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CURRICULUM VITAE Katja M. Langen, Ph.D. Associate Professor and Associate Chief of Medical Physics

Date August 20, 2013 Contact Information Business Address:

Business Phone Number: Fax: E-mail: Foreign Languages:

University of Maryland Department of Radiation Oncology 22 South Green Street Maryland, MD 21201 (410) 328-0773 (410) 328-2618 KLangen@som.umaryland.edu German (native)

Education 1991 1994 1997

Diplom-Ingenieure (BA) Strahlenschutz, Berufsakademie Karlsruhe, Germany, equivalent to B.S. in Health Physics M.S., University of Wisconsin, Madison, Wisconsin, Medical Physics Ph.D., University of Wisconsin, Madison, Wisconsin, Medical Physics, Thesis Advisor- Paul M. Deluca, Jr., “Microdosimetric Investigations at the Fast Neutron Therapy Facility at Fermilab�

Post Graduate Education and Training 1998-2000 2001-2003

Post Doctoral Fellow, National Accelerator Centre, Faure, South Africa. Mentor: Dan T.L. Jones Residency, Department of Radiation Oncology, University of California San Francisco, San Francisco, CA. Mentor: Lynn Verhey

Certifications 2004

Therapeutic Radiological Physics, American Board of Radiology

Medical Licensures Active

Florida, Therapeutic Radiological Physicist

Employment History

2003-2006 2006-2012

Staff Medical Physicist/Research Physicist, MD Anderson Cancer Center Orlando, FL Senior Medical Physicist, MD Anderson Cancer Center Orlando, FL


2013-present

Associate Professor and Associate Chief of Medical Physics at the Maryland Proton Treatment Center, Baltimore, MD

Academic Appointments 2005-2011 2012-2013 2013-present

Adjunct Faculty, University of Texas MD Anderson Cancer Center, Houston, TX Adjunct Assistant Professor, University of Texas MD Anderson Cancer Center, Houston, TX Associate Professor, School of Medicine, University of Maryland, Baltimore, MD

Professional Society Memberships 1991 2002 2004 2008

Member, German-Swiss Health Physics Society Member, American Association of Physicists in Medicine (AAPM) Member, American Society for Therapeutic Radiology and Oncology (ASTRO) Member, European Society for Therapeutic Radiology and Oncology (ESTRO)

Honors and Awards 1992

John Cameron Fellowship, University of Wisconsin-Madison

Clinical Activities 2003-20012

2013-present

MD Anderson Cancer Center Orlando: Responsible for all TomoTherapy related clinical services for two machines (shared with one physics colleague), Weekly chart checks, Monthly machine QA, Physicist-of-the-week rotation, Patient specific IMRT QA, Designated lead physicist for planned Mevion proton facility. University of Maryland, Maryland Proton Treatment Center: Clinical support for the proton therapy center operated at the University of Maryland. Ensure compliance with all regulatory requirements, Startup of proton therapy planning efforts.

Administrative Services National Service 2001-present

2006-2008 2008-2010 2008-2012 2008-present 2009-2012 2009-present 2009-2012 2006, 2011 2011-present

Manuscript Reviewer for: International Journal of Radiation Oncology, Biology and Physics, Radiotherapy and Oncology, Physics in Medicine and Biology, Medical Physics, Technology in Cancer Research and Treatment, Journal of Applied Clinical Medical Physic, Practical Radiation Oncology Member of AAPM Task Group 148, Tomotherapy Quality Assurance Co-chair of AAPM Task Group 148, Tomotherapy Quality Assurance Abstract Reviewer for the AAPM annual meeting Associate Guest Editor, Medical Physics Member of AAPM Task Group 179, Quality assurance for image-guided radiation therapy utilizing CT-based technologies Member of AAPM Working Group on Dosimetry Calibration Protocol for Beams that are not compliant with TG-51 Abstract Reviewer for the ASTRO annual meeting Faculty, AAPM Summer School Examiner for Therapeutic Radiological Physics board certification oral exam, American Board of Radiology

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2010-2012

Radiological Physics Item-writing Task Force for Radiation Oncology written board exam, American Board of Radiology

International Service 2010 2010 2010 2010 2012

External reviewer, Ph.D, Thesis, McGill University, Montreal, Canada External Assessor, Grant review, National Health and Medical Research Council, Australia Grant reviewer, Dutch Cancer Society, Netherlands Abstract Reviewer for the ICCR 2010 (International Conference on the Use of Computers in Radiation Therapy) External Assessor, Grant review, Portuguese Foundation for Science and Technology

Teaching Service Undergraduate Student Teaching 2001-2002

Instructor, City College of San Francisco, Physics for Radiation Therapists, RT 72, San Francisco, California, ~15 Students per semester, 13 lectures and 4 labs per semester. This service was provided on a rotating basis by UCSF Medical Physics residents. It was supervised by Lynn Verhey, chief physicist at UCSF.

Resident and Fellow Teaching 2005-2012

Faculty, Medical Physics Residency program (CAMPEP Accreditation in 2008) MD Anderson Cancer Center Orlando. 2 residents per year, 5 contact hours per resident and semester

Post-Graduate Teaching 1999-2000 2005 2006-2007 2008-2010 2009-2011 2010-present

Co-advisor with Dan T.L. Jones, M.S. student (John Bhengu) University of Cape Town, South Africa Research Mentor, AAPM summer student (Stacy-Ann Stephenson), MD Anderson Cancer Center Orlando, Orlando, Florida Research Mentor, Post-doctoral Fellow (Choonik Lee, Ph.D.), MD Anderson Cancer Center Orlando, Florida Research Mentor, Post-doctoral Fellow (Wilfred Ngwa, Ph.D.), MD Anderson Cancer Center Orlando, Florida Research Mentor, Post-doctoral Fellow (Benjamin Waghorn, Ph.D.), MD Anderson Cancer Center Orlando, Florida Research Mentor, Ph.D. Student/Research Assistant (Jason Pukala, M.S.), MD Anderson Cancer Center Orlando, Florida. Student is enrolled at the University of Florida-Gainesville

Grant Support Active Contract Completed Contracts 04/12-04/13 Katja Langen (PI, 100%) Clinical implementation of adaptive radiation therapy Research contract with Accuray. Direct Funds: 80k US$

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09/08-09/10

Katja Langen (PI, 100%) Assessing the value of daily soft tissue imaging for proton patients Source: Varian Medical Systems Direct Funds: Equipment Loan, Eclipse Treatment Planning System for Proton Planning

04/09-04/11

Katja Langen (PI, 100%) Investigating the sensitivity of compensator based IMRT plans to intra-fraction motion Research contract with .decimal, Inc. Direct Funds: 122k US$

03/10-03/12

Katja Langen (PI, 100%) Clinical implementation of adaptive radiation therapy Research contract with TomoTherapy,Inc. Direct Funds: 160k US$

