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Publications

Robert Splinter

PAPERS Pike P, Parigger C, Splinter R, Lockhart P, Temperature distribution in dental tissue after interaction with femtosecond laser pulses, Appl Opt. 2007 Dec 1;46(34):8374-8378. d'Avila A, Splinter R, Svenson RH, Scanavacca M, Pruitt E, Kasell J, Sosa E, New perspectives on catheter-based ablation of ventricular tachycardia complicating Chagas' disease: experimental evidence of the efficacy of near infrared lasers for catheter ablation of Chagas' VT, J Interv Card Electrophysiol. 2002 Aug;7(1):23-38. Ding L, Splinter R, Knisley SB, Quantifying spatial localization of optical mapping using Monte Carlo simulations, IEEE Trans Biomed Eng. 2001 Oct;48(10):1098-1107. Wu G, Svenson RH, Littmann L, Chuang CH, Thompson M, Nanney GA, Splinter R, Tatsis GP, Dezern KR, Laser photoablation of experimental post-infarction ventricular tachycardia guided by three dimensional activation mapping, Lasers Surg Med. 1997;20(2):119-130. Semenov SY, Svenson RH, Boulyshev AE, Souvorov AE, Borisov VY, Sizov Y, Starostin AN, Dezern KR, Tatsis GP, Baranov VY, Splinter R, (1996) Microwave tomography: twodimensional system for biological imaging, IEEE Trans Biomed Eng. 1996, 43(9), 869-77. Semenov SY, Splinter R, Svenson RH, Baranov VY, Dezern KR, Tuntelder JR, Thompson M, Tatsis GP, Dielectric properties of canine myocardium tissues in the microwave spectrum, IEEE Trans Biomed Eng. 1995, 41(7), 354-361. Hehrlein C, Thompson M, Chuang CH, Splinter R, Tuntelder JR, Littmann L, Svenson RH, Selective coagulation necrosis of canine adventitia and media induces extracellular matrix accumulation without neointima formation, Atherosclerosis. 1995 Feb;113(1):109-15. Splinter R, Svenson RH, Littmann L, Brucker GG, Chuang CH, Tuntelder JR, Dezern KR, Thompson M, Nanney GA, Tatsis GP. Myocardial temperatures during in vivo endocardial Nd:YAG laser irradiation. J. Clin. Lasers Med. Surg, 1995; 13(2) 61-68. Splinter R, Semenov SY, Nanney GA, Littmann L, Tuntelder JR, Svenson RH, Chuang CH, Tatsis GP. Myocardial heat distribution under CW Nd:YAG laser irradiation in in vitro and in vivo situations: theory and experiment. Appl Optics, 1995; 34(3): 391-399. Splinter R, Tuntelder JR, Chuang CH, Thompson M, Littmann L, Svenson RH, Tatsis GP. Ultrasonic characterization of in-vivo photocoagulation lesion size in myocardium during Nd:YAG laser irradiation. Journal of Clinical Ultrasound, 1994; 22: 221-229. Splinter R, Nanney GA, Littmann L, Chuang CH, Svenson RH, Tuntelder JR, Tatsis GP. Monitoring Tissue Optical Characteristics in-situ using a CCD Camera. Lasers in the Life Sciences, 1994; 6(1); 1/24/2013

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Publications 15-25.

