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2/24/14 CURRICULUM VITAE WILLIAM FRANK REGINE, M.D. ____________________________________________________________________________________ DATE & PLACE OF BIRTH: September 23, 1961; Brooklyn, NY UNIVERSITY OF MARYLAND MEDICAL SYSTEM Department of Radiation Oncology 22 S. Greene Street, Room GGK0101 Baltimore, MD 21201 Telephone: (410) 328-2326 E-mail: wregine@umm.edu

OFFICE ADDRESS:

ACADEMIC DEGREES: B.S.

1983

State University of New York at Albany, Albany, New York (Chemistry, Summa Cum Laude)

M.D.

1987

State University of New York Health and Science Center at Syracuse, Syracuse, New York

PROFESSIONAL APPOINTMENTS: 1987-88

Transitional Intern, St. Joseph's Hospital, Syracuse, New York

1988-91

Resident, Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania

1991-92

Fellow, Gastrointestinal – Head and Neck Malignancies, Departments of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania and University of FL, Gainesville, FL

1992-94

Assistant Member, Department of Radiation Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee

1992-94

Assistant Professor, Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee

1994

Assistant Professor and Acting Clinical Chief, Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee

1994-1997

Assistant Professor, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky

1997-2002

Associate Professor, with Tenure, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky

1997-2002

Associate Professor, Joint Appointment, Department of Surgery, Division of Neurosurgery, University of Kentucky, Lexington, Kentucky


William F. Regine, M.D. Curriculum Vitae - Page 2

1998-2000

Associate Director for Clinical Research, Markey Cancer Center, University of Kentucky, Lexington, Kentucky

1998–2002

Co-Director, University of Kentucky Gamma Knife Radiosurgery Program

2000-2002

Vice-Chairman, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky

2002

Co-Director, Department of Radiation Medicine Residency Program, University of Kentucky, Lexington, Kentucky

2002

Professor, with Tenure, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky

2002

Professor, Joint Appointment, Department of Surgery, Division of Neurosurgery, University of Kentucky, Lexington, Kentucky

2004-2012

Director, Department of Radiation Oncology Residency Program, University of Maryland, Baltimore, Maryland

2003 – present

Professor and Chairman, Department of Radiation School of Medicine, Baltimore, Maryland

2010-2012

Professor and Interim Chairman, Department of Diagnostic Radiology and Nuclear Medicine University of Maryland School of Medicine, Baltimore, Maryland

2012 – present

Clinical Director, Department of Radiation Oncology, University of Maryland School ofb Medicine, Baltimore, Maryland

2012 – present

Executive Director, Maryland Proton Treeatment Center (MPTC), University of Maryland, Baltimore, Maryland

Oncology University of Maryland

HONORS: 1979

New York State Regent’s College Scholarship

1981

State University of New York at Albany’s Honor Society: Signum Laudis

1982

Phi Beta Kappa

1984-86

Honors – Epidemiology, Pediatrics, Anesthesiology, Otolaryngology, Radiation Oncology, Surgery

1991

Chief Resident, Radiation Oncology, Thomas Jefferson University Philadelphia, PA

199 1

American Cancer Society Clinical Oncology Fellowship Award

1995

American Society for Therapeutic Radiology and Oncology – European Society for Therapeutic Radiology and Oncology Exchange Program Travel Grant Award

2002-08 2006

Selected for listing among “Best Doctors in America” Elected President of the Simon Kramer Society

Hematology-Oncology, Hospital,


William F. Regine, M.D. Curriculum Vitae - Page 3

2007

National Departmental Rank of “Top 10” in NIH Funding (5th – 2005)

2007-13

Selected for Listing among “Best Doctors in Baltimore”

2010

Radiation Therapy Oncology Group “Outstanding Publication Award for 2008/2009”

2010-13

Selected among “Super Doctors” in Mid-Atlantic-Washington Post Magazine

2011

Selected among “Top 1% of Doctors” U.S. News & World Report

2013

Inducted into Port Richmond High School Hall of Fame

2013

Inducted as a “Fellow” in American College of Radiology

CERTIFICATION/LICENSURE: Diplomat, National Board of Medical Examiners (1987) Medical Physician and Surgeon (Pennsylvania) Medical Physician and Surgeon (Tennessee) Medical Physician and Surgeon (Kentucky) Medical Physician and Surgeon (Maryland) Medical Physician and Surgeon (California) Board Certified in Radiation Oncology (1992) Paul Scherrer Institute (PSI) Winter School for Proton Therapy (2014) LAB RESEARCH EXPERIENCE: 1982-83

Synthesized and studied steric hindrances within sulfonamide series. Supervised by William Closson, Ph.D., State University of New York at Albany

1991

Studied Murine bone marrow macrophage colony-forming unit response to radiation and hyperthermia. Supervised by Michael D. O'Hara, Ph.D., Department of Radiation Oncology, Thomas Jefferson University Hospital

PROFESSIONAL SOCIETY MEMBERSHIPS: American Brain Tumor Association American College of Radiology American College of Radiation Oncology American Medical Association American Radium Society American Society of Therapeutic Radiologists and Oncologists American Society of Clinical Oncology Baltimore City Medical Society Radiation Oncology Institute Radiation Oncology Therapy Group Phi Beta Kappa Simon Kramer Society The Society of Neuro-Oncology The Rare Cancer Network PUBLICATIONS:


William F. Regine, M.D. Curriculum Vitae - Page 4

ORIGINAL PEER-REVIEWED ARTICLES 1.

Sagerman RH, Kotlove DJ, Regine WF, Chung CT, King GA, Dalal PS. Stage II Seminoma: Results of Postorchiectomy Irradiation. Radiology 172: 565-568, 1989.

2.

Regine WF, Ayyangar K, Komarnicky LT, Bhandare N, Mansfield CM. Computer-CT Planning of the Electron Boost in Definitive Breast Irradiation. Int J Radiat Oncol Biol Phys 20(1): 121-125, 1991.

3.

Regine WF, Kramer S. Pediatric Craniopharyngiomas: Long-Term Results of Combined Treatment with Surgery and Radiation. Int J Radiat Oncol Biol Phys 24(4): 611-617, 1992.

4.

Regine WF, Mohiuddin M. Impact of Adjuvant Therapy on Locally Advanced Adenocarcinoma of the Stomach. Int J Radiat Oncol Biol Phys 24(5): 921-927, 1992.

5.

Regine WF, Mohiuddin M, Kramer S. Long-Term Results of Pediatric and Adult Craniopharyngiomas Treated with Combined Surgery and Radiation. Radiotherapy Oncol 27: 13-21, 1993.

6.

Regine WF, Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Million RR. Radiotherapy for Adenoid Cystic Carcinoma of the Palate. Head & Neck 15: 241-244, 1993.

7.

Regine WF, Fontanesi J, Kumar P, Ayers D, Bowman LC, Pappo AS, Coffey DH, Avery L, Rao BN, Kun LE. Local Tumor Control in Rhabdomyosarcoma Following Low-Dose Irradiation:comparison of Group II and select Group III patients. Int J Radiat Oncol Biol Phys 31(3): 485-491, 1995.

8.

Kumar P, Mulhern RK, Regine WF, Rivera GK, Kun LE. A Prospective Neurocognitive Evaluation of Children Treated with Additional Chemotherapy and Craniospinal Irradiation Following Isolated Central Nervous System Relapse in Acute Lymphoblastic Leukemia. Int J Radiat Oncol Biol Phys 31(3): 561566, 1995.

9.

Regine WF, Fontanesi J, Kumar P, Zeitzer K, Greenwald C, Bowman L, Shapiro DN, Rao BN, Kun LE. A Phase II Trial Evaluating Selective Use of Altered Radiation Dose and Fractionation in Patients with Unresectable Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 31(4): 799-805, 1995.

10.

O'Hara MD, Pollard M, Wheatley G, Regine WF, Mohiuddin M, Leeper D. Thermal Response and Hyperthermic Radiosensitization of SCID Mouse Bone Marrow CFU-C. Int J Radiat Oncol Biol Phys 31(4): 905-910, 1995.

11.

Mohiuddin M, Regine WF, Stevens J, Rosato F, Barbot D, Biermann W, Cantor R. Combined Intraoperative Radiation and Perioperative Chemotherapy for Unresectable Cancers of the Pancreas. J Clin Oncol 13: 2764-2768,1995.

12.

Mohiuddin M, Regine WF, Marks G. Prognostic Significance of Tumor Fixation in Rectal Cancer: Implications for Adjunctive Radiation Therapy. Cancer 78(4): 717-722, 1996.

13.

Robbins KT, Kumar P, Regine WF, Wong FSH, Weir III AB, Flick P, Kun LE, Palmer R, Murray T, Fontanesi J, Ferguson R, Thomas R, Hartsell W, Paig CU, Salazar G, Norfleet L, Hanchett CB, Harrington V, Niell B. Efficacy of Targeted Supradose Cisplatin and Concomitant Radiation Therapy for Advanced Head and Neck Cancer: The Memphis Experience. Int J Radiat Oncol Biol Phys 38(2): 263-271, 1997. Regine WF, Valentino J, Sloan DA, Patel P, Mohiuddin M, Kenady DE. Efficacy of Postoperative Radiation Therapy for Recurrent Squamous Cell Carcinoma of the Head and Neck. Int J Radiat Oncol Biol Phys 39(2): 297-302, 1997.

14.


William F. Regine, M.D. Curriculum Vitae - Page 5

15.

Young B, Regine WF, Sanders MF, Strottmann JM . Whole Brain Radiation Therapy for Treating Cerebral Metastasis May Not Be Necessary After Stereotactic Radiosurgery Performed with Magnetization-Prepared, Rapid-Acquisition Gradient Echo MRI with Triple-Dose Contrast. Radiosurgery 2: 72-77,1997.

16.

Mohiuddin M, Regine WF, Marks GJ, Marks JW. High-Dose Preoperative Radiation and the Challege of Sphincter-Preserving Surgery for Cancer of the Distal 2 cm of the Rectum. Int J Radiat Oncol Biol Phys 40(3): 569-574, 1998.

17.

Regine WF, Hodes JE, Patchell RY. Intracranial Germinoma: Treatment with Radiosurgery Alone. J Neuro-Onc 37(1): 75-77, 1998.

18.

Klyachkin ML, Schwartz RW, Cibull M, Munn RK, Regine WF, Kenady DE, McGrath PC, Sloan DA. Thyroid Lymphoma: Is There a Role for Surgery? The American Surgeon 64: 234-238,1998.

19.

Rudoltz MS, Regine WF, Langston JW, Sanford RA, Kovnar EH , Kun LE. Multiple Causes of Cerebrovascular Events in Children with Tumors of the Parasellar Region. J Neuro-Onc 37(3): 251-261, 1998.

20.

Meigooni AS, Valentino J, Regine WF. An Innovative Method for Optimization of Intraluminal Brachytherapy Dose Delivery for Tumors Involving the Carina. Journal of Brachytherapy International 14: 185-189, 1998.

21.

Mohiuddin M, Young BA, Regine WF. The Effects of Gamma Knife Radiosurgery on Tinnitus in Patients with Acoustic Neuromas. Journal of Radiosurgery 1(4): 265-270, 1998.

22.

Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B. Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain: A Randomized Trial. JAMA 280(17): 1485-1489, 1998.

23.

Fujita M, Rudoltz MS, Canaday DJ, Patel P, Machtay M, Pittard MQ, Mohiuddin M, Regine WF. Second Malignant Neoplasia in Patients with T1 Glottic Cancer Treated with Radiation. Laryngoscope 108: 1853-1854, 1998.

24.

Canaday DJ, Regine WF, Mohiuddin M, Zollinger W, Machtay M, Lee J, Schultz D, Rudoltz MS. Significance of Pretreatment Hemoglobin Level in Patients with T1 Glottic Cancer. Radiation Oncology Investigations 7: 42-48, 1999.

25.

Regine WF, Valentino J, Sloan DA , Patel P, Pittard MQ, Kenady DE, Mohiuddin M. Postoperative Radiation Therapy for Primary vs. Recurrent Squamous Cell Carcinoma of the Head and Neck: Results of a Comparative Analysis. Head & Neck 21: 554-559, 1999.

26.

Mohiuddin M, Fujita M, Regine WF, Meigooni AS, Ibbott GS, Ahmed M. High Dose Spatially Fractionated Radiation (GRID): A New Paradigm in the Management of Advanced Cancers. Int J Radiat Oncol Biol Phys 45(3): 721-727, 1999.

27.

Sloan DA, Witzke DB, Plymale MA, Sloan PA, Regine WF, Valentino J, Schwartz RW, Kenady DE. A Multidisciplinary Workshop to Teach Head and Neck Oncology to Residents: Results of a Pilot Study. Journal of Cancer Education 14(4): 228-232, 1999.

28.

Valentino J, Weinstein L, Rosenblum R, Regine WF, Weinstein M. Radiation and Intra-Arterial Cisplatin. Effects on Arteries and Free Tissue Transfer. Arch Otolaryngol Head Neck Surg 126: 215219, 2000.


William F. Regine, M.D. Curriculum Vitae - Page 6

29.

Mohiuddin M, Regine WF, John WJ, Hagihara PF, McGrath PC, Kenady DE, Marks G. Preoperative Chemoradiation in Fixed Distal Rectal Cancer: Dose Time Factors for Pathological Complete Response. Int J Radiat Oncol Biol Phys 46(4): 883-888, 2000.

30.

Regine WF, John WJ, McGrath P, Strodel WE, Mohiuddin M. The Feasibility of Dose Escalation Using Concurrent Radiation and 5-Fluorouracil Therapy Following Pancreaticoduodenectomy for Pancreatic Carcinoma. J of Hepatobiliary Pancreat Surg 7: 53-57, 2000.

31.

Regine WF, Patchell RA, Strottman J, Sanders M, Meigooni AS, Young AB. Preliminary Report of a Phase I Study of Combined Fractionated Stereotactic Radiosurgery and Conventional External Beam Radiation Therapy for Unfavorable Gliomas. Int J Radiat Oncol Biol Phys 48(2): 421-426, 2000.

32.

Regine WF, Valentino J, John J, Storey G, Sloan D, Kenady D, Patel P, Pulmano C, Arnold S, Mohiuddin M. High-Dose Intra-Arterial Cisplatin and Concurrent Hyperfractionated Radiation Therapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Report of a Phase II Study. Head & Neck 22: 543-549, 2000.

33.

Mohiuddin M, Hayne M, Regine WF, Hanna N, Hagihara P, McGrath P, Marks GM. Prognostic Significance of Postchemoradiation Stage Following Preoperative Chemotherapy and Radiation for Advanced/Recurrent Rectal Cancers. Int J Radiat Oncol Biol Phys 48(4): 1075-1080, 2000.

34.

Gamburg ES, Regine WF, Patchell RA, Strottmann JM, Mohiuddin M, Young AB. The Prognostic Significance of Midline Shift on Survival of Patients Presenting with Glioblastoma Multiforme. Int J Radiat Oncol Biol Phys 48(5): 1359-1362, 2000.

35.

Nicol B, Regine WF, Courtney C, Meigooni AS, Sanders M, Young B. Gamma Knife Radiosurgery Using 90 Gy for Trigeminal Neuralgia. J Neurosurg 93(S3): 152-154, 2000.

36.

Regine WF, Patchell RA, Strottman J, Meigooni AS, Sanders M, Young BA. Combined Stereotactic Split-Course Fractionated Gamma Knife Radiosurgery and Conventional Radiation Therapy for Unfavorable Gliomas: A Phase I Study. J Neurosurg 93(S3): 37-41, 2000.

37.

Regine WF, Valentino J, Arnold SM, Haydon RC, Sloan D, Kenady D, Strottman J, Pulmano C, Mohiuddin M. High-Dose Intra-Arterial Cisplatin Boost with Hyperfractionated Radiation Therapy for Advanced Squamous Cell Carcinoma of the Head and Neck. JCO 19(14): 3333-3339, 2001.

38.

Sanghavi SN, Miranpuri SS, Chappell R, Buatti JM, Sneed PK, Suh JH, Regine WF, Weltman E, King VJ, Goetsch SJ, Breneman JC, Sperduto PW, Scott C, Mabanta S, Mehta MP. Radiosurgery for Patients with Brain Metastases: A Multi-Institutional Analysis, Stratified by the RTOG Recursive Partitioning Analysis Methodology. Int J Radiat Oncol Biol Phys 51(2): 426-434, 2001.

39.

Regine WF, Scott C, Murray K, Curran W. Neurocognitive Outcome in Brain Metastasis Patients Treated with Accelerated Fractionation vs. Accelerated Hyperfractionated Radiotherapy: An Analysis From Radiation Therapy Oncology Group Study 91-04. Int J Radiat Oncol Biol Phys 51(3): 711-717, 2001.

40.

Jackson TR, Regine WF, Wilson D, Davis DG. Cerebellar Liponeurocytoma: Case Report, Review of the Literature and Therapeutic Implications. J Neurosurg 95(S4): 700-703, 2001.

41.

Regine WF, Huhn JL, Patchell RA, St. Clair WH, Strottmann J, Meigooni AS, Sanders M, Young AB. Risk of Symptomatic Brain Tumor Recurrence and Neurologic Deficit After Radiosurgery Alone in


William F. Regine, M.D. Curriculum Vitae - Page 7

Patients With Newly Diagnosed Brain Metastases: Results and Implications. Int J Radiat Oncol Biol Phys 52(2): 333-338, 2002. 42.

Meigooni AS, Parker SA, Zheng J, Kalbaugh KJ, Regine WF, Mohiuddin M. Dosimetric Characteristics with Spatial Fractionation Using Electron GRID Therapy Med Dosimetry 27(1): 37-42 2002.

43.

Regine WF, Reid B, Patchell RA, St.Clair WH, Meigooni AS, Sims J, Sanders M, Young AB. Efficacy of 20 Gy Stereotactic Radiosurgery for < 2 cm Brain Metastases. Radiosurgery 4: 134-142, 2002.

44.

Regine WF, Valentino J, Arnold SM, Sloan D, Kenady D, Strottmann J, Mohiuddin M. A Phase II Study of Concomitant Hyperfracionated Radiation Therapy and Double Dose Intra-Arterial Cisplatin for Squamous Cell Carcinoma of the Head and Neck. Technology in Cancer Research and Treatment 1: 133140, 2002.

45.