Publications Peer-reviewed journal articles 1. Azimi-Garakani D, Langen KM, Wernli C, Pihet, P. The Response of various neutron dosimeters at high energy neutrons. Nuclear Instrum. Methods. A320:368-374, 1992. 2. Azimi-Garakani D, Langen KM, Wernli C, Pihet P. Further study of the characteristics of different proton-recoil track detectors at various energies. Radiat. Meas. 23:241-245, 1994. 3. Langen KM, Jones D. Organ motion and its management. International Journal of Radiation Oncology, Biology and Physics. 50:265-278, 2001. 4. Buffer A, Brooks F, Allie M, Binns P, Dangendorf V, Langen KM, Nolte R, Schuhmacher. Measurement of neutron energy spectra from 15 to 150 MeV using stacked liquid scintillators. Nucl. Instrum. Methods. A476:181-185, 2002. 5. Langen KM, Binns P, Lennox A, Kroc T, Deluca, Jr. P. Pileup correction of microdosimetric spectra. Nucl. Instrum. Methods. A484:595-612, 2002. 6. Pouliot J, Aubin M, Langen KM, Liu Y, Pickett B, Roach III M. Non-migration of implanted prostate markers used for daily online verification. International Journal of Radiation Oncology, Biology and Physics. 56:862-866, 2003. 7. Langen KM, Binns P, Schreuder A, Lennox A, Deluca, Jr. P. Measurement of the tissue to A-150 tissue equivalent plastic kerma coefficient ratio at two p(66)Be neutron therapy facilities. Phys. Med. Biol. 48:1345-1359, 2003. 8. Langen KM, Pouliot J, Anezinos C, Aubin M, Gottschalk A, Hsu I, Lowther D, Shinohara K, Weinberg V, Verhey L, Roach III M. Evaluation of ultrasound-based prostate localization for image guided radiation therapy. International Journal of Radiation Oncology, Biology and Physics. 57:635-644, 2003. 9. Liu Y, Ling S, Langen KM, Shinohara K, Weinberg V, Pouliot J, Roach III M. Prostate movement during simulation resulting from retrograde urethrogram compared with “natural� prostate movement. International Journal of Radiation Oncology, Biology and Physics. 60:470-475, 2004. 10. Bhengu KJ, Langen KM, Symons JE, Jones DTL. Thermoluminescence dosimetry on a fast neutron therapy beam. Radiation Physics and Chemistry, 71 (304):981-982, 2004. 11. Langen KM, Zhang Y, Andrews R, Hurley M, Meeks S, Poole D, Willoughby T, Kupelian P. Initial experience with Megavoltage (MV) CT-guidance for daily prostate alignments. International Journal of Radiation Oncology, Biology and Physics. 62(5):1517-1524, 2005. 12. Kupelian P, Ramsey C, Meeks S, Willoughby T, Forbes A, Wagner T, Langen KM. Serial megavoltage CT imagining during external beam radiotherapy for non-small cell lung cancer: Observations on tumor regression during treatment. International Journal of Radiation Oncology, Biology and Physics. 63(4):1024-1028, 2005.

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13. Langen KM, Meeks S, Poole D, Wagner T, Willoughby T, Kupelian P, Ruchala J, Haimerl J, Olivera G. The use of megavoltage CT (MVCT) images for dose recomputations. Phys. Med. Biol. 50(18):4259-4276, 2005. 14. Meeks S, Harmon J, Langen KM, Willoughby T, Wagner T, Kupelian P. Performance characterization of megavoltage computed tomography imaging on a helical tomotherapy unit. Medical Physics. 32(8):2673-2681, 2005. 15. Kupelian P, Willoughby T, Meeks S, Forbes A, Wagner T, Maach M, Langen KM. Intraprostatic fiducials for localization of the prostate gland: Monitoring intermarker distances during radiation therapy to test for marker stability. International Journal of Radiation Oncology, Biology and Physics. 62(5):1291-1296, 2005. 16. Langen KM, Meeks S, Poole D, Wagner T, Willoughby T, Zeidan O, Kupelian P. Evaluation of a diode array for QA measurements on a helical TomoTherapy unit. Medical Physics, 32(11):3424-3430, 2005. 17. Ramsey C, Langen KM, Kupelian P, Scaperoth D, Meeks S, Mahan S. A technique for adaptive image-guided helical tomotherapy for lung cancer. International Journal of Radiation Oncology, Biology and Physics, 64(4):1237-44, 2006. 18. Gonzalez V, Buchholz D, Langen KM, Olivera G, Chauhan B, Meeks S, Ruchala K, Haimerl J, Kupelian P. Evaluation of helical tomotherapy-based techniques for delivery of whole breast intensity modulated radiation therapy. International Journal of Radiation Oncology, Biology and Physics, 65(1):284-290, 2006. 19. Willoughby TR, Forbes AR, Buchholz D, Langen KM, Wagner TH, Zeidan OA, Kupelian PA, Meeks SL. Evaluation of an infrared camera and x-ray system using implanted fiducials in patients with lung tumors for gated radiation therapy. International Journal of Radiation Oncology, Biology and Physics, 66(2):568-575, 2006. 20. Lu W, Olivera GH, Chen O, Ruchala KJ, Haimerl J, Meeks SL, Langen KM, Kupelian PA. Deformable registration of the planning image (kVCT) and the daily images (MVCT) for adaptive radiation therapy. Physics in Medicine and Biology, 51 (17): 4357-4374, 2006. 21. Kupelian PA, Langen KM, Willoughby TR, Wagner TH, Zeidan OA, Meeks SL. Daily variations in the position of the prostate bed in patients with prostate cancer receiving postoperative external beam radiation therapy. International Journal of Radiation Oncology, Biology and Physics, 66(2):593-596, 2006. 22. Kupelian PA, Langen KM, Zeidan OA, Meeks SL. Willoughby TR, Wagner TH, Jeswani S, Ruchala KJ, Haimerl J, Olivera GH. Daily variations in delivered doses in patients treated with radiotherapy for localized prostate cancer. International Journal of Radiation Oncology, Biology and Physics, 66(3):876-882, 2006. 23. Zeidan OA, Stephenson SA, Meeks SL, Wagner TH, Willoughby TR, Kupelian PA, Langen KM. Characterization and use of EBT radiochromic film for IMRT dose verification. Medical Physics, 33(11):4064-4072, 2006. 24. Santhanam, AP, Fidopiastis CM, Davenport P, Langen K, Meeks S, Rolland, JP. Real-time simulation and visualization of subject-specific 3D lung dynamics. Proceedings 窶的EEE Symposium on Computer-Based Medical Systems: 629-634, 2006. 25. Seibert RM, Ramsey CR, Hines JW, Kupelian PA, Langen KM, Meeks SL, Scaperoth DD. A model for predicting lung cancer response to therapy. International Journal of Radiation Oncology, Biology and Physics, 67(2):601-609, 2007. 26. Zeidan OA, Langen KM, Meeks SL, Manon RR, Wagner TH, Willoughby TR, Jenkins DW, Kupelian PA. Evaluation of image-guidance protocols in the treatment of head and neck cancers. International Journal of Radiation Oncology, Biology and Physics, 67(3):670-677, 2007. 27. Herbert MS, Brooks FD, Allie MS, Buffler A, Nchodu MR, Makupula SA, Jones DTL, Langen KM. Determination of neutron energy spectra inside a water phantom irradiated by 64 MeV neutrons. Radiation Protection Dosimetry, 126 (1-4):346-9, 2007. 28. Kupelian PA, Langen KM, Willoughby TR, Zeidan OA, Meeks SL. Image-Guided Radiotherapy for Localized Prostate Cancer: Treating a moving Target. Semin Radiat Oncol. 18(1):58-66, 2008. 29. Kupelian PA, Lee C, Langen KM, Zeidan OA, Maテアon RR, Willoughby TR, Meeks SL. Evaluation of Image-Guidance Strategies in the Treatment of Localized Prostate Cancer.

