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Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Curriculum Vitae CYNTHIA F. BEARER, M.D., PH.D., FAAP Mary Gray Cobey Professor of Neonatology Chief, Division of Neonatology Department of Pediatrics University of Maryland School of Medicine Chair, Board of Directors Children’s Environmental Health Network DATE: August 23, 2011 CONTACT INFORMATION • • • • • • • •

Division of Neonatology Department of Pediatrics University of Maryland Hospital for Children 29 S. Greene St., Suite GS110 Baltimore, MD 21209 Phone number: (410) 328-6003 Email: cbearer@peds.umaryland.edu Foreign languages: None

EDUCATION: Degrees: 1972 B.A. 1977 Ph.D. 1982 M.D.

Smith College, Mathematics Case Western Reserve University, Biochemistry, Dr. Kenneth Neet The Johns Hopkins University, Medicine

Internship and Residency: 1982-1983 Intern, Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland 1982-1984 Clinical Fellow in Pediatrics, The Johns Hopkins University School of Medicine 1983.1984 Resident, Pediatrics, The Johns Hopkins Hospital, Baltimore, Maryland Fellowships: 1977-1978 1978-1979 1984-1986 1986-1987

Research Associate, Department of Cell Biology, Baylor College of Medicine, Dr. Lutz Birnbaumer Postdoctoral Fellow, Department of Pharmacology, University of Texas Medical School at Houston, Dr. Joseph Thompson Fellow, Joint Program in Neonatology, Harvard Medical School Fellow, Division of Newborn Medicine, Washington University School of Medicine

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Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Postgraduate training: 1990-1991 Postgraduate training, Occupational and Environmental Medicine, University of California San Francisco 1992 Executive Leadership in Medicine, Levinson Institute, HarvardUniversity CERTIFICATION: 1987 1989 1996 19962002

Diplomate of the American Board of Pediatrics, #35702 Diplomate of Neonatal Perinatal Medicine, #204022 Recertification, Neonatal-Perinatal Medicine, #204022 Neonatal Resuscitation Provider, American Heart Association, #1147054 Recertification, Neonatal-Perinatal Medicine, #204022

LICENSURES: 1986-1990 1989-1995 19922008-

Missouri Medical License - inactive California Medical License - inactive Ohio Medical License – active Maryland Medical License - active

EMPLOYMENT HISTORY: Academic Appointments: 1987.1989 Instructor in Pediatrics, Washington University School of Medicine, St. Louis, Missouri 1990.1992 Assistant Adjunct Professor, School of Dentistry, University of California San Francisco, San Francisco, California 1990-1992 Assistant Clinical Professor, Dept. of Medicine, University of California San Francisco, San Francisco, California 1992-1994 Associate Professor, Dept. of Pediatrics, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 1994-2001 Assistant Professor, Department of Pediatrics & Neurosciences, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio 2001-2008 Associate Professor, Department of Pediatrics & Neurosciences, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio 2003 Award of tenure, Case Western Reserve University 2008 Professor, Department of Pediatrics, Neurosciences and Environmental Health Sciences, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio 2008 Adjunct Professor, Department of Pediatrics, Neurosciences and Environmental Health Sciences, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio 2008 Mary Gray Cobey Professor of Neonatology, Department of Pediatrics, University of Maryland Hospital for Children, Baltimore, Maryland 2008 Award of tenure, University of Maryland 2


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

2008

02/10/13

Chief, Division of Neonatology, University of Maryland Hospital for Children, Baltimore, Maryland

Other Employment: 1987-1989 1987-1989 1987-1989 1990-1992

Assistant in Pediatrics, Children's Hospital, St. Louis, Missouri Assistant in Pediatrics, Barnes Hospital, St. Louis, Missouri Assistant in Pediatrics, Jewish Hospital, St. Louis, Missouri Director, Division of Pediatric Environmental Health, Children's Hospital Oakland Research Institute, Oakland, California 1990.1992 Associate Research Biochemist, Children's Hospital Oakland Research Institute, Oakland, California 1990.1992 Associate Neonatologist, Children's Hospital Oakland, Oakland, California 1992-1994 Director, Division of Neonatology, Tod Children's Hospital, Youngstown, Ohio 1992.1994 Director, Division of Pediatric Environmental Health, Tod Children's Hospital, Youngstown, Ohio 1999-2002 Co-Director, Neonatology Fellowship Training Program, Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio 2002.2008 Director, Neonatology Fellowship Training Program, Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, Ohio 2003.2008Director of Medical Education, Mary Ann Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio 2006-2008 Associate Director, Medical Scientist Training Program, Case Western Reserve University, Cleveland, Ohio PROFESSIONAL SOCIETY MEMBERSHIPS 1977-present 1987.1994 1990-present 1992-1994 1992-1999 1992-present 1992- 1999 1993-present 1993-present 1995 -present 1996-present 1999-present 2000-present 2005-present

American Association for the Advancement of Science American Federation for Clinical Research American Academy of Pediatrics National Council of Juvenile and Family Court Judges Teratology Society Physicians for Social Responsibility Society of Occupational and Environmental Health Research Society on Alcoholism Fetal Alcohol Syndrome Study Group Society for Pediatric Research American Academy of Pediatrics, Section on Perinatal Pediatrics Perinatal Research Society Society for Neuroscience American Pediatric Society

HONORS AND AWARDS: 1972 1972 1978

Phi Beta Kappa Graduated cum laude Smith College Awarded NIH Postdoctoral Research Fellowship #1 F32 HL 5873-01 3


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

1979-1980

Awarded W. Barry Wood Student Research Fellowship, The Johns Hopkins University School of Medicine 1980 Awarded Cystic Fibrosis Foundation Student Traineeship, #H0022-01 1985 Awarded Farley Fellowship, The Children's Hospital, Harvard Medical School 1991 Nominated for Best Teacher Award, Housestaff, Children's Hospital Oakland 2004 Distinguished Teacher Award, Pediatric Housestaff, Tod Children's Hospital 2001-4 President, Fetal Alcohol Syndrome Study Group 2004 Learning Fellow, University Center for Innovation in Teaching and Education, CWRU 2004-present Listed in “Guide to America’s Top Pediatricians” 2005 Elected to the American Pediatrics Society 2007 Thomas H. Pauly Excellence in Neonatology Lectureship, University of Kentucky 2009-present Listed in “Best Doctors in America” 2009 Mansdorfer Lectureship, Mercy Hospital, Baltimore, MD 2009 Chair, Board of Directors, Children’s Environmental Health Network CLINICAL ACTIVITIES •

Practice of Neonatology including ECMO, ventilator management, pre-op cardiac management, entubation, chest tube placement, neonatal resuscitation, management of extremely premature infants, management of complex congenital malformations. Describe scope of clinical practice: • University of Maryland Hospital for Children, NICU Level IIIc, 40 bed neonatal intensive care unit • 50 Patients within 3 week period • 25% FTE clinical practice

ADMINISTRATIVE SERVICE Institutional Service: 1994-1996 1994.1996 1995-1996 1996-1999 1996-1998 1996-present 1998-2001 2001 2001 2002-present

2002-2003 2003-2004 2003-present

Research Committee, Department of Pediatrics, CWRU Credentialing Committee, Department of Pediatrics, CWRU Medical Advisory Board, Lorain County Pesticide Response Co-Chairman, Environmental Health Committee, Ohio Chapter American Academy of Pediatrics Patent Committee, CWRU, School of Medicine Faculty Steering Committee, Center for the Environment, CWRU Steering Committee, Women Faculty of the School of Medicine Judge, Irwin H. Lepow Student Research Day Organizer, Prevention of Birth Defects, Minimedical school, CWRU Director, Neonatology Fellowship Training Program, CWRU **Enlarged fellowship from 6 to 9 fellows, increased diversity within fellowship program, funded additional fellows by use of training grant support Member, Poster Committee, Research Showcase 2003, CWRU Member, Poster Committee, Research Showcase 2004, CWRU Member, Graduate Studies Committee, CWRU 4


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

2004-2007 2006-present 2005 2008 2008 2009 2009 2009

02/10/13

Member, Committee on Appointments, Promotions, and Tenure, CWRU Associate Director, Medical Scientist Training Program, CWRU Judge, Irwin H. Lepow Student Research Day, CWRU Judge, Irwin H. Lepow Student Research Day, CWRU Search Committee, Assistant Dean for Faculty Development and Diversity, CWRU Clinical Advising Subcommittee, MD-PhD Program, University of Maryland Baltimore School of Medicine Internal Advisory Committee, Toxicology Graduate Program, Graduate Programs in Life Sciences, University of Maryland Baltimore School of Medicine Admissions Committee, BIWRCH Scholarship Program, UMB

NATIONAL AND INTERNATIONAL SERVICE: Editorial Boards 2004 – present 2003 – 2007

Neurotoxicology Alcohol Research & Health

National and International Service 1992-present National Advisory Board, Children's Environmental Health Network 1995-1999 Vice-Chairman, National Board, Children's Environmental Health Network **Convener, Workshop on Pediatric Environmental Health, NIEHS/NIH 1995-1996 Chair, Education Committee, Children’s Environmental Health Network 1995-1999 American Academy of Pediatrics, Committee on Environmental Health 1995-present Board of Sponsors, Physicians for Social Responsibilities 1996.1998 Chair, Nominating Committee, Children’s Environmental Health Network 1996-1997 Children’s Health Initiative Workgroup, Agency for Toxic Substance and Disease Registry, U.S. Dept. of Health and Human Services 1996-present Food Quality Protection Act/Science Review Board, U.S. Environmental Protection Agency 1997 External Scientific Advisory Board: Fetal Alcohol Syndrome, NIAAA/NIH 1997 Chair, Subpanel on Growth and Development, Expert Panel on Pediatric Environmental Health, Agency for Toxic Substances and Disease Registry. 1998-2001 Scientific Advisory Board, Environmental Health Subcommittee, U.S. Environmental Protection Agency 1998-present World Health Organization, Temporary Advisor, Global Assessment of the State of the Science of Endocrine Disrupting Chemicals 1998-present External Scientific Advisory Committee, Mount Sinai Center for Children’s Environmental Health and Disease Prevention, New York, New York 1999 Science Advisory Panel, A Retrospective Analysis of Developmental Neurotoxicity Studies, U.S. Environmental Protection Agency. 1999 Convener, Seventeenth International Neurotoxicology Conference, Little Rock, AR 1999 Peer Reviewer, Peer Review Workshop on ORD’s Strategy for Research on Environmental Risks to Children, U.S. Environmental Protection Agency. 1999-2002 Consultant, Advisory Group to the Director, National Center for Environmental Health, Centers for Disease Control and Prevention 2000-2002 Science and Research Work Group, Children’s Health Protection Advisory Committee, U.S. Environmental Protection Agency 1999 Convener, Eighteenth International Neurotoxicology Conference, Colorado Springs, CO 5


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

2001 2001-present 2001-present 2001-2004 2001-2004 2001-2004 2002 2002-present 2003-2005 2003-present 2004-present 2004 2005-present 2006 2006-present 2007 2011 2011 Study Sections 1998 1999 2002 2003-2006 2004-present 2004 2007 2008 2008 2008 2009 2009