Sathishkumar S, Dey S, Meigooni AS, Regine WF, Kudrimoti M, Ahmed MM, Mohiuddin M. The Impact of TNF-ď Ąď&#x20AC; Induction on Therapeutic Efficacy Following High Dose Spatially Fractionated (GRID) Radiation. Technology in Cancer Research and Treatment 1: 141-147, 2002.

46.

Mohiuddin M, Chendil D, Dey S, Alcock RA, Regine WF, Mohiuddin M, Ahmed MM. Influence of p53 Status on Radiation and 5-Flourouracil Synergy in Pancreatic Cancer Cells. Anticancer Research 22: 825830, 2002.

47.

Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, Regine WF, Weltman E, King VJ, Breneman JC, Sperduto PW, Mehta MP. A Multi-Institutional Review of Radiosurgery Alone vs. Radiosurgery with Whole Brain Raditherapy as the Initial Management of Brain Metastases. Int J Radiat Oncol Biol Phys 53(3): 519-526, 2002.

48.

Valentino J, Spring PM, Shane M, Arnold SM, Regine WF. Interval Pathologic Assessments In Patients Treated with Concurrent Hyperfractionated Radiation and Intraarterial Cisplatin (Hyperradplat). Head and Neck 24: 539-544, 2002.

49.

Hahn SM, Bernard EJ, Regine WF, Mohiuddin M, Haller DG, Stevenson JP, Smith D, Pramanik, B, Tepper J, Delaney TF, Kiel KD, Morrison B, Deutsch P, Muschel RJ, McKenna WG. A Phase I Trial of the Farnesyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Lung and Head and Neck Cancer. Clinical Cancer Research 8: 1065-1072, 2002.

50.

Mohiuddin M, Kudrimoti M, Regine WF, McGrath P, Hanna N, Meeker T, John W. Concurrent Infusional Gemcitabine and Radiation in the Treament of Advanced Unresectable GI Malignancy: A Phase I Study. Cancer Journal 8: 255-262, 2002.

51.

Mohiuddin M, Damodaran C, Swatee D, Alcock R, Regine WF, Mohiuddin M, Ahmed MM. Influence of p53 Status on Radiation and 5 - Flourouracil Synergy in Pancreatic Cancer Cells. Anticancer Research 22: 825-830, 2002.

52.

Patchell RA, Regine WF, Ashton P, Tibbs PA, Wilson D, Shappley D, Young BY. A phase I Trial of Continuously Infused Intratumoral Bleomycin for the Treatment of Recurrent Glioblastoma Multiforme. J Neuro-Onc 60: 37-42, 2002.

53.

Dey S, Spring PM, Arnold S, Valentino J, Chendil D, Regine WF, Mohiuddin M, Ahmed MM. LowDose Fractionated Radiation Potentiates the Effects of Paclitaxel in Wild-type and Mutant p53 Head and Neck Tumor Cell Lines. Clin Ca Res 9: 1557-1565, April 2003.


William F. Regine, M.D. Curriculum Vitae - Page 8

54.

Anderson T, Regine WF, Kryscio R, Patchell RA. Neurologic complications of bladder cancer. A review of 359 cases. Cancer 97: 2267-72, 2003.

55.

Patchell RA, Regine WF. The Rational for Adjuvant Whole Brain Radiation Therapy with Radiosurgery in the Treatment of Single Brain Metastases. Tech Ca Res Treat 2(2): 111-115, 2003.

56.

Chin LS, Szerlip NJ, Regine WF. Stereotactic Radiosurgery for meningiomas. Neurosurg Focus 14(5): 1-6, 2003.

57.

Flannery TW, Suntharalingam M, Kwow Y, Koffman BH, Amin PP, Chin LS, Nicol B, Fowler, Young AB, Regine WF. Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer, 42: 327-333, 2003.

58.

Arnold SM, Regine WF, Ahmed MM, Valentino J, Spring P, Kudrimoti M, Kenady D, Desimone P, Mohiuddin M. Low-dose Fractionated Radiation as a Chemopotentiator of Neoadjuvant Paclitaxel and Carboplatin for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Results of a New Treatment Paradigm. Int J Radiat Oncol Biol Phys 58(5): 1411-1417, 2004.

59.

Shehata MK, Young AB, Reid B, Patchell RA, St Clair W, Sims J, Sanders M, Meigooni AS, Mohiuddin M, Regine WF. Stereotatic Radiosurgery (SRS) of 468 Brain Metastases â&#x2030;¤ 2 cm: Implications for SRS Dose and Whole Brain Radiation Therapy (WBRT). Int J Radiation Oncology Biol Phys 59(1): 87-93, 2004.

60.

Regine WF, Schmitt FA, Scott CB, Dearth C, Patchell RA, Nichols, RC, Gore EM, Franklin RL, Suh JH, Mehta MP. Feasibility of Neurocognitive Outcome Evaluations in Patients with Brain Metastases in a Multi-Institutional Cooperative Group Setting: Results of Radiation Therapy Oncology Group Trial BR0018. Int J Radiation Oncology Biol Phys 58(5): 1346-1352, 2004.

61.

Cheuk AV, Chin LS, Petit JH, Herman JM, Fang HB, Regine WF. Imaging Correlates of Gamma Knife Outcome in Trigeminal Neuraliga. Int. J Radiation Oncology Biol. Phys 60(2): 537-541, 2004.

62.

Regine WF, Rogozinska A, Kryscio RJ, Tibbs PA, Young AB, Patchell RA. Recursive Partitioning Analysis Classifications I And II: Applicability Evaluated In A Randomized Trial For Resected Single Brain Metastases. Am J Clin Onc 27(5): 505-509, 2004.

63.

Martin NE, Brunner TB, Kiel KD, DeLaney TF, Regine WF, Mohiuddin M, Rosato EF, Haller DG, Stevenson JP, Smith D, Pramanik B, Tepper J, Tanaka WK, Morrison B, Deutsch P, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ, Hahn SM. A Phase I Trial of the Dual Farnesyltransferase and Geranylgeranyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Pancreatic Cancer. Clinical Cancer Research, 10: 547- 554, 2004.

64.

DiBiase SJ, Kwok Y, Yavino S, Arena C, Naqvi S, Temple R, Regine WF, Amin P, Guo C, Chin LS. Factors Predicting Local Tumor Control After Gamma Knife Stereotactic Radiosurgery for Benign Intracranial Meningiomas. Int J Radiation Oncology Biol Phys 60(5): 1515-1519, 2004. Patchell R, Tibbs P, Regine WF, Payne R, Saris S, Kryscio R, Mohiuddin M, Young B. A randomized Trial of Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression caused by metastatic cancer. The Lancet 366: 643-648, 2005.

65.

66.

Gaugler J, Hanna N, Linder J, Given CW, Tolbert V, Kataria R, Regine WF. Cancer Caregiving and Subjective Stress: A Multi-Site Multi-Dimensional Analysis. Psycho-Oncology 14: 771-785, 2005.


William F. Regine, M.D. Curriculum Vitae - Page 9

67.

Spring P, Valentino J, Arnold S, Sloan D, Kenady D, Kudrimoti M, Haydon RC, Lee C, Mohiuddin M, Regine WF. Long-Term Results of Hyperfractionated Radiation and High-Dose Intraarterial Cisplatin for Unresectable Oropharyngeal Carcinoma: Cancer, 104(8): 1765-1771, 2005.

68.

Ma L, Kwok Y, Regine WF. Concomitant GRID Boost for Gamma Knife Radiosurgery: Med Phys 32(11): 3419-3423, 2005.

69.

Ma L, Kwok Y, Chin LS, Yu C, Regine WF. Comparative analyses of linac and Gamma Knife Radiosurgery for Trigeminal Neuralgia reatments: Phys. Med Biol. 50: 5217-5227, 2005.

70.

Ha Jonathan, Zhang G, Naqvi SA, Regine WF, Yu CX. Feasibility of delivering grid therapy using multileaf collimator: Med. Phys. 33(1): 76-82, 2006.

71.

Thomas KC, Nosyk B, Fisher CG, Dvorak Marcel, Patchell RA, Regine WF, Loblaw A, Bansback N, Guh D, Sun Huiying, Anis A. Cost-Effectiveness of Surgery Plus Radiotherapy versus Radiotherapy Alone for Metastatic Epidural Spinal Cord Compression. Int. Journal Radiation Oncology Biol. Phys. 66(4): 1212-1218, 2006.

72.

Huhn JL, Regine WF, Valentino J, Meigooni, AS, Kudrimoti M, Mohiuddin M. Spatially Fractionated GRID Radiation Treatment of Advanced Neck Disease Associated with Head and Neck Cancer. TCRT, 5(6): 607-610, December, 2006.

73.

Regine WF, Hanna N, Ahmed M, Garofalo MC, DeSimone P, Arnold S, Mohiuddin M. Low-dose Radiation Therapy as a Chemopotentiator of Gemcitabine in Tumors of the Pancreas/small bowel – A Phase I Study Exploring a New Treatment Paradigm. Int. Journal Radiation Oncology Biol. Phys. 68 (1): 172-177, 2007.

74.

D’Souza WD, Nazareth DP, Zhang B, DeYoung C, Suntharalingam M, Kwok Y, Yu Cx, Regine WF . The Use of Gated and 4D CT Imaging in Planning for Stereotactic Body Radition Therapy. Medical Dosimetry 32 (2): 92-101, 2007.

75.

Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. Work, Gender and Stress in Family Cancer Cargiving. Support Care Cancer 16: 347-357, 2008.

76.

Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. The Proliferation of Primary Cancer Caregiving Stress to Secondary Stress. Cancer Nursing 31 (2): 1-8, 2008.

77.

Balcer-Kubiczek EK, Attarpourl M, Wang Jiang Z, Regine WF. The Effect of Docetaxel (Taxotere®) on Human Gastric Cancer Cancer Cells Exhibiting Low-dose Radiation Hypersensitivity. Clinical Medicine: Oncology (2): 1-11, 2008.

78.

Regine WF, Winter KA, Abrams RA, Safran H, Hoffman JP, Konski A, Benson AB, Macdonald JS, Kudrimoty MR, Fromm ML, Haddock MG, Schaefer P, Willett C, Rich TA. Fluorouracil vs Gemcitabine Chemotherapy Before and After Fluorouracil-based Chemoradiation Following Resection of Pancreatic Adenocarcinoma: A Randomized Controlled Trial [published correction appears in JAMA] 2008;299(18):JCX80010]. JAMA. 2008;299(9):1019-1026.

79.

Flannery TW, Suntharalingam M, Regine WF, Chin LS, Krasna MJ, Shehata MK, Edelman MJ, Kremer M, Patchell RA, Kwok Y. Long-Term Survival in Patients with Synchronous, Solitary Brain metastasis from Non-Small-Cell Lung Cancer Treated with Radiosurgery. Int. Journal Radiation Oncology Biol. Phys. 72 (1): 19-23, 2008.


William F. Regine, M.D. Curriculum Vitae - Page 10

80.

Berger AC, Garcia M, Hoffman JP, Regine WF, Abrams RA, Safran H, Konski A, Benson AB, MacDonald J, Willett C. Postresection CA 19-9 Predicts Overall Survival in Patients with Pancreatic Cancer Treated with Adjuvant Chemoradiation: A Prospective Validation by RTOG 9704. Journal of Clinical Oncology 26 (36): 5918-5922, December 2008.

81.

Farrell, J, Regine WF, et.al. Human Equilibrative Nucleoside Transporter 1 Levels Predice Response to Gemcitabine in Patients with Pancreatic Cancer. Gastroenterology, 136(1): 187-95, January, 2009.

82.

Dhople A, Adams JR, Maggio WW, Naqvi S, Regine WF, Kwok Y. Long Term Outcomes of Gamma Knife Radiosurgery for Classic Trigeminal Neuralgia: Implications of Treatment and Critical Review of the Literature. Journal of Neurosurgery, March 2009.

83.

Berlin J, Hoffman J, Regine WF. Editorial: Combined Modality Treatment of Resectable and Borderline Resectable Pancreas Cancer: Expert Consensus Statement. Annals of Surgical Oncology (16):17571759, April, 2009.

84.

Crane CH, Winter K, Regine WF, Safran H, Rich TA, Curran WJ, Willett CG. Phase II Study of Bevacizumab with Concurrent Capecitabine and Radiation Followed by Maintenance Gemcitabine and Bevacizumab for Locally Advanced Pancreatic Cancer: RTOG 0411. Journal of Clinical Oncology 27 (25): 4089-4095, September, 2009.

85.

Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. Cancer Caregiving and Negative Outcomes: The Direct and Mediational Effects of Psychosocial Resources. Journal of Family Nursing, 15(4) 417-444, November, 2009.

86.

Mohiuddin, Ma, Regine WF. Repeat Computed Tomography Simulation to Assess Lumpectomy Cavity Volume During Whole Breast Irradiation. IJROBP, 75(3): 751-756, November, 2009.

87.

D’Souza W, Malinowski K, Van Liew S, D’Souza G, Asbury K, McAvoy T, Suntharalingam M, Regine WF. Investigation of Motion-Sickness and Inertial Stability on a Moving Couch for Intra-Fraction Motion Compensation. Acta Oncologica, 48(8): 1198-1203, November, 2009.

88.

Nichols EM, Dhople AA, Mohiuddin MM, Flannery TF, Yu CX, Regine WF. Comparative Analysis of the Post-Lumpectomy Target Volume Versus the Use of Pre-Lumpectomy Tumor Volume for Early Stage reast Cancer: Implications for the Future. IJROBP, 77(1): 197-202, May, 2010.

89.

Blackstock AW, Russo SM, Konski AA, Suh WW, Cosman BC, Herman J, Mohiuddin, Mo., Poggi MM, Regine WF, Saltz L, Small W Jr., Zook J. Local Excision in Early Stage Rectal Cancer: Expert Panel on Radiation Onology-Rectal/Anal Cancer. [online publication]. Reston (VA): American College of Radiology (ACR); 2010. 5.p.

90.

Blackstock AW, Russo SM, Konski AA, Suh WW, Cosman BC, Herman J, Mohiuddin, Mo., Poggi MM, Regine WF, Saltz L, Small W Jr., Zook J. Local Excision in Early Stage Rectal Cancer: Expert Panel on Radiation Onology-Rectal/Anal Cancer. Curr Probl Cancer. 2010 May-June;34(3): 193-200 Review. Mutaf YD, Nichols EM, Yu C, Prado K, Feigenberg SJ, Yi B, D’Souza WD, Regine WF. The Dosimetric Advantage of Stereotactic Radiotherapy in Partial Breast Irradiation: A Comparative Analysis. Radiotherapy and Oncology 99, S160-1 (2011).

91.

92.

Yovino S, Poppe M, Jabbour S, David V, Garofalo M, Pandya N, Alexander R, Hanna N, Regine WF. Intensity-Modulated Radiation Therapy Significantly Improves Acute Gastrointestinal Toxicity in Pancreatic and Ampullary Cancers. IJROBP, 79(1): 158-162, January, 2011.


William F. Regine, M.D. Curriculum Vitae - Page 11

93.

Regine WF, Winter K, Abrams R, Safran H, Hoffman JP, Konski A, Benson Al B, Macdonald JS, Rich TA, Willett CG. Fluorouracil Based Chemoradiation with Either Gemcitabine or Flourouracil Chemotherapy Following Resection of Pancreatic Adenocarcinoma: 5-Year Analysis of the US Intergroup/RTOG 9704 Phase III Trial. Ann Surg Oncol 18: 1319-1326, April 2011.

94.

Husain ZA, Regine WF, Kwok Y, Feigenberg SJ. Brain Metastases: Contemporary Management and Future Directions. (Accepted for Publication, Eur J Clin Med Oncol, April, 2011).

95.

Szerlip N, Rutter CE, Ram N, Yovino S, Kwok Y, Maggio WW, Regine WF. Factors Impacting Volumetric White Matter Changes Following Whole-Brain Radiation Therapy. J Neurooncol (2011) 103:111â&#x20AC;&#x201C;119, May 2011.

96.

Koshy M, Rich S, Merchant TE, Mahmood U, Regine WF, Kwok Y. Post-Operative Radiation Improves Survival in Children Younger Than 3 Years with Intracranial Ependymoma.(Published online, J

Neurooncol, June, 2011). 97.

Showalter TN, Winter K, Berger AC, Regine WF, Abrams RA, Safran H, Hoffman JP, Benson AB, MacDonald JS, Willett CG. The Influence of Total Nodes Examined, Number of Positive Nodes, and Lymph Nodes, and Lymph Node Ratio on Survival after Surgical Resection and Adjuvant Chemoradiation for Pancreatic Cancer. A Secondary Analysis of RTOG 9704.Int J. Radiation Onclogy Biol Phys., 81:(5) 1328-35, December 2011.

98.

Abrams RA, Regine WF. Failure to Adhere to Protocol Specified Radiation Therapy Guidelines Was Associated with Decreased Survival in RTOG 9704 â&#x20AC;&#x201C; A Phase III Trial of AdjuvantChemotherapy and Chemoradiotherapy for Patients with Resected Adenocarcinoma of the Pancreas. Int. J. Radiation Oncology Biol.Phys., 82:809-816, 2012.

99.

Neuner G, Mohiuddin MM, Vander Walde N, Goloubeva O, Ha J, Yu CX, Regine WF. High-Dose Spatially Fractionated Grid Radiation Therapy (SFGRT): A Comparison of Treatment Outcomes with Cerrobend vs. MLC SFGRT. Int. J. Radiation Oncology Biol.Phys., 82:(5)1642-49, 2012.

100.

Strongin A, Yovino S, Taylor R, Wolf J, Cullen K, Ord R, Zimrin A, Strome S, Regine WF, Suntharalingam, M. Tumor Volume Predicts Tumor Control and Survival among Patients with Locally Advanced Head and Neck Cancer Undergoing Definitive Chemoradiation Therapy. Int. J. Radiation Oncology Biol.Phys., 82:(5)1823-30, 2012.

101

Neuner G, Badros AA, Meyer TK, Nanaji NM, Regine WF. Complete Resolution of Laryngeal Amyloidosis with Radiation Treatment. Head Neck 34: 748-52, May, 2012.

102.

