCTIC  KRILL  FATTY  ACIDS    

                 p.  36  

-­‐ THE  CRUCIAL  OMEGA  6  TO  OMEGA  3  RATIO  

               p.  36  

-­‐ COMPLETE  BENEFITS    

         

             p.  39  

                 p.  32  

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KRILLIUM PLUS  ®  IN  THE  MEDIA   The  Nutritional  Supplement  of  reference  for  multiple  uses  in  all  media    

Vogue Magazine       July  2011  -­‐  Chosen  as  the  Anti-­‐Aging  (Beauty/Skin/Hair/Nails)     nutritional  supplement  of  reference  by  Carmen  Lanchares  -­‐  Head  of  Beauty    

Cosmopolitan Magazine   November  2013  -­‐  Fall/Winter  Special  Edition   Chosen  as  its  favorite  nutritional  supplement  for  multiple  uses,   Cholesterol  &  Triglycerides  reduction,  Immune  System,  Fatigue,  Antioxidant,  Beauty,   Skin,  Hair,  Nails,  Digestive  track,  Concentration  and  Stress    

Hola magazine  -­‐  Health  blog   November  2013  -­‐  Recommended  for  multiple  uses   by  Meritxell  from  the  prestigious  Meritxell  Pharmacy  in  Andorra    

"Salud Total  -­‐  Médicos  &  Medicinas"  magazine     ("Total  Health  -­‐  Doctors  &  Medicines"  magazine)   April  2013  -­‐  Special  Issue  on  Cholesterol  and  Cardiovascular  diseases   Recommended  Multi-­‐Nutritient  Supplement     also  on  the     March  2013  -­‐  Special  Issue  on  Omega  3  Fatty  Acids   Its  recommendation  on  the  finest  Omega  3s  for  Arthritis,  autoimmune  disorders,   Inflammatory  diseases  and  Cardiovascular  diseases    

Onda Cero  Radio  -­‐  Barcelona  -­‐  Morning  Prime-­‐Time   March  1,  2011  -­‐  Program  "The  city"  with  Albert  Lesan  and  Anna  Clavé      

TVE 1  -­‐  Televisión  Española  -­‐  Channel  1  -­‐  Morning  Prime-­‐Time   March  7,  2011  -­‐  Program:  "Saber  Vivir  -­‐  La  mañana  de  la  1"       The  leading  health  program  on  TV  for  over  10  yrs     Special  segment  on  Digestive  conditions   3


Correo Farmacéutico  (Pharmaceutical  Courier)     Weekly  issue  January  24-­‐30,  2011   Recommended  for  Cardiovascular  diseases,  lower  cholesterol  &  triglycerides    

Europa Press  /  Chance  -­‐  Madrid   December  13,  2010  -­‐  Recommended  for  multiple  uses,  to  improve  health  in  general,  for   the  general  population,  all  ages;  for  liver,  digestive,  cardiovascular  &  immune  diseases,   bones  and  joints,  as  a  an  antioxidant  and  nutritional  support  to  prevent  illnesses    

Radio Libertad  -­‐  107.0  FM  -­‐  Madrid  -­‐  Evening  Prime-­‐Time   December  10,  2010  -­‐  Program  "Luces  y  Sombras"  with  Sofía  Figueroa   Discussing  its  wide  array  of  benefits  to  many  conditions    

Sport Life  Magazine   December  9,  2010  -­‐  Recommended  for  Sport  nutrition,  performance,  faster   recuperation,  and  for  muscle,  bone,  cartilage,  and  all  tissues  health    

Diario Médico    (Medical  Journal)   November  29,  2010    -­‐  Recommended  for  Suppressed  Immune  Systems,  to  increase   defenses,  for  inflammatory  conditions  and  to  help  prevent  illnesses      

La Vanguardia  -­‐  Newspaper   April  20,  2010  -­‐  Title:    "A  step  forward  in  Nutrition"     Covering  its  wide  array  of  benefits  to  many  conditions    

EsRadio /  Grupo  Planeta  -­‐  Madrid  -­‐  89.7  FM   December  5,  2010  -­‐  Program  "Vivir  con  Júbilo"  -­‐  Morning  Prime-­‐Time   Covering  its  wide  array  of  benefits  to  many  conditions   EsRadio  /  Grupo  Planeta  -­‐  Málaga,  Andalucía  -­‐  88.6FM     October  15,  2011  -­‐  Morning  Prime-­‐Time   with  José  Miguel  Carrasco  &  Carlos  Ferragut      

To see  full  Media  details  visit     www.krillium.com   4


INSTITUTIONAL &  MEDICAL  PRESENTATION  TO  THE  PUBLIC   Barcelona  11/11/2010  -­‐  (R&D  started  in  1997  -­‐  EU  approval  2010)  

*  Original  extract  published  in  Medicos  &  Medicinas  magazine,  June  2011  p.  37    

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KEY SPEAKERS:      

Opening        

Hble. Dr.  Marina  Geli     Head  of  Health  -­‐  Generalitat  of  Catalonia  -­‐  The  Catalan  Government.   Noted   that   "when   a   product   demonstrates   its   quality   and   benefits,   as   this   one,   Krillium,   it   is   of   interest   for   the   whole   of   the   population,   and   it   is   only   then,   when   Institutional   support   is   provided,   in   order   to   certify   its   credibility   and   make   it   known   to   the   general   public".          

Immune System  &  Internal  Medicine  segment        

Dr. Gustavo  Gonzalez-­‐Canali       Head   -­‐   Health   &   Human   Development   Department   -­‐   French   Ministry   of   Foreign   and   Europeans  Affairs,  The  Partnership  for  Maternal,  Newborn  and  Maternal  Health,  GAVI   Alliance.     Former   Internal   Medicine   Head   at   Institut   Pasteur´s   External   Hospital   Unit   in   Paris   and   the   medical   doctor   part   of   Nobel   Price   winner,   Pr.   Luc   Montagnier   ´s   team,   (the  discoverer  of  the  HIV  virus).      Former  Medical  Director  at  C.I.R.B.S  -­‐  Centre  Integré   de  Recherches  Biocliniques  sur  le  SIDA,  Paris,  and  also  Medical  Head  at  several  Oncology   Clinics.   Came   from   Paris,   specifically,   for   the   Krillium   presentation,   to   discuss   the   importance   of   supplementing   with   multiple   functional   nutrients   to   prevent   illnesses,   to   support  the  Immune  System  in  the  fields  of  Oncology  and  HIV/AIDS,  and  other  instances   where  the  immune  system  is  compromised.      