02/10/13

Peer Reviewer, Sociodemographic Data Used for Identifying Potentially Highly Exposed Children’s Populations, for U.S. Environmental Protection Agency Biomonitoring Working Group, National Center for Environmental Health, Centers for Disease Control and Prevention Birth Defects and Disabilities Working Group, National Center for Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention President, Fetal Alcohol Syndrome Study Group, Research Society on Alcoholism Review Panel, National Toxicology Program for the Evaluation of Risks to Human Reproduction, National Institute for Environmental Health Sciences Committee on Evaluation of Children’s Health, Board on Children, Youth and Families, National Academy of Sciences/National Research Council/ Institute of Medicine Consultant, Children and Environmental Hazards for Case Studies in Environmental Medicine, Agency for Toxic Substance and Disease Registry Chair, Science Council, Children’s Environmental Health Network Board of Directors, Physician for Social Responsibility Consultant, National Center for Environmental Research (NCER), Office of Research and Development, U.S. Environmental Protection Agency (under contract to ICF Consulting). Developmental Neurotoxicology Testing Steering Committee, The Johns Hopkins Center for Alternatives to Animal Testing, The Bloomburg School of Public Health, Johns Hopkins University Convener, Fetal Alcohol Syndrome Study Group Meeting, Vancouver, British Columbia, Canada Member, External Partners Group, National Center for Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention Chair, Teratology Society/Neurobehavioral Society Joint Symposium, “Early Exposures: Childhood Behavior Disorders” Program Committee, Research Society on Alcoholism Ad hoc expert, NIAAA/NIH Extramural Advisory Board Invited Participant, NIEHS Stakeholders Strategic Planning Committee Invited Member, NIEHS Strategic Planning Meeting NIAAA Special Emphasis Panel NIH Special Emphasis Panel ZAA1 BB(3) ALTX-3 Study Section consultant Permanent member, NAL (formerly ALTX-3) Study Section Ad hoc reviewer, AA-1 Biomedical Research Subcommittee Ad hoc reviewer, scientific review group EHS (T32 & T35), EHS-LKBTG NIH/NIAAA Special Emphasis Panel ZAA1 CC 11 (U01 & U24) Chair, National Children’s Study Biological and Environmental Sample Repository Meeting, review of proposals, NIH/NICHD Neuroscience Review Subcommittee, AA-4, NIH/NIAAA (K08) Chair, Biorepository Meeting, review of proposals, NIH/NICHD Ad hoc reviewer, ZRG1 IFCN-A (58) R Challenge Grants Ad hoc Reviewer, ZAA1 CC (03) R Effect of Alcohol on Glia 6


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

2009 2009 2010 2010 2010

02/10/13

Ad hoc Reviewer, Children’s Environmental Health Center grants Ad hoc Reviewer, Developmental Brain Disorders Study Section Ad hoc Reviewer, ZRG1-ETTN-A (14) SBIR/STTR Ad hoc Reviewer, Developmental Brain Disorders Study Section Co-Chair, ZRG1-ETTN-G (14) B

Other Grant Review Committees 1999-present Grant reviewer, Workplace Safety and Insurance Board Research Advisory Council, Ontario, Canada 2002 Grant reviewer, STAR grants, United States Environmental Protection Agency 2003-present Grant reviewer, Alberta Heritage Foundation for Medical Research 2003 External Grant reviewer, National University of Singapore Academic Research Fund Committee 2003 Special Emphasis Panel, Center for Disease Control and Prevention, Public Health Laboratory Biomonitoring Implementation Program 2009 Ad hoc Reviewer, NIEHS/EPA “Centers for Children's Environmental Health and Disease Prevention Research” Reviewer of Journals: Pediatrics Pediatric Research Teratology Biochemical Pharmacology Environmental Health Perspectives Alcoholism: Clinical and Experimental Research Alcohol Alcohol & Alcoholism Archives of Pediatric and Adolescent Medicine American Journal of Industrial Medicine Journal of Pediatrics Brain Research Neurotoxicology Journal of Neuroscience Research Clinical Chemistry Journal of Neurochemistry FEBS Letter Lancet Cellular and Molecular Life Sciences Journal of the American Medical Association American Journal of Obstetrics & Gynecology Experimental Neurology Neurosciences Birth Defects Research Part A: Clinical and Molecular Teratology Experimental Biology and Medicine TEACHING SERVICE: High School Student Education High School fall science project 2000 Chloe Farkas – Beaumont School FAEE in premature infants’ meconium: A marker for IVH/PVL? (Third 7


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

2001 2002 2002 2003 2004 2005-6 2007-2008 2008 2009

02/10/13

place winner – Northeastern Ohio Science Fair) Final Grade: A Chloe Farkas – Beaumont School L1 ectodomain shedding - A mechanism for neurite outgrowth? (Second place winner – Northeastern Ohio Science Fair) Chloe Farkas – Beaumont School Kinases associated with L1 (Finalist, Intel International Science and Engineering Fair) Natalie Linsalata - Hawken Lead in blood bank blood in Ohio (Author on letter published in Lancet) Ben Farah- St. Ignatius L1 Protein-protein interactions Fulbright Scholar/MSTP applicant Ben Farah – St. Ignatius L1 and Lipid Rafts Fulbright Scholar/MSTP applicant Allison Blatz – Mentor High School Heavy metals in blood bank blood (Finalist, International Science Fair; awarded St. Geme prize, PAS, 2006) Elizabeth Kilbane – Laurel High School Toluene Inhibition of L1 mediated ERK activation – Dose Response Sean Sukys-Walsh – St. Ignatius High School Bilirubin Neurotoxicity – An Effect on Lipid Rafts? Becky Sturner – L1 in CSF of ALS patients

Undergraduate Student Education Summer Undergraduate Research Program 1997 – Lisa Ellberg. Kenyon College Currently 2nd year medical student at CWRU Ethanol inhibition of bFGF and Arachidonic Acid stimulated neurite outgrowth 1997 - Melinda Mulligan, Bowdoin U. FAEE synthase in peripheral blood as a biomarker for alcohol consumption 1998 - Jessica Whalen, L1 cell adhesion molecule expression in cerebrospinal fluid 1999 - Kate Sparger, Miami University Fibroblast growth factor receptor 1 in cerebellar granule cells 2000 – Lauren Harrison, Boston U. Ethanol inhibition of L1-stimulated protein tyrosine phosphorylation 2001-Corena Gamble, Oberlin College Octanol antagonism of ethanol inhibition of L1-mediated neurite outgrowth 2002-Redelia House, Kent State University Preparation of CSF for L1 Western Blotting 2003-Ami Patel, Toledo University L1-Fc mediated neurite outgrowth and cytokines. 2004-Danielle Paulin, John Carroll University Time lapse video microscopy of neurite outgrowth 2005-Anne Gifford, Case Western Reserve University 8


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Cost-benefit analysis of universal screening for prenatal alcohol exposure. 2005-Chris Chang, Case Western Reserve University DNA in meconium: Fetal or Maternal? 2006-Anne Gifford, Case Western Reserve University Feasibility of screening blood donors for lead 2007 – Vera Avkshtol, Case Western Reserve University Toluene inhibition of L1 activation of ERK1/2 Independent Research 1998.1999 Rashmi Phanindra Developmental characterization of L1 expression in cerebrospinal fluid Biology Department (Course #388) Final Grade: A 2002

Carrie Pierce – Oberlin College Coimmunoprecitation of kinases with L1

Preceptor, Medical Apprenticeship Program, Health Care Enhancement Program for Minorities – 2000, 2001, 2002, 2003, 2005 Faculty Mentor, Summer Medical/Dental Education Program, 2008 Medical Student Education Didactic: Leader, Block I of the Western Reserve2 Curriculum-2006 Inquiry Group Facilitator, Block I of the Western Reserve 2 Curriculum-2006 (10 students, 6 hrs/wk, 4 weeks) Gene Environment Interactions (1st year medical students, 1 hour) Teaching medical students routine newborn physical examination (Introduction to Neonatology) Teaching medical students abnormal newborn physical examination (Neonatology Physical Diagnosis) Teaching medical students in elective, Problems of the Newborn Clinical teaching of medical students during pediatric clerkship rotations Clinical Immersion for Second Year students Embryology Lab, University of Maryland 2010 Research: 1989 Paul E. Glaser, M.D., Ph.D. MSTP Student Clinical Mentor 1998

Eric Baden Primary Care Track Summer Research Project Case Western Reserve Univesity School of Medicine Effect of organic solvents on L1 mediated neurite outgrowth

2005

Katie Krone Basic Research Block Cleveland Clinic Lerner College of Medicine Toluene effects on L1 distribution in lipid rafts

2009

Maria Churaman 9


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Research elective University of Maryland School of Medicine Lead and Mercury in Maryland Blood Bank 2009

Hemal Sampat Summer Research Fellowship University of Maryland School of Medicine Use of Neuronal Cell Line to Study Bilirubin Toxicity

Graduate Student Education 2002-

Luis Manuel Santiago, Ph.D. advisory committee Neural network of meconium biomarkers and infant outcome

2005

Stephanie Fox, laboratory rotation, toluene and lipid rafts

2006-2007

Paul Bakaki, M.S. advisory committee Change in maternal weight with duration of breastfeeding among HIV-1 infected Ugandan women during the first six months after delivery

2007-2008

Adam Burgoyne, Ph.D. thesis committee Proteolytic Cleavage of PTPμ Regulates Glioma Cell Migration

2010

Developmental Neurobiology, Neurite Outgrowth

Resident and Fellowship Education Resident training during attending and electives for Neonatalology Pediatric Resident Mentor:

Stacey Memberg, Ph.D., M.D. 1997-2000 Rose Gubitosi-Klug, Ph.D., M.D. 1999-2002

Director, Neonatology Fellowship Program Mentor, Senior Science Project 1999.2000 Mary Nock, M.D. Developmental Expression of L1 in CSF and spinal cord 2000.2002 Rose Gubitosi-Klug, Ph.D., M.D. Ethanol inhibition of L1 prevention of apoptosis 2004-2005 Swetha Krishnamurthi, MD Mercury exposure from blood transfusion 2010 Manisha Patel, MD Neurite formation following lipid raft disruption List of Neonatal Fellowship Trainees in Developmental Neurotoxicology Research Natalie Yeaney, M.D. – Neonatal fellowship 1998 – 2001; Cell surface distribution of L1 cell adhesion molecule in neurons exposed to ethanol. Current position: Assistant Professor, Dept of Pediatrics, Case Western Reserve University Mary Nock, M.D. – Neonatal fellowship 2000 – 2003: Effect of ethanol on association of ERK with L1. Current position: Assistant Professor, Dept of Pediatrics, Case Western Reserve University

10


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Jennifer Peterson, M.D. – Neonatal fellowship 2002 – 2005. Meconium biomarkers predict outcome. Position in 2005 – Assistant Professor, Pediatrics, Case Western Reserve University Yoav Littner, M.D. – Neonatal fellowship 2004 – 2007. dynamically regulated through lipid rafts.

L1 cell adhesion molecule is

Chris Slocum, M.D. – Neonatal fellowship 2004 – 2007. Ethanol induced changes in the lipid raft proteome of cerebellar granule cells. Thomas Lai, M.D. - Neonatal fellowship 2006 – 2009. Effects of drug vehicles on lipid raft proteins. Misty McCaig, M.D. – Neonatal fellowship 2009 – present. Low level lead impact on neurite outgrowth. Faculty Development and Education: Mentor

Multidisciplinary Clinical Research Scholars

Ruth Ann Marrie, M.D., Assistant Professor, Neurology, CCLCOM – 2005 – 2006. Prenatal Origins of Multiple Sclerosis.