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International Journal of Radiation Oncology, Biology and Physics, 70(4):1151-7, 2008. 30. Langen KM, Buchholz DJ, Burch DR, Burkavage R, Limaye AU, Meeks SL, Kupelian PA, Ruchala KJ, Haimerl J, Henderson D, Olivera GH. Investigation of accelerated partial breast alignment and treatment with a helical tomotherapy unit. International Journal of Radiation Oncology, Biology and Physics, 70(4):1272-80, 2008. 31. Langen KM, Meeks SL, Pouliot J. Quality Assurance of Onboard MVCT Imaging and Target Localization Systems for On- and Off-line Image Guided Radiation Therapy. International Journal of Radiation Oncology, Biology and Physics, 71(1):S62-S65, 2008. 32. Shah AP, Langen KM, Ruchala KJ, Cox A, Kupelian PA, Meeks SL. Patient dose from megavoltage computed tomography imaging. International Journal of Radiation Oncology, Biology and Physics, 70(5), 1579-87, 2008. 33. Newhauser WD, Giebeler A, Langen KM, Mirkovic D, Mohan R. Can megavoltage computed tomography reduce proton range uncertainties in treatment plans for patients with large metal implants. Physics in Medicine and Biology, 53(9):2327-44, 2008. 34. Langen KM, Willoughby TR, Meeks SL, Santhanam A, Levine L, Kupelian, PA. Observations on real-time prostate gland motion using electromagnetic tracking. International Journal of Radiation Oncology, Biology and Physics, 71(4):1084-90, 2008. 35. Lee C, Langen KM, Lu W, Haimerl J, Schnarr E, Ruchala KJ, Olivera GH, Meeks S, Kupelian PA, Shellenberger TD, Ma単on RR. Assessment of parotid gland dose changes during head and neck cancer radiotherapy using daily MVCT and deformable image registration. International Journal of Radiation Oncology, Biology and Physics, 71(5): 1563-1571, 2008. 36. Poulson PR, Cho BC, Langen KM, Kupelian PA, Keall PJ. Three-dimensional prostate position estimation with a single x-ray imager utilizing spatial probability density. Physics in Medicine and Biology, 53(16):4331-4353, 2008. 37. Lee C, Langen KM, Lu W, Haimerl J, Schnarr E, Ruchala KJ, Olivera GH, Meeks S, Kupelian PA, Shellenberger TD, Ma単on RR. Evaluation of geometric changes of parotid glands during head and neck cancer radiotherapy using daily MVCT and automatic deformable registration. Radiotherapy and Oncology, 89(1):81-88, 2008. 38. Lopatiuk-Tirpak O, Langen KM, Meeks SL, Kupelian PA, Zeidan OA, Maryanski MJ. Performance Evaluation of an Improved Optical Computed Tomography Gel Dosimeter System for 3-D Dose Verification of Static and Dynamic Phantom Deliveries. Medical Physics, 35(9):3847-3859, 2008. 39. Langen KM, Lu W, Ngwa W, Willoughby TR, Chauhan B, Meeks SL, Kupelian PA, Olivera G. Correlation of dosimetric effect and intrafraction motion during prostate treatments delivered with helical tomotherapy. Physics in Medicine and Biology, 53(24):7073-7086, 2008. 40. Langen KM, Lu W, Willoughby TR, Chauhan B, Meeks SL, Kupelian PA, Olivera G. Dosimetric effect of prostate motion during helical tomotherapy. International Journal of Radiation Oncology, Biology and Physics, 74(4): 1134-42, 2009. 41. Wagner TH, Langen KM, Meeks SL, Willoughby TR, Zeidan OA, Staton RJ, Shah AP, Manon RR, Kupelian PA. Megavoltage computed tomography image-based low-dose rate intracavitary brachytherapy planning for cervical carcinoma. Technol. Cancer Res Treat, 8(2):123-130, 2009. 42. Staton RJ, Langen KM, Kupelian PA, Meeks SL. Dosimetric effects of rotational output variation and x-ray target degradation on helical tomotherapy plans. Medical Physics, 36(7): 2881-8, 2009. 43. Lu W, Chen M, Ruchala KJ, Chen Q, Langen KM, Kupelian PA, Olivera GH. Real-time motion-adaptive-optimization (MAO) in TomoTherapy. Physics in Medicine and Biology, 54(14):4373-98, 2009. 44. Ngwa W, Meeks SL, Kupelian PA, Schnarr E, Langen KM. Validation of a computational method for assessing the impact of intra-fraction motion on helical tomotherapy plans, Physics in Medicine and Biology, 54(21):6611-21, 2009. 45. Zeidan OA, Huddleston AJ, Lee C, Langen KM, Kupelian PA, Meeks SL, Manon RR. A comparison of implanted soft-tissue markers and bony anatomy alignments for image-guided treatments of head and neck cancers. International Journal of Radiation Oncology, Biology, and Physics, 76(3):767-774, 2010

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46. Waghorn BJ, Shah AP, Ngwa W, Meeks SL, Moore JA, Siebers, JV, Langen KM. A computational method for estimating the dosimetric effect of intra-fraction motion on Stepand-Shoot IMRT and compensator plans, Physics in Medicine and Biology, 55(14): 41874202, 2010. 47. Langen KM, Papanikolaou N, Balog J, Crilly R, Followill D, Goddu SM, Grant W, Olivera G, Ramsey CR, Shi C. QA for Helical Tomotherapy: Report of the AAPM Task Group 148, Medical Physics, Medical Physics, 37(9):4817-4853, 2010. 48. Shah AP, Kupelian PA, Willoughby TR, Langen KM, Meeks SL. An evaluation of intrafraction motion of the prostate in the prone and supine positions using electromagnetic tracking, Radiotherapy and Oncology 99(4):37–43, 2011. 49. Waghorn BJ, Meeks SL, Langen KM. Analyzing the impact of intrafraction motion: Correlation of different dose metrics with changes in target D95%. Medical Physics, 38(8):4505-4511, 2011. 50. Pukala J, Meeks SL, Bova FJ, Langen KM. The effect of temporal HU variations on the uncertainty of dose recalculations performed on MVCT images. Physics in Medicine and Biology, 56(24):7829-41, 2011. 51. Bissonnette J-P, Balter PA, Dong L, Langen KM, Lovelock DM, Miften M, Moseley DJ, Pouliot J, Sonke J-J, Yoo S. Quality assurance for image-guided radiation therapy utilizing CT-based technologies: A report of the AAPM TG-179. Medical Physics, 39(4):1946-1963, 2012. 52. Smeenk RJ, Louwe RJW, Langen KM, Shah AP, Kupelian PA, van Lin ENJTh, Kaanders JHAM. An Endorectal Balloon Reduces Intrafraction Prostate Motion During Radiotherapy. International Journal of Radiation Oncology, Biology and Physics, 83(2):661-669, 2012. 53. Langen KM, Chauhan B, Siebers JV, Moore JA, Kupelian P. The dosimetric effect of intrafraction prostate motion on step-and-shoot IMRT plans – magnitude, correlation with motion parameters, and comparison with helical tomotherapy plans. International Journal of Radiation Oncology, Biology and Physics, 84(5):1220-1225, 2012. 54. Waghorn BJ, Staton RJ, Rineer JM, Meeks SL, Langen KM, A comparison of the dosimetric Effects of Intrafraction Motion on Step-and-Shoot, Compensator, and Helical Tomotherapy based IMRT, Journal of Applied Clinical Medical Physics, 14(3):121-132, 2013. 55. Jaffray DA, Langen KM, Mageras G, Dawson LA, Yan D, Adams R, Mundt AJ, Frass B, Safety consideration for IGRT: Executive Summary, Practical Radiation Oncology, Practical Radiation Oncology, 3(3):167-170, 2013. 56. De Los Santos J, Popple R, Agazaryan N, Bayouth J, Bissonnette J-P, Bucci MK, Dieterich S, Dong L, Forster KM, Indelicato D, Langen K, Lehman J, Mayr N, Parsai I, Salter W, Tomblyn M, Yuh WTC, Chetty IP. Image Guided Radiation Therapy (IGRT) Technologies for Radiation Therapy Localization and Delivery, International Journal of Radiation Oncology, Biology and Physics, 87(1):33-45, 2013. 57. Pukala J, Meeks SL, Staton RJ, Bova FJ, Langen KM, A virtual phantom Library for the quantifications of deformable image registration uncertainties with cancer of the head and neck, Medical Physics, In Press, 2013.