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Cardiovascular, Inflammatory  diseases  and  pain  segment    

Dr. Taher  Abbas,  Cardiologist,     Scientific   Coordinator   of   the   Hispanic-­‐Arab   Doctors   of   Catalonia,   and   Health   Head   Advisor  for  Al  Mashreq  Association  (Lebanon,  Jordan,  Siria,  Palestine).      Member  of  the   Catalan  Institute  of  Health  (ICS),  Hospital  Valle  Hebrón,  Hospital  Sant  Pau,  colaborator   at  Clínica  Corachán,  Director  at  the  Center  for  therapeutical  Advances  Dr.  Taher  Abbas.   Furthermore,   he   is   a   Biological   Medicine   expert,   as   well   as,   Anti-­‐homotoxic   therapies   &   pain   treatments.     Also,   supported   the   use   of   Krillium   and   its   organic   functional   multi-­‐ nutrients  for  his  fields  of  expertise.      

Anti-­‐aging Nutrition  segment      

Josefina  Fernández  -­‐  Targeted  Nutrients,  S.L.  Founder  and  R&D  Director.    Anti-­‐aging  Nutrition  expert.    Emphasized  the  need  to  protect  our  bodies  from  within,  with   the   proper   mix   of   varied   functional   nutrients.     In   Anti-­‐aging   and   beauty,   people   spend   fortunes  taking  care  of  the  outside,  the  facade,  which  is  important;  but  where  everything   happens   is   within   our   bodies,   and   without   the   proper   raw   materials,   the   proper   supplementation  of  crucial  nutrients,  our  organism  cannot  be  as  effective  in  delaying  the   effects  of  age,  antiradicals  and  illnesses.        

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RECOMMENDED NUTRITIONAL  SUPPORT  

   

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KRILLIUM PLUS  ®    -­‐    at  a  glance    

KRILLIUM PLUS®   is   a   unique   natural   and   organic   Nutritional   Supplement,   and   the   only   one  in  the  market,  that  merges  the  two  most  powerful  and  bioactive  sources  of  Omega   3  available,  and  with  the  best  ratio  of  Omega  3  to  Omega  6.    Providing  a  rich  delivery  of   such   key   nutrients.   Both   sources,   originate   in   the   cleanest   and   purest   oceans   in   the   world,  Antarctica´s  and  New  Zealand´s.         In  addition,  both  sources  are  presented  together  in  the  same  package,  but  in  different   formats.     Antarctic   Krill   (Euphasia   Superba)   oil   pearls   and   New   Zealand   green-­‐lipped   mussel  (Perna  Canaliculus)  concentrated  powder  capsules,  both  of  the  finest  quality,  in   order   to   increase   the   synergies   between   all   its   organic   (for   best   absorption)   and   functional  nutrients.         Furthermore,   they   have   been   enhanced   with   extra   key   functional   nutrients   to   yet   further  increase  those  synergies  and  its  results.    They  deliver  a  rich  content  in  Selenium   and  vitamins  E  &  C,  and  a  natural  source  of  Proteins,  Amino  acids  (all  of  them,  essential   and   non-­‐essential),   Silicon,   Magnesium   Carbonate,   the   powerful   antioxidant   Astaxanthin,  and  other  vitamins,  minerals  and  marine  fiber  Chitin.    

In addition,   they   are   presented   in   blisters,   in   order   to   protect   its   quality   and   facilitate   transportation  without  having  to  carry  the  whole  box  while  being  away  from  home.      

The union   and   synergies   of   these   two   small   marine   titans,   together   with   the   other   functional   nutrients,   represent   a   huge   leap   forward   in   the   field   of   organic   nutritional   functional  foods  of  high  biological  value.    They  are  vital,  indispensable  and  unique  for   the  balance  of  our  health  and  wellbeing.        

Both sources   are   regarded   as   the   most   bioactive   organic   sources   of   Omega   3,   Eicosatetraenoic   acids   (ETAs),   known   to   date;   and   other   key   oils,   among   which   are   present   in   organic   form,   as   well,   key   Cerebrosides   like   the   crucial   Nervonic   and   Lignoceric  acids;  and  also  provide  Glycosamynoglycans    

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Krill -­‐  Photo  by  Øystein  Pau        

New  Zealand´s  Green  Lipped  mussel  

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Omega 3  found  in  fish/sea,  are  5  to  10  times  more  powerful  than  those  of  vegetal/earth   sources,  reason  for  which  the  marine  type,  are  far  superior.    But  those  of  Antarctic  Krill   and   New   Zealand´s   Green   lipped   mussel   are   multiple   times   stronger,   balanced   with   the   best   ratio   of   Omega   6   to   Omega   3,   (a   crucial   factor),   and   with   the   greatest   biological   activity  of  all  known  species,  both  from  the  vegetal  or  marine  kingdoms.          

The other   great   advantage   of   these   two   sources;   is   that   contrary   to   fish,   they   do   not   accumulate  toxic  metals,  and  other  residues.    Fish  can  accumulate  toxic  metals  and  other   residues  in  their  fats  and  skin  and  increase  the  accumulation  as  they  go  higher  in  the  fish   food   chain,   (toxins   that   are   not   recommended   for   human   consumption,   unless   they   follow  a  strict  distillation  process  or  are  eliminated  with  detergents  or  other  processes).   This  is  not  the  case  with  our  two  sources.      

They both   live   in   the   cleanest   and   most   remote   oceans   in   the   world.     Green   lipped   mussel   feeds   on   a   variety   of   nutrient   rich   plankton,   usually   found   below   the   intertidal   zone,   but   can   also   occur   in   it.     Antarctic   krill,   is   a   tiny   crustacean,   similar   to   a   shrimp,   which  lives  about  3  to  4  Km  under  the  Antarctic  ocean,  withstanding  the  most  intense   oceanic   pressure,   freezing   cold   and   in   total   darkness,   and   is   the   first   animal   of   the   food   chain,  that  generates  its  Omega  3  by  feeding  on  zooplankton  and  phytoplankton.    

As a  curiosity,  the  marvelous  Krill  generates  light  throughout  seven  points  along  its  body.   First  on  the  food  chain,  tiny  in  appearance,  yet  sophisticated  enough  to  emanate  light.  

