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Curriculum Vitae Nilesh N. Mistry, PhD Assistant Professor, Radiation Oncology University of Maryland School of Medicine Date: Dec 17, 2013 Contact Information Business Address:

Office: Phone: Email:

Department of Radiation Oncology University of Maryland Medical Center Gudelski, GGK19 22 South Greene St. Baltimore, MD 21201 Gray Laboratory #212 520 West Lombard St, Baltimore, MD 21201 (410) 706-2772 nmistry@som.umaryland.edu

Education 1999

B.E., Mumbai University, Biomedical Engineering

2003

M.S., University of Maryland Baltimore County, Electrical Engineering Specialty: Image Processing Advisor: Dr. Tülay Adali “Elastic Image Registration for Cardiac MRI”

2008

Ph.D., Duke University, Biomedical Engineering Specialty: Medical Imaging (MRI) Advisor: Dr. G. Allan Johnson Dissertation: “Multimodality Functional Imaging in the Rodent Lung”

Post Graduate Education and Training 2009- 2010

Postdoctoral Research Fellow, Radiology and Radiological Sciences Vanderbilt University Institute of Imaging Sciences, Vanderbilt University Advisor: Dr. Chad C. Quarles and Dr. John Gore Topic: Imaging angiogenesis and hypoxia in tumor models using MRI

Employment History Academic 2013-Present 2010-2013

Assistant Professor, Radiation Oncology, University of Maryland School of Medicine Instructor, Radiation Oncology, University of Maryland School of Medicine

Other Employment 2000 –2001 1999 –2000

Lecturer, Dwarkadas J. Sanghvi College of Engineering, Mumbai University (India) Graduate Engineering Trainee, Larsen & Toubro Ltd., Medical Equipment

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Nilesh Mistry, PhD

Professional Memberships 2013-Present Full Member, International Society for Magnetic Resonance in Medicine (ISMRM) 2004-2013 Trainee Member, International Society for Magnetic Resonance in Medicine (ISMRM) 2011-Present Full Member, American Association for Physicists in Medicine (AAPM) Honors and Awards 2002 Best Student Paper Presentation at 3rd Semi-Annual Student Research Conference, UMBC 2004 Educational Fellowship*, ISMRM 2007 Educational Fellowship*, ISMRM 2008 Educational Fellowship*, ISMRM * Awarded to students and postdoctoral fellows for exceptional research Clinical Activities Clinical Trials Major Role PI for clinical trial on “Improving Cancer Foci Detection in Prostate Cancer Using Multiparametric MRI/MRS and Machine Learning to better manage the disease” PI for clinical trial on “Minimizing Toxicity using Function Based Treatment Planning: Pilot Clinical Trial” Supporting departmental clinical trials involving imaging research in Radiation Oncology driving imaging trials looking at outcomes following radiation therapy for Head and Neck Cancer and Lung Cancer. Departmental Service 2012-Present Member, IT Steering Committee Institutional Service 2011-2013 Council Alternate Representative University of Maryland School of Medicine 2013 Council Member University of Maryland School of Medicine Local and National Service 2009-Present Reviewer, Magnetic Resonance Imaging (Elsevier) 2009-Present Reviewer, Journal of Magnetic Resonance Imaging (Wiley) 2009-Present Reviewer, American Journal Experts Teaching Service Resident Training 2010-Present Instructor, Physics Lecture Series for Radiation Therapy, Radiation Oncology, UMSOM ~6-8 medical residents in radiation oncology, 3 weeks/year, 1 class hour/week Medical Dosimetry School Training 2010-Present Instructor, Physics Lecture Series for Radiation Therapy, Radiation Oncology, UMSOM 2 students, 3 weeks/year, 1 class hour/week

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Nilesh Mistry, PhD

Medical Physics Residency Program 2012-Present Instructor, Physics Lecture Series for Radiation Therapy, Radiation Oncology, UMSOM 1 medical physics resident in radiation oncology, 3 weeks/year, 1 class hour/week Overview of assigned research projects focused on Imaging in Radiation Oncology 1 medical physics resident in radiation oncology, 4 weeks/year, 1 class hour/week One-on-one didactic training on use MRI and Image Registration techniques Undergraduate / Graduate Students, Medical Students and Post-Doctoral Fellows 2010-2011 Sabin Pokharel (Undergraduate – Morgan State University) - Trained the student on medical Image Processing techniques using MATLAB - Part of a team that presented 1 abstract to American Association of Physicist in Medicine (oral presentation), and has submitted a journal publication that is underreview 2011-2013