Book Chapters 1. Langen KM, Meeks SL, Kupelian PA, Ruchala R, Lu L, Haimerl J, Chen Q, Schnarr E and Olivera G. TomoTherapy’s implementation on IGART. In: AAPM Summer School 2006: Integrating new technologies into the clinic: Monte Carlo dose calculations/Image guided radiation therapy. Medical Physics Publishing, Madison, Wisconsin. 2006. 2. Kupelian PA and Langen KM. Helical Tomotherapy, Image Guided and Adaptive Radiotherapy. In: Frontiers of Radiation Therapy and Oncology, Vol 43, Karger AG Basel Switzerland 2011. 3. Langen KM. Uncertainties in Adaptive Radiation Therapy. In: AAPM Summer School 2011: Uncertainties in External Beam Radiation Therapy. Medical Physics Publishing, Madison, Wisconsin. 2011.

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4. Meeks SL, Willoughby TR, Langen KM, Kupelian PA. Optical and remote monitoring IGRT. In Image-Guided Radiation Therapy, D Bourland (ed), Taylor and Francis, 2012.

Abstracts and/or Proceedings 1. Langen K, Pouliot J, Anezinos C, Aubin M, Gottschalk A, Hsu I, Lowther D, Shinohara K, Verhey L, Roach III M. The inter-user variability of the BAT ultrasound system. Medical Physics. 29:1308-1309, 2002. 2. Pouliot J, Xia P, Aubin M, Verhey L, Langen K, Bani-Hashemi A, Svatos M, Ghelmansarai G, Mitchke M. Dose-guided radiation therapy using low-dose megavoltage cone-beam CT. Medical Physics. 29:1308-1309, 2002. 3. Langen K, Pouliot J, Anezinos C, Aubin M, Gottschalk A, Hsu I, Lowther D, Shinohara K, Weinberg V, Verhey L, Roach III M. Investigation of the BAT systems efficacy for daily prostate localization and repositioning. International Journal of Radiation Oncology, Biology and Physics. 54:S317-318, 2002. 4. Aubin M, Liu Y, Langen K, Shinohara K, Anezinos C, Osofsky M, Weinberg V, Pouliot J, Roach III M. Set-up verification using portal images of implanted prostate markers: an interobserver study. International Journal of Radiation Oncology, Biology and Physics. 54:S269270, 2002. 5. Downs T, Roach III M, Grossfeld G, Langen K, Pouliot J, Aubin M, Pickett B, Carroll P, Shinohara K. The University of California San Francisco (UCSF) experience with permanently implanted gold markers for daily prostate realignment during radiation therapy. International Journal of Radiation Oncology, Biology and Physics. 54:S280, 2002. 6. Pouliot J, Xia P, Aubin M, Verhey L, Langen KM, Bani-Hashemi A, Svatos M. Dose-guided Radiation Therapy using low-dose Megavoltage Cone-Beam CT. Medical Physics. 30:13371338, 2003. 7. Aubin M, Langen KM, Faddegon B. Electron Beam verification with an A-Si EPID. Medical Physics. 30:1475, 2003. 8. Zhang Y, Kupelian P, Langen K, McNerny G, Poole D, Willoughby T. Dosimetric evaluation of TomoTherapy plans. Medical Physics. 31:1732, 2004. 9. Poole D, Kupelian P, Langen K, McNerny G, Willoughby T, Zhang Y. Clinical data preparatory to treating on a TomoTherapy, Inc. Hi-ART II accelerator. Medical Physics. 31:1830, 2004. 10. Poole D, Kupelian P, Langen K, McNerny G, Willoughby T, Zhang Y. An independent dose validation technique for TomoTherapy Hi-ART II Tomo IMRT treatment. Medical Physics. 31:1862, 2004. 11. Langen K, Zhang Y, Poole D, McNerny G, Willoughby T, Kupelian P. Changes in prostate position over time periods typical of IMRT treatment times. Medical Physics. 31:1867, 2004. 12. Langen K, Zhang Y, Poole D, McNerny G, Willoughby T, Kupelian P. Image guided therapy for prostate cancer patients treated with a TomoTherapy unit. Medical Physics. 31:1890, 2004. 13. Langen K, Poole D, Zhang Y, Willoughby T, McNerny G, Meeks S, Haimerl J, Ruchala K, Olivera G, Kupelian P. Using daily MVCT images to calculate daily rectal dose volume histograms in prostate cancer patients treated with a helical TomoTherapy unit. International Journal of Radiation Oncology, Biology and Physics. 60:S613, 2004. 14. Zhang Y, Langen K, Poole D, Willoughby T, McNerny G, Meeks S, Kupelian P. Daily Megavoltage CT image guidance in the treatment of localized prostate cancer. International Journal of Radiation Oncology, Biology and Physics. 60:S616, 2004. 15. Willoughby T, Wagner T, Langen K, Forbes A, Buchholz D, Kupelian P, Meeks S. Evaluation of an infrared camera and x-ray system for gated radiation therapy. Medical Physics, 32(6):1893, 2005. 16. Wagner T, Buchholz D, Langen K, Meeks S, Willoughby T, Kupelian P. Megavoltage CT Imaging enables CT-Based Low-Dose rate Brachytherapy planning without CT-Compatible applicators. Medical Physics 32(6):1950, 2005.