    PRODUCT  PRESENTATION    

BLISTERS -­‐  100  Perna  Canaliculus  powder  concentrate  capsules  of  682  mg  each,  and   -­‐  10  soft  gelatin  Euphasia  Superba  oil  pearls  of  724  mg  each.    

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POSOLOGY Under  normal  circumstances  in  a  healthy  person,  (what  we  call  a  “maintenance  dose”):   -­‐  Take  4  capsules  of  powder  concentrate  per  day  (white  capsules);  2  at  breakfast  and  2  at   lunch,  or  4  at  breakfast  if  you  cannot  keep  the  habit.  Furthermore,  take  2  oil  pearls  (red)   per   week   (that   is   to   say,   take   one   oil   pearl   at   breakfast,   or   lunch   every   three   or   four   days   instead   of   taking   the   white   capsules).     The   dosage   may   and   should   be   increased   in   the   event  in  specific  cases  of  a  serious  imbalance  in  health  requiring  more  nutrients  support.     Consult  your  doctor,  therapist  or  nutritionist.       Warning:   Not   recommended   in   cases   of   allergy   to   mollusks   and   crustaceans.   Oil   pearls   should   not   be   taken   during   pregnancy   due   to   their   astaxanthin   content.     Consult   your   doctor.  Store  in  a  cool  and  dry  location  away  from  sources  of  heat.  Ensure  the  product  is   kept  out  of  the  reach  of  children.  Food  supplements  should  not  be  used  as  a  replacement   for  a  balanced  diet.  Do  not  exceed  the  recommended  dosage.  You  are  advised  to  follow  a   balanced  and  varied  diet  and  lead  a  healthy  lifestyle.            

DETAILED NUTRITIONAL  INFORMATION    

FUNCTIONAL NUTRIENT  DESCRIPTION    

A nutrient  may  be  regarded  as  FUNCTIONAL,  IF  in  addition  to  its  nutritive  effect  it  has  a   beneficial   impact   on   one   or   more   functions   of   the   organism,   thereby   improving   the   state   of   an   individual´s   health   or   well   being   or   reducing   the   risk   of   illness.   The   nutritional   value   of   Antarctic   krill,   Euphasia   Superba,   has   been   acknowledged   by   the   World   Health   Organisation   (WHO  –   Geneva,   1985),   as   well   as  the   Food   and   Agricultural   Organization,  (F.A.O.  -­‐  Rome).    

ORGANIC NUTRIENT  DESCRIPTION    

A nutrient  is  a  chemical  that  an  organism  needs  to  live  and  grow  or  a  substance  used  in   an  organism's  metabolism  which  must  be  taken  in  from  its  environment.    They  are  used  

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to build   and   repair   tissues,   regulate   body   processes   and   are   converted   to   and   used   as   energy.   Organic   nutrients   include   carbohydrates,   fats,   proteins   (or   their   building   blocks,   amino   acids),  and  vitamins.    Inorganic  chemical  compounds  such  as  dietary  minerals,  water,  and   oxygen  may  also  be  considered  nutrients.    A  nutrient  is  said  to  be  "essential"  if  it  must   be  obtained  from  an  external  source,  either  because  the  organism  cannot  synthesize  it   or   produces   insufficient   quantities.   Nutrients   needed   in   very   small   amounts   are   micronutrients  and  those  that  are  needed  in  larger  quantities  are  called  macronutrients.   The  effects  of  nutrients  are  dose-­‐dependent  and  shortages  are  called  deficiencies.  

KRILLIUM  PLUS®   is  an  Organic  Functional  Multi-­‐Supplement,  strongly  recommended   for  everyone,  of  all  ages,  (unless  allergic  to  crustaceans  and  mollusks),  for  its  high  quality   profile   of   multiple,   varied   and   organic   functional   nutrients,   with   high   biological   value   and  which  are  easily  and  fully  absorbed  and  metabolized  directly  by  the  organism.    It  is:    

*  Rich  in  OMEGA-­‐3  fatty  acids,  including:  valuable  ETAs  (eicosatetraenoic  acids),  some   of   which   are   Nervonic   and   Lignoceric   acids;   Cerebrosides   which   are   essential   for   our   health.  Cerebrosides  are  glycosphingolipids,  important  components  of  the  muscles  and   nerve   cell   membrane,   molecules   of   the   central   and   peripheral   nervous   system   and   which  form  part  of  the  myelin  sheath.    

*  Rich  in  VITAMIN    C    &    VITAMIN    E.    

*  Rich  in  SELENIUM:    

> Must   be   noted   the   natural   presence   of   the   blocks   required   to   form  

GLUTATHIONE PEROXIDASE,  crucial  for  the  Immune  system,  (organic  selenium  and  the   glutamic  +  glycine,  proline  +  cysteine  amino  acids).    Moreover,  we  have  reinforced  the   content   of   selenium   in   order   to   make   it   rich   in   its   delivery.     These   blocks   are   a   fundamental  group  needed  by  the  body  to  be  able  to  generate  the  GLUTATHIONE  and   its   different   PEROXIDASES,   being   vital   for   the   protection   of   the   cellular   matrix.   It   favors   the   protection   of   the   Immune   system   and   its   proper   functions,   protection   of   cell   damage   and   of   the   premature   ageing   of   the   organism   due   to   the   harmful  

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overproduction of   free   radicals   and   other   toxins   generated   within   the   body   and   from   external  sources.      

* Natural   source   of   ASTAXANTHIN,   a   hydro   and   liposoluble   antioxidant   which   is   10   times   more   powerful   than   any   carotenoid   (such   as   vitamin   A),   but   contrary   to   other   carotenoids,   has   no   toxic   effects   in   high   doses).     Furthermore,   it   is   500   times   more   powerful   than   vitamin   E.     As   an   antioxidant   the   sensational   Astaxanthin   helps   the   organism  in  relation  to:    

> Gastric  protection.  

> The  nervous  system.  

> Improves  cellular  communication  and  membrane  stability.  

> Antimutagenic  agent.  

> Cardiovascular  protection,  regulating  cholesterol  by  reducing  the  synthesis  of    

   LDL  and  increasing  HDL.    

> Improves  ocular  health,  providing  greater  protection  against  UV  rays  than  lutein.  

* Natural  source  of  PROTEINS    

65.60%  

45%  

* Important  source  of  GLYCOSAMINOGLYCANS      

3.5%

* Important  source  of  AMINO  ACIDS      

> The  first  nutrients  the  organism  most  needs  is  proteins  and  their  amino  acids.  