Nichols R, Huh S, Prado K, Sharma NK, Yi BY, Ho MW, Hoppe BS, Mendenahall WM, Mendenhall NP, Regine WF. Protons Offer Reduced Normal Tissue Exposure for Patients Receiving Postoperative. Radiotherapy (RT) for Resected Pancreatic Head Cancer. Int. J. Radiation Oncolgy Biol Physics., 83:(1) 158-63, May 2012. Goodman KA, Regine WF, Dawson L, Ben-Josef E, Haustermans K, Bosch WR, Turian J, Abram RA.RTOG Consensus Panel Guidelines for the Delineartion of the Clinical Target Volume in The Postoperative Treatment of Pancreatic Head Cancer. Int. J. Radiation Oncology Biol. Phys, 83:(3) 901908, 2012.

103.

104.

Goodman KA, Regine WF, Dawson L, Ben-Josef E, Haustermans K, Bosch WR, Turian J, Abrams RA. RTOG Consensus Panel Guidelines for the Delineation of the Clinical Target Volume in the Postoperative Treatment of Pancreatic Head Cancer. Int. J. Radiation Oncology Biol.Phys., 83:(3)901908, 2012.


William F. Regine, M.D. Curriculum Vitae - Page 12

105.

Yovino S, Maidment BW, Herman J, Pandya N, Goloubeva O, Wolfgang C, Schulick R, Laheru D, Hanna N, Alexander HR, Regine WF. Analysis of Local Control in Patients Receiving IMRT for Resected Pancreas Cancer. Int. J. Radiation Oncology Biol.Phys., 83:(3)916-920, 2012.

106.

Gaugler JE, Eppinger A, King J, Sandberg T, Regine WF. Coping and its Effects in Care Giving. Supportive Care in Cancer. 21:385-395, 2013.

107.

Mutaf Y, Zhang J, Yu CX, Yi, BY, Prado K, D’Souza W, Regine WF, Feigenberg SJ. Dosimetric and Geometric Evaluation of a Novel Stereotactic Radiotherapy Device for Breast Cancer: The Gamma Pod TM Med Phys 40 (4), April 2013.

108.

Yu CX, Shao X, Zhang, Regine WF, J, Zheng M, Deng J, Duan Z. GammaPod – A New Device Dedicated For Stereotactic Radiotherapy of Breast Cancer. Med. Phys 40 (5), May, 2013.

109.

Oden J, Toma-Dasu-Iuliana, Yu CX, Feigenberg SJ, Regine WF, Mutaf Y. Dosimetric Comparison Between Intra Cavitary Breast Brachytherapy Techniques for Accelerated Partial Breast Irradiation and A Novel Stereotactic Radiotherapy Device for Breast Cancer: GammaPodTM. Phys. Med. Biol. 58(2013) 4409-4421, June, 2013.

110.

Gleason JF, Kudrimoti M, Van Meter E, Mohiuddin M, Regine WF, Valentine J, Kenady D, Arnold S. Induction Low-Dose Fractionated Radiation with Concurrent Paclitasel and Carboplatin for Locally Advanced Head and Neck Cancer: 5 Year Results of a Prospective Phase II Trial. (Accepted, Journal of Radiation Oncology).

111.

Lu W, Neuner G, George R, Zhendong W, Sasor S, Huang X, Regine WF, Feigenberg SJ, D’Souza W. Audio-Visual Biofeedback Does Not Improve the Reliability of Target Delineation Using Maximum Intensity Projection (MIP) in 4DCT Radiotherapy Planning. (Accepted, IJROBP, October, 2013).

INVITED SUBMISSIONS/LETTERS: 1.

Regine WF, Ayyangar K, Komarnicky LT, Bhandare N, Mansfield CM. To Boost, Why and How. Int J Radiat Oncol Biol Phys 20(1): 179, 1991. [Letter]

2.

Mohiuddin M, Regine WF, Rosato F, Barbot D, Schuricht A, Biermann W, Cantor R. A Comparison of Intraoperative Radiation Therapy (IORT) and I-125 Implantation for Cancer of the Pancreas. Proceedings of the 4th International Symposium on Intraoperative Radiation Therapy: 315-323, 1994.

3.

Regine WF, Kun LE. Retrospective Results Need Prospective Confirmation. Int J Radiat Oncol Biol Phys 31(3): 681, 1995. [Letter]

4.

Regine WF, Kramer CK. To Boost or Not to Boost? . . . It’s Not the Only Question! Int J Radiat Oncol Biol Phys 32(1):273 1995. [Letter] Regine WF, Mohiuddin M. Extrahepatic Biliary Duct Carcinoma: the Continuing Evolution of Multidisciplinary Management. Int J Radiat Oncol Biol Phys 34(4): 963-964, 1996.

5. 6.

Regine WF, Mohiuddin M. Does Neck Stage Predict Local Control After Irradiation for Head and Neck Cancer Oncology 10(3):384-386, 1996.

7.

Regine WF, John WJ, Mohiuddin M. Current and Emerging Treatments for Pancreatic Cancer. Drugs & Aging 11(4): 285-295, 1997.


William F. Regine, M.D. Curriculum Vitae - Page 13

8.

Regine WF, Abrams RA. Adjuvant Therapy for Pancreatic Cancer: Back to the Future. Int J Radiat Oncol Biol 42(1): 59-63, 1998.

9.

Regine WF, John WJ, Mohiuddin M. Evolving Trends in the Combined Modality Therapy for Pancreatic Cancer. J of Hepatobiliary Pancreat Surg 5(3): 227-234, 1998.

10.

Regine WF, John WJ, Mohiuddin M. Adjuvant Therapy for Pancreatic Cancer: Current Status. Frontiers in Bioscience 3: 186-192, 1998.

11.

Patchell RA, Tibbs PA, Regine WF, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B, Dempsey RJ. Postoperative Radiotherapy for Single Brain Metastases. JAMA 281(18): 1696, 1999. [Letter]

12.

Mohiuddin M, Regine WF, Mohiuddin Ma, Marks G. Defining the Multiple Modality Approach to the Treatment of Cancer of the Rectum. JAMA 31: 217-221, 1999.

13.

Regine WF, The Radiation Oncologistâ&#x20AC;&#x2122;s Perspective on Stereotactic Radiosurgery. TCRT 1(1): 43-49, 2002.

14.

Regine WF, Sperduto PW, Scott CB, Mehta, MP. What is the Appropriate Primary Endpoint for Clinical Trials for Patients With Brain Metastases. Int J Radiat Oncol Biol Phys 53(5):1394, 2002.

15.

Kenady DE, Arnold SM, Regine WF, Mentzer RM. Oral/Pharyngeal Squamous Carcinoma: Treatment Strategies. Journal of KMA 100: 318-324, 2002.

16.

Regine WF, Stereotactic Radiosurgery â&#x20AC;&#x201C; State of the Art. Tech Ca Res Treat 2(2):77-78, 2003.

17.

Willett CG, Safran H, Abrams RA, Regine WF, Rich TA, and the Gastrointestinal Committee of the RTOG. Clinical Research in Pancreatic Cancer: The Radiation Therapy Oncology Group Trials. Int J Radiat Oncol Biol Phys 56(4):31-37, 2003.

18.

Sloan AE, Arnold SM, St Clair WS, Regine WF. Brain Injury: Current Management and Investigations. Sem in Rad Onc 13(3):309-321, 2003.

19.

St. Clair WS, Arnold SM, Sloan AE, Regine WF. Spinal Cord and Peripheral Nerve Injury: Current Management and Investigations. Sem in Rad Onc 13(3):322-332, 2003.

20.

Garofalo M, Kwok Y, Regine WF. The Evolving Role of Postoperative Adjuvant Radiation Therapy for Pancreatic Cancer, Surg Oncol Clin N Am 13:589-604, 2004.

21.

Kwok Y, Patchell RA, Regine WF. Radiation Therapy Alone for Spinal Cord Compression: Time to Improve Upon a Relatively Ineffective Status Quo. J Clin Oncol 23:3308-3310, 2005.

22.

Patchell RA, Tibbs PA, Regine WF. Surgical Resection in Metastatic Spinal Cord Compression. Lancet 366 643-648, 2005. [Letter]

23.

Kwok Y, DeYoung C, Garofalo MC, Dhople A, Regine WF. Radiation Oncology Emergencies. Hematology/Oncology Clinics of North America 20: 507-522, 2006.

24.

Garofalo MC, Tan MT, Regine WF. On Statistical Reanalysis, the EORTC Trial is a Positive Trial for Adjuvant Chemoradiation in Pancreatic Cancer. Annals of Surgery 244: 332-333, 2006.


William F. Regine, M.D. Curriculum Vitae - Page 14

25.

Regine WF, Abrams RA. Adjuvant Therapy for Pancreatic Cancer: Current Status, Future Directions. Seminars in Oncology 33: (6) (S10-S13), 2006.

26.

Patchell RA, Regine WF, Loeffler JS, Sawaya R. Radiosurgery Plus Whole-Brain Radiation Therapy for Brain Metastasts. JAMA 296: (17) 2006. [Letter].

27.

Garofalo, MC, Abrams RA, Regine WF. Review of “Adjuvant Therapy for Pancreatic cancer – To Treat or Not to Treat?” Oncology 21: (6) May 2007. [Editorial]

28.

Garofalo MC, Nichols EM, Regine WF. Optimal Adjuvant Therapy for Resected Pancreatic Cancer: Chemotherapy or Chemoradiotherapy. Proceedings of Journal of the International Society of Gastrointestinal Oncology 1(5)182 - 186, September 2007.

29.

Regine WF, Winter KA, Safran H. Further discussion of Phase III Adjuvant Pancreas U.S.

30.

Intergroup/Radiation Therapy Oncology Group Trial 9704. JAMA [Letter] In Press.

31.

Berlin J, Hoffman J, Regine, WF. Combined Modality Treatment of Resectable and Borderline Resectable Pancreas Cancer: Expert Consensus Statement by Abrams, et al. Annals of Surgical Oncology [Editorial] Accepted 1/09.

32.

Berger AC, Hoffman JP, Winter K, Regine WF, Safran H, Abrams R, Willet C. Reply to Editorial Comment of CD Atkins. J Clin Oncol. 2009; 27(15) 2753.

33.

Mohiuddin MM, Regine WF. Consenting the Patient with Early Stage Breast Cancer: “Informed” Only after Multi-Disciplinary Evaluation. Journal of Clinical Oncology 27(30) 158-159, October 2009.

34.

Mahmood U, Kwok Y, Regine WF, Patchell RA. Whole-Brain Irradiation for Patients with brain Metastases: Still the Standard of Care. Lancet 11, 221-222, 2010 [Letter].

35.

Nichols E, Regine WF, Feigenberg S. What is the Target Volume for Pre-operative Accelerated Partial Breast Irradiation (APBI)? [Letter] Int J Radiat Oncol Biol Phys 2010;80 (1)315-316.

36.

Regine WF, Ryu S, Chang EL. Spine Radiosurgery for Spinal Cord Compression: The Radiation Oncologist’s Perspective. Journal of Radiosurgery and SBRT, Vol 0 1-7, 2011.

37.

Sharma N, Regine WF, Radiation Therapy in Resectable/Resected Pancreatic Adenocarcinomas: Clearing Up the Fog. Commentary, Oncology, Vol 25, No. 8, July, 2011.

ABSTRACTS ( Manuscript not Published): 1.

Regine WF, O'Hara MD, Mohiuddin M. Murine Bone Marrow Macrophage Colony Forming Units Response to Radiation +40-420C: Potential Implications for Combined Total Body Irradiation and Hyperthermia. Int J Radiat Oncol Biol Phys 21:202-203, 1991.

2.

O'Hara MD, Pollard M, Wheatley G, Regine WF, Mohiuddin M, Leeper D. Thermal Response and Hyperthermic Radiosensitization of SCID Mouse Bone Marrow CFU-C. Int J Radiat Oncol Biol Phys 27: 225, 1993.

3.

Meigooni AS, Mohiuddin M, Ibbott GS, Regine WF, Ahmed VR, Kolarparthi VSR, Fruitwala S. Physical Dosimetry and Biological Basis of GRID Radiation Therapy. Medical Physics 23(6): 1105, June 1996.


William F. Regine, M.D. Curriculum Vitae - Page 15

4.

Mohiuddin M, Regine WF, Marks G. Long-Term (Ten Year) Results of High Dose Preoperative Radiation for Cancer of the Rectum. Int J Radiat Oncol Biol Phys 32(S1): 261, 1996.

5.

Mohiuddin Me, Mohiuddin Ma, Patel N, Dey S, Chendil D, Regine WF, Mohiuddin Mo, Ahmed MM. 5FU Sensitizes Radiation by a Mechanism Independent of p53 to Cause Clonogenic Inhibition and Apoptosis in Pancreatic Tumor Cell Lines. Int J Radiat Oncol Biol Phys 42(S2): 236(#2018), 1998.

6.

Kudrimoti M, Regine WF, John W, McGrath P, Hanna N, Mohiuddin M. Concurrent Infusional Gemcitabine and Radiation in the Treament of Advanced Unresectable GI Malignancy: A Phase I/II Study. Proceedings of ASCO, J Clin Oncol 18: 242a(#928), 1999.

7.

Regine WF. Non – Invasive Treatment for Acoustic Neuromas. Physician’s Practice Digest 9(3): A3, 1999.

8.

Regine WF, Young AB. Gamma Knife Radiosurgery Now an Option for More Patients. Physician’s Practice Digest 9(6): A4-5, 1999.

9.

Sanghavi SN, Miranpuri BS, Chapell R, Mabanta S, Suh JH, Regine WF, Weltman E, Sneed PK, Goetsch SJ, Breneman JC, Sperduto PW and MAPP, Scott C, Buatti JM, Mehta MP. Multi-Institutional Survival Analysis of Brain Metastases Patients Treated with Radiosurgery,Stratified by RTOG RPA Classification. Int J Radiat Oncol Biol Phys 45(S3): 171(#48), 1999.

10.

Mohiuddin M, Kudrimoti M, Regine WF, McGrath P, Hanna N, Meeker T, John W. Concurrent Infusional Gemcitabine and Radiation in the Treament of Advanced Unresectable GI Malignancies. Int J Radiat Oncol Biol Phys 45(S3):255(#204), 1999.

11.

Staryszak M, Meigooni AS, Drogin A, Gearheart D, Meade J, Sanders M, Young B, Regine WF. Measurement of Dose to the Normal Tissue for Treatment with Multiple Targets Using Radiosurgery Techniques. Scientific program LINAC Radiosurgery – 1999 Meeting, 58, 1999.

12.

Regine WF. The Role of Radiotherapy in Colorectal Cancer. Proceedings of the 4th Annual National VA Oncology Symposium, VHSJ 5(7): 21-22, 2000.

13.

Regine WF. The Radiation Oncologist’s Perspective on Stereotactic Radiosurgery. Proceedings of International Conference on Technology in Cancer Research and Treatment in the New Millennium 1516, 2001.

14.

Kudrimoti M, Regine WF, Huhn JL, Meigooni AS, Ahmed M, Mohiuddin M. Spatially. Fractionated Radiation Therapy (SFR) in the Palliation of Large Bulky (>8 cm) Melanomas Int J Radiat Oncol Biol Phys 54 (S1):342 (#2225), 2002. Petit JH, Herman JM, Biggins T, Regine WF, Chin LS. Repeat Gamma Knife Radiosurgery for Refractory of Recurrent Trigeminal Neuralgia. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 57(2):S137 (#22), 2003.

15.

16.

Dutta PR, Kwok Y, Herman JM, Chin LS, Colliver C, St. Clair WH, Petit JH, Young B, Regine WF. Comparison of Repeat GK-SRS for Refractory or Recurrent Trigeminal Neuralgia: Does Dose Matter. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60(1) S405(#2118), 2004.

17.

Kwok Y, Murali N, Chin L, Bangalore M, Amin P, Regine WF. Long-Term Results of Gamma Knife. Stereotactic Radiosurgery for Non-Functioning Pituitary Adenomas. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60(1) S551 (#2361), 2004.


William F. Regine, M.D. Curriculum Vitae - Page 16

18.

Kudrimoti M, Mohiuddin M, Ahmed M, Meigooni AS, Hanna N, Regine WF, Huhn J. Use of High Dose Spatially Fractionated Radiation (GRID Therapy) in Management of Large, Poor Prognostic Stage III (>10cms) Soft Tissue Sarcomas. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60(1) S575 (#2400), 2004.

19.

Dhople AA, Kwok Y, Jaboin J, Sorkin JD, Slawson R, Amin P, Chin LS, Regine WF. Efficacy and Quality of Life in Patients with Atypical Trigeminal Neuralgia Treated with Gamma-Knife Stereotactic Radiosurgery. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S106 (#175), 2005.

20.

Garofalo MC, Malloy P, Amin P, Jaboin J, Gutt R, Van Echo D, Regine WF. Treatment of Unresectable Chemorefractory Liver Metastases with Selective Intrahepatic Application of Yttrium-90 Microsphere (SIR-Spheres): Early U.S. Experience. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S161 (#1028), 2005.

21.

Jaboin J, James R, Stallmeyer B, Shaw N, Slawson R, Amin P, Chin LS, Simard J, Regine WF. An Analysie of Dose-Staged Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S258, (# 2048), 2005.

22.

Patel S, Kwok Y, Shepard D, Chin LS, Slawson R, Amin P, Regine WF. Evaluating the Influence of Dose- Rate on Outcome with Gamma Knife Stereotactic Radiosurgery in the Treatment of Trigeminal Neuralgia. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S429 (#2336), 2005.

23.

SM Arnold, WW Graham, J Valentino, Y Brill, Regine WF, P Spring, C Given, M Mohiuddin, W St. Claire, M Kudrimoti. Results of intraarterial cisplatin and hyperfractionated radiotherapy in locally advanced cancer of the oropharynx and oral cavity. Proceedings of ASCO Annual Meeting, June, 2006.

24.

GW Warren, SM Arnold, G Curtis, J Valentino, Y Brill, Regine WF, PM Spring, M Mohiuddin, WH St. Clair, MR Kudrimoti.The effect of induction therapy with carboplatin-paclitaxel and low dose radiotherapy followed by hyperfractionated radiotherapy and intraarterial chemotherapy on advanced cancers of the head and neck. Proceedings of ASCO Annual Meeting, June, 2006.

25.

Yu CX, Feng Y, Castro-Pareja C, Shekhar R, Regine WF. On-Line Aperture Morphing – An InterFraction Image Guidance Strategy. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66 (3)S51, (# 91), 2006.