Tejan Diwanji (Medical Student, UMSOM) - Trained the medical student on Image Processing to extract Lung Ventilation - Imparted training on acquiring MRI images for Lung Perfusion - The student submitted 3 first author abstracts to international conferences (2/3 oral presentations) - Helped in submitting a patent application from the work - Helped in submitting a journal publication that is currently under-review (resubmitted – after 2 rounds of reviews) - Submitted 1 clinical case study based on research work to PRO - Currently preparing 1 first author publication from research work

2012-Present

Xiutao Shi (Post-doctoral Fellow) - Imparted training on utilizing medical image processing techniques for motion management - Submitted 3 first author abstracts to international conferences (2/3 oral presentation) - 1 co-author publication: Published in IJROBP (Red Journal) - Submitted 1 first author publication from research work - Currently preparing 2 first author publications from research work

2013-Present

Yanan Liu (Post-doctoral Fellow) - Imparted training on utilizing medical image processing techniques for detecting Prostate Cancer - Developing CT image reconstruction for retrospective respiratory gating in mice

Grant Support Active 2012 - 2013 Improving Cancer Foci Detection in Prostate Cancer Using Multiparametric MRI/MRS and Machine Learning to better manage the disease UMB-UMCP Seed Grant Role: Principal Investigator (No salary support) Total Costs: $75,000 2014

Minimizing Toxicity using Function Based Treatment Planning: Pilot Clinical Trial Departmental Seed Grant Role: Principal Investigator (No salary support) Total Costs: $9,750

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Nilesh Mistry, PhD

Pending 2014 - 2018

Multimodality imaging to access radiation effects on lung and radiation countermeasure efficacy FDA – White Paper (Pre-Application) Role: Co-Principal Investigator (30%) Total Direct Costs: $ 2,403,194 ($ 2.4M) Total Costs: $ 3,652,910 ($ 3.6M)

Patents / Inventions 2013 N. Mistry, T. Diwanji, S. Feigenberg, W. D. D’Souza. Quantitative Evaluation of Fractional Regional Ventilation Using Four-Dimensional Computed Tomography- US Non-Provisional Patent Application 13/894,314 Patent Pending Publications Peer-reviewed journal articles 1)

Mistry NN, Hsu EW. “Retrospective distortion correction for 3D MR diffusion tensor microscopy using mutual information and Fourier deformations.” Magn Reson Med. 2006 Aug; 56(2): 310-6. PubMed PMID: 16773654.

2)

Driehuys B, Walker J, Pollaro J, Cofer GP, Mistry N, Schwartz D, Johnson GA. “3He MRI in mouse models of asthma.” Magn Reson Med. 2007 Nov; 58(5): 893-900. PubMed PMID: 17969115; PubMed Central PMCID: PMC2746053.

3)

Mistry NN, Pollaro J, Song J, De Lin M, Johnson GA. “Pulmonary perfusion imaging in the rodent lung using dynamic contrast-enhanced MRI.” Magn Reson Med. 2008 Feb; 59(2): 28997. PubMed PMID: 18228577; PubMed Central PMCID: PMC2738602.

4)

Badea CT, Wetzel AW, Mistry N, Pomerantz S, Nave D, Johnson GA. “Left ventricle volume measurements in cardiac micro-CT: the impact of radiation dose and contrast agent.” Comput Med Imaging Graph. 2008 Apr; 32(3): 239-50. PubMed PMID: 18243656; PubMed Central PMCID: PMC2276250.

5)

de Lin M, Ning L, Badea CT, Mistry NN, Qi Y, Johnson GA. “A high-precision contrast injector for small animal x-ray digital subtraction angiography.” IEEE Trans Biomed Eng. 2008 Mar; 55(3): 1082-91. PubMed PMID: 18334400; PubMed Central PMCID: PMC2685207.

6)

Mistry NN, Qi Y, Hedlund LW, Johnson GA. “Ventilation/perfusion imaging in a rat model of airway obstruction.” Magn Reson Med. 2010 Mar; 63(3): 728-35. PubMed PMID: 20146375; PubMed Central PMCID: PMC2832088.

7)

Mistry NN, Thomas A, Kaushik SS, Johnson GA, Driehuys B. “Quantitative analysis of hyperpolarized 3He ventilation changes in mice challenged with methacholine.” Magn Reson Med. 2010 Mar; 63(3): 658-66. PubMed PMID: 20187176.

8)

Brinegar C, Schmitter SS, Mistry NN, Johnson GA, Liang ZP. Improving temporal resolution of pulmonary perfusion imaging in rats using the partially separable functions model. Magn Reson Med. 2010 Jun 17. PubMed PMID: 20564601.