Perna Canaliculus   has   a   high   protein   content,   and   its   concentration   of   amino   acids,   glycosaminoglycans,   Omega-­‐3   and   valuable   ETAs   (Eicosatetraenoic   acids),   including   Nervonic  and  Lignoceric  acids  makes  it  unique  in  its  species  due  to  the  organic  provision   of  these  essential  nutrients.    

*  Enhanced  with  MAGNESIUM  CARBONATE.    

*  Enhanced  with  SILICON.    

* Naturally   contains   marine   food   fiber   -­‐   CHITIN   (2.4g/100g);   the   group   B   vitamins   B-­‐1   Thiamine,   B-­‐2   Riboflavin,   B-­‐3   Riboflavin,   B-­‐6   Pyridoxine   and   B-­‐12   Cobalamin;   D-­‐3,   minerals   (including   manganese,   calcium,   iron,   sodium,   potassium)   and   trace   elements   such    as  copper  and  zinc,  among  others.  

21


WHITE CAPSULES    ENHANCED  POWDER  CONCENTRATE       NEW  ZEALAND´s  GREEN-­‐LIPPED  MUSSEL  -­‐  PERNA  CANALICULUS    

(Contains 100  Perna  Canaliculus  powder  concentrate  capsules  of  682  mg  each).              (  PER  4  CAPSULES  )     Proteins  

1.5 g  

EPA      

30 mg  

DHA      

23.5 mg  

Vitamin C    

80 mg  (100%  CDR)  

Vitamin E    

20 mg  (166%  CDR)  

Selenium

55 μg  (100%  CDR)  

Silicon  

37.4 mg  (CDR  not  established)  

Magnesium Carbonate   Energy  value      

100 mg  (26%  CDR)  

37 kJ  /  9  Kcal  

22


AMINO ACIDS  PROFILE  

 

AMINO ACID  

g /100  

Aspartic acid  

4.5

Glutamic acid  

5.39

Serine

2.14

Glycine

3.20

Histidine

0.80

Arginine

3.25

Threonine

1.98

Alanine

2.21

Proline

1.51

Tyrosine

1.25

Valine

1.86

Methionine

1.05

Isoleucine

1.67

Leucine

2.51

Phenylalanine

1.41

Lysine

2.79

Taurine

2.47

Cysteine

2.30

-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐   Note:    The  4  amino  acids  highlighted  in  red  together  with  selenium,  are  the  fundamental   blocks  which  comprise  glutathione  and  its  peroxidases  –  vital  to  the  perfect  working  order   of  the  immune  system  and  the  creation  of  defenses.    

23


AMINO ACIDS  FUNCTIONS  FOUND  ORGANICALLY  IN  PERNA  CANALICULUS   POWDER  CONCENTRATE  (NEW  ZEALAND  GREEN-­‐LIPPED  MUSSEL)   PROVIDED  BY  KRILLIUM  PLUS®     •

Aspartic acid   Increases  energy  levels:    Fatigue  and  low  physical  resistance.   Hepatic  protector:  Excess  ammonia  in  the  organism.   Emotional  and  behavioral  disorders:    Emotional  instability.   Other  uses:    Immunostimulant  -­‐  protection  against  the  harmful  effects  of   radiation.    

Glutamic acid   Mental  stimulant:    Mental  sharpness  –  memory  enhancement.   Intestinal  repairer/healer:    “  Intestinal  permeability  ”  -­‐  colitis  ulcerosa  -­‐  Crohn´s   disease.   Anti-­‐ulcer  agent:    Gastric  and  duodenal  ulcers.    Protects  the  digestive  mucous.   Muscular  repair  and  construction:    Sport  nutrition.   Wounds  healer:    Burns  –  and  surgical  and  traumatic  wounds.   Alcohol  abstinence:    Alcoholism.   Protects  the  immune  system.  

Serine Chronic  fatigue  syndrome.   Dermatology:    Skin  hydration.   Phosphatidylserine  production.   Potential  use  of  phosphatidylserine:    Senile  dementia.   Alzheimer´s.   Excessive  mental  stress  and  mental  fatigue.   Depression,  particularly  in  the  elderly.   Poor  memory.   Sports:  improved  post-­‐effort  recuperation.  

24


Glycine Tranquilizing  agent:    Anxiety  –  nervous  tension  –  panic  attacks  –  insomnia.   Mental  function  support:    Improves  cognitive  capacity  –  memory  enhancement.     Wounds  healer.   Anti-­‐acidic:    Hyperchlorhydria  -­‐  gastric  and  duodenal  ulcers.   Anticonvulsive  and  antispasmodic:    Epilepsy  –  spasticity.   Muscular  repair  and  regeneration.   Sporting  performance:  improves  anaerobic  power.   Prostatic  protector:  benign  prostatic  hyperplasia.   Hepatobiliary  system  tonic:  hepatic  detoxification  –  gallstones.  

Histidine Anti-­‐arthritic.   Detoxification  of  heavy  metals.   Female  and  male  sexual  function.  

Arginine Muscular  development:  muscular  strength.   Muscular  energy:    Fatigue  –  weakness  –  exhaustion.   Immunostimulant:    Conditions  where  there  is  a  suppressed  immune  system.   Hepatic  protection:  excess  ammonia  cirrhosis.   Chronic  pain  and  fatigue:    Fibromyalgia.   Interstitial  cystitis.   Wound  healing.   Male  and  female  infertility.   Male  impotence:    Improves  sex  drive  and  the  quality  of  semen.   Cardiovascular  pathologies:    Angina  –  congestive  heart  failure  –  anticoagulant  –   atherosclerosis.   Reduces  cholesterol  levels.     25


Treonine Protects  the  neuromuscular  system:  helps  amyotrophic  lateral  sclerosis.    Multiple   sclerosis.   Depression  and  irritability.   Anti-­‐infection  –  antiviral.   Lipotropic  agent:  fatty  liver.  

Alanine Works  on  immunosuppression.   Prostatic  pathology:  HPB.   Intense  physical  activity:    Carbohydrates  load  –  post-­‐effort  recuperation.   Alcoholic  hepatitis  –  unipolar  depression  –  hypoglycemia  –  diabetes  (ketoacidosis).   Epilepsy  –  gallstones.    

Proline Repair  of  the  joints:    Arthritis  –  sprains,  etc.   Tissue  healing:    Ulcers  –  burns.   Dermatology:      Premature  ageing  of  the  skin.   Cardiovascular  protection:    Atherosclerosis.   Antitumoral  protection  effect:    Prevention  of  metastasis,  colon,  breast  and   melanoma  cancer.  