26.

Garofalo MC, Winter K, Regine WF, Rich TA, Komaki R, Tepper JE, Gunderson LL, Willett CG. Recursive Partitioning Analysis (RPA) of Prognostic Factors in Six Radiation Therapy Oncology Group (RTOG) Trials of Chemoradiotherapy for Unresectable Pancreatic Cancer. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66(3) S80, (# 144), 2006. Kudrimoti MR, Warren G, Valentino J, Spring P, Brill Y, Given C, St. Clair W, Mohiuddin M, Regine WF, Arnold S. Stratification of Therapy Basd on Response to Novel Induction Therapy in Stage III/IV Squamous Cell Carcinoma of the Head/Neck (SCCA H/N). Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66(3) S442, (# 2417), 2006.

27.

28.

Arnold SM, Warren GW, Valentine J, Brill Y, Regine WF, Spring P, Given C, Mohiuddin M, Huhn JL, Kudrimoti M. Long Term Results of Regional Control in Stage III-IV Node Positive Patients with Squamous Cell Carcinoma of the Head an Neck Using Hyperfractionated Radiation Therapy and Intraarterial Chemotherapy (HYPERRADPLAT). Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66 (3)S446, (# 2427), 2006.

29.

Regine WF, Garcia M, Berger AC, Abrams RA, Safran H, Konski A, Benson AB, MacDonald JS, Rich TA,Willett CG. Post-Resectional CA 19-9 Values ≥ 90 are Associated with Significantly Worse Survival in Patients with Pancreatic Carcinoma Treated with Adjuvant Therapy on RTOG 9704 – Implications for


William F. Regine, M.D. Curriculum Vitae - Page 17

Current and Future Trials. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 69 (3) S78, (# 137), 2007 30.

Kwok Y, Won M, Regine WF, Mehta M, Schmitt F, Patchell RA, Watkins-Bruner D. Neurocognitive Impact of Whole-Brain Radiation on Patients with Brain Metastases: Secondary Analysis of RTOG BR0018.Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 69 (3) S103, (# 184), 2007.

31.

Dhople AA, Adams JR, Kwok Y, Yu CX, Simard M, Maggio WW, Regine WF. Long Term Follow-up of Repeat Gamma Knife Stereotactic Radiosurgery for Refractory or Recurrent Trigeminal Neuralgia. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 69 (3) S123, (# 222), 2007.

32.

Berger AC, Garcia M, Regine WF, Abrams R, Safran H, Hoffman J, Benson A, Macdonald J, Willett CG. Evaluation of the Relationship Between Lymph Node Ratio (LNR) and Survival in Patients Undergoing Pancreaticoduodenectomy (PD) Followed by Adjuvant Chemoradiation (CRT) for Pancreatic Cancer â&#x20AC;&#x201C; A Secondary analysis of RTOG 9704. Proceedings of 2008 ASCO Gastrointestinal Cancers Symposium Science and Multidisciplinary Management of GI Malignancies. (#200) 168-170, 2008.

33.

Garofalo MC, Nazareth DP, Errens M, DSouza WD, Regine WF. A Comparison of 3D-CRT and IMRT Planning for Patients with T3N or T4Nx or T4Nx Mid/Distal Rectal Cancers: Potential for Small Bowel Sparing and Reductions in Dose-limiting Acute GI Toxicity. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 72 (1) S250, (# 2179), 2008.

34.

Regine WF, Hanna NN, Wong R, Major P, Garofalo MC, Alexander HR, Pandya N, Kennedy NL, Mohiuddin M. Radiation Therapy (RT) as a Chemopotentiator of Gemcitabine (G) in Patients with Advanced Pancreatic Cancer: A Multi-institutional Phase II Study. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 72 (1) S258, (# 2198), 2008.

35.

Neuner GA, Vander Walde N, Ha JK, Yu CX, Mohiuddin M, Regine WF. High-dose Spatiallyfractionated GRID Radiation Therapy (SFGRT): A Comparison of Outcomes of Threatment Delivered Through Cerrobend GRID versus MLC Grid. (Presented at ASTRO, 2008) 2007-2008.

36.

Gilbert MR, Wang K, Aldape A, Lassman AG, Sorensen T, Mikkelson M, Groves M, Werner-Wasik, Regine WF, Mehta M. A Phase II Study of Bevacizumab with Irinotecan in Recurrent Glioblastoma. Proceedings of ASCO, Journal of Clinical Oncology 27 (15) 2009.

37.

Yovino SG, Rutter C, Szerlip N, Kwok Y, Regine WF. Long-term Survivors of Brain Metastases (BM)Have Optimal Brain Tumor Control with Combined Whole Brain Radiation (WBRT) and Stereotactic Radiosurgery (SRS). Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 75 (3) S247, (# 2143) 2009.

38.

Strongin A, Yovino S, Taylor R, Wolf J, Cullen K, Ord R, Zimrin A, Strome S, Regine WF, Suntharalingam, M. Tumor Volume Predicts Tumor Control and Survival among Patients with Locally Advanced Head and Neck Cancer Undergoing Definitive Chemoradiation Therapy. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 75 (3) S405 (#2499) 2009.

39.

Regine WF. Factors Impacting White Matter Changes Following Whole Brain Radiation Therapy. Proceedings of ASTRO, Int. J. Radiat Oncol Biol Phys 78 (8) S268 (#2148) 2010.

40.

TP Diwanji, Dhople AA, Chin LS, Maggio WW, Adams JR, Regine WF, Kwok Y. Long-term Outcome of Gamma Knife Stereotactic Radiosurgery for Multiple Sclerosis Associated Trigeminal Neuralgia. Proceedings of ASTRO, Int. J. Radiat Oncol Biol Phys 78 (8) S262 (#2134) 2010.


William F. Regine, M.D. Curriculum Vitae - Page 18

41.

Berger AC, Winter K, Hoffman JP, Regine WF, Abrams RA, Safran H, Freedman GM, Benson AB, MadDonald J, Willett C. Five Year Results of US Intergroup/RTOG 9704 with Postoperative Ca 19-9 <90 and Comparison to the Conko-001 Trial. Proceedings of ASTRO, Int. J. Radiat Oncol Biol Phys 78 (8) S98 (#214) 2010.

42.

Sharma NK, Pandya N, Wong R, Herman J, Hanna NN, Laheru DA, Major P, Alexander HR, Kennedy N, Regine WF. Low Dose Upper Abdominal Radiation Therapy (LD-UART) Potentiates Gemcitabine in Patients with Advanced, Unresectable Pancreatic Cancer (PC): Final Results from a Phase II MultiInstitutional Study. Proceedings of ASTRO, Int. J. Radiat Oncol Biol Phys 78 (8) S105 (#220) 2010.

43.

Maidment B, Yovino SG, Herman J, Goloubeva O, Wolfgang C, Shulick R, Laheru D, Hanna NN, Alexander HR, Regine WF. Analysis of Local Control in Patients Receiving IMRT for Resected Pancreas Cancer. Proceedings of ASTRO, Int. J. Radiat Oncol Biol Phys 78 (8) S192 (#1121) 2010.

44.

Feigenberg SJ, Yu CX, Regine WF. Development of Stereotactic Body Radiation Therapy (SBRT) System Dedicated to the Treatment of Early Stage Breast Cancer: The Gammapod. Proceedings of ASTRO, Int. J. Radiat Oncol Biol Phys 78 (8) S206 (#2008) 2010

45.

Nichols EM, Feigenberg SJ, Marter K, Lasio G, Cheston SB, Tkaczuk K, Buras R, Hanna NN, Regine WF. Pre-operative Therapy Increases Patient Eligibility for Accelerated Partial Breast Irradiation (APBI) and Decreases Normal Tissue Exposure. Proceedings of ASTRO, Int. J. Radiat Onocl Biol Phys 78 (8) S253 (#2104) 2010.

46.

Neuner GA, Lu W, Wang Z, Sassor S, George R, Feigenberg SJ, Regine WF, D’Souza WD. Biofeedback During 4D-CT Image Acquisition Does not Enhance the Reliability of ITVMIP for Radiation Treatment Planning of Thoracic and Abdominal Malignancies: A Prospective Trial. Proceedings of ASTRO, Int. J. Radiat Oncol Biol Phys 78 (8) S673 (#3046) 2010.

47.

Lu W, Neuner G, Wang Z, George R, Wu J, Sassor S, Regine WF, Feigenberg SJ, D’Souza WD. Evaluating Inter-fraction Variations in Tumor Volumes with Repeated 4D-CT. Proceedings of ASTRO, Int. J. Radiat Oncol Biol Phys 78 (8) S746 (#3215) 2010.

48.

Neuner GA, Wang Lu W, Sassor S, George R, Regine WF, Feigenberg SJ, D’Souza WD. Biofeedback During 4DCT Image Acquisition Does Not Enhance the Reliability of ITV MIP for Radiation Treatment Planning of Thoracic and Abdominal Malignancies: A Prospective Trial. IJROBP, 78(3): S671, November, 2010.

49.

Lu W, Neuner G, Wang Z, George R, Wu J, Sassor S, Regine WF, Feigenberg S, D’Souza WD. Evaluating Inter-Fraction Variations in Tumor Volumes with Repeated 4D CT. IJROBP, 78(3): S748S749, November, 2010.

50.

Regine WF, Nichols EM, Feigenberg SJ. Preoperatiave Accelerated Partial Breast Irradiation (APBI) versus Postoperative APBI: The Potential for Improved Cosmetic Outcomes. Proceedings of ASTRO, J. Radiat Oncol Biol Phys 81 (2) S51 (#2080) 2011.

51.

Yi BY, Zhang J, Mutaf Y, Prado KL, Yu CX, D’Souza W, Wang C, Zhou B, Regine WF, Feigenberg SJ. Using a Novel, Completely Non-invasive Approach to Stereotactic Breast Radiotherapy: Similar Dose Distributions to Brachytherary are Achievable for Candidates of Accelerated Partial Breast Irradiation (APBI. Proceedings of ASTRO, J. Radiat Oncol Biol Phys 81 (2) S261 (#2102) 2011.

52.

Feigenberg SJ, Buras R, Dragula C, Citron W, Dolgovskij A, Marter K, Nichols EM, Dhople A, Tkaczuk, Regine WF. Preliminary Results of a Prospective Feasibility Study Testing Preoperative Accelerated


William F. Regine, M.D. Curriculum Vitae - Page 19

Partial Breast Radiotherapy (APBI) Using 3 Dimensional Conformal Radiotherapy (3D CRT). Proceedings of ASTRO, J. Radiat Oncol Biol Phys 81 (2) S264 (#2108) 2011. 53.

Sharma NK, Mahmood U, Horiba NM, Hanna NN, Alexander HR, Pandya NB, Regine WF. Effects of Racial/Social Factors and INT-0116/MAGIC Trials Publication on Radiation Therapy (RT) Utilization for Gastric Cancer. Proceedings of ASTRO, J. Radiat Oncol Biol Phys 81 (2) S327 (#2239) 2011.

54.

Nichols EM, Grabowski SF, Hanlon A, Regine WF, Patel R, Kudryasheva S, Moeslein FM, Garofalo M, Amin PP, Sharma NK. Persormance Status (PS), Number of Lesions and Interval from Metastatic Diagnosis to Treatment (IMDTT) Predict for Overall Survival (OS) in Patients Treated With Hepatic Transarterial Radioembolization (TARE) with Yttrim-90 (Y90) Microspheres. Proceedings of ASTRO, J. Radiat Oncol Biol Phys 81 (2) S46 (#2281) 2011.

55.

Grabowski SF, Nichols EM, Kudryasheva S, Patel R, Garofalo M, Amin PP, Moeslein FM, Regine WF, Sharma NK. The Efficacy of Selective Internal Radiation Therapy (SIRT) With Yttrium-90 (Y90) is Enhanced When Given in Low Volume Disease and in Conjunction With Other Liver-Directed Therapies. Proceedings of ASTRO, J. Radiat Oncol Biol Phys 81 (2) S353 (#2296) 2011.

56.

Yi BY, Zhang J, Mutaf Y, Prado K, Yu C, Dâ&#x20AC;&#x2122;Souza WD, Wang C, Zhou B, Regine WF, Feigenberg SJ.Using a Novel, Completely non-invasive Approach to Stereotactic Breast Radiotherapy, Similar Dose Distributions to Brachytherapy are Achievable for Candidates of Accelerated Partial breast Irradiation (APBI). Fuel and Energy Abstracts, 81(2): S261-S261, 2011.

57.

Nichols EM, Feigenberg SJ, Marter K, Cheston SB, Lasio G, Tkacuk K, Kesmodel S, Buras R, Regine WF. Pre-Operative Radiation Therapy Significantly Increases Patient Eligibility for Accelerated Partial Breast Irradiation using 3- D Conformal Radiotherapy. (Am J Clin Oncol. 2012 April 30 [Epub ahead of print]. 2011.

58.

Williams TM, George A, Regine WF, Thomas DG, Schaefer P, Safran H, Small W, Guha C, Ben-Josef, E. Caveolin-1 Expression Correlates With Outcomes in Pancreatic Ductal Carcinoma: A Secondary Analysis of RTOG 9704. IJROBP, 84,(3S): S26, November, 2012.

59.

Feigenberg SF, Staats P, Citron W, Dragula C, Cohen R, Kesmodel S, Bellavance E, Chumsri S, Tkaczuk K, Regine WF. Near 25% Complete Pathologic Response Following Preoperative Accelerated Partial Breast Radiation Therapy (APBI) Using 3-dimensional Conformal Radiation Therapy (3D CRT). IJROBP, 84(3S):S238, November, 2012.

60.

Feigenberg SJ, Christenson E, Staats P, Webb T, Chumsri S, Tkaczuk K, Nichols E, Kesmodel S, Bellavance E, Regine, WF. Preoperative Accelerated Partial Breast Irradiation is Associated with Decreased Cd8+ Cells with Early Breast Cancer. IJROBP, 84, (3S): S243, November, 2012.

61.

Reese AS, Yang X, Lu W, Sharma NK, Feigenberg SJ, Regine WF, Yi BY. Deformable Image Registration as a Method to Assess Motion for Pancreatic Cancer Using 4D Computed Tomography (CT) scans. IJROBP, 84(3S): S771, November, 2012.

62.

Yang X, Reese AS, Mutaf YD, Prado KL, Sharma NK, Feigenberg SJ, Regine WF, Yi BY. Dosimetric Validation of Respiratory Motion Margins for Patients with Pancreatic Cancer Using Deformable 4D Contour Propagation. IJROBP, 84(3S) S778-779, November, 2012. Mishra MV, Regine WF, Mehta MP. An Evaluation of Worldwide Proton Beam Therapy Clinical Trials. IJROBP, 87(2S):S178, October, 2013.

63.


William F. Regine, M.D. Curriculum Vitae - Page 20

64.

Rutenberg M, Errens MA, Sharma N, Yang X, Yi BY, Regine WF. A Comparison Between Consensus Guidelines-Based PTVs and 4D-CT-Based PTVs for Locally-Advanced Pancreatic Cancer: Implications for Therapy. IJROBP, 87(2S):S189, October, 2013.

65.

Chaudhry H, Hanlon AL, Kesmodel S, Bellavance EC, Tkaczuk K, Drogula C, Citron WK, Cohen RJ, Regine WF. A Prospective Tial of Peroperative Accelerated Partial Breast Irradiation (APBI): Predictors of Asymptomatic and Symptomatic Seroma Formation. IJROBP, 87(2S):S215-S216, October, 2013.

66.

Sours C, Mistry N, Zhang H, Kwok Y, Mehta MP, Regine WF. Feasibility Study Testing the Incorporation of Resting State fMRI Dat in Raditation Therapy Planning to Limit Dose to Cognitive Function Networks in Patients With Primary Brain Tumors. IJROBP, 87(2S):S254-S255, October, 2013.

67.

Chaudhry H, Ellison TA, Maidment BW, Regine WF, Alexander H, Hanna N, Wolfgang CL, Morris CG. Radiation Therapy in Pancreatic Neuroendocrine Tumors: Favorable Outcomes and Low Toxicity in a Multi-institutional Experience. IJROBP, 87(2S):S308, October, 2013.

68.

Mooney K, Lasio G, Lu W, Feigenberg SJ, Regine WF, D’Souza W. An Approximate Entropy-Based Method for Prediction of 4D-CT Quality from Respiratory Signals. IJROBP, 87(2S):S386-S387, October, 2013.

69.

Chaudhry H, Mutaf YD, Yu CX, Yi BY, Prado KL, D’Souza W, Regine WF, Feigenberg SJ. The Dosimetric Effect Of Tumor Size and Position in Prone Radiation Therapy of Breast Using a Novel Stereotactic Breast Irradiation Device. IJROBP, 87(2S):S748, October, 2013.

BOOK CHAPTERS/TEXTBOOKS: 1.

Regine WF. Postoperative Adjuvant Therapy for Pancreatic Cancer: Past, Present, and Future Trial Development. In: MD Anderson Solid Tumor Oncology Series: Pancreatic Cancer. Evans DB, Pisters PWT, Abbruzzese JL, eds. Spinger-Verlag, 2001;235-242.

2.

Regine WF, Hanna N, DeSimone P, Cohen A. Rectal Cancer. In: Clinical Oncology, 3rd Edition Abeloff M, ed. Churchill Livingstone, 2003; 1943-1966.

3.

Kwok Y, Garofalo MC, Regine WF. Postoperative Adjuvant Therapy and the Rationale for the US Intergroup Trial. In: “Van Hoff D, Evans D, Hruban, RH, eds. Jones and Bartlett, 2005;395-404.

4.

Garofalo MC, Flannery T, Regine WF. The Case for Adjuvant Chemoradiation for Pancreatic Cancer. In: Best Practice & Research Clinical Gastroenterology, eds. Elsevier, Vol 20, No 2, pp. 403-416, 2006.

5.

Patel S, Garofalo MC, Regine WF. Role of Radiotherapy in Treatment of Pancreatic Cancer. (Chapter 81) In: Rao B, Beger H, Neoptolemos J, Shiratori K, Lerch M, eds. The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, Blackwell Publishing, Ltd., April 2008.

6.

Kwok Y, Patchell RA, Regine WF. Palliation of Brain and Spinal Cord Metastases. In: Principles & Practice of Radiation Oncology, 5th Edition, Lippincott, Williams and Wilkins Publishing. 2008;19741985.