9)

Mistry NN, Rosenkrantz A, Roys S, Papadimitiriou J, Siddiqui K, Naslund M, Borin J, 1 D’Souza W, Gullapalli R. Prostate Cancer: Detection using Multiparametric H-MRI. Mol Cell Pharmacol 2013; 5(1): 5-17.

10)

Nilesh N Mistry, Tejan Diwanji, Xiutao Shi, Sabin Pokharel, Steven Feigenberg, Steven M Scharf, Warren D D’Souza. Evaluation of Fractional Regional Ventilation Using 4D-CT and Effects of Breathing Maneuvers on Ventilation, Volume 87, Issue 4, 15 November 2013, Pages 825–831, IJROBP, http://www.sciencedirect.com/science/article/pii/S0360301613029040

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Nilesh Mistry, PhD

11)

Nilesh N Mistry, James V Gambrell, Christopher C Quarles. Nitrite Induces Extravasation of Iron Oxide Nanoparticles in Hypoxic Tumor Tissue, NMR in Biomedicine (Revised)

12)

X. Shi, T. Diwanji, K. Mooney, W. D’Souza, N. Mistry. Evaluation of template matching for tumor motion management with cine-MR images in lung cancer patients, Medical Physics (under review) Diwanji T, Mistry NN, Zhang H, D’Souza W, Laser B, Feigenberg S. A case highlighting the utility of functional imaging prior to radiation treatment planning, Frontiers in Radiation Oncology (under review)

13)

Book Chapters: 1)

“Quantitative MRI in Cancer (Imaging in Medical Diagnosis and Therapy)” Editors: Thomas E. Yankeelov, David R. Pickens, Ronald R. Price, CRC Press Taylor & Francis Book, ISBN: 978-1-4398-2057-5, Page: 193 – 202 Chapter 14: Imaging Tissue Oxygenation Status with MRI, Authors: Nilesh Mistry, C. Quarles

Abstracts and Proceedings 1)

N. Mistry, G. Beache, “Improvement in the Measurement of Physiological Parameters in the Analysis of Myocardial BOLD MRI”, Student Research Conference-Computer Science and Electrical Engineering 2002, University of Maryland Baltimore County

2)

N. Mistry, M. Solaiyappan, G. Beache, “Effect of Elastic Registration on Reliability of Cardiac Physiological Measurement”, – Oral Presentation - International Society of Magnetic Resonance in Medicine, Toronto, Ontario, CANADA 2003

3)

G. Beache, N. Mistry, B. Zhang, “The Lagrangian multiplier method as a basis for elastic image registration”, - International Society of Magnetic Resonance in Medicine, Kyoto, Osaka, JAPAN 2004

4)

N. Mistry, E. Hsu, “Gradient distortion correction for 3D diffusion tensor microscopy”, International Society of Magnetic Resonance in Medicine, Kyoto, Osaka, JAPAN 2004

5)

N. Mistry, Edward Hsu: “Distortion Correction using Mutual Information in 3D Diffusion Tensor Microscopy”. International Symposium on Biomedical Imaging, Washington DC, DC, USA 2004

6)

N. Mistry, Lin, M. Hedlund, L., Johnson, G. A., “Multimodality Imaging of Pulmonary Function in the Rodent”, – International Symposium on Biomedical Imaging, Arlington, VA, USA 2006

7)

N. Mistry, J. Pollaro, L. Hedlund, G. Johnson, “Registered He Ventilation and H Perfusion Dynamic Contrast Enhanced MRI in the Rodent Lung”, - International Society of Magnetic Resonance in Medicine, Seattle, Washington, USA 2006

8)

N. Mistry, J. Pollaro, J. Song, G. A. Johnson, “ Pulmonary perfusion imaging in the rodent lung using DCE-MRI”, - Joint Annual Meeting of the International Society of Magnetic Resonance in Medicine and European Society of Magnetic Resonance in Medicine and Biology, Berlin, GERMANY 2007

9)

N.Mistry, B. Driehuys, G. A. Johnson, “Quantitative analysis of MCh induced ventilation changes in mouse lungs”, Joint Annual Meeting of the International Society of Magnetic Resonance in Medicine and European Society of Magnetic Resonance in Medicine and Biology, Berlin, GERMANY 2007

10)

J. Song, N. Mistry, Q. Liu, G. A. Johnson, “Total variation denoised dynamic reconstruction applied to pulmonary perfusion imaging in the rat”, - Joint Annual Meeting of the International Society of Magnetic Resonance in Medicine and European Society of Magnetic Resonance in Medicine and Biology, Berlin, GERMANY 2007

