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Molecular Mechanisms of Cellular Mechanoreception in Bone

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Boise State University/NASA Human Exploration & Operations Mission Directorate

Boise State University Microgravity University students fly on the Weightless Wonder - an aircraft that flies extreme parabolic maneuvers over the Gulf of Mexico, simulating hyper gravity (two times Earth gravity) and microgravity (very little gravity that results in weightlessness). In 2014, the team’s project, “Gravitational Effects on Cerebrospinal Fluid Pressure and Flow in an Anatomical Model” focused on examining the aftereffects of microgravity in astronauts’ cerebrospinal fluid following return to normal gravity. Dr. Julia Oxford advised the team on their research.

Establish the cell culture system in which to evaluate how changes in the ECM influence cellular response to simulated microgravity. Investigate intermediates of signaling pathways that influence osteoblast differentiation under conditions of simulated microgravity in a defined extracellular matrix. Investigate novel intermediates in the mechanism of mechanotransduction. This work is being conducted through a collaboration involving NASA Johnson Space Center, Microgravity University, Sapidyne, Inc., and University of Texas Health Science Center at San Antonio.

Dr. Julia Thom Oxford, Science PI, Boise State University

Dr. Jean D. Sibonga, NASA Technical Monitor, Johnson Space Center

www.nasa.gov/epscor/stimuli

NASA EPSCoR Stimuli 2014-15

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EPSCoR Stimuli 2014-15  

NASA Office of Education’s Aerospace Research & Career Development (ARCD) is pleased to release NASA EPSCoR Stimuli, a collection of univers...

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