7.

Suh JH, Barnett GH, Regine WF. Stereotactic Radiosurgery for Brain Metastases. In: Chin LC, Regine WF eds. Principles & Practice of Stereotactic Radiosurgery. Springer Publishing. 2008; 181-191.

8.

Patchell RA, Regine WF. Whole Brain Radiation Therapy for Brain Metastases. In: Chin LC, Regine WF, eds. Principles & Practice of Stereotactic Radiosurgery. Springer Publishing 2008; 201-206.


William F. Regine, M.D. Curriculum Vitae - Page 21

9.

Chin LS, Regine WF. Editors. Principles and Practice of Stereotacic Radiosurgery, Springer Publishing, April, 2008.

10.

Pandya N, Garofalo MC, Regine WF. The Case for Adjuvant Chemoradiation Therapy for Pancreatic Cancer. In: Handbook of Pancreatic Cancer. Abbruzzese J, Buchler M, Neoptolemos J, Urrutia R, eds(In Press).

11.

Garofalo MC, Regine WF. Adjuvant Chemoradiation for Pancreatic Cancer: Past, Present, and Future. In: M.D. Anderson Solid Tumor Oncology Series. Pancreatic Cancer. Lowy, Leach, Philip, eds. 2008; 535-548.

12.

Cohen AM, Garofalo MC, DeSimone PA, Hanna NN, Regine WF. Cancer of the Rectum. In: Clinical Oncology 4th Edition. Abeloff M, Armitage JO, Neiderhuber JE, Kastan MB, McKenna WG, eds. Churchill Livingstone, 2008; 1535-1556.

13.

Kwok Y, Patchell RA, Regine WF. Management of Overt Central Nervous System Metastases: Brain and Spinal Cord. In: Principles and Practice of Lung Cancer, Fourth Edition. Pass, HI, Carbone DP, Johnson DH, Minna JD, Scagliotti GV, Turris III AT, eds. Lippincott Williams & Wilkins, 2010; 911926.

14.

Kwok Y, Patchell, Regine WF. Palliation of Brain and Spinal Cord Metastases. In: Perez and Bradyâ&#x20AC;&#x2122;s Principles and Practice of Radiation Oncology, Sixth Edition. Edward C. Halperin, MD, David E. Wazer, MD, Carlos A. Perez, MD, and Luther W. Brady, MD. eds. Lippincott Williams & Wilkins, 2013; 17661777.

15.

Herman JM, Regine WF, Shokek O, Gastrointestinal Pancreatic Cancer Section. In: Radiation Oncology Difficult Cases and Practical Management, eds. William Small, Jr, Tim R. Williams, Eric D. Donnelly, 2013; 43-51.

16.

Mahmod U, Husain Z, Kwok Y, Regine WF. Stereotactic Radiosurgery (SRS) versus Whole Brain Radiation Therapy (WBRT) in the Management of Multiple Brain Metastases. In: Controversies in Neuro-Oncology, Best Evidence Medicine for Brain Tumor Surgery, Alfredo Quinones-Hinojosa, Shaan M. Raza, 2013; 244-251.

17.

Yovino S, Kwok Y, Regine WF. Brain and Cranial Nerves. In: Adverse Late Effects of Cancer Treatment, Volume 2: Normal Tissue Specific Sites and Systems. (Springer-Verlag Berlin Heidelberg 2014); 1-21.

PATENTS/INVENTIONS: 1.

2006 Dâ&#x20AC;&#x2122;Souza W., Yu CX, Suntha M, Regine WF, McAvoy T. Movement of a Treatment Target in a Patient

2.

2008 Yu CX, Yu YS, Regine WF, Method and Equipment for Image-Guided Stereotactic Radiosurgery of Breast Cancer (Gammapod)

PRESENTATIONS:

Techniques for Compensating


William F. Regine, M.D. Curriculum Vitae - Page 22

NATIONAL 1.

Murine Bone Marrow Macrophage Colony-Forming Unit Response to Radiation +40-420C: Potential Implications for Combined Total Body Irradiation and Hyperthermia. 33rd Annual Scientific Meeting of the American Society for therapeutic Radiology and Oncology, Washington, DC, November, 1991. [Poster].

2.

Evaluation of Local Control with Selective Use of Low-Dose Irradiation Following Induction/Preoperative Chemotherapy for Locally AdvancedRhabdomyosarcoma. 35th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, New Orleans, LA, October, 1993.

3.

Use of Altered Radiation (RT) Dose and Fractionation in Patients with Unresectable Rhabdomyosarcoma (RMS) Based Upon Disease Status Following Induction Therapy:The St. Jude experience.34th Annual Meeting of the American Society of Clinical Oncology, Dallas, TX, May, 1994. [Poster]

4.

Efficacy of Postoperative Irradiation for Recurrent Squamous Cell Carcinoma of the Head and Neck. 4th International Conference on Head and Neck Cancer, Toronto, Canada, July, 1996.

5.

Dose-Intensive Chemoradiation Following Pancreaticoduodenectomy for Pancreatic Carcinoma â&#x20AC;&#x201C; A Phase I Study. 38th Annual Scientific Meeting of the American Society of Radiology and Oncology, Los Angeles, CA, October, 1996.[Poster]

6.

Results of Postoperative Irradiation for Squamous Cell Carcinoma of the Head and Neck: Is There a Difference Between Primary and Recurrent Disease? 39th Annual Scientific Meeting of the American Society of Radiology and Oncology, Orlando, FL, October, 1997. [Poster]

7.

Results of High-Dose Intra-Arterial Cisplatin and Hyperfractionated Radiation Therapy in Patients with High Volume Unfavorable Squamous Cell Carcinoma of the Head and Neck. 34th Annual Meeting of the American Society of Clinical Oncology, Los Angeles, CA, May, 1998. [Poster]

8.

A Randomized Prospective Trial of the Benefit of Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain. 40th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Phoenix, AZ, October, 1998.

9.

A Phase I Study of Fractionated Stereotactic Radiosurgery and Conventional External Beam Radiation Therapy for Unfavorable Intracranial Tumors. LINAC Radiosurgery â&#x20AC;&#x201C; 1999 Meeting, Orlando, FL, December, 1999.

10.

Combined Fractionated Gamma Knife Stereotactic Radiosurgery and Conventional Radiation Therapy for UnfavorableGliomas: A Phase I Study. 10th International Meeting of the Leksell Gamma Knife Society, Squaw Valley, CA, April, 2000.

11.

High-Dose Intra-Arterial Cisplatin Boost with Hyperfractionated Radiation Therapy for Advanced Squamous Cell Carcinoma of the Head and Neck. 36th Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA, May, 2000. [Poster Discussion]

12.

Neurocognitive Outcome in Brain Metastasis Patients Treated with Accelerated Fractionation vs. Accelerated Hyperfractionation Whole Brain Radiotherapy: An Analysis from RTOG Study 91-04. 42nd Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Boston, MA, October, 2000.


William F. Regine, M.D. Curriculum Vitae - Page 23

13.

Gamma Knife Radiosurgery Alone following High Resolution MRI in Patients with Newly Diagnosed Brain Metastases: Results and Implications. 5th Annual Meeting of the Society for Neuro-Oncology, Chicago, IL, November, 2000.

14.

A Phase II Study of concomitant Hyperfractionated Radiation Therapy and Double Dose Intra-Arterial Cisplatin for Squamous Cell Carcinoma of the Head and Neck. 37th Annual Meeting of the American Society of Clinical Oncology, San Francisco, CA, May, 2001. [Poster]

15.

Risk of Symptomatic Brain Tumor Recurrence and Neurologic Deficit Following Gamma Knife Radiosurgery Alone for Single Metastases to the Brain. 14th International Conference On Brain Tumor Research and Therapy, Asheville, NC, May, 2001. [Poster]

16.

Efficacy of 20 Gy Gamma Knife Stereotactic Radiosurgery With or Without Whole Brain Radiation Therapy for < 2 cm Brain Metastases. 5th International Stereotactic Radiosurgery Society Congress, Las Vegas, Nevada, June, 2001.

17.

Prognostic Factors in Patients with Resected Single Brain Metastases: Evaluation of Recursive Partitioning Analysis Classes I and II. 43rd Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, San Francisco, CA, November, 2001.

18.

Feasibility of Neurocognitive Outcome Evaluations in Patients with Brain Metastases in a MultiInstitutional Cooperative Group Setting: Results of Radiation Therapy Oncology Group (RTOG) Trial BR-0018. 44th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, New Orleans, LA, October, 2002.

19.

Metastatic spinal cord compression: A Randomized Trial of Direct Decompressive Surgical Resection plus Radiotherapy vs. Radiotherapy Alone. 45th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Salt Lake City, UT, October 2003.

20.

Radiation Therapy as a Chemosensitizer of Gemcitabine in Patients with Metastatic/Unresectable Tumors of the Gastrointestinal Tract – a Phase I/II Study Exploring a New Treatment Paradigm. 47th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Denver, CO, October 2005.

21.

A Phase III study of adjuvant pre and post chemoradiation 5-FU vs. gemcitabine for resected pancreatic adenocarcinoma. 42nd Annual Meeting of the American Society of Clinical Oncology, Atlanta, GA, June, 2006.

22.

RTOG 9704: A Phase III Study of Adjuvant Pre and Post Chemoradiation 5-FU vs. Gemcitabine for Resected Pancreatic Adenocarcinoma. 48th Annual Scientific Meeting of the American Society of Therapeutic Radiology and Oncology, Philadelphia, PA, November, 2006.

23.

Post-Resectional CA 19-9 Values ≥ 90 Are Associated with Significantly Worse Survival In Patients With Pancreatic Carcinoma Treated With Adjuvant Therapy on RTOG 9704 – Implications For Current And Future Trials. 49th Annual Scientific Meeting of the American Society of Therapeutic Radiology and Oncology, Los Angeles, PA, October, 2007.

24.

5-Year Results of the Phase III Intergroup Trial (RTOG 97-04) of Adjuvant Pre and Post Chemoradiation (CRT) 5-FU vs. Gemcitabine (G) for Resected Pancreatic Adenocarcinoma: Implications for Future International Design, 51st Annual Scientific Meeting of the American Society of Therapeutic Radiology and Oncology, Chicago, IL, November, 2009.


William F. Regine, M.D. Curriculum Vitae - Page 24

REGIONAL 1.

The Combined Modality Treatment of Rectal Cancer. Section on Radiation Oncology, Philadelphia Roentgen Ray Society Meeting, Philadelphia, PA, January, 1992.

2.

The Role of Radiation in the Treatment of Adenoid Cystic Carcinoma of the Palate. 22nd Annual Radiation Oncology Clinical Research Seminar, Gainesville, FL, April, 1992.

3.

Pancreatic Cancer - Beyond Surgery is There a Role for Adjuvant Therapy? University of Kentucky/Department of Radiation Medicine Symposium: New Trends in the Management of G.I. Cancer, Lexington, KY, June, 1996.

4.

New Combined Treatment Modalities for Advanced Cancer of the Head and Neck. University of Kentucky/Department of Radiation Medicine Symposium: New Trends in the Management of Head and Neck Cancer, Lexington, KY, September, 1996.

5.

Use of Gamma Knife Radiosurgery in the Management and Treatment of Malignant Primary Brain Tumors. University of Kentucky Neurosciences Institute Symposium: New Trends in the Management of Central Nervous System Disease, Lexington, KY, February, 1997.

6.

Gamma Radiosurgery for Trigeminal Neuralgia. Kentucky Neurosciences Institute Symposium: New Trends in the Management of Trigeminal Neuralgia, Lexington, KY, July, 1997.

7.

Introducton to Gamma Knife Radiosurgery. The First Annual University of Kentucky Radiaton Therapy Conference, Lexington, KY, October, 1997.

8.

Current Status of Adjunctive Therapy Trials in the Management of Resectable Pancreatic Cancer. University of Kentucky/Department of Radiation Medicine Symposium: New Trends in the Treatment of Upper G.I. Cancer, Lexington, KY, August, 1999.

9.

High Dose Spatially Fractionated Radiation (GRID): A New Paradigm in the Management of Advanced Cancers. Second Annual Simon Kramer Institute Oncology Conference, New Philadephia, PA, August, 2002. [Poster].

10.

Radiotherapy & Surgery/Radiosurgery in the Treatment of Brain Metastases. Greenebaum Cancer Center Hematology/Oncology Grand Rounds, Baltimore, MD, September, 2003.

11.

“Introduction of the Gammapod System”, University of Maryland, Baltimore Foundation Board of Trustees, Baltimore MD, February, 2010.

12.

Radiation Oncology – The Power of Partnership”, University of Maryland Medical System Board Retreat, St. Michael’s MD, October, 2010.

13.

“Redefining the Paradigm for Cancer Care: The Future of the University of Maryland Department of Radiation Oncology at the UM Marlene and Stewart Greenebaum Cancer Center. University of Maryland School of Medicine Development Event, The Breakers Palm Beach, FL, February, 2012

14.

“The Power of Partnerships, Passion and People! – Much to be Proud of and a Glimpse into the Future”, University of Maryland School of Medicine Board of Visitors Spring Meeting, Baltimore, MD, April, 2013.


William F. Regine, M.D. Curriculum Vitae - Page 25

15.

“University of Maryland Radiation Oncology: The Power of Partnerships, Passion and People! A 10Year Review and a Glimpse into the Future:, University of Maryland Greenebaum Cancer Center, Board of Visitors, Baltimore MD, May, 2013.

16.

“University of Maryland Radiation Oncology: Cutting Edge Clinical Care and Protons – Benefiting the State of Maryland and Beyond! State of Maryland House Appropriations Committee, Baltimore, MD 2013.

17.

“University of Maryland Radiation Oncology: Cutting Edge Clinical Care and Protons – Benefiting the State of Maryland and Beyond! Prospective Hotel Developers for University of Maryland BioPark, Baltimore, MD, August, 2013.

VISITING PROFESSORSHIPS AND INVITED PRESENTATIONS: 1.

All Rectal Cancers Are Not Alike - Optimizing the Use ofAdjuvant Therapy. “Visiting Professor” at the Department of Radiation Oncology,University of Maryland, Baltimore, MD, July 1997.

2.

Trimodality Therapy for Malignancies of the Gastrointestinal Tract: The Evolving Roles of Surgery, Chemotherapy and Radiation. “Invited Speaker” at St. Vincent’s Medical Center, Jacksonville, FL, January 1998.

3.

Adjuvant Therapy for Pancreatic Cancer: Current Status. “Invited Speaker” at Gulf Coast Medical Center, Panama City,FL, January 1999.

4.

What is the Role of Radiotherapy in the Management of Colorectal Cancer? “Invited Speaker” at 4th Annual National VA Oncology Symposium, Washington DC, October 1999.

5.

What are the Roles of Adjuvant Therapy in Pancreatic Cancer and Radiation Therapy in the Management of Colorectal Cancer: Current Status. “Invited Speaker” at Centre Community Hospital, State College, PA, February 2000.

6.

Preoperative Chemoradiation in Fixed (T4) Distal Rectal Cancer: Dose Time Factors for Pathologic Complete Response. “Invited Speaker” at American College of Surgeons, Kentucky Chapter, Spring Meeting, Lexington, KY, March, 2000. Is Whole Brain Radiation Therapy a Standard of Care Following resection of a Single Brain Metastases? Yes. “Invited Speaker & Panelist” for Panel Presentation – ‘Controversies in the Management of Brain Metastases’ at 42th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Boston, MA, October 2000.

7.


William F. Regine, M.D. Curriculum Vitae - Page 26

8.

The Radiation Oncologist’s Perspective on Stereotactic Radiosurgery. “Invited Speaker” at International Conference on Technology in Cancer Research and Treatment in the New Millennium, Albany, NY, June 2001.

9.

CNS Criteria Development for the common Toxicity Criteria. “Invited Speaker & Panelist” for ‘Validation Studies and Criteria Development Process’ at NCI Sponsored Late Effects Workshop, St. Petersburg Beach, FL, April, 2002.

10.

Something Old, Something New, and Something Blue: Evolving Paradigms from the University of Kentucky Head & Neck & GI Cancer Programs. “Invited Speaker” at Gulf Coast Medical Center, Panama City, FL, July 2002.

11.

Use of Low–Dose Radiation as a Chemosensitizer for H&N Carcinomas–A New Treatment Paradigm. “Invited Speaker” at Sixth Annual International Conference & Workshop-New and Future Developments in Radiotherapy. Las Vegas, NV, August, 2002.

12.

Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Old and New Treatment Paradigms – The Joseph Marconis, MD Memorial Lecture. “Invited Speaker” at Second Annual Simon Kramer Institute Oncology Conference. New Philadephia, PA, August 2002.

13.

Radiotherapy and Surgery/Radiosurgery in the Treatment of Brian Metastases. “Invited Speaker” at Current Approaches To The Treatment Of Brain Metastases Symposium, CME Symposium in conjunction with 44th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, New Orleans, LA, October 2002.

14.

Current Management of Low-grade Gliomas. “Invited Speaker” at Exploring Advances in the Management of Gliomas Symposium. CME Symposium in conjunction with 45th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Salt Lake City, UT, October 2003.

15.

Adjuvant Multimodality Treatment with Gemcitabine vs. 5-FU in Pancreatic Cancer: Status of U.S. Intergroup Trial. “Invited Speaker” at Chemotherapy Foundation Symposium XXI. Innovative Cancer Therapy for Tommorrow. New York City, NY, November 2003.

16.

Metastatic spinal cord compression: A randomized trial of directo decompressive surgical resection plus radiotherapy vs. radiotherapy alone. “Invited Speaker” at Radiological Society of North American Scientific Assembly and Annual Meeting Program. Chicago, IL, December 2003.

17.

Quality of Life in Brain Neoplasms. “Invited Speaker” at Neuro-Oncology 2004 – Current Concepts Meeting, Cleveland Clinic Education Foundation. Orlando, FL, February 2004.

18.

“Pancreatic Cancer: Status of Adjuvant Multimodality U.S. Intergroup Phase III Trial” and “Metastatic Epidural Spinal Cord Compression (MESCC): Clinical Update”. “Visiting Professor” at the Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, September 2004.

19.