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Nilesh Mistry, PhD

11)

A. Wetzel, C. Badea, S. Pomerantz, D. Nave, N. Mistry, D. Nave, G. A. Johnson, “Measurement and modeling of 4D live mouse heart volumes from CT time series”, Videometrics IX – International Society of Optics and Photonics, San Diego, California, USA 2007

12)

S. Schmitter, N. Mistry, C. Brinegar, G. A. Johnson, Z-P. Liang, “High-resolution Pulmonary Perfusion Imaging in Rodents using a Spatiotemporal Model”, - Oral Presentation International Society of Magnetic Resonance in Medicine, Toronto, Ontario, CANADA

13)

N. Mistry, B. Driehuys, B. Fubara, W. Foster, E. Potts, B. Chen, D. Slipetz, G. A. Johnson, “Quantitative Analysis of MCh-Induced Ventilation Changes in Mouse Lungs in a Time Series”, - Oral Presentation - International Society of Magnetic Resonance in Medicine, Toronto, Ontario, CANADA

14)

N. Mistry, C. Christopher Quarles, “Assessment of nitrite induced changes in C6 glioma oxygenation and blood volume using BOLD-MRI”, - Vanderbilt Ingram Cancer Center Symposium, Nashville, TN, USA 2009

15)

N. N. Mistry, J Zhou, K. Malinowski, R. Gullapalli, W. D. D’Souza, “Real-time target displacement prediction using Dynamic MRI for radiotherapy”, International Society of Magnetic Resonance in Medicine, Montreal, Quebec, CANADA 2011

16)

N. N. Mistry, J. V. Gambrell, C. C. Quarles, “Nitrite induces the extravasation of iron oxide nanoparticles in C6 brain tumors”, Nominated for best poster award – Oral Presentation to the MRI of Cancer Group Meeting- International Society of Magnetic Resonance in Medicine, Montreal, Quebec, CANADA 2011

17)

N Mistry, J Hou , R Ballard , S Feigenberg , W D'Souza, “Pulmonary Ventilation and Perfusion Imaging Using 4DCT”, Med Phys 38, 3831 (AAPM 2011), - Oral Presentation Joint Meeting of The American Association of Physicists in Medicine and the Canadian Organization of Medical Physicists, Vancouver, CANADA, 2011

18)

H Zhang, N Mistry, W D'Souza, “Beyond Utilizing Functional Imaging for Contours and Visualization, Towards Physiological Radiotherapy to Improve Patient Outcome”, Med Phys. 38 3550 (AAPM 2011), Oral Presentation - Joint Meeting of The American Association of Physicists in Medicine and the Canadian Organization of Medical Physicists, Vancouver, CANADA, 2011

19)

N. N. Mistry, H. H. Zhang, R. Ballard, J. Hou, S. Feigenberg, W. D'Souza, “High-Resolution Regional Ventilation and Perfusion Imaging in the Lung using 4D-CT”, Int J Radiat Oncol Biol Phys 2011; 81;S123-S124, - Oral Presentation – The American Society for Radiation Oncology, Miami Beach, Florida, USA, 2011

20)

H Zhang, T Diwanji, N Mistry, W Lu, W D'Souza, “Personalized Utility Function for Radiotherapy Based On Pulmonary Ventilation of Locally Advanced Lung Cancer Patients”, Oral Presentation - The American Association of Physicists in Medicine, Charlotte, NC, USA, 2012

21)

N Mistry, S Pokharel, T Diwanji, S Feigenberg, W D'Souza, “Breathing Maneuvers Result in Regional Changes in Ventilation as Assessed by 4D-CT”, - Oral Presentation - The American Association of Physicists in Medicine, Charlotte, NC, USA, 2012

22)

T Diwanji, S Feigenberg, W D'Souza, N Mistry, “Validation of 4D Computed Tomography (4D-CT) to Evaluate Fractional Regional Ventilation Against the Clinical Gold-Standard Scintigraphy V/Q”, - Oral Presentation - The American Association of Physicists in Medicine, Charlotte, NC, USA, 2012

23)

T. Diwanji, S. Feigenberg, W. D’Souza, N. Mistry, “Dynamic Contrast Enhanced Magnetic Resonance Imaging (DCE-MRI) for High-Resolution Lung Perfusion Evaluation in Pulmonary Neoplasms Prior to Radiotherapy”, - Oral Presentation - The American Association of Physicists in Medicine, Charlotte, NC, USA, 2012

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Nilesh Mistry, PhD

24)

T Diwanji, S Pokharel, S Feigenberg, W D’Souza, N Mistry, (2012) – Validation of HighResolution Multi-Modality Imaging of Pre-Treatment Lung Function in Pulmonary Neoplasms, The American Society for Radiation Oncology (ASTRO), Boston, MA, October 2012.

