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Patient Instructions Amifostine (Ethyol) Your doctor has ordered Amifostine (Ethyol) to protect your salivary glands (parotid glands) during your daily radiation therapy treatment. Salivary glands are located on the bottom of your mouth within each cheek and near your front teeth. They produce saliva, a watery substance that moistens your mouth making it easier to talk, chew, and swallow. When your treatment area includes your salivary glands, it can cause the side effect, dry mouth. When your mouth is dry, it can be difficult to speak, chew and swallow. Amifostine (Ethyol) protects the salivary glands and prevents dryness of the mouth .

Directions Please follow the steps below before taking your Amifostine (Ethyol) and radiation treatment. 1. Tell your doctor if you are taking any medications for high blood pressure, including diuretics (water pills). 2. Take your anti-nausea medication __________ 1.5-2 hours before your scheduled treatment. For Example: If your treatment is scheduled for 1:00 P.M. you will need to take your anti-nausea medication _________ between 11:00-11:30 A.M. To prevent dehydration: Take your anti-nausea medication with 2-4, 8 ounce glasses of water, sports drink (Gatorade, Powerade) or PediaLyte. (8 ounce glass = standard size coffee cup) 3. When your arrive for your treatment, please use the restroom. This will allow you to remain comfortably seated during your treatment. 4. Please arrive and check in ________ minutes before your scheduled treatment. A nurse will give you your Amifostine (Ethyol) and monitor you for side effects. 5. For the rest of the day, drink fluids to prevent dehydration and the possibility of side effects. Drink at least 1 liter of fluids a day (1 liter of fluid = 4, 8 ounce glasses)

Possible Side Effects: - Nausea - Vomiting - Dizziness - Fever -Light-headedness - Lower Blood Pressure - Rash

Let your Nurse Know if you Experience: - Rash or itching at the injection site - Swelling or pain at the injection site - Unexpected nausea or vomiting

Call Your Doctor: - If you have a fever (Oral Temperature = 100F/38C or above) - A rash that covers more than 1 area of you body including your hands and feet


Paitient education piece for Amifostine (Ethyol).

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