Neurologic sequelae of Brain Metastases: Recognition and Impact on Therapeutic Approach. “Invited Speaker” at WBRT for the Management of Brain Metastases: Novel Approaches to Improve the Therapeutic Index, CME Syposium in conjunction with 46th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology. Atlanta Georgia, October 2004.

20.

Management of GI Tumors-ASTRO 2004 Review. “Invited Speaker” at The Cleveland Clinic Callahan Center for Radiation Oncology 6th Annual ASTRO Review 2004. Cleveland, OH, November 2004.


William F. Regine, M.D. Curriculum Vitae - Page 27

21.

Pancreatic Cancer: Review of Adjuvant Multimodality Trials and Status of U.S. Intergroup Phase III Trial. “Visiting Professor” at The Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, November 2004.

22.

Malignant Gliomas: ‘Impacting Survival with New Treatment Strategies’ and ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Central Baptist Hospital, Cancer Center, Lexington Kentucky, February 2005

23.

‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Southern Illinois Cancer Center, Marion, Illinois, February 2005.

24.

‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Norris Cancer Center at USC, Los Angeles, CA, March 2005.

25.

‘Use of Gamma Knife Radiosurgery for Brain Tumors’ – “Invited Speaker” at Baltimore Oncology Club Annual Meeting, Sheraton Baltimore North, Towson, MD, March 2005.

26.

‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Akron City Hospital, Akron City, OH, March 2005.

27.

‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Houston Northwest Cancer program, Houston, TX, April 2005.

28.

‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Sinai Hospital Cancer Institute, Baltimore, MD May 2005.

29.

‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Tate Cancer Center, Glen Burnie, MD, May 2005.

30.

‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Pluta Cancer Center, Rochester, NY, May 2005.

31.

‘Resolved: Currently available Adjuvant Therapies of Pancreatic Cancer are effective – Agree’ (Debate) “Invited Speaker” at International Society of Gastrointestinal Oncology – The 2005 Gastrointestinal Oncology Conference, Arlington, VA, July 2005.

32.

‘Pancreatic Cancer – Adjuvant Postoperative Chemoradiation’ - “Invited Speaker” at 12th International Gastrointestinal Cancer Conference, Charlottesville, VA, October 2005.

33.

‘Glioblastoma Multiforme (& AA): The Multidisciplinary Approach to Treatment’ - “Invited Speaker” for Christiana Medical Center at The Hilton, Wilmington, DE, October 2005.

34.

‘Glioblastoma Multiforme (&AA): The Multidisciplinary Approach to Treatment’ – “Invited Speaker” for University of Kentucky, Markey Cancer Center, Lexington, KY, December 2005.

35.

‘Management of Brain Metastases: Concepts and Controversies’ “Invited Speaker” Harbor Hospital, Baltimore, MD April 2006.

36.

‘Brain Metastases: Truths and Misconceptions’: “Visiting Professor” at the Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, April 2006.

37.

‘Management of Brain Metastases’: Radiosurgery, Whole Brain Radiation Therapy and Quality of Life. “Invited Speaker” Washington Hospital Center, Washington, DC, May 2006.


William F. Regine, M.D. Curriculum Vitae - Page 28

38.

‘Management of Metatatic Brain Tumors - A Case Study “Invited Speaker” Sixth Annual Simon Kramer Institute Oncologic Symposium, New Philadelphia, PA, May 2006.

39.

‘Management of Brain Metastases: Concepts and Controversies’ “Invited Speaker” University of New Mexico Cancer Research and Treatment Center, Albuquerque, NM, June, 2006.

40.

‘Should Whole Brain Radiation Therapy follow Focal Therapy of a Single and Multiple Brain Metastases? “Invited Speaker” at Educational Session, 42nd Annual Meeting of the American Society of Clinical Oncology, Atlanta, GA, June, 2006.

41.

‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at University of Colorado, Anschutz Cancer Pavillion, Aurora, CO, June, 2006.

42.

‘Pancreatic Cancer – Adjuvant Postoperative Chemoradiation: Where We Have Been and Where We Are Going; “Invited Speaker” at Southern Illinois Cancer Center, Marion, Illinois, June, 2006.

43.

‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at University of Virginia, Charlottesville, VA, June, 2006.

44.

‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at Oregon Health and Science University, Department of Radiation Oncology, Portland OR, July, 2006.

45.

‘Management of Brain Metastases: Concepts and Controversies’ – “Invited Speaker” at Central Baptist Hospital, Cancer Center, Lexington KY, July, 2006.

46.

‘Management of Brain Metastases: Concepts and Controversies’ – “Invited Speaker” for University of Kentucky, Markey Cancer Center, Lexington, KY, July, 2006.

47.

‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at University of Louisville/James Brown Cancer Center and Department of Radiation Oncology, Louisville, KY, July, 2006.

48.

‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at University of Texas Southwest Medical Center and Department of Radiation Oncology, Dallas TX, July, 2006.

49.

‘The Role of Gemcitabine in the Adjuvant Treatment of Pancreatic Cancer’ and ‘Management of Brain Metastases: Concepts and Controversies’ – “Visiting Professor” at Norris Cancer Center and Department of Radiation Oncology as USC, Los Angeles, CA, August, 2006.

50.

‘Brain Metastases: Facts and Fiction’ – “Recrutiment Seminar” at The M.D. Anderson Cancer Center, Houston, TX, September, 2006.

51.

‘Management of Brain Metastases: Concepts and Controversies’ at Rocky Mountain Cancer Center, Casper Wyoming, September, 2006.

52.

‘Adjuvant Therapy for Pancreatic Cancer “Invited Speaker” at International Society of Gastrointestinal Oncology – The 2006 Gastrointestinal Oncology Conference, Arlington, VA, September, 2006.

53.

‘Management of Brain Metastases: Concepts and Controversies’ at Bay Medical Regional Cancer Center, Panama City, FL, October, 2006.

54.

‘Surgery, Radiosurgery, or Whole Brain Radiation Therapy for Brain Metastases: When & Why’ – “Visiting Professor” at Hahneman University, Department of Radiation Oncology, Philadelphia, PA, October, 2006.


William F. Regine, M.D. Curriculum Vitae - Page 29

55.

‘Management of Brain Metastases: Concepts and Controversies’ at St. Mary’s Medical Center, Huntington, West VA, October, 2006.

56.

‘Management of Brain Metastases: Concepts and Controversies’ at York Cancer Center, York, PA, October, 2006.

57.

Low-Grade Gliomas, “Invited Speaker” at Management of Gliomas: A Case Based Approach, CME Symposium in conjunction with Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Philadelphia, PA, November, 2006.

58.

‘Management of Brain Metastases: Concepts and Controversies’ at Mt. Nittany Medical Center, College Park, PA, December, 2006.

59.

‘Glioblastoma Multiforme: The Multidisciplinary Approach to Treatment; and ‘Management of Brain Metastases: Concepts & Controversies’ “Visiting Professor” at the University of Florida/Shands Cancer Center and Department of Radiation Oncology, Gainesville, FL, December, 2006.

60.

‘Contemporary Management of Brain Metastases: ‘The Patricia Hunt Reynolds Memorial Lecture’ “Invited Speaker” at the Reading Hospital and Medical Center, Grand Rounds, West Reading, PA, April, 2007.

61.

‘Adjuvant Management of Pancreatic Carcinoma’ – “Visiting Professor”, Department of Radiation Oncology Grand Rounds, Henry Ford Health System, Detroit, Michigan, May, 2007.

62.

‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at the University of Kentucky, Department of Radiation Medicine, Hematology Oncology and Neurosurgery, Lexington, KY, July, 2007.

63.

‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at Vanderbilt University, Department of Radiation Oncology, Nashville, TN, August, 2007.

64.

‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at the UPMC Cancer Center, Radiation Oncology Department, Philadelphia, PA, August, 2007.

65.

‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at the Valley Hospital, Paramus, NJ, September, 2007.

66.

‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ “Invited Speaker” at the Community Medical Center, Toms River, NJ, September, 2007.

67.

‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ “Visiting Professor” and “Invited Speaker” at Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, September, 2007

68.

‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at Rocky Mountain Cancer Center, Casper Wyoming, November, 2007.

69.

‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Invited Speaker” at Prince William Hospital, Manassas, Virginia, November, 2007.

70.

‘Combined Modality Treatment’ “Panel Discussant” – AHPBA Sponsored Consensus Conference on Resectable and Borderline Resectable Pancreas Cancer, Orlando, Fl, January, 2008.


William F. Regine, M.D. Curriculum Vitae - Page 30

71.

‘Cancers of the Pancreas, Small Bowel, and Hepatobiliary Tract – Multidisciplinary Treatment’ “Moderator” – General Session –, Science and Multidisciplinary Management of GI Malignancies 2008 American Society of Clinical Oncology Gastrointestinal Cancers Symposium, Orlando, FL, January, 2008.

72.

‘Pancreatic Cancer: Review and Current Status of Postoperative Adjuvant Multimodality Therapy’ “Invited Speaker” at Philadelphia Roentgen Ray Society Meeting, Philadelphia, PA, May 2008.

73.

‘Cases in Glioblastoma Multiforme: The Multidisciplinary Approach’. Plough Oncology, Baltimore, MD, May 2008.

74.

‘Cases in Glioblastoma Multiforme: The Multidisciplinary Approach’. “Invited Speaker” Schering Plough Oncology, University of Mississippi, Jackson, MS, June 2008.

75.

‘Cases in Glioblastoma Multiforme: The Multidisciplinary Approach’. “Invited Speaker” Schering Plough Oncology, Emory University, Atlanta, GA, June, 2008.

76.

‘Brain Metastases Management: Facts & Fallacies’ “Invited Speaker” FDA White Oak Seminar Series, Silver Spring, MD, August, 2008.

77.

‘The Impact of Whole Brain Radiation Therapy After Focal Therapy: Facts, and Fiction’. “Invited Speaker” Seventh Annual International Neuro Oncology Updates, The Johns Hopkins Comprehensive Brain Tumor Center. Baltimore, MD September, 2008.

78.

‘Stereotactic Radiosurgery for Brain Metastases: Alone or with Whole Brain Radiation Therapy’. “Invited Speaker” Second Annual Lecture Series, Advances in Stereotactic Radiosurgery, Boston University School f Medicine, Boston, MA, September, 2008.

79.

‘Novel Radiation Approaches in the Treatment of Pancreas Cancer’. “Invited Speaker” Fourth Annual Oncology Congress, San Francisco, CA, September, 2008.

80.

‘Adjuvant Postoperative Chemoradiotherapy for Pancreatic Cancer: Results of the U.S. Intergroup Study’. “Invited Speaker” The 15th International Gastrointestinal Oncology Conference, Arcachon, France, October, 2008.

81.

‘Pancreatic Carcinoma – Adjuvant Postoperative Chemoradiation: Past, Present and Future’. “Visiting Professor” UMDNJ-Robert Wood Johnson Medical School and The Cancer Institute of New Jersey, New Brunswick, NJ, January, 2009.

82.

‘Cancers of the Colon and Rectum: “Prevention, Screening, and Diagnosis’ Chairman of General Session American Society of Clinical Oncology 2009 Gastrointestinal Cancers Symposium, Science and Multidisciplinary Management of GI Malignancies San Francisco, CA, January 2009

83.

‘Surgery, Radiosurgery and/or Whole Brain Radiotherapy for Brain Metastases: When, Why and How? “Keynote Speaker” 39th Annual University of Florida Radiation Oncology Outcomes Tracking Seminar, University of Florida College of Medicine, February, 2009.

84.

‘Pancreatic Carcinoma – Adjuvant Postoperative Chemoradiation: Where Have We Come and Where Are We Going? “Keynote Speaker” 39th Annual University of Florida Radiation Oncology Outcomes Tracking Seminar, University of Florida College of Medicine, February, 2009.

“Invited Speaker” Scherin


William F. Regine, M.D. Curriculum Vitae - Page 31

85.

‘Use of Gamma Knife Radiosurgery for Primary, Metastatic and enign Brain Tumors: “Invited Speaker, South Carolina Oncology Society Conference – American Community Cancer Centers, Charleston, SC, August, 2009.

86.

“Surgery, Radiosurgery and/or Whole Brain Radiotherapy: Concepts and Controversies”. “Visiting Professor” United States National Cancer Institute – Radiation Oncology Branch, Bethesda, MD, September, 2009.

87.

“Brain Metastases Management” Invited Speaker & Visiting Professor, University of Arizona Cancer Center and Department of Radiation Oncology, Tucson, AZ, January, 2010.

88.

‘Cancers of the Pancreas, Small Bowel and Hepatobiliary Tract: Multidisciplinary Mangement, Chairman of General Session, American Society of Clinical Oncology 2010 Gastrointestinal Cancers Symposium, Science and Multidisciplinary Management of GI Malignancies Orlando, FL January, 2010.

89.

“Pancreatic Carcinoma and Brain Metastases – Adjuvant Postoperative Therapy: Review and Rationale”, Invited Speaker and Visiting Professor, The Kaiser Permanente Radiation Oncology Department, Los Angeles CA, January, 2012.

90.

“Pancreatic Carcinoma – Adjuvant Postoperative Chemoradiation: Review and Current Status”, 2) “The Role of RT in Combined Modality Therapy for Esophageal Cancer”, 3) “Best of ASTRO 2011 Gastrointestinal”. Invited Speaker, Los Angeles Radiological Socient 64th Annual Midwinter Conference, Pasadena, CA, January, 2012.

91.

“Evolving Status of Postoperative Adjuvant Chemoradiation for Pancreatic Cancer” “Invited Speaker and “Visiting Professor” United States National Cancer Institute – Radiation Oncology Branch, Bethesda, MD, March, 2012.

92.

“Brain Metastases Management,” “Invited Speaker and Visiting Professor”, Department of Radiation Oncology, State University of New York, Syracuse, NY, May, 2012.

93.

“Brain Metastases: Truth and Consequences”, Invited Speaker, Perelman Cancer Center, University of Pennsylvania, Philadelphia, PA, January, 2013.

94.

“The Gammapod System: A Paradigm Change in the Treatment of Early Stage Breast Cancer”, Visiting Professor, Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, January, 2013.

95.

“How to Make An Offsite Program Successful”, Invited Speaker, 2013 Society of Chairs of Academic Radiation Oncology Programs (SCAROP), Washington, DC, April, 2013.

96.

“Adjuvant Therapy for Pancreatic Cancer: Past, Present and Future”, Visiting Professor, Department of Radiation Oncology and Cancer Center at the University of Kansas, Kansas City, MO, September, 2013.

97.

“Phase III Radiotherapy Trials: Lessons Learned and Moving Forward”, Invited Speaker, 2nd Annual Course on Clinical Trials in Radiation Oncology, University of Pennsylvania, Philadelphia, PA, October, 2013.

WORKS-IN-PROGRESS: 1.

Sharma NK, Pandya N, Wong R, Herman JM, Hanna N, Major P, Alexander HR, Kennedy N, Regine WF. Low Dose Upper Abdominal Radiation Theapy ( LD-UART ) Potential Gemcitabine Therapy is an Effective Therapeutic Alternative in patients with Advanced, Unresectable Pancreatic Cancer: Final


William F. Regine, M.D. Curriculum Vitae - Page 32

Results from a Phase II Multi-Institutional Study. ( Submitted, Journal of Radiation Oncology, August, 2013 ). 2.

Rhee JG, Ha J, Whang Z, Regine WF, Yu CX. A Mouse Model to Study the Skin Complication Following Hypo-Fractionation for SBRT. (Submitted to Radiation Research Society 2010).

3.

Farrell J, Garcia M, Liu A, Ammar A, Regine WF, Abrams A, Benson AB, Madonald J, Schaefer P, Yun Y, Elsaleh H. Ribonucleotide Reductase Subunit M2: Predictive of Response to Gemcitabine in Pancreatic Cancer: RTOG 9704. (Submitted to Molecular Cancer Therapeutics).

4.

Mutaf YD, Nichols EM, Yu C, Prado K, Feigenberg SJ, Yi B, D’Souza WD, Regine WF. The Dosimetric Advantage of Stereotactic Radiotherapy in Partial Breast Irradiation: A Comparative Analysis. ( Submitted to ESTRO ).

5.

Li D, Moughan J, Crane C, Hoffman JP, Regine WF, Abrams RA, Safran H, Freedman GM, Guha C, Abbruzzesel JL. RecQ1 A159C Polymorphism is Associated with Overall Survival of Patients with Resected Pancreatic Cancer: A Replication Study in RTOG 9704. (Accepted for oral presentation at 2011 ASCO GI meeting).

6.

Tempero M, Winter K, Kim G, Kakar S, Regine WF, Mowat RA, Depetrillo A, Small Jr., W, Guha C, Chang DK, Biankin AV. S100A2 as a Prognostic Marker in Patients Receiving Adjuvant Therapy for Pancreatic Cancer (PC): A Secondary Analysis of RTOG 9704. ( Submitted to ASCO ).

7.

Mutaf Y, Zhang J, Zhou B, Nichols EM, Yu C, Prado K, Yi BY, D’Souza W, Regine WF, Feigenberg S. Optimization of the Collimator for Design for a Novel Stereotactic Radiotherapy Device for Breast Cancer. ( Submitted to AAPM, February 2011 ).

8.

Mutaf Y, Nichols EM, Yu C, Prado K, D’Souza WD, Regine WF, Feigenberg SJ. NTCP Projections for Breast Fibrosis Following a Novel Breast SBRT System and Comparison to Accelerated Partial Breast Irradiation. ( Submitted for 2011 ASTRO Annual Meeting ).

9.

Temporo MA, Moughan J, Kim GE, Kakar S, Hyun TS, Regine WF, Mowat RB, Charpentier K, Small Jr. W, Guha C, Chang DK, Biankin V. S100A4 As a Biomarker of Resistance to Gemcitabine: A Secondary Analysis of RTOG 9704. (Submitted for Gastrointestinal Cancers Symposium, January, 2012).

10.

Tempero M, Moughan J, Kim GE, Sanjay K, Hyun TS, Regine WF, Mowat RA, Charpentier KP, Small W, Guha C, Chang DK, Biankin AV. S100A4 as a Biomarker of Resistance to Gemcitabine: A Secondary Analysis of RTOG 9704. (Accepted, ASCO GI).

11.

