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Research Links Multiple Genes to Depression Etiology Depression can manifest in anyone due to chemical imbalances in brain, certain medical conditions, environmental factors and genetic make-up. Not much has been studied as far as the genetic factor is concerned. Now, a recent study has established that at least 44 genes can make a person vulnerable to depressive disorders. As per researchers, the study can help people understand why depression affects some people and not others and why antidepressants do not work for all. The study, published in the journal Nature Genetics in April 2018, was carried out by a team of 200 scientists who identified the genes. Interestingly, 30 out of the 44 genes were not discovered so far. The novel research is expected to pave the way for establishing new therapies for managing depression, which afflicts millions of people in the United States and is a leading cause of disability globally. Understanding genetic influence can help devise better interventions The research team studied the genomes of 135,458 people with depression and of 344,000 people without depression. They identified 44 genes with different clinical presentation that were associated with different anatomical structures in the brain. The scientists also found that many genes increasing the risk of depression also played a role in causing other psychiatric issues like schizophrenia and bipolar disorder. They also had a link with depression-related problems related to weight and insomnia. Additionally, gene variants controlling neurotransmitters were ideal sites for antidepressant therapy, while other genes with no relation to the neurotransmitters did not respond well to depression medication. Senior author Cathryn Lewis, professor of statistical genetics at King’s College London, stated that depression is not regulated by a single gene. She also highlighted the need for a larger study to explore the genetic underpinnings of depression and how they are affected by external stressors.

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According to Dr. Gerome Breen, who worked on the study, new research will pave the way for the discovery of novel therapies. He shared that the team is currently working on an online tool so that depressed people can serve as volunteers for future genetic studies. “With this study, depression genetics has advanced to the forefront of genetic discovery,� he said. Unfortunately, presently only half of the diagnosed patients respond to therapies for symptom alleviation. Many people fail to seek treatment as they fear stigma and discrimination. To disseminate awareness about mental health disorders and encourage more and more people to open up about their problems, may is observed as the Mental Health Month. Throughout the month, events and awareness campaigns are organized to educate the masses and spread the message of understanding, compassion and empathy for people afflicted with mental illnesses. Depression is treatable Oftentimes, people fail to recognize that they are struggling with depression because they perceive their symptoms as bad mood or temporary phase. It is important to understand that depression is a serious illness that can be cured with timely diagnosis. The treatment may involve medication, therapies like cognitive behavioral therapy, or both. The most common antidepressants prescribed are serotonin reuptake inhibitors (SSRIs) and they usually take at least four weeks to exert their action. In addition to the traditional mode of treatment, health care experts may also suggest patients to join support groups. If you or your loved one is suffering from depression and needs help, get in touch with the Depression Treatment Helpline of Colorado to get connected to one of the finest depression rehab centers in the United States. You can call our 24/7 helpline (866) 427-5668 and talk to an expert to know more about some reputed depression treatment centers in Colorado.

www.depressiontreatmentcolorado.com

Research links multiple genes to depression etiology  

Depression can manifest in anyone due to chemical imbalances in brain, certain medical conditions, environmental factors and genetic make-up...

Research links multiple genes to depression etiology  

Depression can manifest in anyone due to chemical imbalances in brain, certain medical conditions, environmental factors and genetic make-up...

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