11


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Table of Past Trainees and Current Positions Current/ Trainee Pre- or Past Post Doctoral Cynthia Current Misty Post Bearer McCaig, (Neonatology MD Fellow)

Degree/ Institution (Year) MD/American University of the Caribbean

Training Period

Research Title

Current/past support

Current Position

7/1/09present

Low level lead effects on neurite outgrowth Lipid rafts govern neurite branching Cost-benefit analysis of Universal screening for FAS Pediatric Drug Vehicles – Toxic to the lipid raft? Bilirubin Neurotoxicity

Divisional

Neonatology Fellow, UMB

Divisional

Pediatric Resident, UMB

Swetland Center

Intn'l Society for Disease Surveillance

Hearst Foundation

Kaiser Permanente, Roseville, CA

Current

Manisha Patel, MD

Post

DO/

7/1/10present

Past

Anne Gifford

Pre

BS/MPH CWRU 2009

7/1/04 – 2008

Past

Thomas Lai, MD

Post MD/Princeton (Neonatology U. Fellow)

7/1/06 – present

Past

Sean SukysWalsh

Pre

7/1/08 – 8/30/08

Past

Yoav Littner, MD

St. Ignatius High School Student Post MD/Technion, (Neonatology Haifa, Israel Fellow)

Past

Chris Slocum, MD

Post MD/Univ. of (Neonatology MD Fellow)

7/1/046/30/07

12

7/1/04 – 6/30/07

Bearer Revolving St. Ignatius Fund High School Student Cleveland Clinic Assistant Foundation Professor, CWRU

Effect of ethanol on tyrosine Phosphorylation of L1 A proteomic Divisional analysis of Lipid rafts

Neonatologist, Carillion Clinic and Children’s


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Past

Allison Blatz Pre

Mentor High School Student

2/1/056/30/06

Metals in blood bank blood

Swetland Center

Past

Ruth Ann Marrie, MD, MPH

Post

MD/Dalhousie U. (1996) MPH/CWRU (2003)

7/1/05 – 6/30/07

1K12HD04909101

Past

Katie Krone

Pre

BA/Westminster 7/1/05College, PA 9/1/05

Past

Chris Chang

Pre

Undergrad

7/1/0412/1/05

Past

Luis Manuel Santiago

Pre

BA, University of Puerto Rico

7/1/03 present

Past

Ningfeng Tang, MD, PhD

Post

Ph.D., Chinese Academy of Medical Sciences & Peking Union Medical College,

7/1/04 – present

Validation of MS using Self Report, Perinatal risk factors for MS using a Danish population based study The Effect of Toulene on L1 distribution to the lipid raft Ethics of pediatric environmental health research A differential equations model of FAEE and maternal drinking Lipid rafts: A target for ethanol?

13

CCFLCOM

Swetland Center

Hospital Undergraduate student, Johns Hopkins University Assistant Professor, Dalhousie U.

Medical Student, CCF Lerner College of Medicine Undergraduate, CWRU

CDC

HIV/AIDS coordinator, Puerto Rico

R01 AA01639801A1

Research Associate, UMB


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Nanjing, China (2000) M.D., Anhui Medical University, Hefei, China (1994) BA/

Past

Stephanie Fox

PrePhD

Past

Jennifer Peterson, MD

Post MD/Duke U. (Neonatology (1996) Fellow)

7/1/046/30/05

Past

Mary Nock, MD

Post MD/Univ. (Neonatology Cincinnati Fellow) 1995

7/1/996/30/03

Past

Natalie Yeaney, MD

Post MD/CWRU (Neonatology 1994 Fellow)

7/1/986/30/02

Past

Sarah Post MD;Univ. of Kenney, MD (Neonatology Iowa (1996) Fellow)

14

2/05-4/05

7/1/976/30/01

Effect of long chain alcohols on L1 distribution in lipid rafts Correlation of meconium biomarker of alcohol exposure and infant development Developmental expression of L1 in CSF and spinal cord Effect of ethanol on the tyrosine based sorting signal of L1 Ethanol effects of L1 mediated phosphorylation of the fibroblast growth factor

5T32AG00027107

Grad Student, Dept of Neurosciences, CWRU

Cleveland Clinic Foundation

Assistant Professor, CWRU

Division

Assistant Professor, CWRU

Division (currently on leave)

Assistant Professor, CWRU Neonatologist, Great Falls, MT


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Past

Kurt Griffin, MD, PhD

Post

M.D., PhD, Univ of Colorado,

Past

Rose GubitosiKlug, MD, PhD

Post

MD, PhD, Wash 7/1/99U (1999) 6/30/02

Past

Benjamin Farah

Pre

7/1/038/30/04

Past

Chloe Farkas Pre

7/1/018/30/03

Assorted projects

Past

Eugene Kim

Pre

High school student (St. Ignatius) High school student (Beaumont) Medical Student CWRU

L1 Cell NICHD K08 Adhesion Molecule is Neuroprotective of Alcohol Toxicity in Cerebellar Granule Cell Cultures Preparation of lipid rafts

3/1/048/1/04

Past

Natalie Linsalata

Pre

High School Student (Laurel)

1/1/035/1/03

Apoptosis and Mitochondrial coupling Lead in blood transfusions

Past

David Pre Rodenbaugh, PhD Paul E. Pre Glaser, MD, PhD

PhD, Wayne State U. (2003)

8/1/922/28/94

FAEE uncouple mitochondria

1F32HL07811101

MD, PhD, Wash 7/1/87 – Clinical Mentor U (1996) 12/31/989 during PhD training

5K08MH070840 -02

Past

15

7/1/006/30/03

receptor Pregnancy outcomes

NICHD

Fellow, Developmental Endrocinology Branch, NICHD Fellow, Pediatric Endocrinology, CWRU

Junior, Northwestern U. CWRU undergraduate CWRU medical student High school student (Laurel) Postdoctorate, University of Michigan Assistant Professor, Univ. of KY


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Curriculum Development 1987-1989 1990 1990 1995 1994.1997 1999 2006

Developed Core Curriculum for Neonatal Fellows, Washington University, St. Louis, Missouri. Developed Pediatric Residency Training Course, "Kids and the Environment: Toxic Hazards". Adapted "Kids & the Environment: Toxic Hazards" for CME course for pediatricians, Berkeley, CA. Organized 5 part Grand Round Series on Pediatric Environmental Health, Rainbow Babies and Children’s Hospital, Cleveland, OH. Developed and lead workshop to train physicians on how to teach future leaders in pediatric environmental health, Train-the-Trainers, One Day Workshop, Society for Pediatric Research Developed curriculum, “Training Manual on Pediatric Environmental Health: Putting It Into Practice” Block I leader for new medical school curriculum

RESEARCH GRANT SUPPORT: All Listed Grants are Peer-Reviewed Current Funding 2010

Title: Position: Source: Duration Total Direct Costs:

Mercury in Donor Blood: A Possible Hazard for Preterm Infants Principle Investigator, 10% effort Gerber Foundation 2 years, 7/1/10-6/30/12 $100,000

2007

Title: Position: Source: Duration: Total Direct Costs:

The Role Of Lipid Rafts In Fetal Alcohol Spectrum Disorder. Principal Investigator, 25% effort NIH/NIAAA 1 R01 AA016398-01A1 5 years, 5/1/07 – 4/30/12 $1,000,000

Contracts (Awarded but Remain in OH) 2008

Title: Position: Source: Duration: Total Direct Costs:

National Children’s Study – Lorain County Study Center Principle Investigator, 10% effort NIH/NICHD Contract 5 years, 9/26/08 – 9/25/13 $11,805,585

2008

Title: Position: Source: Duration: Total Direct Costs:

National Children’s Study – Lorain County Study Center Principle Investigator, 10% effort NIH/NICHD Contract 5 years, 9/26/08 – 9/25/13 $11,805,585

Completed National Institutes of Health and Other Federal Grants 16


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

2005

Title: Position: Source: Duration: Total Costs:

2003

Title: Position: Source: Duration: Total Direct Costs:

2001

Title: Position: Source: Duration: Total Costs:

2001

Title:

02/10/13

Building On A Decade of Research Skills Training To Enhance Pediatric Environmental Health Consultant (PI – L. Frisch) U.S. Environmental Protection Agency 3 years (9/1/05 – 8/31/08) $149,881 Prenatal Tobacco Use: Auditory Processing and Language Consultant, Year 1 Co-investigator, Year 5, 5% effort NIH/NICHD 1 R01 HD041203-01A2 (Coles-PI) 5 years, 5/15/03 – 5/14/08 $380,756 (Year 1) Meconium Test to Identify Alcohol-Exposed Pregnancies Principle Investigator, 25% effort AAMC/CDC/ATSDR Cooperative Agreement, MM-012202/02 3 years, 10/1/01 – 9/30/04 (1 year no cost extension) $637, 627

Position: Source: Duration Total Direct Costs:

Center Title: Study of Prevalent Neurotoxicants in Children; Subproject Title: Project 2: Validation of meconium markers of fetal neurotoxicant exposures Subcontract, Principle Investigator, 15% effort NIEHS/EPA PO1 ES11261-01 5 years, 9/1/01 – 8/31/06 $5,787,687 (Total)

2000

Title: Position: Source: Duration: Total Direct Costs:

Fatty Acid Ethyl Esters in Sheep Meconium Principal Investigator, 5% effort NIH RO3 AA12618 2 years 3/1/00 – 2/28/02 $100,000

1999

Title: Position: Source: Duration: Total Direct Costs:

Ethanol and L1-mediated Neurite Outgrowth Principal Investigator, 50% effort NIH RO1 AA011839 5 years 1/1/99 – 12/31/03 $925,327

1997

Title: Position: Source: Duration: Total Direct Costs:

Fetal Alcohol Exposure: Commercial Assay Development Consultant (Principal Investigator – C. Moore) NIH R43 AA11483 (SBIR I) 6 months, 7/1/97 – 12/31/97 $99,954

1993

Title: Position: Source: Duration:

Fetal Alcohol Syndrome and Fatty Acid Ethyl Esters Principal Investigator, 50% effort NIH RO3 AA09836 2 years, 3/1/93 – 2/28/95 17


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

Total Direct Costs:

02/10/13

$100,000

Current Non-Federal Grants 2010 Title: Mercury in Donor Blood – A Possible Hazard for Preterm Infants Position: Principal Investigator, 10% effort Source: Gerber Foundation Duration: 2 years, 7/1/10 – 6/30/12 Total Direct Costs: $100,000 2010

Title: Position: Source:

Safety of Chlorhexidine in Premature Infants Subcontract, 5% effort Institute for Clinical and Translational Research, Johns Hopkins University Duration: 1 year, 7/1/10 – 6/30/11 Total Direct Costs (subcontract): $10,000

2010

Title: Position: Source: Duration: Total Direct Costs:

Center for Infant and Child Loss Principal Investigator, 2.2% effort Maryland Department of Health and Mental Hygiene 3 years, 7/1/10 – 6/30/13 $411,000

Non-Federal Grants 2010

Title: Position: Source: Duration: Total Direct Costs:

2nd Baltimore-Washington Perinatal Club Principal Investigator, 0% effort Abbott Laboratories 5 months, 2/1/10 – 7/1/10 $10,000

2009

Title: Position: Source: Duration: Total Direct Costs:

1st Baltimore-Washington Perinatal Club Principal Investigator, 0% effort Abbott Laboratories 5 months, 2/1/09 – 7/1/09 $10,000

2008

Title: Position: Source: Duration: Total Direct Costs:

3rd Annual Ohio Perinatal Club Principal Investigator, 0% effort Abbott Laboratories 5 months, 2/1/08 – 7/1/08 $9,000

2007

Title: Position: Source: Duration: Total Direct Costs:

Blood Lead Screening Pilot Principal Investigator, 5% effort Sears-Swetland Foundation 1 year, 2/1/08 – 1/31/09 $4,000 18


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

1997

Title: Position: Source: Duration: Total Direct Costs:

Ethanol Inhibition of L1 - Mediated Neurite Outgrowth Principal Investigator Children’s Research Foundation Faculty Fund Grant 1 year 1/1/98 $19,963

1996

Title: Position: Source: Duration: Total Direct Costs:

L1-CAM and Fetal Alcohol Syndrome Principal Investigator Children’s Research Foundation Faculty Fund Grant 1 year 1/1/97 – 12/31/97 $19,864