Boeck S, Rapone M, Richardson B, Towne P, Isaacson J, Moore JR, Powell E, Clements J, Feng J, McElhinny A, Ormanns S, Kirchner T, Regine WF, Winter K, Ansari D, Rolfe L, Allen AR, Anderson R, Heinemann V, Dicker AP. Development of the SP 120 Rabbit Monoclonal Antibody for Determining hENT1 Status & Predicting Response to Gemcitabine in Pancreatic Ductal Adenocarcinoma.(Submitted ASCO 2012).

12.

Raponi M, Boeck S, Richardson B, Towne P, Isaccson J, Ranger-Moore J, Clements J, Feng J.D., Bartosiewicz M, Mann E, Voong C, McElhinny A, Omanns S, Kirchner T, Regine WF, Winter K, Ansari D, Rolfe L, Allen AR, Anderson R, Heinemann V, Dicker AP, Ikdahl T, Poplin E. Two-thirds Of Pancreatic Ductal Adenocarcinomas (PDAC) Have Low Expression of hENT1 as Determined by The SP120 Rabbit Monoclonal Antibody Immunohistochemistry Test. Submitted to the 14th World Congress on Gastrointestinal Cancer.


William F. Regine, M.D. Curriculum Vitae - Page 33

13.

Isaacson J, Boeck S, Raponi M, Moore JR, Clements J, Feng JD, Richardson B, Towne P, McElhinny A, Ormanns S, Kirchner T, Regine WF, Winter K, Ansari D, Rolfe L, Allen AR, Heinemann V, Dicker AP, Anderson R. Comparison of Primary and Metastatic Pancreatic Ductal Adenocarcinoma Tumor Tissue in he SP120 Rabbit Monoclonal Antibody for Determining hENT1 Expression. (Accepted for Poster Presentation at CAP ‘12 Meeting and also Accepted for Publication in the September issue of Archives Of Pathology & Laboratory Medicine).

14.

Raponi M, Boeck, Isaacson J, Moore JR, Clements J, Richardson B, Towne P, Ormanns S, Kirchner T, Regine WF, Bradley F, Winter K, Rolfe L, Allen AR, Anderson R, Heinemann V, Dicker AP. Development of a Rabbit Monoclonal Antibody for Determining hENT1 Status and Predicting Response to Gemcitabine in Pancreatic Ductal Adenocarcinoma ( Submitted April 2012 for the 2012 meeting of the European Congress of Pathology).

15.

Isaacson J, Richardson B, Towne P, Ranger-Moore J, Clements J, Feng JD, Bartosiewicz M, Mann E, Voong C, McElhinny A, Regine WF, Winter K, Rolfe L, Allen AR, Dicker AP, Raponi M. Identification Of Predictive and Prognostic Factors for Overall Survival in Patients with Pancreatic Ductal Adenocarcinomas (PDAC) Based on RTOG 97-04 Study. (Submission to the 20th United European Gastroenterology Week, October 2012).

16.

Lawrence YR, Mouthan J, Magliocco A, Klimowicz A, Regine WF, Mowat RB, DiPetrillo T, Small W, Winter, K, Chandan G, Crane C, Dicker AP. Elevated Expression of Mismatch Repair Enzyle MLH1 Is Associated with Prolonged Overall Survival in Resected Pancreatic Cancer Treated with Adjuvant Chemoradiation, a Biomarker Analysis of RTOG 9704. ( Submitted for AACR Nov 2012 ).

17.

Regine, WF. “Utilization of IMRT and IGRT in Pancreatic Cancer: Is It Necessary.” ( In Press, Seminars in Radiation Oncology ).

18.

Yovino, S, Kwok, Y, Regine WF. Brain and Cranial Nerves ( In Press, ALERT – Adverse Late Effects of Cancer Treatment ).

19.

Mutaf Y, Yu C, Nichols E, Yi B, Prado K, D’Souza W, Regine WF, and Feigenberg S. Evaluation of Localization Accuracy with a Novel Breast Stereotactic Radiotherapy ( Accepted for Radiosurgery Society Meeting 2014 ).

20.

Neuner G, Lu, W, George R, Zhendong W, Sassor S, Regine WF, Feigenberg S, D’Souza W. AudioVisual Feedback Does Not Improve the Reliability of Target Delineation using Maximum Intensity Projection (MIP) In 4DCT Radiotherapy Planning. (Submitted to IJROBP, 2/2013).

21.

Zhang H, Prado K, Langen K, Mehta MP, Regine WF, D’Souza W. Achieving Optilal Patient Setup Imaging And Treatment Workflow Configurations in Multi-Room Proton Centers via Monte Carlo Simulation. (Accepted for Abstract Oral Presentation at RSNA).

22.

Regine WF, Chuong, M. Adjuvant Chemoradiation for Pancreatic Cancer: What does the evidenct tell us? ( Upcoming Focus Issue for Radiation Therapy for Gastrointestinal Cancers: The State of the Art’ Journal of Gastrointestinal Oncology, JGO, ISSN 2078-6891 ).

23.

Heestand GM, Murphy JD, Moughan J, Regine WF, Luo J, Graber MS, Kunz PL, Fisher GA, Guha C, Mowat RB, Gaur R, Buyyounouski MK, Chen Y, Chang DT, Koong A. A Novel Biomarker Panel Examining Response to Adjuvant Pancreatic Cancer Therapy in RTOG 9704. Presented at GI ASCO 2014 meeting.


William F. Regine, M.D. Curriculum Vitae - Page 34

24.

Mutaf Y, Yu C, Nichols E, Oden J, Regine WF, Feigenberg S. Dosimetric Capabilities of a Novel Stereotactic Radiotherapy Device for Breast Cancer: Comparative Analysis with Linac-Based External Beam and Intracavitary Brachytherapy Techniques. ( Accepted for Radiosurgery Society Meeting 2014 ).

25.

Hanna A, Boggs H, Mehta MP, Regine WF. Factors Predicting for Increase in Peritumoral Edema Following Radiosurgery. ( Submitted for ASTRO 2014 ).

26.

Sherr D, Winter K, Regine WF, Mowat R, Hayes J, Kessel I, Narayan S, Chen Y, Singh A, Delouya G, Meyer J, DiPetrillo T, Yost K, Gaur R, Crane C. Is Marital/Partner Status Associated with Overall Survival in Patients with Resectable Pancreatic Cancer Treated with Adjuvant Post-operative Multimodality Therapy? Results of a Secondary Analysis of RTOG 97-04. ( Submitted for ASTRO 2014 ).

27.

Snider J, Mutaf Y, Feigenberg S, Hall A, Vagnais P, Regine WF, Nichols E. A Dosimetric Comparison of a Novel Breast Stereotactic Radiotherapy (BSRT) – Device for the Delivery of Partial Breast Irradiation (PBI) VS. Intensity Modulated Radiotherapy (IMRT) PBI. ( Submitted for ASTRO 2014 ).

28.

Snider J, Mutaf Y, Feigenberg S, Hall A, Vagnais P, Regine WF, Nichols E. Theoretical Improvements in Cosmetic Outcomes Utilizing a Novel Breast Stereotactic Radiotherapy (BSRT) – device compared to 3-Dimensional Partial Breast Irradiation Using IMRT (IMRT-PBI): A Dosimetric Analysis. ( Submitted for ASTRO 2014 ).

INVESTIGATIONAL STUDIES/ GRANT SUPPORT INSTITUTIONAL: 1.

Phase I study of combined fractionated stereotactic radiosurgery and conventional external beam irradiation in the treatment of intracranial tumors [ Principal Investigator ] – Unfunded – 1994 – 2003.

2.

Paclitaxel, carboplatin and radiotherapy as induction therapy in advanced head and neck cancer [Co– Investigator ] –$Funded Study – 9/00-4/02 - $90,000 (Total)

3.

An open label phase I study of TNF-alpha gene therapy with radiation therapy for locally advanced, recurrent, or metastatic solid tumors [ Co-Investigator ] - $Funded Study – 10/00-10/01 - $180,349 (Total).

4.

An open-label, dose-esclation study of TNFeradeTM biologic with radiation therapy as an adjunct to surgery or for palliation in soft tissue sarcoma of the extremities [ Co-Investigator ] $Funded Study 1/02-12/03 - $93,210 ( Total).

5.

The effect of cancer on the cancer patient caregiver [ Co-Investigator ] – $Funded Pilot Study ( ACS – 10K ) – 2001-2002.

6.

Phase I/II evaluation of radiation and gemcitabine in locally advanced or metastatic tumors of the gastrointestinal tract [ Principal Investigator ] – $Funded Study – 7/99-12/00 - $48,010 (Total): $38,111(Direct) + $9,899 (Indirect) – sponsor – Eli Lilly

7.

A multinational, multicenter, double-blind, placebo-controlled, randomized, phase III clinical trial to determine the efficacy and safety of IB-367 rinse in reducing the severity of oral mucositis in patients receiving radiotherapy for head and neck malignancy [ Institutional Principal Investigator ] $Funded Study – 9/00-6/02 - $136,895 (Total): $107,360 (Direct) + $29,535 (Indirect) – Sponsor – Pharmanet Inc.


William F. Regine, M.D. Curriculum Vitae - Page 35

8.

Radiation Therapy Oncology Group Studies [ Institutional – Full Member – Principal Investigator ] $Funded Study – 8/96-12/02 - $284,433 (Total): $247,638 (Direct) + $36,795 (Indirect) – Sponsor – American College of Radiology.

9.

A Phase I Study of Low-Dose Upper Abdominal Radiation Therapy (UART) or Whole (W) ART as a Chemosensitizer in Patients with Locally Advanced or Metastatic Tumors of the Gastrointestinal Tract or Ovary [ Prinicipal Investigator ] - $ Funded Study – 11/00-11/02 - $19,700 (Total): $15,641 (Direct) = $4,059 (Indirect) – Sponsor – Eli Lilly.

10.

Families and Cancer: Stress, Resources, and Outcomes [ Co-Investigator ] - $Funded Pilot Study ((Institutional – 15K ) – 2002-2003.

11.

Cancer caregiving and the stress process. Submitted May 2002 for RFA for funding ( 100 K ) by Small Grants Program for Behavioral Research in Cancer Control [ Co-Investigator ]

12.

Compreshensive support for Breast Cancer Caregivers. Submitted Jun 2002 for funding ( 425K ) by US Department of Defense [ Co-Investigator ]

13.

A Phase I/II Study of Low-Dose Upper Abdominal Radiation Therapy (UART) or Whole (W) ART as a Chemosensitizer in Patients with Locally Advanced or Metastatic Tumors of the Gastrointestinal Tract or Ovary [ Prinicipal Investigator ] - $ Funded Study – 10/03-03/06 - $213,000 (Total): $170,800 (Direct) = $42,700.00 (Indirect) – Sponsor – Eli Lilly.

14.

Master Research Agreement – Varian Medical Systems. $Funded study – 4/05 – 4/10 - $1.25M (Total) [Co-Investigate]

NATIONAL 1.

A phase III postoperative adjuvant protocol for pancreatic adenocarcinoma. Intergroup/RTOG protocol #97-04 [ Principal Investigator/Study Chairman ] – Activated 7/98; closed 7/02.

2.

A feasibility study of neurocognitive evaluation in patients treated for brain metastases. RTOG Protocol #BR-0018 [ Principal Investigator/Study Chairman ] – Activated 11/00; closed 8/01

3.

A Phase II trial of conventional radiation therapy followed by intratumoral bleomycin delivered using a refillable, sustained release device (IND# 46,592) for the treatment of supratentorial glioblastoma. RTOG Protocol #BR-0013 [ Study Co-Chairman ] – Activated 6/01; closed 6/04

4.

A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma. RTOG Protocol #0848 [Study Co-Chairman] Activated 11/09

TEACHING/ EDUCATION AND MENTORING EXPERIENCE:INSTITUTIONAL Medical Student Education - Monthly lecture to senior students in radiology elective; Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee 1992 – 1994 Medical Student Education – Preceptor for students rotating through department, 1994 – present (~ 2/ year) University Hospital Tumor Board - Biannual presentation/lecture in clinical radiation oncology, 1992 – 2001


William F. Regine, M.D. Curriculum Vitae - Page 36

Radiation Oncology Resident Education a) Annual lectures in clinical radiation oncology, 1994 – present ( ~ 8 students) b) Annual lecture in radiation biology, 1996, 1998, 1999 c) Morning quality assurance/teaching conference ( 3-5 X’s/week ), 1994 – present ( ~ 12 students) d) Monthly journal club, 1994 – present ( ~ 8 students) e) Quarterly morbidity and mortality conference, 1994 – present ( ~ 8 students) f) Oral Mock Boards (quarterly), 1997 – present ( ~ 4 students) Radiation Therapy Student Education - Annual lectures in clinical radiation oncology, 1994 – 2002 (~ 6 students) Medical Physics Student Education - Annual lectures in clinical radiation oncology, 1994 – 2001(~ 6 students) Hematology – Oncology Fellow Education – Preceptor for fellows rotating through department, 1994 – 2002 ( 1/ year) and annual lectures (2006) Neurosurgery Resident Education - Grand Rounds/Annual lecture in clinical radiation oncology, 1995 – 2002 ( ~ 10 students) Gamma Knife Radiosurgery/Neuro-Oncology Conference - Weekly, 1996 – present Neuroradiology Conference - Weekly, 1994 – 2002 E.N.T. Resident Education - Annual lecture in clinical radiation oncology, 1995 – 2002 ( ~ 6 students) Multidisciplinary Head and Neck Cancer Conference - Weekly, 1994 – 2002 ( ~ 10 students) Multidisciplinary Gastrointestinal Conference - Weekly, 1996 – present ( ~ 10 students) Ophthalmology Resident Education - Lecture in clinical radiation oncology, 1995 Radiation Therapist Education - Lecturer in University of Kentucky Radiation Therapist Seminar Series, 1997 Neurology Resident Education - Grand Rounds - lecture in clinical radiation oncology, 1997 Surgery Resident Education - Head and Neck Working Group and Head and Neck Skills Course Co-Instructer in developing and implementation ofstructured clinical instruction module for head and neck cancer - Radiation Therapy Section, 1997 Dental Residents – Lecture in use of Gamma Knife for Trigeminal Neuralgia – 2000 St. Claire Oral Examiner for Institutional Medical Physics Masters Degree Program - 1996 – 2002 Sponsor of Resident Research – Mihoko Fugita, MD, PhD – Second Malignant Neoplasia in Patients with T1 Glottic Cancer Treated with Radiation (Manuscript Published) – 1997 Sponsor of Resident Research – Gregory H. Carlsen, MD – Use of Spatially Fractionated (GRID) Radiation as a Novel Means of Dose Escalation in the Treatment of Large Volume Carcinomas Involving Head and Neck Sites (Paper Published) -1998-1999 Sponsor of Medical Student Research – Eugene S. Gamburg, MS III – The Prognostic Significance of Midline Shift on Survival of Patients Presenting with Glioblastoma Multiforme (Presented at National Meeting and Manuscript Published) – 1998-1999


William F. Regine, M.D. Curriculum Vitae - Page 37

Sponsor of Resident Research – Jennifer Huhn, DO – Gamma Knife Radiosurgery Alone Following High Resolution MRI in Patients with Newly Diagnosed Brain Metastases: Results and Implications (Presented at National meeting and Manuscript Published) – 1999 Sponsor of Resident Research - Anil Dhople, MD – Gamma Knife Radiosurgery for Atypical Trigeminal Neuralgia (Presented at National Meeting and Paper, Published) – 2005 Sponsor of Resident Research - Todd Flannery, MD – The Impact of Definitive Thoracic Management in Patients with Single Brain Metastasis Treated with Raidosurgery (Presented at National Meeting paper published) – 2003 Sponsor of Medical Student Research – T. Brady Reid, MS II – Safety and Efficacy of Utilizing 20Gy Target Dose Gamma Knife Radiosurgery for Metastatic Brain Tumors with a Maxiumum Volume of 5 cc (Presented as Finalist at 2001 University of Kentucky Alpha Omega Alpha Student Research Day – paper published) – 20002001 Sponsor of Visiting Physician Research – Anna Rogosinska, MD – Prognostic Factors in Patients with Resected Single Brain Metastases: Evaluation of Recursive Partitioning Analysis (RPA) Classes I and II (Presented at National meeting and paper published) – 2001 – 2002 Sponsor of Medical Student Research – Michael Shehata, MS III – Gamma Knife Radiosurgery for Metastatic Brain Tumors with a Maximum Volume of 5 cc - The University of Kentucky Experience – (Presented at National meeting and paper published) - 2001-2003. Sponsor of Medical Student Research - Alice Cheuk, MS IV – Imaging Correlates of Gamma Knife Outcome in Trigeminal Neuralgia (Paper published) – 2003-2004. Sponsor of Medical Student Research - Pinaki Dutta, MS IV – Results of Repeat Gamma Knife Radiosurgery for Retractory or Recurrent Trigeminal Neuralgia (Presented ASTRO 2004) – 2003-2004 Sponsor of Medical Student Research - Jerry Jaboin, MS IV – An Analysis of Dose-Staged Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations (Presented ASTRO 2005) – 2004-2005 Sponsor of Resident Research - Shilpen Patel, MD – Evaluating the Influence of Dose-Rate on Outocme with Gamma Knife Stereotactic Radiosurgery in the Treatment of Trigeminal Neuralgia (Presented ASTRO 2005) – 2004-2005. Sponsor of Medical Student Research - Josh R. Adams, MS IV - Long Term Follow-up of Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia (Presented ASTRO 2007, Paper Published) – 2006-2007 Sponsor of Resident Research - Susannah Yovino, MD – IMRT Decreases Acute GI Toxicity Among Patients Receiving Concurrent Chemoradiation for Upper Abdominal Malignancies (Presented at ASTRO 2008, paper published 2007-2013) and “Optimizing Brain Control in One-Year Survivors of Brain Metastases: A Single Institution Experience (Accepted for Publication in Journal of Radiation Oncology, 2013. Sponsor of Resident Research – Geoffrey Neuner, MD – High-Dose Spatially fractionated GRID Radiation Therapy (SFGRT): A Comparison of Outcomes of Treatment Delivered Through Cerrobend GRID versus MLC Grid. (Presented at ASTRO 2008) – 2007-2008. Sponsor of Resident Research – Elizabeth Nichols, MD – Post-Lumpectomy Target Colume Versus the Use of Pre-Lumpectomy Tumor Volume for Early Stage Breast Cancer: Implications for the Future. (Presented at ASTRO and the National Breast Meeting and published 2008-2009).