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17. Chen Q, Lu W, Kupelian P, Langen K, Meeks S, Ruchala K, Olivera G. Automatic seed detection in MVCT Images for prostate radiotherapy. Medical Physics 32(6):1939, 2005. 18. Wagner T, Langen K, Poole D, Meeks S, Willoughby T, Ruchala K, Olivera G. Evaluation of a commercial diode array (Tomodose) for Tomotherapy beam profile measurements. Medical Physics 32(6):1994, 2005. 19. Langen K, Meeks S, Poole D, Wagner T, Willoughby T, Kupelian P, Ruchala K, Haimerl J, Olivera G. The use of Megavoltage CT (MVCT) Images for dose recomputation. Medical Physics 32(6):2025, 2005. 20. Olivera G, Ruchala K, Lu W, Haimerl J, Schnarr E, Langen K, Kupelian P, Meeks S, Mackie T. Dynamic tangents and Topotherapy: New delivery capabilities for Helical Tomotherapy. Medical Physics 32(6):2034, 2005. 21. Meeks S, Langen K, Wagner T, Willoughby T, Kupelian P. The use of MVCT Images for dose calculation in the presence of metallic objects. Medical Physics 32(6):2115, 2005. 22. Lu W, Chen Q, Kupelian P, Langen K, Meeks S, Ruchala K, Olivera G. Deformable registration of the planning image (KVCT) and daily treatment images (MVCT) for adaptive radiation therapy. Medical Physics 32(6):2132, 2005. 23. Meeks S, Harmon J, Langen K, Willoughby T, Wagner T, Kupelian P. Performance characterization of Megavoltage CT Imaging on a Helical Tomotherapy Unit. Medical Physics 32(6):2159, 2005. 24. Langen K, Meeks S, Poole D, Wagner T, Willoughby T, Kupelian P, Ruchala K, Haimerl J, Oilvera G. Evaluation of TomoTherapy’s MVCT number integrity. Medical Physics 32(6):2162, 2005. 25. Langen K, Buchholz D, Victor G, Meeks S, Wagner T, Willoughby T, Olivera G, Ruchala K, Haimerl J, Kupelian P. Evaluation of breast tumor bed alignment techniques for image guided radiotherapy. International Journal of Radiation Oncology Physics 63(2):S179, 2005. 26. Wagner T, Buchholz D, Forbes A, Willoughby T, Meeks S, Kupelian P, Zeidan O, Langen K. Megavoltage CT image-based intracavitary low dose rate brachytherapy for cervical carcinoma. International Journal of Radiation Oncology Physics 63(2):S338, 2005. 27. Willoughby T, Meeks S, Wagner T, Langen K, Kupelian P, Forbes A. Gated radiotherapy for lung tumors using infrared detectors, stereoscopic x-rays and implanted markers. International Journal of Radiation Oncology Physics 63(2):S413, 2005. 28. Zeidan O, Langen K, Meeks S, Olivera G, Ruchala K, Hameirl J, Wagner T, Willoughby T, Kupelian P. Daily dose recalculation using megavoltage CT images during TomoTherapy for localized prostate cancer: dosimetric analysis for the prostate gland, rectum and bladder for the full treatment course. International Journal of Radiation Oncology Physics 63(2):S309, 2005. 29. Kupelian P, Willoughby T, Meeks S, Forbes A, Wagner T, Maach M, Langen K. Intraprostatic fiducials for localization of the prostate gland: Monitoring intermarker distances during radiation therapy to test for marker stability. International Journal of Radiation Oncology Physics 63(2):S302, 2005. 30. Burkavage R, Langen K, Wagner T, Willoughby T, Zeidan O, Olivera G, Ruchala K, Hameirl J, Meeks S, Kupelian P. Daily megavoltage CT imaging in patients with prostate cancer receiving postoperative radiation therapy: Does the prostate bed move? International Journal of Radiation Oncology Physics 63(2):S308, 2005. 31. Jenkins W, Langen K, Meeks S, Olivera G, Ruchala K, Haimerl J, Wagner T, Willoughby T, Kupelian P. Use of daily megavoltage CT imaging to determine delivered dose variations in head and neck cancer patients. International Journal of Radiation Oncology Physics 63(2):S361, 2005. 32. Forbes A, Ramsey C, Langen K, Meeks S, Willoughby T, Wagner T, Kupelian P. Serial megavoltage CT imaging for non-small cell lung cancer: Observations on tumor regression during treatment. International Journal of Radiation Oncology Physics 63(2):S404, 2005. 33. Olivera G, Lu W, Ruchala K, Chen Q, Langen K, Meeks S, Kupelian P. Image guided radiotherapy plan evaluation based on deformable dose registration from daily on-line positioning images. International Journal of Radiation Oncology Physics 63(2):S508, 2005.

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34. Ruchala K, Olivera G, Lu W, Haimerl J, Schnarr E, Chen Q, Meeks S, Langen K, Kupelian P. A dose-guided adaptive therapy process for treatment evaluation and correction. Medical Physics, 33(6):1988, 2006 35. Langen K, Meeks S, Limaye A, Zeidan O, Kupelian P, Manon R, Olivera G, Ruchala K, Haimerl J, Lu W. Accuracy testing of deformable registration using dosimetric end-points. Medical Physics, 33(6):1994, 2006 36. Ruchala K, Olivera G, Homp J, Schnarr E, Haimerl J, Lu W, Chen Q, Meeks S, Langen K, Kupelian P. A fast scan-plan-treat mode for topographic breast treatment delivery. Medical Physics, 33(6):2053, 2006 37. Meeks S, Manon R, Kupelian, P, Langen K, Lu W, Chen Q, Haimerl J, Ruchala K, Olivera G. Adaptive radiation therapy using helical TomoTherapy. Medical Physics, 33(6):2024, 2006 38. Pan Y, Lu W, Ruchala K, Chen M, Chen Q, Kupelian, P, Langen K, Meeks S, Olivera G. An optimized dose-based patient alignment method for on-line adaptive radiotherapy. Medical Physics, 33(6):2025, 2006 39. Zeidan O, Stephenson S, Meeks S, Willoughby T, Wagner T, Kupelian P, Langen K. Characterization and use of EBT Radiochromic film for IMRT dose verification. Medical Physics, 33(6):2077, 2006 40. Zeidan O, Langen K, Meeks S, Willoughby T, Wagner T, Kupelian P. Dose verification in moving targets during helical TomoTherapy beam delivery. Medical Physics, 33(6):2089, 2006 41. Wagner T, Langen K, Willoughby T, Zeidan O, Ruchala K, Olivera G, Kupelian P, Meeks S. Helical TomoTherapy Radiosurgery Planning. Medical Physics, 33(6):2106, 2006 42. Bhavin C, Langen K, Meeks S, Zeidan O, Jeswani S. The influence of field length, pitch, and modulation factor on the quality of helical TomoTherapy plans. Medical Physics, 33(6):2142, 2006 43. Burch D, Langen K, Buchholz D, Limaye A, Burkavage R, Meeks S, Kupelian P. Partial Breast Irradiation with a helical Tomotherapy Using RTPG 0413 Planning Constraints. International Journal of Radiation Oncology Physics 66(3):S235-S236, 2006. 44. Meeks S, Manon RR, Kupelian PA, Lu W, Chen Q, Langen K, Ruchala KJ, Haimerl J, Olivera G. Deformable Image Registration and Replanning in Head and Neck Radiotherapy for Optimization of Parotid Sparing. International Journal of Radiation Oncology Physics 66(3):S99-S100, 2006. 45. Zeidan OA, Langen KM, Meeks S, Manon R, Wagner T, Willoughby T, Jenkins D, Kupelian PA.. Evaluation of Image-Guidance Strategies in the Treatment of Head and Neck Cancers. International Journal of Radiation Oncology Physics 66(3):S141-S142, 2006. 46. Staton RJ, Langen KM, Kupelian PA, Manon RR, Zeidan OA, Willoughby TR, Shah AP, Buchholz D, Meeks SL, Wagner TH. Comparison of Megavoltage CT Image-Based Volumetric Dose Calculations with ICRU Reference Point Estimates of Bladder and Rectal Doses during Low Dose Rate Intracavitary Brachytherapy for Cervical Cancer. International Journal of Radiation Oncology Physics 66(3):S161, 2006. 47. Langen KM, Kupelian PA, Zeidan OA, Meeks SL, Jeswani S, Ruchala KJ, Haimerl J, Olivera G. Daily Variations in Delivered Doses in Patients Treated with Radiotherapy for Localized Prostate Cancer. International Journal of Radiation Oncology Physics 66(3):S341, 2006. 48. Manon R, Langen K, Meeks S, Limaye A, Kupelian P, Olivera G, Lu W, Ruchala K. Clinical Application of Deformable Image Registration in Head and Neck Cancer Radiotherapy: Does Planned Dose to Tumor and Normal Structures Change during Treatment? International Journal of Radiation Oncology Physics 66(3):S416, 2006. 49. Forbes A, Meeks SL, Willoughby TR, Wagner TH, Johnston AD, Herran JJ, Langen KM, Kupelian PA. Stability of Implanted Fiducials for x-Ray Localization of Lung Tumors during Radiation Therapy. International Journal of Radiation Oncology Physics 66(3):S476, 2006. 50. Wagner TH, Meeks SL, Langen KM, Willoughby TR, Kupelian PA, Zeidan OA, Shah AP, Manon RR, Ruchala KJ, Olivera G. Feasibility of Image-Guided Tomotherapy for FrameBased Stereotactic Radiosurgery. International Journal of Radiation Oncology Physics 66(3):S630-S631, 2006.

