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оригинални статии

DEPRESSIVE SYMPTOMS IN PATIENTS WITH RESPIRATORY DISORDERS DURING SLEEP

ДЕПРЕСИВНИ СИМПТОМИ ПРИ ПАЦИЕНТИ С ДИХАТЕЛНИ НАРУШЕНИЯ ПО ВРЕМЕ НА СЪН

Tоракална Медицина Том III, март 2011, бр.1

R. Biliukov, Tz. Mondeshki, R. Cherneva, О. Georgiev, D. Petrova UMHAT “Alexandrovska”, Medical University - Sofia Abstract The aim of the study is to describe the frequency of depression among patients with SDB; to determine whether there is an association between the severity of SDB and sleep fragmentation with depression; to evaluate the effect of BiPAP therapy on depressive symptoms and sleepiness on the first, third and sixth month of treatment. Material and method: Fifty-eight patients with polysomnographically proven sleep disordered breathing have partcipated in the study. A 64-channel polysomnograph – Compumedics, have been used. The acid-base analysis was done with RapidLab apparatus. The overnight capnography in exhaled air was performed by LifeSense LS1-9R (Nonine) capnograph. The degree of depression was scored using Zung scale. Results: Based on Zung score thirty patients have depressive symptoms. Twenty one (36.2%) have light; seven (12.1%) have moderate and two (3.4%) are with severe depressive symptoms. Twenty eight patients (48.3%) have no depressive symptoms. The analysis of the parameters that characterize SDB (apnea index, hypopnea index, apnea-hypopnea index) show that they have no influence regarding the occurrence of depression. Similar are the results concerning the parameters of acid-base disorders during sleep. No association could be observed between intermittent hypoxia-desaturation index and the duration of sleep in saturation under 90%. In contrast a borderline association between overnight hypercapnea in exhaled air and depressive symptoms could be found. Sleep fragmentation (arousal index) has a statistical significance with the probability of having depression. Conclusions: There is a versatile and complex association between SDB and depression. It could be attributed to the influence of diverse factors: body-mass index, arousal index, sleep fragmentation. Intermittent hypoxia, the desaturation index or the duration of sleep with saturation under 90% are of no significant importance for the development of depression. Key words: depressive episodes, respiratory disorders during sleep, intermittent hypoxia, sleep fragmentation

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Thoracic Medicine Journal issue 7  
Thoracic Medicine Journal issue 7  

Official Journal of the Bulgarian Thoracic Society

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