1996

Title: Position: Source: Duration: Total Direct Costs:

Ethanol Responsive Genes in Developing Cerebral Cortex Principal Investigator Research Initiation Grant, Case Western Reserve University 1 year 7/1/96 – 8/31/97 $5,000

1994

Title: Position: Source: Duration: Total Direct Costs:

Apoptosis and NCAM Expression in Reaggregating Cultures Principal Investigator RB&C Hospital Board of Trustees 1 year 1/1/95 – 12/31/95 $20,000

1994

Title: Position: Source: Duration: Total Direct Costs:

Fatty Acid Ethyl Ester Synthase: Biomarker for Fetal Alcohol Effects Principle Investigator The ARC 1 year 1/1/95 – 12/31/95 $25,000

1992

Title: Position: Source: Duration: Total Direct Costs:

Dietary Fats and Fetal Alcohol Syndrome Principle Investigator The ARC 1 year, 1/1/92 – 12/31/92 $25,000

1992

Title: Position: Source: Duration: Total Direct Costs:

Kids & the Environment: Toxic Hazards Co-Investigator ATSDR 1 year, 9/1/91 – 8/31/92 $35,000

1991

Title: Position: Source: Duration: Total Direct Costs:

Kids & the Environment: Toxic Hazards Co-Investigator ATSDR 1 year, 9/1/90 – 8/31/91 $35,000

1991

Title: Position: Source: Duration: Total Direct Costs:

Mechanisms of Fetal Alcohol Syndrome Principle Investigator Association of Retarded Citizens of the United States 1 year, 1/1/91-12/31/91 $25,000

1990

Title:

Persistent Pulmonary Hypertension and Maternal Smoking 19


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Position: Source:

1990

Duration: Total Direct Costs:

Principle Investigator Tobacco-Related Disease Research Program, University of California 2 years, 7/1/90 – 6/30/92 $200,000

Title: Position: Source: Duration: Total Direct Costs:

Pediatric Environmental Health Principle Investigator East Bay Neonatology Foundation 1 year 1/1/90 – 12/31/90 $15,000

PATENTS: Bearer CF.

Detection of Teratogen Exposure, Patent Number 5,952,235. Awarded September 14, 1999.

PUBLICATIONS: Peer Reviewed (Mentees names in italics): 1.

Bearer CF, Neet KE. Threonine inhibition of the aspartokinase-homoserine dehydrogenase I of E. coli: Threonine binding studies. Biochemistry 1978; 17:35123516.

2.

Bearer CF, Neet KE. Threonine inhibition of the aspartokinase-homoserine dehydrogenase I of E. coli: Stopped-flow kinetics and the cooperativity of inhibition of the homoserine dehydrogenase activity. Biochemistry 1978; 17:3517-3522.

3.

Bearer CF, Neet KE. Threonine inhibition of the aspartokinase-homoserine dehydrogenase I of E. coli: A slow transient and cooperativity of inhibition of the aspartokinase activity. Biochemistry 1978; 17:3523-3530

4.

Birnbaumer L, Bearer C, and Iyengar R. A two-state model of an enzyme with an allosteric regulatory site capable of metabolizing the regulatory ligand. Simplified mathematical treatments of transient and steady state kinetics of an activator and its competitive inhibition as applied to adenylyl cyclases. J Biol Chem 1980; 255:35523557.

5.

Bearer CF, Knapp RD, Kaumann AJ, Swartz TL, and Birnbaumer L. Iodohydroxybenzylpindolol: Preparation, purification, localization of its iodine to the indole ring, and characterization as a partial agonist. Mol Pharmacol 1980; 17:328-338.

6.

Rosenfeld GC, Strada SJ, Dial EJ, Bearer CF, and Thompson WJ. Histamine, cyclic nucleotides, and gastric parietal cell secretion. Adv Cyclic Nucleotide Res 1980; 12:255266.

7.

Bearer CF, Chang K, Rosenfeld GC, and Thompson WJ. Histamine stimulation of rat gastric parietal cell adenyl cyclase: Modulation by guanine nucleotides. Arch Biochem Biophys 1981; 207:325-336. 20


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

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8.

Gropper R, Brandt RA, Elias S, Bearer CF, Mayer A, Schwartz AL, and Ciechanover A. The ubiquitin-activating enzyme, El, is required for stress-induced lysosomal degradation of cellular proteins. J Biol Chem 1991; 266:3602-3610.

9.

Bearer CF, Gould S, Emerson R, Kinnunen P, and Cook CS. Fetal alcohol syndrome and fatty acid ethyl esters. Pediatr Res 1992; 31:492-495.

10.

Warshaver Y, Bearer CF, and Belchis D. Osteogenesis Imperfecta and Ebstein's Anomaly: A case report with autopsy findings. Pediatr Pathol 1992; 12:425-431.

11.

Bearer CF and Phillips R. Pediatric environmental health training: Impact on resident behavior. Am J Dis Child 1992; 147:682-684.

12.

Bearer CF. EMF and infant incubators. Arch Environ Health 1994; 49:352-354.

13.

Bearer CF and Emerson RK. Fetal activity of fatty acid ethyl ester synthases. Research Communications in Alcohol and Substances of Abuse 1995; 16:189-194.

14.

Crump C, Bearer CF, Paschal DC, Rodenbaugh D, and Etzel RA. Mercury exposure in high school chemistry teachers. Arch Environ Contam Toxicol 1996; 31:206-209.

15.

Bearer CF, Emerson RK, Roitman ES, and Shackleton C. Maternal tobacco smoke exposure and persistent pulmonary hypertension of the newborn. Environ Health Perspect 1997; 105:202-206.

16.

Horowitz RS, Dart RC, Jarvie DR, Bearer CF, and Gupta U. Placental transfer of Nacetylcysteine following human maternal acetaminophen toxicity. J Toxicol Clin Toxicol 1997; 35:447-51.

17.

Bearer CF, Lee S, Salvator AE, Minnes S, Swick A, Yamashita T and Singer L. Ethyl linoleate in meconium: A biomarker for prenatal ethanol exposure. Alcohol Clin Exp Res 1999; 23:487-493.

18.

Claudio L, Bearer CF, Wallinga D. Assessment of the U.S. Environmental Protection Agency methods for identification of hazards to developing organisms. Part I: The reproductive and fertility testing guidelines. Am J Ind Med 1999; 35:543-553.

19.

Claudio L, Bearer CF, Wallinga D. Assessment of the U.S. Environmental Protection Agency methods for identification of hazards to developing organisms. Part II: The developmental toxicity testing guidelines. Am J Ind Med 1999; 35:554-563.

20.

Bearer CF, Swick AR, O’Riordan MA and Cheng G. Ethanol inhibits L1 mediated neurite outgrowth in postnatal day 6 cerebellar granule cells. J Biol Chem 1999; 274:13264-13270.

21.

Bearer CF, O’Riordan MA, and Powers R. Lead exposure from blood transfusion to premature infants. J Pediatr 2000; 137:549-54.

22.

Bearer CF. The special and unique vulnerability of children to environmental hazards. Neurotoxicology 2000: 21:925-934. 21


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

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23.

Bearer CF. L1 Cell Adhesion Molecule Signal Cascades: Targets for Ethanol Developmental Neurotoxicity. Neurotoxicology 2001;22:625-33.

24.

Nagy LE, Lakshman MR, Casey CA, Bearer CF. Ethanol and membrane protein trafficking: diverse mechanisms of ethanol action. Alcohol Clin Exp Res. 2002 Feb;26(2):287-93.

25.

Bearer CF. Meconium as a biological marker of prenatal exposure. Pediatrics, 2003;3:40-43.

26.

Noland JS, Singer LT, Arendt RE, Minnes S, Short EJ, Bearer CF. Executive functioning in preschool-age children prenatally exposed to alcohol, cocaine, and marijuana. Alcohol Clin Exp Res. 2003 Apr;27(4):647-56.

27.

Bearer CF, Linsalata N, Yomtovian R, Walsh M, Singer L. Blood transfusions: a hidden source of lead exposure. Lancet 2003;362(9380):332.

28.

Bearer CF, Jacobson JL, Jacobson SW, Barr D, Croxford J, Molteno CD, Viljoen DL, Marais AS, Chiodo LM, Cwik AS. Validation of a new biomarker of fetal exposure to alcohol. J Pediatr 2003 Oct;143(4):463-9.

29.

Moya J, Bearer CF, Etzel R. Children’s behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics 2004;113(4 Suppl):996-1006.

30.

Bearer CF, Santiago LM, O’Riordan MA, Buck K, Lee S, Singer LT. Fatty acid ethyl esters: Quantitative biomarkers for maternal alcohol consumption. J Pediatr 2005; 146:824-830.

31.

Lanphear B, Bearer CF. Biomarkers in paediatric research and practice. Archives of Disease in Childhood, 2005;90:594-600.

32.

Noland JS, Singer LT, Short EJ, Minnes S, Arendt RE, Kirchner HL, Bearer CF. Prenatal drug exposure and selective attention in preschoolers. Neurotoxicology and Teratology 2005;27:429-438.

33.

Bearer CF, Stoler JM, Cook JD. Biomarkers of alcohol use in pregnancy. Alcohol Research and Health, NIAAA publications 2005;28:38-43 (pubs.niaaa.nih.gov/publications/arh28-1/38-43.pdf).

. 34.

Ambulatory

Tang, N, O’Riordan MA, Farkas C, Lemmon V, Bearer CF. Ethanol inhibits L1 cell adhesion molecule activation of mitogen activated protein kinases. J Neurochem 2006; 96:1480-90.

35.

Nock ML, O'Riordan MA, Tang N and Bearer CF. L1 cell adhesion molecule found in human CSF varies as a function of age. Experimental Neurology 2006;202:262-265.

36.

Lindsley T, Miller MW, Littner Y, Bearer CF. Signaling pathways regulating cell motility: A role in ethanol teratogenicity? Alcohol Clin Exp Res 2006;30(8):1445-50.

37.

Littner Y, Bearer CF. Detection of alcohol consumption during pregnancy-Current and future biomarkers. Neurosci Biobehav Rev. 2007;31(2):261-9.

22


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

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38.

Gubitosi-Klug R, Larimer CG, Bearer CF. L1 cell adhesion molecule is neuroprotective of alcohol induced cell death. Neurotoxicology, 2007;28:457-462.

39.

Littner Y, Cudd TA, O'Riordan MA, Cwik A, Bearer CF. Elevated Fatty Acid Ethyl Esters in Meconium of Sheep Fetuses Exposed In Utero to Ethanol-A New Animal Model. Pediatr Res. 2008 Feb;63(2):164-8. Epub 2007 Dec 10.

40.

Lai TT, Bearer CF. Iatrogenic environmental hazards in the neonatal intensive care unit. Clin Perinatol. 2008 Mar;35(1):163-81.

41.

Peterson J, Kirchner HL, Xue W, Minnes S, Singer LT, Bearer CF. Fatty acid ethyl esters in meconium are associated with poorer neurodevelopmental outcomes to two years of age. J Pediatr. 2008 Jun;152(6):788-92. Epub 2008 Jan 10.

42.

Bearer CF, Stefanak MA. Looking Ahead to a Tobacco Free Future (editorial). J Pediatr. 2009 Jan;154(1):4-5. Epub 2008 Nov 5.

43.

Yeaney N, He M, Tang N, Malouf A, O'Riordan M, Lemmon V, Bearer CF. Ethanol inhibits L1 cell adhesion molecule tyrosine phosphorylation and dephosphorylation and activation of pp60src. J Neurochem 2009 Aug;110(3):779-90. Epub 2009 May 3.

44.

Bearer C, Bailey S, Hoek J. Advancing alcohol biomarkers research. Alcohol Clin Exp Res 2010, Jun;34(6):941-5. Epub 2010 Apr 5.

