Drug class
A)
Oral agent
1.insuline seretagogues - Sulfonylureas 1)Glipizide 2)Glyburide 3)glimepiride
MOA USES closing ATP-sensitive K" channels Type 2 diabetes to Increases insulin secretion From pancreatic beta cells
Same as Sulfonylureas
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-
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Type 2 diabetes
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SE Hypoglycemia weight gain hyperinsulinemia,
Used in caution with hepatic impairment patient
- Glinides
-biguanides.
Stimulates insulin secretion Endogenous glucose production decreasing
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1)metformin
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Decreases hepatic production of glucose
-Thiazolidinediones
1)pioglitazone
2)rosiglitazone
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Binds to peroxisome proliferator–activated receptor-_ in muscle, fat and liver to decrease insulin resistance
Gastrointestinal disturbances, Lactic Acidosis (rate)
acute myocardial infarction exacerbation of heart failure sepsis
Type 2 diabetes binds to PPAR-y to Regulates gene expression
CI Should be cautioned with hepatic or renal insufficiency
Fluid retention, Edema Anemia weight gain Bone fractures in women May worsen heart disease increase risk of Myocardial infarction
acute renal failure. bladder cancer heart failure Avoid in liver disease