William F. Regine, M.D. Curriculum Vitae - Page 38

Sponsor of Resident Research – Elizabeth Nichols, MD - Factors Impacting White Matter Changes Following Whole Brain Radiation Therapy: (Submitted for 2010 ASTRO) 2009-2010. Sponsor of Medical Student Research – Bert Maidment, MSIV – Analysis of Local Control in Patients Receiving IMRT for Resected Pancreas Cancer (Presented at ASTRO, 2010) – 2009-2010. E.N.T. Resident Education – Preceptor for residents rotating through department, 2002. Nurse Practitioner Student Medical Dosimetrist Student Education – Annual lectures in clinical radiation oncology, ( ~ 2 students), 2003. Course Director – “New Trends in the Management of Trigeminal Neuralgia”, University of Maryland Medical System – CME – 2003 – 2005. Education – Lecture on Head & Neck Cancer (~ 10 students), 2003. “Gamma Radiosurgery for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Greater Baltimore Medical Center Hospital, Trigeminal Neuralogic Support Group Baltimore, MD, December, 2003. “Gamma Radiosurgery for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Bethesda, MD, January 2004. “Gamma Radiosurgery for Trigeminal Neuralgia”, Unversity of Maryland Medical System CME: Current Management of Trigeminal Neuraligia, Annapolis, MD, March 2004. “Gamma Radiosurgery for Trigeminal Neuralgia”, and “Surgical Management for Trigeminal Neuralgia” University of Maryland Medical System CME: Current Management of Trigeminal Neuraligia, Cambridge, MD, October 2004. “Surgical Management for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Holy Cross Hospital, Silver Spring, MD, November 2004. “Gamma Radiosurgery for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Holy Cross Hospital, Silver Spring, MD, November 2004. “Gamma Radiosurgery for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Valley Dental Society meeting, Pikesville, MD January 2005. “State-of-the-Art Treatment Approaches for Brain Metastases” – “Invited Speaker” at Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, March, 2005. “Malignant Gliomas: Impacting survival with New Treatment Strategies: - “Invited Speaker” – at Marlene and Stewart Greenebaum Cancer Center, April, 2005. “Use of Gamma Knife Radiosurgery for Brain Tumors”, - “Invited Speaker” at Marlene and Stewart Greenebaum Cancer Center, January, 2006 Course Director – “Radiation Oncology Symposium”(formerly known as “ASTRO Review”), University of Maryland School of Medicine – CME – 2005 to present.


William F. Regine, M.D. Curriculum Vitae - Page 39

Panel Discussant – “The Changing Approach to High-Grade Glioma Treatment”, CME Symposium in Conjunction with the American Association of Neurological Surgeons Annual Meeting, San Francisco, CA, April 2006. “Adjuvant Postoperative Chemoradiation for Pancreatic Cancer: Where We Have Been and Where Are We Going” - Invited Speaker Hematology/Oncology Grand Rounds, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, January, 2007. “Moderator Pancreatic Session” The First Annual Gastrointestinal Cancer Symposium, University of Maryland Medical Center, Baltimore, MD, April 2009. “Current Trends in The Treatment of Glioblastoma Multiforme” Moderator, Baltimore MD, April 2009. “Stereotactic Radiosurgery, Surgery and/or Whole Brain Radiotherapy for Brain Metastases: When, How and Why?” CME Grand Rounds, Providence Hospital, Washington DC, September, 2009. “Treatment for Brain Metastases When, How and Why”: Visiting Professor, Holy Cross Hospital, Silver Spring, Maryland, September 2009 “Pancreatic Carcinoma – Adjuvant Postoperative Chemoradiation: Speaker, University of Maryland GI Grand Rounds, January 2010

Review and Current Status” – “Invited

“Moderator Innovations in Radiation-Based Diagnostics & Therapeutics for GI Malignancies” The Second Annual Gastrointestinal Cancer Symposium, University of Maryland Medical Center, Baltimore, MD, April 2010. “Pancreatic Carcinoma – Adjuvant Postoperative Chemoradiation: Review and Current Starus” – Invited Speake. University of Maryland Marlene & Stewart Greenebaum Cancer Center, Physician Outreach CME, July 2011. “Best of ASTRO 2011 – Gastrointestinal” – CME – 7th Annual Mid-Atlantic ASTRO Review, Baltimore, MD, January, 2012. “Best of ASTRO 2011 and Evolving Radiation Techniques – Gastrointestinal” – Invited Speaker, University of Maryland GI Grand Rounds, February, 2012. “The Gammapod System: A Paradigm Change in the Treatment of Early Stage Breast Cancer and an Opportunity for Multidisciplinary Collaboration: - Invited Speaker, University of Maryland Diagnostic Radiology and Nuclear Medicine Grand Rounds, December, 2012. NATIONAL American Board of Radiology Examiner in Radiation Oncology – Oral Exam GI, H&N & CNS/Peds -1998 – Present American Board of Radiology Examiner in Radiation Oncology – Written Exam – 2000 – 2007 Radiation Therapy Oncology Group New Invesitgators Committee (G.I. Cancer) – 2004 – 2007 “Meet the Professor Luncheon” at 46th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology – 2004 “Meet the Professor Luncheon” at 48th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology – 2006


William F. Regine, M.D. Curriculum Vitae - Page 40

Metastatic Brain Tumor – Concepts and Controversies: A Roundtable Discussion – Mehta MP, Gilbert MR, Lassman AB, Regine WF, Stieber VW. CME/CE accredited Grand Rounds program on Metastatic brain cancer, 2006. The Gastrointestinal Cancers Symposium, (Sponsored by ASCO, ASTRO & SSO) Program Committee – Member 2007 – 2010. The Gastrointestinal Cancers Symposium - Cancers of the Pancreas, Small Bowel and Hepatobiliary Tract Subcommittee member – 2007 – 2010. American Board of Radiology Examiner in Radiation Oncology – Oral Exam Chairman – GI – 2007 – present “Meet the Professor Luncheon” at 51st Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology – 2009 ARRO Poster Walk, 51st, Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology,2009. “Meet the Professor Luncheon” at 52nd Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, 2010. ARRO Poster Walk, 52nd Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, 2010. The Gastrointestinal Cancers Symposium, (Sponsored by ASCO, ASTRO & SSO) Program Committee – Member 2012 – present. The Gastrointestinal Cancers Symposium, (Sponsored by ASCO, ASTRO & SSO) News Planning Team Member, 2012 – present. The Gastrointestinal Cancers Symposium, Oral Abstract Session – Cancers of the Colon and Rectum, Chair and Moderator, San Francisco, CA, 2013. “Management of Gastrointestinal Cancers”, ASTRO Spring Refresher Course, Chicago, IL 2013. The Gastrointestinal Cancers Symposium, Oral Abstract Session – Cancers of the Pancreas, Small Bowel and Hepatobiliary Tract, Moderator, San Francisco, CA, 2014. 2014 – present Member, American Council for Graduate Medical Education (ACGME) Residency Review Committee (RRC) for Radiation Oncology REVIEW / EDITORIAL POSITIONS: 1994 - present Reviewer, International Journal of Radiation Oncology-Biology-Physics 1994 - present Reviewer, Cancer 1996 - present Reviewer, Journal of Clinical Oncology 1998 - present Reviewer, Journal of Neuro-Oncology 2001 – present Reviewer, Critical Reviews in Oncology/Hematology 2001 – 2002

Reviewer, Head & Neck


William F. Regine, M.D. Curriculum Vitae - Page 41

2002 – present Reviewer, Annals of Surgical Oncology 2001 – present Board of Editors, Technology 2003 – 2006

Board of Editors, American Journal of Clinical Oncology

2007 – present Reviewer, Nature Clinical Practice Gastroenterology & Hepatology 2008 – present Board of Editors, Journal of Clinical Oncology 2010 – present Reviewer, Annals of Oncology 2010 – present Board of Editors, Journal of Gastrointestinal Oncology in Cancer Research and Treatment

ADMINISTRATIVE EXPERIENCE / POSITIONS: INSTITUTIONAL 1992 – 1994

Coordinator of Departmental Medical Student Rotations, Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee

1994

Acting Clinical Chief, Section of Radiation Oncology, University of Tennessee, Memphis Tennessee

1994 – 2002

Coordinator of Departmental Hematology-Oncology Fellow Rotations

1994 – 2002

Departmental Clinical Research Coordinator

1994 – 1995

Member of Departmental Quality Assurance Committee

1995 – 1998

Member of Institutional Gastrointestinal Oncology Clinic Planning Committee

1996 – 1998

Member of Institutional Scientific Advisory Committee

1996 – 1998

Member of Institutional Gamma Knife Radiosurgery Business Planning Committee

1996 – 1998

Member of Institutional Lung Cancer Business Planning Committee

1996 – 1998

Member of Institutional Gastrointestinal Cancer Business Planning Committee

1996 – 2002

Member of Institutional Gastrointestinal Tumor Site Committee

1996 – 2002

Member of Institutional Central Nervous System Tumor Site Committee

1996 – 2002 1997 – 2000

Coordinator of Institutional Head & Neck Tumor Site Committee Member of Institutional Oncology Advisory Committee

1997 – 1999

Member of Kentucky Medical Services Foundation Faculty Advisory Committee

1997

Participant in University of Kentucky Executive Development Program for Physicians


William F. Regine, M.D. Curriculum Vitae - Page 42

1997 – 2002

Alternate Member/Representative from Department of Radiation Medicine for Institutional Council of Chairs

1998 – 2002

Member of Markey Cancer Center Protocol Review and Monitoring System Committee

1998 – 2002

Institutional Principal Investigator for Radiation Therapy Oncology Group

1998 – 1999

Member of Institutional Associate Chiefs of Clinical Affairs Committee

1998 – 2002

Member of Institutional Tumor Registry Audit Group

1998 – 2000

Medical Director of Clinical Research Office, Markey Cancer Center, University of Kentucky

1998 – 2000

Member of Institutional Ocular & Orbital Tumors Regional Center Business Planning Committee

1998 – 1999

Member of Institutional Cancer Center Clinical Coordinating Committee

1998 – 2002

Member of Institutional Advisory Committee for Clinical Research and Investigator Services

1998 – 1999

Member of Institutional Educational Review Committee for Department of Diagnostic Radiology

1999 – 2002

Member of St. Agnes House ( Community Patient Housing Facility ) Board of Management

1999 – 2002

Member of St. Agnes House ( Community Patient Housing Facility ) Board of Management Fundraising Committee

1999 – 2002

Member of Departmental Billing Procedures Review Committee

1999 – 2002

Institutional Alternate Member/Representative for the Association of Community Cancer Centers

1999 – 2000

Member of Institutional Educational Review Committee for Department of Radiation Medicine

1999 – 2000

Director, University of Kentucky Gastrointestinal Oncology Program

1999 – 2000

Member of Institutional Clinical Research Activities Working Group

2000 – 2002

Departmental Representative for University Physicians Governing Board

2000 – 2002

Vice-President of St. Agnes House ( Community Patient Housing Facility ) Board of Management

2000 – 2002

Chairman Departmental Clinical Research Committee

2000 – 2002

Institutional Member VA Oncology Research Network

2000 – 2002

Departmental Manager of Nursing

2000 – 2002

Departmental Manager of Research Associates

2000 – 2002

Member of St. Agnes House (Community Patient Housing Facility) Board Long Range Planning Committee


William F. Regine, M.D. Curriculum Vitae - Page 43

2001 – 2002

Member of University Physicians Strategic Task Force

2001 – 2002

Member of Institutional Radioactive Drug Research Committee

2001

Member of Insitutional Educational Review Committee for Department of Obstetrics and Gynecology

2001 – 2002

Member of Institutional Head and Neck Cancer Clinical Care and Research Team

2001 – 2002

Director of Institutional Gastrointestinal Cancer Clinical Care and Research Team

2001 – 2002

Member of Institutional Central Nervous System Cancer Clinical Care and Research Team

2001 – 2002

Member of Instutional Strategic Task Force – Focused on Improvement in Payer Mix

2001 – 2002

Chairman of Departmental Clinical Operations Committee

2001 – 2002

Chairman of Departmental Quality Assurance Committee

2002

Member of Institutional Task Force Reviewing Faculty Salaries

2002

Member of Institutional Clincal Affairs Committee, Markey Cancer Center

2002

Coordinator of Departmental E.N.T. Resident Rotations

2002

Member of Markey Cancer Center Clinical Practices Task Force

2002

President of St. Agnes House ( Community Patient Housing Facility ) Board of Management

2002

Member of Institutional Neurosciences Business Planning Committee

2004 - 2009

Member of Institutional Clinical Affairs Advisory Committee


William F. Regine, M.D. Curriculum Vitae - Page 44

2004-2012

Member of Graduate Medical Education Committee

2004

Baltimore Area Council, Boy Scouts of America, Health Services Leadership Awards Luncheon, Event Committee Member

2005 - 2011

Member of Cancer Center Clinical Research Oversight Committee

2005

Member of Institutional Educational Review Committee for Nephrology Program

2005 – 2009

Member of Technology Research Review Committee

2005 – 2008

Member of Ambulatory Care Center Project Operations Committee

2006 - present Member of University Physicians Incorporated Compliance Committee 2006 – 2009

Member of Appointment, Promotion, and Tenure Committee

2006

Member of Institutional Committee Developing Orientation Manual for New Chairs and Administrators

2007

Member of Institutional Educational Review Committee for Neuroradiology Program

2008 – 2009

Member of Appointment, Promotion, and Tenure Committee - Subcommittee to Establish Guidelines for “Non-Traditional” Candidates

2008 – 2009

Interim/Acting Chairman – Appointment, Promotion, and Teunure Committee

2008 – 2009

Member of Search and Evaluation Committee for Chairs of Emergency Medicine and Medical Research Technology Program

2009 – present Member of Institutional Fiscal Affairs Advisory Committee 2010 – present Member of OB/GYN Chairman Search Committee 2011 – present University Physicians Inc. Faculty Fringe Benefits Committee 2011 – 2012

Consultant for Department of Diagnostic Radiology & Nuclear Medicine Search Committee

2012

Member of Dean’s Ad-Hoc Appeals Committee for the Appointment, Promotion and Tenure Committee

2012

Member of Institutional Research Affairs Advisory Committee

2013

Member of Institutional Reportable New Information Review Committee

2013

Chairman of Dean’s Ad-Hoc Appeals Committee for the Appointment, Promotion and Tenure Committee

2013

Member of Dean’s Ad-Hoc Committee for Review of Presentation on “Vision 2020 and Strategic Disruptive Innovations for Success: Thriving in Challenging Times”

2013

Chairman of Dean’s Resource Advisory Group for Clinical Care


William F. Regine, M.D. Curriculum Vitae - Page 45

2013

Chairman of Dean’s Ad-hoc Subcommittee of Appointment, Promotion and Tenure – To Establish Guidelines for “Team Science” Efforts

NATIONAL 1994

National Cancer Institute Ad Hoc Reviewer for grants and contracts

1998 – 2002 Committee

Member of Radiation Therapy Oncology Group Full Member Principal Investigator

1998 – 2002

Member of Radiation Therapy Oncology Group Head and Neck Cancer Steering Committee

1998 – 1999

Member of National Cancer Institute Gastrointestinal Cancer Strategy Committee

1998 – present Member of Radiation Therapy Oncology Group Gastrointestinal Cancer Steering Committee 1999 – 2005

Member of Radiation Therapy Oncology Group Central Nervous System Cancer Steering Committee

2001 – 2005

Member of Radiation Therapy Oncology Group Central Nervous System Cancer Steering Committee – Brain Metastases Working Group/Subcommittee

2001 – 2002

Member of Patterns of Care Study Committee on CNS – Role of Radiosurgery in Brain Metastases

2002 – 2004

Secretary/Treasurer for The Simon Kramer Society

2003 – 2010

Member of Genvec Data Safety Monitoring Board

2003

Member of RTOG Review Committee for proposes NCI Common Toxicity Criteria – Greenebaum Cancer Center, Baltimore, MD, March, 2005. Version 3

2004

Member of External Advisory Board for Wake Forest/Ed Shaw (PI) PO-1 Application – “The RAS and Radiation Induced Brain Injury”

2005

Chairman – Image Guided Radiotherapy Session, Varian Medical Systems RT 2010 meeting – Las Vegas, NV – January, 2005

2005

Vice-President/President Elect for The Simon Kramer Society

2005

Member of ASTRO Committee Responding to Neurosurgery Request to NRC for Gamma Knife Exemption

2006 - 2008

President for The Simon Kramer Society

2006 – 2010

Member of ACR Radiation Oncology Rectal/Anal Expert Panel

2006 – 2012

Member of Radiation Therapy Oncology Group New Investigators Committee

2006 – 2007

Member of U.S. Intergroup Hepatobiliary Cancer Clinical Trials Task Force


William F. Regine, M.D. Curriculum Vitae - Page 46

2007 – present Member of U.S. Intergroup Pancreatic Cancer Clinical Trials Task Force 2007

Co-Chaired Radiation Therapy Oncology Group Gastrointestinal Cancer Steering Committee

2007 – 2010

Member of ASCO GI Cancer Symposium Steering Committee

2010 – 2011 Member of NCI Initial Review Group Subcommittee H – Clinical Groups 2011 – present American College of Radiation Oncology Gastrointestinal Cancer Medical Accreditation Review Team Leader INTERNATIONAL 2001

Chairman CNS Committee – Late Effects Normal Tissues IV NCI sponsored Workshop

2004

Co-Chairman of 2nd Annual 3D Line User Meeting. 3D Line Medical Systems. Atlanta, GA, October, 2004

2005

Co-Chairman and Panel member – Pancreatic Cancer Session – International Society of Gastrointestinal Oncology – The 2005 Gastrointestinal Oncology Conference, Arlington, VA, July, 2005

2006

Co-Chairman and Panel member – Pancreatic Cancer Session – International Society of Gastrointestinal Oncology – The 2006 Gastrointestinal Oncology Conference, Arlington, VA, September, 2006

2007

Protocol Reviewer (Proposed Phase III Locally Advanced Pancreas Trial) for European Study Group for Pancreatic Cancer, (ESPAC) Trials Advisory Committee

2009

Protocol Reviewer (Proposed Phase III Adjuvant Pancreas Trial) for the German Ministry of Educational ResearchMedical Center Tumor Board – Bi-Monthly, 1997 – 2002


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