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51. Ruchala KJ, Lu W, Olivera G, Pan Y, Chen Q, Kupelian P, Langen K, Meeks S. An On-line Dose Guided Adaptive Approach for Prostate Patient Positioning. International Journal of Radiation Oncology Physics 66(3):S637-S638, 2006. 52. Chen Q, Olivera GH, Lu W, Ruchala KJ, Langen KM, Meeks SL, Kupelian PA. Use of Daily CT-Based Registration to Track Lung Daily Tumor Volumes and Position. International Journal of Radiation Oncology Physics 66(3):S654-S655, 2006. 53. Shah A, Langen K, Meeks S, Kupelian P, Staton R, Cox A, Ruchala K. Commissioning and Validation of a Beam Model for Calculating Megavoltage CT Dose from Imaging with a Helical Tomotherapy Unit. Medical Physics, 34(6):2608, 2007. 54. Newhauser W, Giebeler A, Langen K, Mohan R. MVCT may reduce Proton Range Errors in Treatment Plans for Patients with Metal Implants. Medical Physics, 34(6):2576, 2007. 55. Ramsey C, Seibert R, Hines W, Meeks S, Langen K, Li X. Assessment of Lung Tumor Response using CT-based Image Guided Therapy. Medical Physics, 34(6): 2548, 2007. 56. Staton R, Langen K, Shah A, Meeks S, Kupelian P. Dosimetric Effect of Rotational Variation on Helical Tomotherapy Treatment Plans. Medical Physics, 34(6): 2441, 2007. 57. Langen K, Willoughby T, Meeks S, Kupelian O, Santhanam A, Levine L, Cunningham A. Prostate Movement during Radiation Therapy Delivery. Medical Physics, 34 (6): 2388, 2007. 58. Zeidan O, Kupelian P, Langen K, Manon R, Meeks S. Evaluation of Daily Tumor Localization Shifts in the H&N region based on Bony Anatomy and soft–tissue implanted Markers. Medical Physics, 34(6):2381, 2007. 59. Lee C, Kupelian P, Langen K, Zeidan O, Meeks S. Evaluation of Image-Guidance Strategies in the Treatment of Localized Prostate Cancers. Medical Physics, 34(6): 2380, 2007. 60. Zeidan OA, Lee C, Langen K, Kupelian P, Manon R, Meeks S. A dosimetric evaluation of Markers vs. Bony Anatomy Alignments for a Head and Neck case. International Journal of Radiation Oncology Physics 69(3):S460, 2007. 61. Manon R, Lee C, Langen K, Meeks S, Kupelian P, Haimerl J, Shellenberger T, Olivera G. Do Anatomical changes during radiation impact normal tissue and target dosimetry? An analysis of calculated cumulative dose in Head and Neck Patients. International Journal of Radiation Oncology Physics 69(3):S329-S430, 2007. 62. Meeks S, Kupelian PA, Lee C, Willoughby T, Zeidan O, Langen K. Does Image Guidance need to be performed daily in the Treatment of Localized Prostate Cancers? Implications on treatment margins. International Journal of Radiation Oncology Physics 69(3):S82-S83, 2007. 63. Lee C, Langen K, Kupelian P, Meeks S, Manon R, Lu W, Haimerl J, Olivera G. Positional and volumetric changes in Parotid Glands during Head and Neck radiation therapy assessed using deformable Image Registration. International Journal of Radiation Oncology Physics 69(3):S203-S204, 2007. 64. Langen K, Kupelian P, Willoughby T, Meeks S, Lu W, Olivera G. Intra-fraction prostate motion: Dosimetric impact on delivered dose. International Journal of Radiation Oncology Physics 69(3):S336-S337, 2007. 65. Staton R, Meeks S, Chauhan B, Langen K, Kupelian P, Manon R. IMRT Planning for Head and Neck Cancers: Sparing of the Larynx in Helical Tomotherapy Treatment Plans. International Journal of Radiation Oncology Physics 69(3):S455, 2007. 66. Ramsey CR, Seibert R, Hines W, Meeks S, Langen K, Kupelian P, Li X. Predictive Adaptive Radiation Therapy for Lung Cancers. International Journal of Radiation Oncology Physics 69(3):S24, 2007. 67. Shah A, Langen K, Ruchala K, Cox A, Kupelian P, Meeks S. Patient-specific dose from Megavoltage CT imaging with a helical Tomotherapy unit. International Journal of Radiation Oncology Physics 69(3):S193-S194, 2007. 68. Ramsey, C, Gibbons J, Holmes T, Jeong K, Langen K, Low D, Meeks S, Papanikolaou N, Schubert K, Tomsej M. Mechanical and dosimetric Quality Assurance for helical Tomotherapy. International Journal of Radiation Oncology Physics 69(3):S699, 2007. 69. Kupelian P, Langen K, Santhanam A, Willoughby T, Zeidan O, Solberg T, Meeks S. Impact of real-time Prostate Motion in the Accuracy of static Image Guidance Techniques. International Journal of Radiation Oncology Physics 69(3):S349, 2007.