45.

Braun JM, Daniels JL, Poole C, Olshan AF, Hornung R, Bernert JT, Xia Y, Bearer C, Barr DB, Lanphear BP. A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight. Environ Health. 2010 Aug 27;9(1):53.

46.

Gifford AE, Farkas KJ, Jackson LW, Molteno CD, Jacobson JL, Jacobson SW, Bearer CF. Assessment of benefits of a universal screen for maternal alcohol use during pregnancy. Birth Defects Res A Clin Mol Teratol 2010, Oct;88(10):838-46.

47.

Tang N, Farah B, He M, Fox S, Malouf A, Littner Y, Bearer CF. Ethanol causes the redistribution of L1 cell adhesion molecule in lipid rafts. J Neurochem 2011 Sep 2. doi: 10.1111/j.1471-4159.2011.07467.x. [Epub ahead of print]

. Other Publications: Bearer CF. How are school aged children and adolescents different from adults? 1994, Office of Technology Assessments, Congress of the United States Bearer CF. Environmental health hazards: How children are different from adults. The Future of Children 1995; 4:11-26. Bearer CF. How are children different from adults? Environ Health Perspect 1995; 103 (Suppl 6):7-12. American Academy of Pediatrics Committee on Environmental Health. ETS - A Hazard to 23


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Children. Pediatrics 1997; 99:639-642. American Academy of Pediatrics Committee on Environmental Health. (Bearer CF - primary author). Noise - hazard for the fetus and newborn Pediatrics 1997; 100:724-727. Child Health Workgroup. Healthy children - toxic environments. (1997). U.S. Department of Health and Human Services, Agency for Toxic Substance and Disease Registry, Atlanta, GA. Bearer CF. Book Review: Abel EL (ed) “Fetal Alcohol syndrome: From Mechanism to Prevention.” J Studies Alcohol 1997; 59:350-351. Bearer CF. Biomarkers in pediatric environmental health: A cross-cutting issue. Environ Health Perspect 1998; 106 (Suppl 3):813-816. Landrigan PJ, Carlson JE, Bearer CF, Cranmer JS, Bullard RD, Etzel RA, Groopman J, McLachlan JA, Perera FP, Reigart JR, Robison L, Schell L, and Suk WA. Children’s health and the environment: A new agenda for prevention research. Environ Health Perspect 1998; 106 (Suppl 3):787-794. Bearer CF. Commentary: Pediatricians urged to support tougher new food safety law. AAP News 1999; 15:30. Bearer CF. Markers to detect drinking during pregnancy. Alcohol Research & Health. 2001;25(3):210-8. Bearer CF. Book Review: Fleming TP (ed) “Cell-Cell Interactions.” Quarterly Review of Biology, 2003;78(2):222. Chronicle Guidance Publications, Inc. Neonatologists, 2004, Moravia, NY. Needleman HL, Reigart JR, Landrigan P, Sass J, Bearer C. Benefits and risks of pesticide testing on humans. Environ Health Perspect. 2005 Dec;113(12):A804-5. Commentary. Farah B, Chang C, Bearer C, editors. Ethical Issues in Children's Environmental Health Research. Mini-monograph. Environ Health Perspect. 114:1603-1629. Books: National Research Council and Institute of Medicine. (2004). Children’s Health, the Nation’s Wealth: Assessing and Improving Child Health. Committee on Evaluation of Children’s Health.NAS/NRC/IOM. Committee to Evaluate Children’s Health. Children’s Health. Board on Children, Youth, and Families, Division of Behavioral and Social Sciences and Education. Washington, DC: The National Academies Press. Book Chapters: Bearer CF. Commentator, IN: Klaus, M. and Fanaroff, A. Care of the High Risk Neonate, 4th edition, WB Saunders Company, Philadelphia, 1993. Bearer, C.F. Reviewer, IN: Klaus, M. Yearbook of Neonatology, Mosby-Yearbook, St. Louis, 1991, 1992, 1993, 1994, 1995, 1996, 1998, 2000, 2001, 2002.

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Bearer CF: Developmental toxicology. IN: Brooks S (ed) Comprehensive Textbook of Environmental Medicine, Mosby-Yearbook, St. Louis, 1995. Bearer CF. Occupational and environmental risks to the fetus. IN: Martin R, Fanaroff A (eds) Neonatal-Perinatal Medicine, 6th edition, Mosby-Yearbook, St. Louis, 1997. Bearer CF. Occupational and environmental risks to the fetus. IN: Martin R, Fanaroff A (eds) Neonatal-Perinatal Medicine, 7th edition, Mosby-Yearbook, St. Louis, 2001. Bearer CF. Developmental neurotoxicity, IN: Paulson J (ed), Pediatric Clinics of North America, W.B. Saunders Company, Philadelphia, 2001,48:1199-1213. Bearer CF. Mechanisms of brain injury, IN: Bodensteiner JB (ed) Seminars in Pediatric Neurology, Scher M (guest ed) Fetal and Neonatal Brain Disorders, W.B. Saunders Company, Philadelphia, 2001; 8:100-107. Gitterman BA, Bearer CF. A developmental approach to pediatric environmental health, IN: Pediatr Clin North Am. 2001 Oct;48(5):1071-83. Bearer CF. Contributor, Committee on Environmental Health, American Academy of Pediatrics. Handbook of Pediatric Environmental Health, 1st, 2nd, and 3rd editions. Etzel RA, Balk SJ (eds). American Academy of Pediatrics, Elk Grove Village, IL.. Bearer CF. Occupational and environmental risks to the fetus. IN: Martin R, Fanaroff A (eds) Neonatal-Perinatal Medicine, 8th edition, Mosby-Yearbook, St. Louis, 2005. Bearer CF. Occupational and environmental risks to the fetus. IN: Martin R, Fanaroff A, Walsh, M (eds) Neonatal-Perinatal Medicine, 9th edition, Mosby-Yearbook, St. Louis, 2010.

Abstracts: (* Presentations at National Meetings, mentees are italicized) *Bearer CF, Neet KE. Aspartokinase-homoserine dehydrogenase (AK-HSD): Stopped-flow kinetics and cooperativity. Fed. Proc 1977; 36:858. Swartz TL. Bearer CF, Iyengar R, Abramowitz J, Birnbaumer L. A two-state model for regulation of liver adenylyl cyclase by guanyl nucleotides: dependency on the presence of a GTPase. Fed Proc 1979; 38:645. *Bearer CF, Chang LK, Rosenfeld GC, Thompson WJ Interactions of acid secretagogues with adenylyl cyclase of rat gastric parietal cells. Fed Proc 1979; 38:596. *Bearer CF, Mattes PM, Littlefield JW, Pedersen PL Respiratory coupling, Ca ++ and Mg++ Levels, and aging in cystic fibrosis and normal fibroblasts. Pediatr Res 1982; 16:344A. *Bearer CF, Ciechanover A, Schwartz AL. Degradation of cell surface proteins by the ubiquitin pathway. J Cell Biol 1987; 105:54a. 25


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*Bearer CF, Gould S, Cho S, Kinnunen PK, Cook CS. Fatty acid ethyl esters and fetal alcohol syndrome. Teratology 1991; 43:438. *Bearer CF, Meiko J, Irias JJ. Lead exposure from blood transfusion. Clin Res 1992; 40:4A. *Bearer CF, Meiko J, Irias JJ, Lubin B. Lead exposure from blood transfusion. Pediatr Res 1992; 31:137A. *Bearer CF, Emerson R, Harm L. Fatty acid ethyl esters in peripheral blood. Pediatr Res 1992;. 31:68A. *Bearer CF, Roitman E, Gemmel D. Persistent pulmonary hypertension and maternal smoking. Pediatr Res 1993; 33:255A. *Bearer CF, Emerson R. Fetal activity of fatty acid ethyl ester synthase. Pediatr Res 1993; 33:72A. *Powers RJ, Lee C, Irias JJ, Lubin B, Bearer CF. Lead exposure from blood transfusions in VLBW infants. Pediatr Res 1993; 33:144A. Bearer CF, Phillips R. Pediatric environmental health training: impact on pediatric residents. Pediatr Res 1993; 33:114A. Bearer CF, Long PJ. Electromagnetic fields and infant incubators. Pediatr Res 1993; 33:202A. Bearer CF, McQuitty J, Durand D, Asselin J, Birch M. Pediatric consequences of methyl isothiocyanate exposure. Pediatr Res 1993; 33:378A. *Bearer CF, Rodenbaugh D. Uncoupling of mitochondria by fatty acid ethyl esters. Alcohol Clin Exp Res 1995; 19:79A. *Bearer CF, Rodenbaugh D. Uncoupling of mitochondria by fatty acid ethyl esters. Pediatr Res 1995; 37:81A. *Bearer CF, Swick A, Singer L. FAEE: biomarker for prenatal alcohol use. Alcohol Clin Exp Res 1996; 20:139A. *Bearer CF, Swick A. Developmental expression of FAEE synthase activity in fetal brain reaggregate cultures. Alcohol Clin Exp Res 1996; 20:29A. *Bearer CF, Swick A, Singer L. FAEE: Biomarker for prenatal alcohol use. Am J Public Health 1996; 277A. *Bearer CF, Swick A, Buck KJ, Lemmon V. Ethanol inhibits L1-mediated neurite outgrowth. Alcohol Clin Exp Res 1997; 21:47A. *Bearer CF, Yamashita T, Lee SC, Minnes S, Singer L. Meconium FAEE and maternal ethanol use. Alcohol Clin Exp Res 1997; 21:119A.

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*Bearer CF, Swick AR, Cheng G, Buck K. Ethanol inhibition of L1 mediated neurite outgrowth is independent of L1 mediated cell adhesion. Alcohol Clin Exp Res 1998; 22:23A. *Bearer CF, Moore C, Salvatore AE, Lee SC, Buck KJ, Singer L. Meconium FAEE: development of a biological marker. Alcohol Clin Exp Res 1998; 22:103A. *Bearer C, Buck K, Swick A, O’Riordan M. Ethanol inhibits both L1 mediated neuritogenesis and neurite outgrowth. Alcohol Clin Exp Res 1999; 23:29A. *Yeaney NK, Bearer C. Effects of ethanol on axonal sorting of L1 cell adhesion molecule. Neurotoxicology 2000; 21:260. *Bearer CF, Salvator AE, Washah SK, Lee S, Buck K, Singer LT. Quantitating prenatal ethanol exposure by meconium analysis. Pediatr Res 2000; 47:81A. *Yeaney N, Bearer CF. Effects of ethanol on L1 cell adhesion molecule distribution at the growth cone. Alcohol Clin Exp Res 2000, 24:31A. *Bearer CF, Salvator AE, Lee S, Buck K, Swick A, Haxhui R, Washah S, Singer LT. FAEE in meconium predicts outcome.. Alcohol Clin Exp Res 2000, 24:102A. *Yeaney N, Bearer CF. Ethanol and L1 cell adhesion molecule distribution. Pediatr Res 2001; 49:183A. *Bearer CF, Salvator AE, Lee S, Buck K, Singer L. A comparison of FAEE in meconium to maternal self reported drinking in predicting neurodevelopment. Pediatr Res 2001; 49:183A. *Farkas C, Bearer CF. FAEE in meconium of premature infants: A marker of increase risk for IVH/PVL? Pediatr Res 2001; 49:183A. *Bearer CF, Buck K. Ethanol inhibits L1 cell adhesion molecule activation of mitogen activated protein kinases. Pediatr Res 2002; 51:66A. *Bearer CF, Buck K. Ethanol Inhibits L1 activation of ERK1/2. Alcohol Clin Exp Res 2002; 26:9A. *Bearer CF, Jacobson JL, Jacobson SW, Barr D, Croxford J, Chiodo L, Molteno C, Viljoen D. Investigation of a biomarker for prenatal ethanol exposure in a South African population. Pediatr Res 2003; 53:567A (Abstract 3211). *Bearer CF, Jacobson JL, Jacobson SW, Barr D, Croxford J, Chiodo LM, Molteno CD, Viljoen D. Validation of a new biomarker of fetal exposure to alcohol. Alcohol Clin Exp Res 2003; 27:39A (Abstract 201). *Yeaney NK, Bearer CF. Ethanol and growth cone membrane expression of L1. Alcohol Clin Exp Res 2003; 27:83A (Abstract 464). *Santiago LM, Bearer CF. A linear combination of fatty acid ethyl esters as quantitative 27