Tyrosine Anti-­‐depressant.   Mental  sharpness.   Anti-­‐stress  and  anti-­‐fatigue  effect.   Thyroid  hormone  synthesis  –  hypothyroidism.   Other  uses:  Parkinson´s  –  male  sexual  impotence  –  phenylketonuria.  

26


Valine/Isoleucine/Leucine, (BCAAs  or  branched-­‐chain  amino  acids)   Hepatic  protection:    Hepatic  cirrhosis  –  protein  malnutrition  in  hepatic   encephalopathic  cirrhosis.   Neuromuscular  protection:    Amyotrophic  lateral  sclerosis  -­‐    muscular  dystrophy  –   multiple  sclerosis.   Tissue  repair:    Traumatism  –  extreme  physical  stress  –  surgical  intervention.   Chronic  kidney  failure  –  phenylketonuria  -­‐  tardive  dyskinesia  -­‐  repair  and   development.   Muscular  –    athletic  performance  –    post-­‐effort  recuperation.    

Methionine Lipotropic  agent:  fatty  liver  –  weight  control.   Hepatic  protection:  depressed  hepatic  function.  Detoxifier.   Anti-­‐allergic:  food  allergies  –  environmental  allergies.   Premenstrual  syndrome.   Histadelia.   Depression:  high  levels  of  histamine  –  schizophrenia.   Degeneration  of  the  nervous  system.   Other  uses:  Parkinson´s  –  pancreatitis  during  pregnancy  (prevention  of  neural   tube  defects).  

Phenylalanine Anti-­‐depressant.   Abstinence  syndrome:    Cocaine  –  alcohol  –  amphetamines.   Appetite  control:    Weight  control.   Mental  sharpness.     Chronic  pain:  Painkiller  -­‐  rheumatoid  arthritis  –  fibromyalgia  –  osteoarthritis  –  LBP.  

27


Lysine Prevention  and  treatment  of  simple  and  zoster  herpes.   Cardiovascular  protection.   Detoxification  of  heavy  metals,  particularly  lead.   Bone  health.   Canker  sores.   Anti-­‐tumor  protection:    Prevention  of  metastasis,  colon,  breast  and  melanoma   cancer.    

Taurine Cardiovascular  protection.   Anti-­‐hypertension.   Reduces  cholesterol  levels.   Hepatobiliary  system  tonic.   Detoxification  agent.   Anti-­‐convulsive  agent.   Tranquilizing  agent.   Ocular  protection:    Age-­‐related  ocular  degeneration.   Helps  diabetes.   Abstinence  syndrome.    

Cysteine Hepatic  protection  and  disorders.   Detoxification.    Poisoning  by  heavy  metals.   Disorders  related  to  free  radicals  in  general.   Cardiovascular  protection:    Atherosclerosis.   Mucolytic  agent:    Bronchitis  –  bronchiectasis  –  emphysema  –  tuberculosis  –  cystic   fibrosis  –  tobacco  addiction.   Gastric  mucosal  protection.   Immune  system  protection.   Hypoglycemia.   Dermatology:    Skin,  hair  and  nail  health.      

28


FATTY ACIDS  PROFILE  FOUND  IN  PERNA  CANALICULUS  POWDER   CONCENTRATE  (NEW  ZEALAND  GREEN-­‐LIPPED  MUSSEL)    PROVIDED  BY  KRILLIUM  PLUS®   -­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐  

Total Fat                                                                                           11.0    g/100g       AOAC    16  th  Adn  948.15mod.   Monounsaturated      Fat                                                1.0        “          “                   AOAC    963.22   Polyunsaturated  Fat                                                     4.1        “          “     AOAC    963.22   Saturated  Fat                                                                                  3.0        “          “     AOAC  16th  ed.963.22   …………………………………………………………………………………………………………………………….….…………   C12:0  Lauric  acid                                                           <0.1    “          “    oil             AOAC  16th  Edn  963.22   C12:1  Lauroleic    acid                                             <0.1    “        “          “             AOAC          “            “              “   C14:0  Myristic    acid                                                             5.8        “          “        “             AOAC        “              “              “   C14:1  Myristoleic  acid                                                    <0.1    “        “          “             AOAC        “              “              “   C16:0  Palmitic  acid                                                             15.8    “        “          “             AOAC        “              “              “   C16:1  Palmitoleic  acid                                               7.7        “        “          “             AOAC        “              “              “   C18:0  Stearic  acid                                           4.7        “      “            “           AOAC        “              “              “   C18.1  Oleic  acid                                                                         1.6        “      “            “           AOAC        “              “              “   C18:2  Linoleic  acid                                                       1.9        “      “            “           AOAC        “              “              “   C18:3  Alpha  Linolenic  acid  (ALA)     <0.1    “      “            “             AOAC        “              “              “   C18:3  Gamma  Linolenic  (GLA)                     1.6        “      “            “           AOAC          “            “              “   C18:4  Stearidonic  acid    (OTA)                         2.3        “      “            “           AOAC          “            “              “   C20:0  Arachidic  acid                                                 <0.1    “      “            “           AOAC          “            “              “   C20:1  Gadoleic  acid                                                   3.0        “      “            “           AOAC          “            “              “   C20:2                                                                                               <0.1    “      “            “           AOAC          “            “              “   C20:3                                                                                                     <0.1    “      “            “           AOAC          “            “              “   C20:4  Arachidonic  acid  (ETA)                       1.8        “      “            “           AOAC          “            “              “   C20:5  Icosa  pentaenoic  acid  (EPA)     16.4    “      “            “           AOAC          “            “              “   C22:0  Behenic  acid                                                             0.4        “      “            “           AOAC          “            “              “   C22:1Cetoleic/Erucic  acid                           <0.1    “      “            “         AOAC          “            “              “   C22:2                                                                                                             <0.1    “      “          “           AOAC          “            “              “   C22:4                                                                                       <0.1    “      “          “         AOAC          “            “              “   C22:5  Docosapentaenoic  acid  (DPA)  1.3          “      “          “       AOAC          “            “              “   C22:6  Docosahexaenoic  acid  (DHA)   12.9      “      “          “       AOAC          “            “              “   C24:0  Lignoceric  acid                                                      0.2          “      “          “       AOAC          “            “              “   C24:1  Nervonic  acid                                         <0.1      “      “          “       AOAC          “            “              “   Omega-­‐3  acids                                                                         3.2          “      “          “         AOAC          “            “              “       29


