Hemostasis is a procedure that assists in stopping the bleeding from injured blood vessels. Hemostasis process is done in three steps, namely blood coagulation, platelet plug formation, vasoconstriction, in which liquid state blood changes into the gelatinous state. During the angioplasty and angiography procedures, the hemostasis valves are used for reducing the blood loss. Once the flap is locked, it creates the pressure inside the vessel, which in turn helps in the reduction of blood loss. Various kinds of hemostatic methods are prevalent in medical practices from simple manual pressure application with one finger to systemic administration of blood products, electrical tissue cauterization, and systemic administration or topical use of pro coagulation agents. The global demand for hemostasis valves is expected to increase with rising in patients in need of interventional procedures, number of hospitals, and grow in the geriatric population.