Robert Splinter

Hehrlein C, Thompson M, Chuang CH, Splinter R, Tuntelder JR, Littmann L, Svenson RH. Selective coagulation necrosis of canine adventitia and media induces extracellular matrix accumulation without neointima formation. Atheroscerosis 1994; 113, 109-115. Kempler P, Hayes WJ, Dezern KR, Tuntelder JR, Splinter R, Svenson RH, Littmann L. Direct current induction of atrial fibrillation. Am Heart J 1994; 127: 945-946. Littmann L, Svenson RH, Chuang CH, Splinter R, Kempler P, Norton HJ, Tuntelder JR, Thompson M, Tatsis GP. Neodymium:YAG contact laser photocoagulation of the in vivo canine epicardium: dosimetry, effects of various lasing modes, and histology. Lasers Surg Med 1993; 13(2): 158-167. Littmann L, Svenson RH, Chuang CH, Kempler P, Splinter R, Tuntelder JR, Tatsis GP. Catheterization technique for laser photoablation of the atrioventricular conduction from the aortic root in dogs. PACE 1993; 16: 401-406. Splinter R, Svenson RH, Littmann L, Chuang CH, Tuntelder JR, Thompson M, Tatsis GP, Keijzer M. Computer simulated light distributions in myocardial tissues at the Nd:YAG wavelength of 1064 nm. Lasers Med Sci 1993; 8: 15-21. Littmann L, Svenson RH, Bharati S, Lev M, Chuang CH, Kempler P, Splinter R, Tuntelder JR, Tatsis GP. Selective elimination of retrograde conduction by intraoperative Neodymium:YAG laser photocoagulation in dogs. J Amer Coll Cardiol 1993; 21(3): 523-530. Svenson RH, Littmann L, Splinter R, Tatsis GP, Chuang CH. Current status of lasers for arrhythmia ablation. J Cardiovasc Electrophysiol 1992; 3: 345-353. Splinter R, Svenson RH, Littmann L, Chuang CH, Tuntelder JR, Thompson M, Tatsis GP, Keijzer M. Can CW Nd:YAG photocoagulation lesion dimensions in myocardium be predicted by Monte Carlo light propagation simulations? J Clin Eng 1992; 17(5): 409-418. Splinter R, Svenson RH, Littmann L, Tuntelder JR, Chuang CH, Tatsis GP, Thompson M. Optical properties of normal, diseased, and laser photocoagulated myocardium at the Nd:YAG wavelength. Lasers Surg Med 1991; 11: 117-124. Hehrlein C, Splinter R, Littmann L, Tuntelder JR, Tatsis GP, Svenson RH. Influence of probe motion on laser probe temperature in circulating blood. Lasers Surg Med 1991; 11: 13-17. Littmann L, Svenson RH, Tomcsanyi I, Hehrlein C, Gallagher JJ, Bharati S, Lev M, Splinter R, Tatsis GP, Tuntelder JR. Modification of atrioventricular nodal transmission properties by intraoperative neodymium:YAG laser photocoagulation in dogs. J Amer Coll Cardiol 1991; 17(3): 797-804. 1/24/2013

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Publications Robert Splinter Littmann L, Svenson RH, Tuntelder JR, Hehrlein C, Splinter R, Tatsis GP, Thompson M, Dezern KR. Electrophysiologic characteristics of manifest and latent retrograde conduction in dogs. Am Heart J 1991; 121: 96-104. Splinter R, Cheong WF, Van Gemert MJC, Welch AJ. In vitro optical properties of human and canine brain and urinary bladder tissues at 633 nm. Lasers Surg Med 1989; 9: 37-41. Littmann L, Svenson RH, Tomcsanyi I, Hehrlein C, Splinter R, Tatsis GP, Gallagher JJ, Bharati S, Lev M. Nd:YAG laser modification of anterograde AV nodal transmission properties in dogs. Circulation 1989; 80: II-40. Splinter R, Cheong WF, van Gemert MJ, Welch AJ, In vitro optical properties of human and canine brain and urinary bladder tissues at 633 nm, Lasers Surg Med. 1989;9(1):37-41. BOOKS, PROCEEDINGS AND BOOK CHAPTERS Splinter R, Illustrated Encyclopedia of Engineering and Applied Physics, CRC Press (In Progress, 2012) Pike P, Parigger C, Splinter R, High Resolution Biological Visualization Techniques, In: Laser Pulses, Vienna: Intech, 2010 Splinter R, Handbook of Physics in Medicine and Biology, Boca Raton: CRC/Taylor & Francis, 2010. Scott H, Archuleta A, Splinter R, Calcified lesion modeling for Excimer laser ablation, SPIE Proceedings Photonics North 2009. Parigger CG, Splinter R, Pike PJ, Biomedical Optics, Tissue Scaffolding Diagnostics with Femtosecond Laser Radiation, in Laser Applications to Chemical, Security and Environmental Analysis, OSA Technical Digest (CD) (Optical Society of America, 2008), paper JMA35. Splinter R, Hooper BA, An introduction to Biomedical Optics, New York: Taylor & Francis, 2007. Najarian K, Splinter R, Biomedical Signal and Image Processing, Boca Raton: CRC/Taylor & Francis, 2006. Splinter R, Lasers in biophysics and medicine, 14th International School on Quantum Electronics: Lasers-Physics and Applications, 18 - 22 September 2006, Sunny Beach, Bulgaria, Volume 6604 -14th International School on Quantum Electronics: Laser Physics and Applications. Peter A. Atanasov, Tanja N. Dreischuh, Sanka V. Gateva, Lubomir M. Kovachev, Editors , March 2007 [International School on Quantum Electronics (14th : 2006 : SlĹ­nchev briÍĄag, Bulgaria), http://www.isqe2010.dir.bg/sqe2006/Lect.htm] 1/24/2013