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biomarkers for maternal alcohol consumption. NIH Digital Biology: The Emerging Paradigm 2003. *Yeaney NK, O’Riordan MA, Buck K, Bearer CF. Ethanol increases filopodial length of growth cones on L1 cell adhesion molecule: A role for lipid rafts? Pediatr Res 2004;55:275A (Abstract 1567). *Santiago LM, Singer LT, Bearer CF. A linear combination of fatty acid ethyl esters as quantitative biomarkers for maternal alcohol consumption. Pediatr Res 2004;55:271A (Abstract 1540). *Bearer CF, Chen Y, Buck K. Ethanol abolishes tyrosine phosphorylation of L1 cell adhesion molecule. Pediatr Res 2004;55:580A (Abstract 3296). *Santiago LM, Singer LT, Bearer CF. A linear combination of fatty acid ethyl esters as quantitative biomarkers for maternal alcohol consumption. Alcohol Clin Exp Res 2004;2841A (Abstract 207). *Croxford J, Jacobson J, Bearer C, Jacobson S, Molteno C, Viljoen D. The influence of variable storage conditions in the preservation of meconium specimens used for assessment of FAEEs in neonates prenatally exposed to alcohol. Alcohol Clin Exp Res 2004;28:41A (Abstract 208) *Bearer CF, Chen Y, Buck K. Ethanol abolishes tyrosine phosphorylation of L1 cell adhesion molecule. Alcohol Clin Exp Res 2004;28:52A (Abtract 275). *Yeaney NK, Buck K, O’Riordan MA, Bearer CF. Ethanol increases filopodial length of growth cones on L1 cell adhesion molecule: A role for lipid rafts? Alcohol Clin Exp Res 2004;28:88A (Abstrract 490). *Tang NF, Farah B, Bearer CF. Ethanol shifts L1 cell adhesion molecule into lipid rafts. Pediatr Res 2005; 6890:514. *Peterson J, O’Riordan MA, Minnes S, Singer L, Bearer CF. Effect of fatty acid ethyl esters on neurodevelopmental outcome. Pediatr Res 2005;6890:519A. *Littner Y, Cwik A, Chang C, Cudd T, Bearer CF. Fatty acid ethyl esters in meconium of fetuses exposed in utero to ethanol – a new animal model. Pediatr Res 2005;6890:520. *Peterson J, O’Riordan MA, Minnes S, Singer L, Bearer CF. Relationship of fatty acid ethyl esters in meconium to neurodevelopmental outcome. Alcohol Clin Exp Res 2005;29:44A (Abstract 225). *Littner Y, Cwik A, Chang C, Cudd T, Bearer CF. Fatty acid ethyl esters in meconium of fetuses exposed in utero to ethanol – a new animal model. Alcohol Clin Exp Res 2005;29:44A (Abstract 224). *Tang N, Farah B, Bearer CF. Ethanol shifts L1 cell adhesion molecule into lipid rafts. Alcohol Clin Exp Res 2005;29:178A (Abstract 31).

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Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

*Littner Y, Bearer CF. Ethanol and neurite outgrowth. Alcohol Clin Exp Res 2005;29:184A (Abstract 71). *Blatz AM, Walsh MC, Dearborn D, Bearer CF. Metal contamination of blood bank blood. Pediatr Res 2006, Abstract 461. (Winner, St. Geme Award) *Tang N, Min H, Bearer CF. Ethanol alters the distribution of target proteins in lipid rafts. Pediatr Res 2006, Publication 4124.6 (Platform symposium). *Littner Y, Tang N, He M, Bearer CF. Binge ethanol feeding induces dose dependent inhibition of L1 dephosphoryation. Pediatr Res 2007, Publication 7735.7 (Platform symposium). *Tang N, He M, Bearer CF. GM1 gangliosides and choline reverse the effect of ethanol on lipid rafts. Pediatr Res 2007, Publication 7735.8 (Platform symposium). *He M, Tang N, Bearer CF. Choline and GM1 ganglioside supplementation abolish the ethanol inhibition of L1 cell adhesion molecule activation.of extracellular signal-related kinases (ERK1/2). Pediatr Res 2009, Publication 3871.343 *Tang N, He M, Bearer CF. Ethanol acts on L1 cell adhesion molecule activation of pp60src to inhibit downstream signal transduction. Pediatr Res 2009, Publication 3882.454 *Tang N, He M, Bearer CF. Changes in palmitoylation of L1 cell adhesion molecule do not underlie its redistribution to lipid rats in the presence of ethanol. Pediatr Res 2009, Publication 4343.263 *Lai TT, Tang N, He M, Bearer CF. The effects of benzyl alcohol and propylene glycol on L1 mediated activation of ERK 1/2. Pediatr Res 2009, Publication 3871.334 *Lai TT, Anesi G, Donavan L, Reddy M, Young J, Bearer CF, Walsh MC. Noise reduction in the neonatal intensive care unit. Pediatr Res 2009, Publication 5505.85 *He M, Hopkins I, Bamford P, Tang N, Shi D, McKenna MC, Bearer CF. Hypoxic-ischemic insult redistributes L1 cell adhesion molecule in lipid rafts. Pediatr Res 2010, Publication 2849.288 *Tang N, Bamford P, He M, McKenna MC, Bearer CF. Ethanol redistributes L1 cell adhesion molecule in lipid rafts. 4th ISN Special Neurochemistry Conference, Erice, Sicily. *Tang N, He H, Bamford P, Bearer CF. Ethanol targets lipid rafts leading to redistribution of L1. Research Society on Alcoholism, 2010. *He M, Tang N, Bamford P, Bearer CF. Lipid rafts are essential for activation of pp60src and ERK1/2. Research Society on Alcoholism, 2010. *Bamford P, Tang N, He M, Bearer CF. Choline and GM1 ganglioside attenuate the inhibition of L1 mediated neurite outgrowth by ethanol. Research Society on Alcoholism, 2010.

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Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

INTERNATIONAL PRESENTATIONS Poland – Toxins and Tots, PSR/WHO, Katowice, Poland, March 1993. Poland – Moderator, Risk Communication Roundtable, International Pediatric Environmental Health Conference, Sosnowiec, Poland, May 8 – 10, 1996. Finland – Keynote Speaker, Perinatal Society, Invited March, 2003. Slovakia- Pediatric Environmental Health, September 9,10, 2006 Italy - Biomarkers of Fetal Alcohol Exposure, June 19, 2007 Slovakia – Pediatric Environmental Health, November 10, 11, 2007 Sicily, Italy – Ethanol redistributes L1 cell adhesion molecule in lipid rafts, May 26, 2010 NATIONAL PRESENTATIONS (SINCE 1990) 1990 Windows of Effects, Windows of Danger. Testimonial to the U.S. House of Representatives Subcommittee on Children, Youth and Families. September 6. Fetal Alcohol Syndrome. Conference on Parental Exposures, Commonweal, Bolinas, CA. November 15. Windows of Danger, Windows of Effect". Keynote speaker for American Cancer Society Great American Smoke Out, Bakersfield, CA. November 16. 1991 Fetal Alcohol Syndrome. Panelist on "People Are Talking". April 10. Kids and the Environment: Toxic Hazards. National Conference for Community Health Centers, San Francisco, CA. September 22. Environmental Hazards. American Society of Medical Technologists - Annual Meeting, April 22. Developmental Approach to Environmental Toxins. EPOCH Epi, Lexington, Kentucky. May 30. Health Effects of Electromagnetic Fields. Public Hearing sponsored by League of Women Voters, Fresno, CA. November 23. 1992 Medical Consequences of Toxic Exposures: Issues for Judges. Winter College, National Council of Juvenile and Family Court Judges, Reno, NV. January 30. Developmental Approach to Pediatric Environmental Health. AAP National Conference, San Francisco, CA. October. Fetal Alcohol Syndrome. Faculty, National Council of Juvenile and Family Court Judges, Winter College, University of Nevada at Reno, Reno, NV. December. 1993 Fetal Alcohol Syndrome. The Twelfth Annual Triple Header Conference, Faculty, National Council of Juvenile and Family Court Judges, National College of Juvenile and Family Law, Sarasota, FL. April 25-29.

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Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Pediatric Environmental Health Research Workshop, National Institute of Environmental Health Science, Research Triangle Park, NC. June 24-25. 1994 How are Children Different from Adults? Plenary Speaker, Preventing Child Exposure to Environmental Hazards: Research and Policy Issues, The Children's Environmental Health Network National Symposium, Washington, DC. March 18. Developmental Approach to Pediatric Environmental Health. Physicians for Social Responsibility National Meeting, Washington, DC. March 19-20. Biochemical Mechanisms of Fetal Alcohol Syndrome. Midwest Teratology Conference, Spencerville, OH. April 15. Diet-Induced Alterations in Tissue Fatty Acids, Protection from Alcohol Teratogenesis? Dysmorphology/Teratology Club Meeting, Society for Pediatric Research, Seattle, WA. May 3. Prenatal Exposure to Lead. The Alliance to End Child Poisoning, Washington, DC. May 16-17. Developmental Toxicology: The Hostile Fetal Environment. The Fetus & Newborn: State-ofthe-Art-Care, New Orleans, LO. September 19-21. Kids and the Environment: Lead and Beyond. American Academy of Pediatrics Annual Meeting/Spring Session, Dallas, TX. October 22-23. Great Lakes Environmental Health Curriculum Workshop, Medical College of Wisconsin, Racine, WI. November 4-6. 1995 Environmental Risks to the Fetus. Fifth Annual Hidden Valley Neonatology Conference, Hidden Valley, PA. February 15. Developmental Stages in Environmental Health. Pediatric Grand Rounds, Medical University of South Carolina, Charleston, SC. April 7. Fatty Acid Ethyl Ester: Mediators of Fetal Alcohol Syndrome? Research Seminar, Medical University of South Carolina, Charleston, SC. April 7. Children-Vulnerable and Susceptible. Executive Staff Briefing, The White House, Washington, DC. September 7. Invited participant, Workshop on Human Variability. Group on Reproductive/Developmental Effects. International Life Sciences Institute: Risk Science Institute, Washington, DC. October 16-17. 1996 Children and the Environment. Electronic seminar. Coalition for America’s Children, February 22. Healthy Child, Healthy World Workshops, New York State Association of County Health Officials, Rochester and Albany, NY. August 13-14. Environmental Vignettes from a Neonatologist. Invited Seminar, School of Public Health SUNY, Albany, NY. August 15. Children and the Environment. Congressional Staff Briefing, Washington, DC, September 10. Children and Environmental Hazards Conference, A Susceptible Population: How Children Develop & Behave, Pennsylvania State University, University Park, PA. October 17. Genetic Susceptibility: What Role Does it Play in Pediatric Environmental Health? Plenary Session - Emerging Issues in Children’s Environmental Health, American Public Health Association Annual Meeting, NYC. November 19. 1997 31