MINERAL PROFILE   Iodine  mg/kg  

                         7.5  

Sodium (Na)  

                         1.5  

Potassium (K)  

                         0.9  

Magnesium (Mg)  

                         0.2  

Calcium (Ca)  

                         0.3  

Cadmium (Ca)  

                         0.001%  

Copper (Cu)  

                         0.001%  

Zinc (Zn)  

                         1.01  

Magnesium (Mn)  

                         0.001%  

Iron (Fe)  

                         0.015%  

Nickel (Ni)  

                         0.001%  

Selenium (Se)  

0.00005%(0.5ppm)

Mercury (Hg)  

0.000009%(0.09ppm)

30


REINFORCED FORMULA  FOR  ENHANCED  SYNERGIES:          

*  Selenium:    55  µg  (100%  CDR)  –  (dosage  of  4  capsules)   Contributes  to:   -­‐  the  protection  of  cell  constituents  against  oxidative  damage.   -­‐  the  normal  functioning  of  the  immune  system.   -­‐  the  normal  functioning  of  the  thyroids.   -­‐  a  normal  spermatogenesis  (something  which  affects  many  males  in  western  society).  

*  Magnesium  Carbonate:    100  mg  (26%  CDR)  –  (dosage  of  4  capsules)   Contributes  to:   -­‐  a  normal  energy  metabolism   -­‐  balanced  electrolytes.   -­‐  the  muscular  function  including  that  of  the  heart.   -­‐  the  functioning  of  the  nerves.   -­‐  cell  division.   -­‐  the  normal  preservation  of  the  bones.   -­‐  the  normal  preservation  of  the  teeth.   -­‐  the  normal  synthesis  of  proteins.   -­‐  normal  psychological  functions.   -­‐  reduced  fatigue  and  tirdeness.  

*  Silicon:    37.4  mg  -­‐  (dosage  of  4  capsules)   An  essential  component  of  ALL  the  tissues  in  the  organism,  skin,  bonés,  hair,  muscles,   nails,  organs,  etc.  Necessary  for  the  conservation,  protection,  repair  and  regeneration  of   all  tissues.    

* Vitamin  C  +  Vitamin  E   Antioxidant  strength,  enzymatic  activities,  gene  expression,  neurological  functions,  etc.    

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WHAT IS  KRILL?   Antarctic   krill   is   a   crustacean,   which   lives   in   enormous   shoals   under   the   ice   of   the   Antarctic   Ocean,   one   of   the   richest   and   purest   ecosystems   on   the   planet.   Krill   shoals   represent  one  of  the  biggest  reserves  of  biomass  and  the  biggest  reserve  of  protein  in  the   world.  The  press  has  dubbed  krill  as  “the  food  of  the  future”  and  “pink  gold”  due  to  the   abundant   biomass,   (estimated   at   500   million   tons   -­‐   the   size   of   a   continent   under   the   ocean),  and  to  the  properties  of  its  nutrients.      

32


TINY This   minute   and   fascinating   crustacean   is   the   main   food   of   penguins,   whales   and   seals,   and  is  responsible  for  penguins  having  zero  cholesterol  levels  and  a  perfectly  preserved   cardiovascular  system.    Of  the  approximately  80  species  of  krill  that  exist,  Antarctic  krill,   Euphasia  Superba,  stands  out  for  its  rich  and  varied  nutritive  properties,  turning  it  into  a   little  yet  gigantic  friend  of  human  nutrition.    

                                                                                                                                                                                                                                                                 Photo:  La  Razón  

HEALTHY

Three main  factors  make  the  Euphasia  Superba  species  a  powerful  and  exceptional  source   of   nutrition,   transforming   it   into   a   functional   food   supplement   of   high   aggregate   value   and   an   outstanding   clinical-­‐therapeutic   efficacy   (Clínica   Corachan,   Barcelona,   2000),   which  are:   -­‐

The variety,  quality  and  quantity  of  nutrients.  

-­‐

All these   nutrients   exist   naturally   in   this   specie,   meaning   absorption   by   the   organism  is  complete.  

-­‐

The effect  of  the  synergies  generated  among  these  nutrients.  

33


LUMINOUS This   amazing   crustacean   has   a   biological   structure   which   provides   it   with   bioluminescence,   or   in   other   words,   it   is   capable   of   emitting   and   generating   light   from   several   points   along   its   body.   Its   habitat,   which   can   be   up   to   4   kilometers   below   the   surface,   is   one   of   total   darkness.   It   is   therefore   known   that   oxygen   molecules   play   an   important   role,   in   addition   to   other   mechanisms   which   are   still   unknown   today.   This   is   one  of  the  biggest  challenges  facing  science  -­‐  discovering  how  a  live  organism  is  capable   of  generating  light  (energy)  itself.  

                                                                     

           Photo  by  Uwe  Kils  

34


RED OIL  PEARLS  OF  ANTARCTIC  KRILL  EUPHASIA  SUPERBA     NUTRITIONAL  INFORMATION  PER  2  PEARLS   (10  soft  gelatin  Euphasia  Superba  oil  pearls  of  724  mg  each)   -­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐   E.  Superba  Krill  oil  

1000 mg    

Omega-­‐3

250 mg  

EPA

140 mg  

DHA

70 mg  

Astaxanthin

0.1 mg  

Energy value  

40 kj  /10  kcal  

-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐-­‐ No  GMO.  No  BSE/TSE.  Non-­‐irradiated.  Complies  with  EU  standards  1829/2003  and   1830/2003.  

35


PROFILE LIST  OF  ANTARCTIC  KRILL  FATTY  ACIDS     (in  addition  to  those  of  Perna  Canaliculus  capsules)     Total  phospholipids  

NA881/AM-­‐AKMB-­‐012

43+/-­‐3 G/100  

Omega-­‐3 phospholipids  of  total  PL2  

<7

96(w/w)

Triglycerides

NA881/AM-­‐AKMB-­‐012

<5

g/100

Total Omega-­‐3  (expressed  in  g/100g)  

AOCS Ce  1b-­‐89/AM-­‐ABM-­‐013  

24+/-­‐2 g  /100  

         -­‐  C20:5  Omega-­‐3  (EPA)  

“  

“ “  

14+/-­‐2

   “  

         -­‐  C22:6  Omega-­‐3  (EPA)  

“  

“ “  

6.5 +/-­‐1  

   “  

         -­‐Total  Omega-­‐6  

“  

“ “  

<3.0

   “    

Astaxanthin  

NA233/AM-­‐ABM-­‐011

100+/-­‐20 mg/kg  

 

THE CRUCIAL  RATIO  OF  OMEGA  6  TO  OMEGA  3  IN  HEALTH   THE  FOLLOWING  GRAPH  DOES  NOT  INCLUDE  NEW  ZEALAND´s  GREEN  LIPPED  MUSSEL,   WHICH,  ALONG  WITH  ANTARCTIC  KRILL,  RANKS  #1  -­‐  WITH  THE  BEST  RATIO.  

