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WARMING: The information provided herein is for general information and educational purposes only. The product we offer are intended for laboratory research use only. The products we offer are NOT intended to prevent, treat, or cure disease conditions or to affect the structure or function of the body. THE PRODUCT WE OFFER ARE NOT FOR HUMAN CONSUMPTION.


Avanafil


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Avanafil

• Avanafil is a strong, competitive inhibitor of PDE5. It is also 100times more potent for PDE5 than PDE6. The IC50 of avanafil is 5.2 nM. • Compared to other PDE5 inhibitor like sildenafil and vardenafil, it is 16- and 21-fold more selective for PDE5 respectively. • Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor used for the treatment of erectile dysfunction caused by diabetes, age induced oxidative stress or other complications. • Buy Avanafil of high quality only at Research Liquids.


Avanafil

Description: Avanafil is a new highly selective PDE5 inhibitor that is faster acting and more selective than other drugs belonging to the same class. Targets: PDE5 Inhibitor


Avanafil

Biological Activity In Vitro: Avanafil (T-1032) is a specific inhibitor of PDE5 with IC50 of 1 nM in a competitive manner. Avanafil binds to the catalytic site of PDE5 and inhibits cGMP hydrolysis. Avanafil also inhibits PDE6 with IC50 of 28 nM. In contrast, the IC50 values of Avanafil for PDE1, PDE2, PDE3 and PDE4 are more than 1μM. Avanafil increases the intracellular concentrations of cGMP with and without CNP in cultured rat VSMCs. In Vivo: Intravenous (1-100 μg/kg) and intraduodenal (3, 30, 300 μg/kg) treatment with Avanafil dose dependently potentiates the tumescence induced by pelvic nerve stimulation in dogs. Furthermore, i.v. Avanafil augments the tumescence induced by sodium nitroprusside (SNP) but not by vasoactive intestinal polypeptide (VIP).


“Quality without Compromise” WARMING: The information provided herein is for general information and educational purposes only. The product we offer are intended for laboratory research use only. The products we offer are NOT intended to prevent, treat, or cure disease conditions or to affect the structure or function of the body. THE PRODUCT WE OFFER ARE NOT FOR HUMAN CONSUMPTION.


avanafil  

dysfunction caused by diabetes, age induced oxidative stress or other complications.

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