25)

N Mistry, C Badea, R Gullapalli, Z Vujaskovic, W D'Souza, (2013) – Extracting Fractional Regional Ventilation in Mice, - Oral Presentation – The American Association of Physicists in Medicine, Indianapolis, IN, USA, 2013

26)

X Shi, T Diwanji, K Mooney, W D'Souza, N Mistry, (2013) - Error of Template Matching for Tracking Tumor Motion Is No Larger Than Inter-Operator Variability, - Oral Presentation – The American Association of Physicists in Medicine, Indianapolis, IN, USA, 2013

27)

X Shi, T Diwanji, S Chen, W D'Souza, N Mistry, (2013) - Does Combining Lung Ventilation Information to Perfusion Provide Any Additional Value for Treatment Planning? - The American Association of Physicists in Medicine, Indianapolis, IN, USA, 2013

28)

H Ghaffari, X Shi, N Mistry, W D'Souza, H Zhang, (2013) - Functional Imaging Based Radiotherapy for Locally Advanced Lung Cancer with Motion Management, Oral Presentation – The American Association of Physicists in Medicine, Indianapolis, IN, USA, 2013

29)

C Hung, Y Kuo, E Choi, N Mistry, S Raghavan, R Lapidus, S Xu, J Zhuo, M Suntharalingam, R Gullapalli, W D'Souza, (2013) - Multifunctional Molecular Probes for Targeting and Imaging of Epidermal Growth Factor Receptors in Vivo, Oral Presentation – The American Association of Physicists in Medicine, Indianapolis, IN, USA, 2013

30)

S Chen, W D'Souza, R Gullapalli, N Mistry, (2013) - Prediction of Prostate Gleason Score Using Neural Network and Multi-Parametric MRI, Oral Presentation – The American Association of Physicists in Medicine, Indianapolis, IN, USA, 2013

31)

C. Sours, N. Mistry, H. Zhang, Y. Kwok, M. P. Mehta, W. Regine, W. D'Souza, R. Gullapalli, (2013) Feasibility Study Testing the Incorporation of Resting State fMRI Data in Radiation Therapy Planning to Limit Dose to Cognitive Function Networks in Patients with Primary Brain Tumors, The American Society for Radiation Oncology (ASTRO), Atlanta, GA, September 2013.

 

32)

X. Shi, S. Chen, W. D. D'Souza, N. N. Mistry, (2013) - Margins Determined Using 4DCT Often Underestimate Tumor Motion in Thoracic Tumors, Oral Presentation - The American Society for Radiation Oncology (ASTRO), Atlanta, GA, September 2013.

 

Invited Talks 1)

“Multimodality Function Imaging in Small Animals” – Workshop on Small Animal Imaging at Duke University, Durham, NC, USA, May 2007

2)

“Pulmonary Function Imaging in Rats” – Department of Radiology, Brigham and Women’s Hospital, Boston, MA, USA, 2008

3)

“Imaging of Lung Physiology in Small Animals” – Department of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA, 2008

4)

“Nitrite induces the extravasation of iron oxide nanoparticles in C6 brain tumors” – Young Investigator Poster Award Presentation - Cancer Group Meeting, International Society for Magnetic Resonance in Medicine 2011, Toronto, CANADA

Proffered Talks 1)

“Quantitative Analysis of MCh-Induced Ventilation Changes in Mouse Lungs in a Time Series” – ISMRM 2008, Toronto, CANADA

2)

“Real-time target displacement prediction using Dynamic MRI for radiotherapy”, ISMRM 2011, Toronto, CANADA

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3)

“Pulmonary Ventilation and Perfusion Imaging Using 4DCT”, AAPM Annual Meeting 2011, Montreal, CANADA

4)

“High-Resolution Regional Ventilation and Perfusion Imaging in the Lung using 4D-CT”, ASTRO Annual Meeting 2011, Miami Beach, FL, USA

5)

“Breathing Maneuvers Result in Regional Changes in Ventilation as Assessed by 4D-CT”, AAPM Annual Meeting 2012, Charlotte, NC, USA

6)

“Extracting Fractional Regional Ventilation in Mice”, - AAPM Annual Meeting 2013, Indianapolis, IN, USA

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