                                                               

 

       Source:  www.foodwatch.nl   36


Essential fatty  acid  interactions   The   actions   of   the   omega-­‐3   and   omega-­‐6,   essential   fatty   acids   (EFAs)   are   best   characterized  by  their  interactions;  they  cannot  be  understood  separately.   Arachidonic   acid   (AA)   sits   at   the   head   of   the   "arachidonic   acid   cascade"   –   more   than   20   different   signalling   paths   that   control   a   wide   array   of   bodily   functions,   but   especially   those  functions  involving  inflammation  and  the  central  nervous  system.  Most  AA  in  the   human   body   derives   from   dietary   linoleic   acid   (another   essential   fatty   acid,   18:2   ω-­‐6),   which  comes  both  from  vegetable  oils  and  animal  fats.   Low   dietary   intake   of   these   less   inflammatory   essential   fatty   acids,   especially   the   Omega  3,  is  associated  with  a  variety  of  inflammation-­‐related  diseases.   The  usual  diet  in  industrial  countries  contains  much  less  Omega-­‐3  fatty  acids  than  the   diet   of   a   century   ago.   The   diet   from   a   century   ago   had   much   less   ω-­‐3   than   the   diet   of   early  hunter-­‐gatherers.    We  can  also  look  at  the  ratio  of  ω-­‐3  to  ω-­‐6  in  comparison  of  their   diets.    These  changes  have  been  accompanied  by  increased  rates  of  many  diseases  –  the   so-­‐called   diseases   of   civilization   –   that   involve   inflammatory   processes.   There   is   now   very   strong   evidence   that   several   of   these   diseases   are   ameliorated   by   increasing   dietary   Omega-­‐3,   and   good   evidence   for   many   others.   There   is   also   more   preliminary   evidence   showing   that   dietary   Omega-­‐3   can   ease   symptoms   in   several   psychiatric   disorders.  

Arachidonic acid  cascade  in  inflammation    

The Arachidonic  acid  cascade,  showing  biosynthesis  of  AA's  eicosanoid  products.  EPA  and   DGLA  compete  for  the  same  pathways,  moderating  the  actions  of  AA  and  its  products.   In   the   arachidonic   acid   cascade,   dietary   linoleic   acid   (18:2   ω-­‐6)   is   desaturated   and   lengthened   to   form   arachidonic   acid,   esterified   into   the   phospholipid   fats   in   the   cell   membrane.     Next,   in   response   to   many   inflammatory   stimuli,   phospholipase   is   generated   and   cleaves   this   fat,   releasing   AA   as   a   free   fatty   acid.   AA   can   then   be   oxygenated   and   then   further   modified   to   form   eicosanoids   –   autocrine   and   paracrine   agents  that  bind  receptors  on  the  cell  or  its  neighbors.  Alternatively,  AA  can  diffuse  into   the  cell  nucleus  and  interact  with  transcription  factors  to  control  DNA  transcription  for   cytokines  or  other  hormones.   37


ESSENTIAL FATTY  ACID  PRODUCTION  AND  METABOLISM  TO  FORM  EICOSANOIDS  

 

EICOSANOID SYNTHESIS  

38


COMPLETE BENEFITS  PROVIDED  BY  ALL   THE  ORGANIC,  ESSENTIAL,  FUNCTIONAL  MULTI-­‐NUTRIENTS     AND  THEIR  SYNERGIES  CONTEINED  IN    

KRILLIUM PLUS®       Ø Contains  significant  anti-­‐inflammatory  properties.   Ø Improves  the  cardiovascular  system,  reducing  cholesterol  levels,  atheromatous   plaques  and  triglycerides,  thereby  facilitating  the  absorption  of  nutrients  into  the   blood  flow  and  blood  fluidity.    Its  functional  nutrients  help  protect  the   cardiovascular  system  and:   Ø  

>Peripheral vascular  insufficiency.  

>Hypertension and  other  metabolic  problems.  

>Anti-­‐platelet function  with  a  reduction  in  the  pre-­‐thrombotic  state.    

>Intermittent claudication.    

Ø Diabetes: Helps  regulate  sugar  levels  in  the  blood,  uric  acid  levels  and  provides   functional  nutrients  that  help  with  most  of  the  other  related  problems.   Ø Helps  cerebral  irrigation,  development  and  functions,  memory,  concentration,   mental  clarity,  fatigue,  stress  and  depressive  moods.   Ø Highly  recommended  for  anti-­‐ageing  treatments/nutrition.  Anti-­‐ageing  effect,   ideal  for  people  of  over  30  years  of  age,  as  it  provides  nutrients  that  help  combat   the  effects  of  ageing.  (Particularly  recommended  for  the  elderly).   Ø Helps  arthritis,  osteoarthritis,  osteoporosis,  the  muscles,  joints,  bones  and   tissues.  Protects  the  basic  substance  of  the  articular  cartilage,  providing  flexibility   and  agility  to  the  joints.   Ø The  activity  of  the  proteoglycans  helps  protect  and  maintain  the  elasticity  and   structure  of  the  tissues,  stimulating  the  formation  of  collagen.   Ø Dermatology:  significantly  strengthens  and  improves  tissues  in  general,  hair,  skin   and  nails,  tissue  hydration,  and  helps  a  number  of  skin  disorder   Ø Helps  the  immune  system  with  important  nutrients  for  stronger  defenses.   Ø Helps  the  liver  function  and  to  reduce  toxicities.  