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Presenter, NIH/NIAAA Special Emphasis Panel on Fetal Alcohol Syndrome, May 12-13. Pre-and Post-natal Markers for Fetal Alcohol Exposure. Keynote Speaker, Fetal Alcohol Syndrome Study Group, RSA, San Francisco, CA, July 19. 1998 Presenter, Interagency Coordinating Committee on Fetal Alcohol Syndrome, NIH, December 23. Keynote Speaker, How Habitable is the Village? Translating Research into Clinical Practice and Policy. NIH/NIEHS/EPA/CDC Children’s Environmental Health and Disease Prevention Research Centers, Grantees Meeting. November 4-6. 1999 Presenter, Susceptibility Related to Differential Sensitivity. Workshop on The Role of Human Exposure Assessment in the Prevention of Environmental Disease, NIH/NIEHS, Rockville, MD. September 22-24. Invited Speaker, Seventeenth International Neurotoxicology Conference, “Children’s Health and the Environment: Mechanisms and Consequences of Developmental Neurotoxicology,” Little Rock, AK, October 17-20. Co-Chair, Session VII. Developmental Neurotoxicology in Children: Framing the Problem, Seventeenth International Neurotoxicology Conference, Little Rock, AK, October 19. 2000 Panelist, Cellular & Molecular Mechanisms. Endocrine Disruptors & Children’s Health: A Workshop to Examine the Effects of Endocrine Disruptors on Child Development for a National Longitudinal Study. Center for Children’s Health and the Environment, New York Academy of Medicine, March 16-17. Presenter, What is Behavioral Teratology and What Does It Have To Do with Pediatric Psychology? The Millennium Conference of the Great Lakes Society of Pediatric Psychology: Practice, Research, and Policy Concerning Interventions with Pediatric Populations, Cleveland, OH, March 30. Presenter, L1 Cell Adhesion Molecule: A Target for Developmental Neurotoxicants. Superfund Conference, SUNY Albany School of Medicine, April 3. Keynote Speaker, Health Effects of Persistent Organic Pollutants. SUNY Albany School of Medicine, April 3. Biological markers of prenatal ethanol exposure and effect. Fetal Alcohol Syndrome Study Group, RSA, Denver, CO June 24. Invited Speaker, Eighteenth International Neurotoxicology Conference, “Children’s Health and the Environment 2000,” Colorado Springs, CO September 23. Co-Chair, Session II. Tutorials. Eighteenth International Neurotoxicology Conference, Colorado Springs, CO, September 23. Co-Chair, Session XII. Hot New Topics/Controversial Issues, Eighteenth International Neurotoxicology Conference, Colorado Springs, CO, September 26. 2001 Faculty: New Data on Neurological/Behavioral Effects of Persistent Organic Pollutants. In: Global Environmental Change: The Science and Human Health Impacts: A Course for Senior Congressional Staff. Center for Health and the Global Environment, Harvard Medical School. Airlie Center, Warrenton, VA, April 9-10. Invited Speaker, RSA Satellite Workshop, Detection of Prenatal Fetal Alcohol Exposure, sponsored by NIH/NIAAA, “Fatty acids ethyl esters in meconium,” Montreal, Cananda, June 22. 32


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Symposium presentation, “Ethanol and L1-mediated neurite outgrowth: receptor recycling and L1 signal transduction,” in Ethanol and Membrane Protein Trafficking: Diverse mechanisms of Ethanol Action, Research Society on Alcoholism, Montreal, Canada, June 24. Platform Presentation, “Biomarkers of Prenatal Alcohol Exposure”, International Society on Exposure Analysis, November 6. 2002 Invited speaker/participant, “Biomarkers for the assessment of exposure and toxicity in children”, Workshop on Chemicals and Drugs in Breast Milk, NICHD/FDA/OWHDHHS, April 24-25. Department of Neuroscience Research Seminar, “Ethanol Inhibition of L1 Cell Adhesion Molecule”, SUNY Albany School of Medicine, September 9. 2003 Grand Rounds, Department of Pediatrics, “Developing a Biomarker for Prenatal Alcohol Exposure”, Tuft University School of Medicine, Boston, MA, February 22. Invited lecturer, Graduate Program in Pathobiology, “New Insights into Fetal Alcohol Syndrome”, Brown University, Providence, RI, April 24. Cincinnati Children’s Neonatology Grand Rounds, “Fetal Alcohol Syndrome: Linking Cellular Mechanisms of Toxicity, Exposure & Neurodevelopmental Outcome”, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, August 15. Invited Speaker, 30th Anniversity Conference, The Truth and Consequences of Fetal Alcohol Syndrome, Atlantic City, NJ, October 27-28. Resident Rounds, Department of Pediatrics, “What’s an Environmentalist Doing in the NICU?”, Oakland Children’s Hospital, Oakland, CA, November 17. Sponsored speaker, 6th National Environmental Public Health Conference, CDC/ATSDR. “NHANES and Beyond.” December 4. Invited speaker, 6th Annual Frontiers in Pediatrics, Medical University of South Carolina, “Biomarkers in the Nursery” and “Meconium Screening: Toxic Effects on Fetus and Newborn.” December 5,6. 2004 Winter Quarter Department of Environmental Health Seminar Series, “Fetal Alcohol Syndrome: Linking Cellular Mechanisms of Toxicity, Exposure & Neurodevelopmental Outcome”, University of Cincinnati, Cincinnati, OH, February 18. Invited Interview, Living on Earth, National Public Radio, February 20. Speaker, Town Hall Meeting, Fetal Alcohol Spectrum Disorder, Ohio Department of Health, Columbus, OH, September 9. Invited Faculty, 65th Perinatal and Developmental Medicine Symposium, “Toxic Therapies and Exposures of Fetuses and Newborns”, Marco Island, FL, November 18 – 21. 2005 Invited to Present, PASS Meeting, “FAEE in Meconium as Biomarkers of Prenatal Alcohol Exposure”, NICHD/NIH, Rockville, MD, April 28. Invited Speaker, The Pittsburgh Neonatal Society Meeting, “What’s an Environmentalist Doing in the NICU?”, Pittsburgh, PA, June 2. Invited Speaker, Town Hall Meeting with David Schwartz, M.D., Director, NIEHS. International Neurotoxicology Conference XXII, Research Triangle Park, NC, Sept. 11

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Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Session Moderator, Children’s Environmental Health, Neurotoxicology Conference XXII, Research Triangle Park, NC, Sept. 12 Invited Speaker, International Neurotoxicology Conference XXII, “Effects of Solvents on L1 Distribution in Lipid Rafts,” Research Triangle Park, NC, Sept. 12 Visiting Professor, University of Rochester, School of Medicine, Environmental Health Science Center, “Mechanisms and Markers of Developmental Neurotoxicants,” Rochester, NY, Oct. 13. Visiting Professor, Texas A&M University, “New Insights into Fetal Alcohol Syndrome,” College Station, TX, Nov. 10. 2006 Invited Lecturer, KSOHIA Project (Pediatric Environmental Health Training in Eastern Europe via Elluminate), “Developmental Approach to Pediatric Environmental Health,” Feb 9. Invited Speaker, Creating a Humane and Efficient Approach to Developmental Neurotoxicity Testing, Center for Alternatives to Animal Testing, Johns Hopkins University Bloomburg School of Public Health, “A Pediatrician Looks at DNT”, Reston, VA, March 15. Invited Lecturer, KSOHIA Project (Pediatric Environmental Health Training in Eastern Europe via Elluminate), “Lead, An Element of Toxicity”, April 20. Invited Speaker, Neurobehavioral Teratology/Teratology Society Joint Session, “Biomarkers of Prenatal Ethanol Exposure Correlate With Poor Developmental Outcomes”, Tucson, AZ, June 25. Invited Speaker, American Academy of Pediatrics, District VIII, Section on Perinatal Pediatrics, 31st Annual Conference, “What’s an Environmentalist Doing In the NICU?”, Girdwood, Alaska, July 1. Visiting Professor, University of Louisville,”FAEE: Biomarker of Prenatal Ethanol Exposure and Outcome”, August 28. Invited Faculty Member, KSOHIA Project, Bratislava, Slovakia, September 8 – 10. Invited Lecturer, KSOHIA Project (Pediatric Environmental Health Training in Eastern Europe via Elluminate), “Solvents,” November 9. 2007 Visiting Scientist, Center for Research in Occupational and Environmental Toxicology, “L1 Cell Adhesion Molecule: Target for Developmental Neurotoxicity,” Oregon Health & Science University, Portland, OR, January 8. Invited Lecturer, KSOHIA Project (Pediatric Environmental Health Training in Eastern Europe via Elluminate), “Developmental Approach to Pediatric Environmental Health,” January 16. Invited Speaker, Nemacolin Neonatology Conference, “What’s an Environmentalist Doing in the NICU?”, February 14-16. Invited Lecturer, KSOHIA Project (Pediatric Environmental Health Training in Eastern Europe via Elluminate), “Lead, An Element of Toxicity”, March 20. Visiting Scientist, University of Maryland, Baltimore, MD. Grand Rounds, “What’s an Environmentalist Doing in the NICU?”, March 22. Invited Speaker, Società Italiana per il Trattamento dell’Alcolismo e le sue Complicanze, Roma, Italy,, "FAEE: biomarkers of prenatal alcohol exposure and effect", June 22. Distinguished Visiting Scientist, Oklahoma State University School of Veterinary Medicine, Stillwater, OK, “Fetal Alcohol Syndrome, Lipid Rafts and L1 Cell Adhesion Molecule – A Problem with Trafficking?”, Sept. 10. Invited Lecturer, KSOHIA Project (Pediatric Environmental Health Training in Eastern Europe via Elluminate), “Solvents and Children”, September 18. 34


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Invited Speaker, Public Health Implications for Human Biomonitoring, EPA-ICCA Biomonitoring Meeting. Research Triangle Park, NC. “Biomarker for Prenatal Ethanol Exposure: Identifying a Vulnerable Population”, Sept 24. Thomas H. Pauly Excellence in Neonatology Lectureship, University of Kentucky Medical Center, Lexington, KY. “What’s an Environmentalist Doing in the NICU?”, Oct. 4. Children’s Cancer Research Fund Distinguished Speaker, Children’s Oncology Group Symposium, Denver, CO. “Little footprints: Biomarkers of prenatal exposure.” Oct. 11. Invited Faculty Member, KSOHIA Project, Bratislava, Slovakia, November 9 – 11. 2008 Grand Rounds, Sinai Hospital, Baltimore, MD. “What’s an Environmentalist Doing in the NICU?”, Feb 19. Invited Speaker, Collaborative In Fetal Alcohol Syndrome, NIAAA/NIH, Rockville, MD. “Biomarkers for Prenatal Ethanol Exposure”, June 10. Invited Panelist, Research Society on Alcoholism Satellite Meeting, NIAAA/NIH, Rockville, MD “Biomarkers for Alcohol-Induced Disorders”, June 27. Invited Plenary Speaker, Adverse Neurodevelopmental Outcome - The Role for In Vitro , TestSmart DNT2, Center for Alternatives to Animal Testing, Johns Hopkins University Bloomburg School of Public Health, “A Pediatrician Looks at DNT”, Reston, VA, November 12. 2009 Invited Speaker, Technical Seminar Series, “Lipid Rafts: A Novel Target for Toxicity?” U.S. Army Center for Health Promotion & Preventive Medicine, Directorate of Toxicology, Aberdeen Proving Grounds, MD, February 4. Invited Speaker, Department of Toxicology, University of Maryland School of Medicine weekly Seminar, “Lipid Rafts: A Target for Toxicity,” February 17. Invited Professor, Department of Environmental Health Sciences, Case Western Reserve University School of Medicine, “Environmental Determinants of Health”, July 31. Invited Presenter, Maryland Coalition of Children’s Environmental Health Centers, “Environmental Determinants of Health”, September 12. Mansdorfer Lecture, Mercy Hospital, “Environmental Influences on Fetal Development”, Oct 21. CityWide Conference, The Johns Hopkins Hospital, “The Role of Lipid Rafts in Neurodevelopmental Toxicity”, Dec. 1. 2010 Grand Rounds, Greater Baltimore Medical Center, “Prevention of Birth Defects”, Jan. 29. Invited Speaker, Graduate Nutrition Seminar at the Hopkins School of Public Health, “Alcohol Biomarkers and Outcomes at 2 years of Age”, Feb 4. Testimony to U.S. Senate Committee on Environment & Public Works, March 18. Invited Presenter, The Maryland FASD Social Workers Workshop, University of Maryland School of Social Work, April 9. Invited Professor, Georgetown University School of Medicine, NOFAS FASD Selective, “Primary Prevention of FASD”, April 16. Testimony to U.S. House Committee on Appropriations, May 12. RSA Symposium Speaker, “Considering The Role Of Maternal-Fetal Interactions In Addressing Mechanisms And Amelioration Strategies For FASD – Overview”, San Antonio, TX, June 28. RSA Symposium Speaker, “Considering The Role Of Maternal-Fetal Interactions In Addressing Mechanisms And Amelioration Strategies For FASD – Maternal Nutritional Status of