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70. Lopatiuk-Tirpak O, Langen K, Meeks S, Kupelian P, Maryanski M, Hsi W, Palta J, Zeidan A. Evaluation of a Novel 3-D Polymer Gel Dosimetry System for Proton Radiotherapy. Medical Physics, 35(6):2787, 2008. 71. Lopatiuk-Tirpak O, Langen K, Meeks S, Kupelian P, Maryanski Zeidan A. Performance of an Improved Optical Computed Tomography Polymer Gel Dosimeter System for 3_D Dose Verification of Static and Dynamic Phantom Deliveries. Medical Physics, 35(6):2791, 2008. 72. Staton R, Langen K, Meeks S. Dosimetric Effect of Target Degradation on Helical TomoTherapy Treatment Plans. Medical Physics, 35(6):2919, 2008. 73. Langen K, Siebers J, Moore J, Kupelian P. The dosimetric consequence of intra-fraction prostate motion for two IMRT delivery techniques. Radiotherapy and Oncology, 92(1), S86, 2009. 74. Langen K, Moore J, Kupelian P, Siebers J. Assessing the dosimetric Impact of Intra-Fraction Motion on Step-and-Shoot IMRT Plans. Medical Physics, 36(6):2550, 2009. 75. Langen K. Performance-Based QA for Radiotherapy: TG-148 – Tomotherapy Quality Assurance. Medical Physics, 36(6):2744, 2009. 76. Ngwa W, Shah A, Meeks S, Kupelian P, Langen K., Impact or no impact of Respiratory Motion on Helical Tomotherapy Dose Delivery. Medical Physics, 36(6):2783, 2008. 77. Shah AP, Meeks SL, Willoughby TR, Langen KM, Kupelian PA. Evaluating Intra-fraction Motion of the Prostate in the Prone and Supine Positions using Electromagnetic Tracking. International Journal of Radiation Oncology Physics 75(3):S597, 2009. 78. Staton RJ, Meeks S, Willoughby TR, Langen KM, Shah AP, Zeidan OA, Kupelian, PA . Image-guided Stereotactic Radiotherapy for Peripheral Lung Tumors: Gating vs. Motion Encompassing Approaches. International Journal of Radiation Oncology Physics 75(3):S458, 2009. 79. Langen, KM, Shah AP, Willoughby TR, Meeks SL. Real-time Position Adjustment during treatment for localized Prostate Cancers: Observations on Clinical Use and Acute Toxicity. International Journal of Radiation Oncology Physics 75(3):S294, 2009. 80. Waghorn, B, Shah S, Meeks S, Langen K. A computational Method for estimating the dosimetric effect of Intra-fraction Motion on Step-and-Shoot IMRT and Compensator Plans. Medical Physics, 37(6):3340, 2010. 81. Smeenk, R, Louwe RJW, Langen KM, Shah AP,Kupelian PA, van Lin ENJT, Kaanders JHAM. The Influence of an Endorectal Balloon on Intrafraction Prostate Motion. International Journal of Radiation Oncology Physics 78(3):S674-S675, 2010. 82. Pukala J, Meeks S, Langen K. The dosimetric uncertainty of helical MVCT images for use in adaptive radiotherapy. Medical Physics, 38(6):3610-3611, 2011. 83. Langen K, Papnikolaou N, Balog J, Crilly R, Followill D, Goduu S, Grant W, Olivera G, Ramsey C, Shi C. QA of helical tomotherapy TG-148. Medical Physics, 38(6):3799, 2011. 84. Waghorn B, Meeks S, Langen K. Analyzing the Impact of Intra-fraction Motion: Correlations of IMRT QA Metrics with D95%. Medical Physics, 38(6):3805, 2011. 85. Waghorn BJ, Chauhan BD, Rineer JM, Meeks SL, Langen KM. Analysis of the Dosimetric Effect of Intra-Fraction Motion on Step-and-Shoot IMRT Plans. International Journal of Radiation Oncology Physics 81(2):S847-S848, 2011. 86. Waghorn BJ, Staton RJ, Rineer, JM, Meeks SL, Ngwa WF, Langen KM. The Dosimetric Effects of Intra-Fraction Motion on Step-and-Shoot, Compensator and Helical Tomotherapy based IMRT. International Journal of Radiation Oncology Physics 81(2):S809, 2011. 87. Pukala J, Staton R, Langen K. What is the importance of dose recalculation for adaptive radiotherapy dose assessment? Medical Physics, 39(6):3699, 2012. 88. Staton R, Biddle J, Langen K, Meeks S. Evaluation of dose control system performance of a TomoTherapy Hi-Art system. Medical Physics, 38(6):3789, 2012. 89. Langen KM, Pukala J, Staton R, Manon R. Effect of Re-imaging frequency in Adaptive Radiation Therapy (ART) for Head and Neck Patients. International Journal of Radiation Oncology Physics 84(3):S780, 2012. 90. Langen KM, Pukala J, Staton R, Manon R. Do Adaptive Radiation Therapy (ART) Assessments depend on the employed ART workflow? International Journal of Radiation Oncology Physics 84(3):S781, 2012.

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91. Pukala J, Langen KM, Dvorak, Rineer J, Manon RR. The dosimetric uncertainty resulting from contour variability of the parotid glands and its application to Adaptive Radiation Therapy. International Journal of Radiation Oncology Physics 84(3):S798, 2012. 92. Kane E, Langen K, Buchholz D, Dvorak T. Compliance to previously treated Left Breast Cancer patients with RTOG 1005 Guidelines. International Journal of Radiation Oncology Physics 84(3):S187-S188, 2012. Proffered communications 1. Wernli C, Langen K. The new personnel neutron dosimetry system at the Paul Scherrer Institute, Eighth International Congress of the International Radiation Protection Association, Montreal, Canada, 1992. 2. Langen K, Lennox, AJ, Kroc TK, Deluca PM, A feasibility study on the utilization of boron neutron capture therapy in the fast neutron therapy beam at Fermilab, Seventh International Symposium on Neutron Capture Therapy for Cancer (IMR-PSI), Zurich, Switzerland, 1996. 3. Kota C, Hong RL, Yudelev M, Maughan M, Lennox AJ, Langen KM, Risler R, Wielopolski L, Deluca PM, Ross A, Schmidt R, Rosenfeld A, Allen B. An intercomparison of dosimetry techniques used in BNCT and BNCEFNT, Seventh International Symposium on Neutron Capture Therapy for Cancer (IMR-PSI), Zurich, Switzerland, 1996. 4. Langen KM, Lennox AJ, Deluca PM. Microdosimetric Investigations in the fast neutron therapy beam at Fermilab – work in progress, Twelfth Symposium on Microdosimetry (MRCEC-USDOE-GSF), Oxford, UK, 1996. 5. Langen KM, Lennox AJ, Deluca PM. A feasibility study on the use of boron neutron capture therapy (BNCT) in the fast neutron therapy beam at Fermilab, Annual Conference of the South African Association of Physicists in Medicine and Biology (SAAPMB), Kruger Park, South Africa, 1998. 6. Langen KM, Binns PJ, Lennox AJ, Kroc TK, Deluca PM. Correcting microdosimetric spectra for pileup, Combined Meeting on Hadron Therapy PTCOG XXX/EHTG/ECHED (NAC), Cape Town, South Africa, 1999. 7. Bhengu J, Binns PJ, Jones DTL, Langen KM, Meincken M, Symons JE. TLD measurements in hadron therapy beams at NAC, Combined Meeting on Hadron Therapy PTCOG XXX/EHTG/ECHED (NAC), Cape Town, South Africa, 1999. 8. Brede HJ, Greif KD, Hecker O, Binns PJ, Langen KM, Jones DTL, Schreuder AN, Hesse J, Kluge H., Water calorimetry and ionization chamber dosimetry in collimated photon, proton and neutron beams of various energies, Combined Meeting on Hadron Therapy PTCOG XXX/EHTG/ECHED (NAC), Cape Town, South Africa, 1999. 9. Langen KM, Jones DTL. Organ motion, Combined Meeting on Hadron Therapy PTCOG XXX/EHTG/ECHED (NAC), Cape Town, South Africa, 1999. 10. Schreuder AN, Kiefer A, van der Merwe J, Muller A, Langen KM, Symons JE. The new energy degrading system for the NAC proton therapy beam, Combined Meeting on Hadron Therapy PTCOG XXX/EHTG/ECHED (NAC), Cape Town, South Africa, 1999. 11. Bhengu J, Langen KM, Binns PJ, Jones DTL. Investigation of TLD glow curves in the buildup region of a neutron therapy beam, Annual Conference of the South African Association of Physicists in Medicine and Biology (SAAPMB), Durban, South Africa, 2000. 12. Bhengu J, Langen KM, Binns PJ, Jones DTL. TLD Measurements for in-vivo dosimetry in a fast neutron beam, Annual Conference of the South African Association of Physicists in Medicine and Biology (SAAPMB), Durban, South Africa, 2000. 13. Langen KM, Anezinos C, Aubin M, Liu YM, Verhey LJ, Roach III M, Pouliot J. A comparison of the ultrasound-based BAT system with portal images of implanted radio-opaque markers for daily prostate localization, Seventh International Workshop on Electronic Portal Imaging, EPI2K2, Vancouver, British Columbia, 2002. Major invited presentations Local 1. Initial experience with a TomoTherapy unit, Florida Chapter AAPM, Orlando, FL, 2004