39


Ø Helps the  digestive  system,  the  growth  of  bifidobacteria  in  the  intestines,   facilitating  intestinal  transit.   Ø Women  on  their  period  and  perimenopausal  women.     Ø The  perfect  supplement  to  accompany  weight-­‐loss  diets.    Its  supplementation   helps  follow  a  balanced  and  varied  diet  and  a  healthy  lifestyle.    (it  is  not  a   substitute  of  a  rich  and  varied  diet,  but  a  complement  of  it,  in  order  to  ensure  the   intake  of  key  essential  nutrients  that  cannot  be  ignored).    Furthermore,  it  has  a   satiating  effect  between  meals  which  is  conducive  to  the  weigh-­‐loss  process.   Ø Youth  in  the  diverse  growing  stages,  (requiring  sources  of  important  key  nutrients   for  their  development).   Ø Highly  recommended  in  Sport  nutrition.  As  they  use  up  more  nutrients  than   average  and  as  such  need  to  take  more  supplements.   Ø The  entire  population  as  a  whole,  as  this  is  a  food  supplement  which  helps  to   follow  a  healthier,  more  varied  and  balanced  diet.      

DUE TO  ITS  FAT/LIPID  CONTENT    

The balance  of  POLYUNSATURATED  FAT  –  MONOUNSATURATED  FAT  –  SATURATED  FAT   helps:   -­‐  Reduce  platelet  aggregation.   -­‐  Arteriolar  vasodilator.   -­‐  Acts  on  the  immune  system.  Activates  the  interleukins,  the  chemotactic  effect  and            leukocyte  aggregation.   -­‐  Anti-­‐tumor  and  metastatic  effect.   -­‐  Reduces  cholesterol  levels.   -­‐  Reduces  VLDL  synthesis.   -­‐  Increases  the  viscosity  of  the  erythrocyte  membranes.       Its  vascular  action  is  largely  based  on  the  balanced  content  and  composition  of  the   Omega-­‐3/EPA-­‐DHA  fatty  acids  and  oleic  acid.    

40


Omega-­‐3 fatty  acids  the  synthesis  of  the  prostanoids  to  the  3  series  prostaglandins  and   the  5  series  leukotrienes  via  different  routes:     1  –  Via  the  cyclooxygenase:   PGI  –  TXA  3  –  PGD  3  –  PGF  3.   1.1.

Which produce:  

-­‐A reduction  in  platelet  aggregation.   -­‐Arteriolar  vasodilation.   -­‐An  increase  in  endogenous  fibrinolytic  activity.     -­‐A  reduction  in  vascular  contractile  response  against  catecholamines.     2  –  Via  the  lipoxygenase:   LTB  5  –  LTC  5  –  LTD  5  –  LTE  5  –  LIPOXIN  B   2.1.  Which  produce:   -­‐  A  reduction  in  platelet  aggregation.   -­‐  A  reduction  in  the  synthesis  of  the  cell  growth  factor.   -­‐  A  reduction  in  the  synthesis  of  the  necrosis  factor.     -­‐  A  reduction  in  the  chemotactic  effect.     -­‐  A  reduction  in  the  synthesis  of  interleukins.       3  –  Via  the  direct  action  of  Omega-­‐3  fatty  acids  on:   3.1  –  The  lipid  metabolism:   -­‐  Reduces  the  synthesis  of  VLDLs  at  hepatic  level.   -­‐  Increases  the  return  of  cholesterol  to  the  liver  via  the  HDLs.     3.2  –  The  membranes:   -­‐Increases  the  flexibility  (deformation)  of  the  erythrocyte.   -­‐Reduces  the  viscosity  of  the  blood.       In   short,   the   Omega-­‐3   fatty   acids   in   Krillium   Plus®   have   a   normolipidemic,   anti-­‐ atherogenic,  anti-­‐thrombotic,  anti-­‐hypertensive  and  anti-­‐inflammatory  effect.       41


42


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BIBLIOGRAPHY     McPhee   S,   Hodges   LD,   Wright   PF,   et   al.   Anti-­‐cyclooxygenase   effects   of   lipid   extracts   from   the   New   Zealand   green-­‐lipped   mussel,   Perna   canaliculus.   Comp   Biochem   Physiol   B   Biochem   Mol.Biol   2007;146(3):346-­‐356.     Cobb   CS   and   Ernst   E   (2006).   "Systematic   review   of   a   marine   nutriceutical   supplement   in   clinical   trials   for   arthritis:   the   effectiveness   of   the   New   Zealand   green-­‐lipped   mussel   Perna   canaliculus.".  Clin  Rheumatol  25  (3):  275–284.     Perna   canaliculus   Cultured   Aquatic   Species,   FAO,   Rome.   Retrieved   September  2012.     Potterton.   D.   1980.   Arthritis   medicine   from   the   sea.   Bestways   January:52-­‐  55.     Rainsford.   K.   D.   &   M.   W.   Whitehouse.   1980.   Gastroprotective   and   anti-­‐   inflammatory   properties   of   green-­‐lipped   mussel   {Perna   canaliculus)  preparation.  Arzneimittelforsch.  30:2128-­‐2132.     Zwer.   D.   1983.   The   Magic   Mussel.   Arthritis   Another   Way.   Ideas   Unlimited.  Cairns.  Australia.  90  pp.     Palmer,  D.  G.  1980.  Anti-­‐inflammatory  effects  of  mussel  extracts.  A'.Z   Med.  J.  92:187-­‐193.     Butters   DE,   Whitehouse   MW.   Treating   inflammation:   some   (needless)   difficulties   for   gaining   acceptance   of   effective   natural   products   and   traditional   medicines.   Inflammopharmacology.   2003;11(1):97-­‐110.     Mani   S,   Lawson   JW.   In   vitro   modulation   of   inflammatory   cytokine   and   IgG   levels   by   extracts   of   Perna   canaliculus.   BMC   Complement   Altern  Med  2006;6:1.     Waite,   R.   P.   1989.   The   nutritional   biology   of   Pema   canaliculus   with   special   reference   to   intensive   mariculture   systems.   Ph.D.   thesis.   University  of  Canterbury,  Christchurch.  New  Zealand.     Wellstead.   D.   1985.   New   Zealand's   green   mussels   are   in   demand.   Fish  Farmer  November/December  1985:18-­‐19.     Sheppard.  R.  L.  1982.  Market   potential   for  New   Zealand  green   lipped   mussels.  Lincoln  College.  Canterbury.  New  Zealand.  32  pp.     Whitehouse.   M.   W„   T.   A.   Macrides.   N.   Kalafatis,   W.   H.   Betts,   D.   R.   Haynes   &   J.   Broadbent.   1997.   Anti-­‐inflammatory   activity   of   a   lipid   fraction   from   the   New   Zealand   green-­‐lipped   mussel,   lnflammo-­‐ pharmacology.  5:237-­‐246.  


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