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Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Choline and GM1 Ganglioside May Mediate Ethanol’s Effects Via Lipid Rafts in Fetal Neurons”, San Antonio, TX, June 28. Guest lecturer, CWRU SOM, “Environmental Determinants of Health”, July 30. Invited Speaker, Children First Symposium, “Health Implications of Prenatal/Early Childhood Exposures”, Oct 1. Invited Speaker, AAP-NCE, “Fetal Environmental Exposures: State of the Science and Relevance to Pediatric Practice”, San Francisco, Oct. 4. Panelist, MDH2E Environmental Excellence in Health Care, UMB SON, Baltimore, Nov. 18. 2011 Grand Rounds, Sinai Hospital, “New Insights into Fetal Alcohol Syndrome.” Baltimore, Feb. 8. Pediatric Grand Rounds, “What’s an Environmentalist Doing in the NICU?”, University of New Mexico, Albuquerque, March 18. Neuroscience Department Seminar, “New Insights into Fetal Alcohol Syndrome”, University of New Mexico, Albuquerque, March 19. Workshop Leader, Biomonitoring Conference, Dept. of Environment, State of Maryland, April 1 Organizer, Baltimore-Washington Perinatal Club, Airlie Conference Center, Warrenton, VA, April 14-15. Invited speaker, Clinical Ground Rounds, “What’s an Environmentalist Doing in the NICU?”, Anne Arundel Medical Center, June 3. Invited Speaker, Biomarkers of Alcohol Use Satellite Meeting, Research Society on Alcoholism, Atlanta, June 25. Invited professor, Year 1 Medical School, “Environmental Determinants of Disease”, Case Western Reserve University, Aug. 10. LOCAL PRESENTATIONS (since 1994): Environmental Hazards to Children. Westminster College, New Wilimington, PA. April 29, 1994. Children at Risk: Lead Poisoning an Environmental Challenge. Mahoning County Childhood Lead Posioning Prevention Program. A One-Day Seminar, Holiday Inn Metroplex, Youngstown, OH. May 6, 1994. Pediatric Environmental Health. Pediatric Clinical Staff Conference, Department of Pediatrics, St. Lukes Medical Center, Cleveland, OH. July 5, 1994. Introduction to the Environment of Children. General Academic Pediatric Session, Rainbow Babies & Children’s Hospital, Cleveland, OH. September 15, 1994. Fatty Acid Ethyl Esters: A Role in Fetal Alcohol Syndrome? Pediatric Research Seminar, Rainbow Babies & Children’s Hospital, September 23, 1994. The Hostile Fetal Environment. The Neonatal Nurse Practitioners, Cleveland, OH. November 15, 1994. Indoor Air Pollution. General Academic Pediatric Session, Rainbow Babies & Children’s Hospital, Cleveland, OH. January 12, 1995. Pediatric Environmental Health Pediatric Grand Rounds, Mt. Sinai Medical Center, Cleveland, OH. January 13, 1995. Pesticides. General Academic Pediatric Session, Rainbow Babies & Children’s Hospital, Cleveland, OH. March 15, 1995. Childhood Lead Poisoning: The Silent Epidemic. Attending Grand Rounds, Warren General Hospital, Warren, OH. April 13, 1995 Pediatric Environmental Health - A Developmental Approach. Occupational and Environmental 36


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

Health Grand Rounds, MetroHealth Medical Center, Cleveland, OH. April 19, 1995. Pediatric Environmental Health. Grand Rounds, Rainbow Babies & Children’s Hospital, Case Western Reserve University. September 14, 1995. Environmental Hazards in the NICU. Tenth Annual Conference, Current Challenges in Perinatal Nursing. November 8, 1995. Fetal Alcohol Syndrome, Neonatology Physiology Course, October 25, 1996. A Women’s Choice: Tobacco and Alcohol During Pregnancy. 8th Annual Symposium - Current Trends in Women’s and Children’s Health, Western Reserve Care System, Northside Medical Center, Youngstown, OH. November 7, 1996. Molecular Basis of Fetal Alcohol Syndrome. Clinical Genetics Grand Rounds, Case Western Reserve University, November 22, 1996. Occupational and Environmental Risks to the Fetus. Neonatal-Perinatal Conference, MacDonald House, University Hospitals, June 10, 1997. Role of L1 Cell Adhesion Molecule in Alcohol-Related Neurodevelopmental Disorder. Pediatric Research Conference, Case Western Reserve University, October 23, 1998. Biomarkers of Prenatal Ethanol Exposure. Pediatric Research Conference, Case Western Reserve University, January 2000. Biomarkers of Prenatal Ethanol Exposure. Ob/Gyn Grand Rounds, Case Western Reserve University, February 2000. Bottoms Up! A Look at the Cause and Effects of Prenatal Ethanol Exposure. Nutrition Research Seminar, Department of Nutrition, Case Western Reserve University, October 5, 2000. Pediatric Environmental Health. Introduction to Environmental and Occupational Health Course, Master of Public Health Program, Case Western Reserve University, October 17, 2000. Bottoms Up! New perspectives on Fetal Alcohol Syndrome. Department of Pharmacology Research Seminar, February 6, 2001. Bottoms Up! New perspectives on Alcohol related Neurodevelopmental Disorder, Neurosciences Grand Rounds, March 2, 2001. Fetal Environmental Health. Grand Rounds, Department of Pediatrics, Rainbow Babies & Children’s Hospital, Case Western Reserve University, Cleveland, OH. March 29, 2001. Preventing Birth Defects, Minimedical School, Case Western Reserve University, Cleveland, OH. September 25, 2001. Pediatric Environmental Health. Introduction to Environmental and Occupational Health Course, Master of Public Health Program, Case Western Reserve University, October 3, 2001. Pediatric Environmental Health, Pediatric Resident’s Core Lecture Series, Cleveland Clinic, November 2, 2001. Bottoms Up! Identifying alcohol exposed newborns. Grand Rounds, Department of Pediatrics, Cleveland Clinic, March 12, 2002. Bottoms Up! Identifying alcohol exposed newborns. Grand Rounds, Department of Pediatrics, Fairview, May 24, 2002. Pediatric Environmental Health. Introduction to Environmental and Occupational Health Course, Master of Public Health Program, Case Western Reserve University, September 17, 2002. Panelist, The health consequences of spraying pesticides to control West Nile Virus (WNV), a public forum. The Ohio Coalition Against the Misuse of Pesticides (OCAMP) and the Biology Department of John Carroll University. May 13, 2003. Pediatric Environmental Health. Introduction to Environmental and Occupational Health Course, Master of Public Health Program, Case Western Reserve University, November 37


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

4, 2003. Pathology Grand Rounds. Meconium: What It Can Tell Us About Prenatal Exposures. Case Western Reserve Univeristy/University Hospitals January 14, 2004 Case/CCF Cell Biology Retreat. Ethanol and L1 Mediated Neurite Outgrowth. Sawmill Creek State Park, May 17, 2004 Panelist, Environmental Health for Tomorrow’s Promise, WVIZ, June 24, 2004 (aired 7/8/04). Premed Club, John Carroll University. What’s an Environmentalist Doing in the NICU? November 15, 2004 Swetland Center Research Seminar Series. What’s an Environmentalist Doing in the NICU? January 6, 2005 Neurosurgery Residents Lecture. Travels with L1. January 26, 2005 Translational Neuroscience Interest Group. Developmental Neurotoxicology, June 1, 2005 RB&C Alumni Meeting, “Is Lead Contamination of Blood the Newest Risk to the Blood Supply?,” October 1, 2005 Proteomics Center Seminar Series, “Who Gets Fetal Alcohol Syndrome and Why?,” December 1, 2005 Pediatrics Grand Rounds, “Gene Environment Interactions and the Prevention of Birth Defects.” January 5, 2006 Clinical Genetics Rounds, “Who Gets Fetal Alcohol Syndrome and Why?,” January 20, 2006 Process of Discovery, Second Year Medical Students, CCLCOM, “Developmental Neurotoxicology or How Did I Ever Wind Up in Cleveland?”, April 7, 2006 Noon Conference, Neonatology. “Research Projects in My Lab”, August 14, 2006 Department of Neurosciences Seminar, “L1, Lipid Rafts, Love and Liquor: New Insights into Fetal Alcohol Syndrome”, March 15, 2007. Perinatal Physiology and Pathology Conference, MetroHealth Medical Center. "Alcohol exposure during pregnancy; the drug exposed neonate". October 16, 2007 Family Practice Resident Lecture Series. “A Developmental Approach to Pediatric Environmental Health”. October 31, 2007. NURS 609, “Overview of Pediatric Environmental Health,” School of Nursing, CWRU, November 7, 2007. EVHS 429, Introduction to Environmental Health, "Prenatal Exposures and lifetime outcomes," School of Medicine, January 29, 2008. Department of Environmental Health Science Seminar, “Two Tales: A Different Look at Metals and Solvents”, March 3, 2008. Alcohol Research Group Seminar, Cleveland Clinic Foundation, “Ethanol Disrupts Brain Development: Effects On Lipid Rafts”, March 7, 2008. Plenary Speaker, Current Challenges in Newborn and Women’s Health Nursing, “Environmental Influences on Infant Development,” Oct. 1, 2008 Plenary Speaker, NANN Conference “Metals and Solvents in the NICU and PICU,” October 14, 2008 2009 Grand Rounds, Department of Pediatrics, University of Maryland “ Love, Liquor, L1 and Lipid Rafts: New Insights Into Fetal Alcohol Syndrome” February, 2009

Grand Rounds, Department of Pediatrics, University of Maryland “ What’s an Environmentalist Doing in the NICU?”, April, 2009

MD/PhD Physician Seminar Series, University of Maryland School of Medicine “ Love, Liquor, L1 and Lipid Rafts: New Insights Into Fetal Alcohol Syndrome,” April 29, 2009

Medical Student Research Day, keynote speaker, University of Maryland School of Medicine, “The Role of Lipid Rafts in Developmental Toxicity,” September 24, 2009 38


Cynthia F. Bearer, M.D., Ph.D. Curriculum Vitae

02/10/13

2010 Grand Rounds, Department of Pediatrics, University of Maryland “ Heavy Metal in Blood Transfusions – A Hazard for Preterm Infants?”, January, 2011

Speaker, “Molecules to Medicine” MSTP students, February 2, 2011. 2011 Moderator, MSTP Journal Club “Bugs to Bedside”, March 30, 2011 OTHER President, Trillium Hollow Farms – Paso Finos, livery, honey, candles, cider

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