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2. Using TomoTherapy’s megavoltage images for dose computations, Florida Chapter AAPM, Orlando, FL, 2005. 3. The use of TomoTherapy’s MVCT images for dose re-computations, American College of Medical Physics (ACMP), Orlando, FL, 2005. 4. Uncertainties in Radiation Therapy: Planning and Delivery, Florida Chapter of AAPM, St. Petersburg, FL, 2005. 5. Tomotherapy, Florida Chapter AAPM, Orlando, FL, 03/2008. 6. Intra-fraction prostate motion, .Decimal Compensator-based IMRT Symposium, Orlando, 2009. National 7. Evaluation of ultrasound based image guidance for prostate localization, Massachusetts General Hospital, Boston, MA, 2002. 8. Evaluation of ultrasound-based image guidance for prostate localization, New England Chapter AAPM, Plymouth, MA, 2003. 9. Clinical implementations and research opportunities for TomoTherapy, M. D. Anderson Cancer Center, Houston, TX, 2005. 10. Uncertainties in Radiation Therapy and Planning. ASTRO-Image Guided Radiation Therapy (IGRT) Symposium, Las Vegas, 2006. 11. TomoTherapy’s Implementation of Adaptive Radiotherapy. 2nd TomoTherapy meeting on image guided radiation therapy. Long Beach, 2006. 12. Megavoltage CT-Based Image Guidance and adaptive radiation Therapy, Department of Radiation Oncology at the University of California San Francisco (UCSF). Image guided radiation therapy Symposium, San Francisco, 2006. 13. Clinical Integration of TomoTherapy MVCT-based IGART, Department of Radiation Oncology at the University of California San Francisco (UCSF). Image guided radiation therapy Symposium, San Francisco, 2006. 14. Quality Assurance of Onboard MVCT Imaging and Target Localization Systems for On- and Off-line Image Guided Radiation Therapy. ASTRO-Quality Assurance of Radiation Therapy and the Challenges of Advanced Technology, Dallas, 2007. 15. In Room CT: What have we Learned so Far? Interactive Panel. ASTRO Annual Mtg., –Los Angeles, 2007. 16. Radiation Therapy of Moving and Deforming Patients, University of Wisconsin-Madison, Department of Medical Physics, 2008. 17. Radiation Therapy of Moving and Deforming Patients, Duke University, Department of Radiation Oncology, 2008. 18. Tomotherapy’s Implementation of Image-guided Adaptive Radiation Therapy, Radiological Society of North America (RSNA) annual Mtg., Chicago, 2008. 19. Quality Assurance of MVCT Imaging, American College of Medical Physics (ACMP), Seattle, WA, 2008. 20. Image Guided Adaptive Radiotherapy- New Tools and Directions, EPID2K Meeting, San Francisco, CA, 2008. 21. Radiation Therapy of Moving and Deforming Patients, University of California San Francisco, Department of Radiation Oncology, 2009. 22. Radiation Therapy of Moving and Deforming Patients, Virginia Commonwealth University, Department of Radiation Oncology, 2009. 23. Quality Assurance of IGRT systems. ASTRO-Educational Seminar co-presented with J.-P. Bissonnette. ASTRO Annual Mtg., Boston, 2008. Chicago, 2009. San Diego, 2010, Miami 2011. 24. Quality Assurance of IGRT systems, ASTRO-IGRT/SBRT Symposium, Miami, 2009 and Dallas, 2010. 25. Tomotherapy. Vendor break-out sessions: ASTRO IGRT/SBRT Symposium, Miami, 2009. Dallas, 2010. Las Vegas 2011. Las Vegas 2012. 26. Implementation of IGRT systems, Panel discussion. ASTRO- IGRT/SBRT Symposium, Miami, 2009.

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27. TG-148: QA for helical Tomotherapy, AAPM Educational Seminar. AAPM Annual Mtg. Anaheim, 2009. Philadelphia, 2010. Vancouver, 2011. 28. Imaging Challenges for Radiation Oncology, RSNA Refresher course. Chicago, 2009, 2010, 2011. 29. Imaging for adaptive planning (What if the target changes?) CT- imaging. RSNA Refresher course. Chicago. 2009, 2010, 2011. 30. The effect of Intra-fraction motion on IMRT Delivery Systems, Northwest Chapter AAPM, Portland, OR, 2010. 31. Dosimetric effect of target motion during IMRT treatments, University of Maryland, Department of Radiation Oncology, 2012. 32. Clinical use of Tomotherapy, University of California San Francisco, Department of Radiation Oncology, 2012.

International 33. Uncertainties in Radiation Therapy: Planning and Delivery, AAPM/European Federation of Organizations for Medical Physics (EFOMP) Scientific Symposium, Nürenberg, Germany, 2005. 34. Image guided radiation therapy (IGRT) for prostate cancer patients, International Prostate Cancer Treatment workshop (IPCT-2005), University of Wollongong, Australia, 2005. 35. Treatment of prostate cancer patients with a TomoTherapy unit-2 years of experience, International Prostate Cancer Treatment workshop (IPCT-2005), University of Wollongong, Australia, 2005. 36. Image guided radiation therapy (IGRT) for prostate cancer patients, Newcastle Mater Hospital, Newcastle, Australia, 2005. 37. Treatment of prostate cancer patients with a TomoTherapy unit-2 years of experience, Newcastle Mater Hospital, Newcastle, Australia, 2005. 38. Bildgeführte Radiotherapy für die Positionierung von Prostata Patienten (Image guided radiation therapy for the setup of prostate patients), German Society for Radiation Oncology annual meeting (DEGRO), Dresden, Germany, 2006. 39. Tomotherapy’s Implementation of Image-guided Adaptive Radiation Therapy, AAPM, Summer School on Integrating new Technologies into the Clinic: Monte Carlo and ImageGuided Radiation Therapy, Windsor, Canada, 2006. 40. MVCT Characteristics: Implementation of Adaptive Radiation Therapy. Grupo IMO Sympsium “New Horizons in Cancer Treatment: TomoTherapy”, Madrid, Spain, 2006. 41. TomoTherapy Solutions for IGRT and Correction Strategies. European Society for th Therapeutic Radiology and Oncology (ESTRO), 9 . Biennial ESTRO Mtg. on Physics and Radiation Technology for Clinical Radiotherapy, Barcelona, Spain, 2007. 42. TomoTherapy QA- from the patient’s perspective. Institute Curie, Paris, France, 2007. 43. Strahlentherapie von sich bewegenden und verformenden Patienten. Strahlenklinik, University of Essen, Germany, 2008. 44. TomoTherappy DQA with the ArcCheck: An early experience. SunNuclear User Meeting, th 10 . Biennieal ESTRO Annual Mtg. on Physics and Radiation Technology for Clinical Radiotherapy, Maastricht, Netherlands, 2009. 45. Innovative methods for patient positioning, World Congress- Medical Physics and Biomedical Engineering, Munich, Germany, 2009. 46. Intra-fraction organ motion during Tomotherapy treatments. Observations in Head and Neck. Lund University Hospital and TomoTherapy “Progress in Photon and Proton Treatment Technology”, Lund, Sweden, 2011. 47. Adaptive radiation therapy. Lund University Hospital and TomoTherapy “Progress in Photon and Proton Treatment Technology”, Lund, Sweden, 2011. 48. Uncertainties in adaptive radiation therapy. AAPM, Summer School on Uncertainties in External Radiation therapy, Vancouver, Canada, 20011. 49. The physical aspects of breast irradiation with Tomotherapy. ICT 2011, International Tomotherapy Conference. Heidelberg, Germany, 2011.

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