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Publications

Robert Splinter

Parigger CG, Pike PJ, Splinter R, Photo-Acoustic Analyses of Dental Materials, in Technical Digest of Optics in the Southeast (OISE) conference, paper SE01-D1 (2005). Najarian K, Splinter R, A Novel Photo-Acoustic System for Tomographic Imaging of Dental Pulp Tissue, International Conference on Holography, Optical Recording, and Processing of Information, Varna, Bulgaria, 2005 Pike P, Parigger C, Splinter R, Lockhart P, Modeling of the Temperature Distribution in Dental Pulp Subsequent to Interaction with Ultrashort Laser Pulses, in Proceedings of Optics in the Southeast (OISE), OSA Annual Meeting and Exhibit (2004). Parigger C, Jeleva P, Splinter R, Photo-acoustic Imaging of Dental Pulp Inflammation, in Proceedings of the Southern Biomedical Conference (2003). Davis MJ, Splinter R, Lockhart P, Brennan M, Fox PC, Optical Diagnostics for Classifying Stages of Dental Erythema, Proc. Internat. Conf. Appl. Photonics Technol. 2002, 316-323. Svenson RH, Splinter R, Littmann L, Tatsis GP, Photoablation of Ventricular Arrhythmias, Progress in Catheter Ablation: Clinical Applications of New Mapping and Ablation Technology, Eds. Liem LB, Downar E, 2001, 409-423, Kluwer Academic Publishers, Dordrecht. Splinter R, Optical methods in medical treatment and diagnostics. Res. Adv. Photochem. & Photobiol., Ed. Mohan RM, 2000, Vol. 1, 43-75, Global Research Network, Kerala. Ding L, Splinter R, Knisley S. Quantifying Spatial Localization of Optical Mapping Using Monte Carlo Simulation. World Congress 2000 on Medical Physics and Biomedical Engineering, Chicago, July 23-28, 2000, Medical Physics, June 2000, Vol. 27, No. 6, p. 1389 Splinter R, Ramaiah R, Deshmukh H, Raja MYA. 3-D interactive visualization of light-tissue interaction using Java. Proc. Internat. Conf. Appl. Photonics Technol. 2000; 1067-1078. Splinter R, d'Avila ALB, Svenson RH, Sosa E, Scanavacca M. Feasibility study on the potential for laser ablation of arrhythmias in chagasic heart with extensive diffuse myocardial damage. Proceedings of The Canadian Medical and Biological Engineering Society Conference, 1999: 104-105. Splinter R, Farahi F, Raja MYA, Svenson RH. Optical methods for medical applications. Proc. Optics 1999, Proc. Optical Technology in the Carolinas 1999; 6. Splinter R, Raja MYA, Svenson RH. Anomalous optical behavior of biological media: Modifying the optical window of myocardial tissues. Proc. SPIE, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, 1996; Vol 2671: 125-131. Splinter R, Farahi F, Raja MYA, Svenson RH. Tissue diagnostics by depth profiling of optical 1/24/2013

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Publications Robert Splinter characteristics using broadband fiber-optic interferometry, Chapter 4. In: Coherence-domain methods in biomedical optics, Proc. SPIE 2732, Tuchin VV (Ed.), Bellingham, Wa: SPIE, 1996: 242-250. Shukes S, Farahi F, Raja MYA, Splinter R. White light fiber optic interferometry: A technique for monitoring tissue properties. Proceedings NATO ASI Series, Porto, Portugal, July 1994, Trends in Optical Fibre Metrology and Standards, Soares ODD (ed.), 1995; 833. Shukes S, Splinter R, Farahi F, Raja MYA, Nanney GA, Dezern KR, Thompson M, Tatsis GP. Broadband fiber optic interferometry: Diagnostics by depth profiling of optical properties of biological media. Proc SPIE, Biomedical Optoelectronic Instrumentation, 1995; Vol 2396: 151- 156. Shukes S, Raja MYA, Splinter R, Liu J. A high power dual pump CW Ti:Sapphire laser: Setting new records. Proc SPIE, Solid State Lasers and Nonlinear Crystals, 1995; Vol 2379: 62-67. Shukes S, Splinter R, Raja MYA, Svenson RH, Tuntelder JR, Dezern KR, Thompson M, Tatsis GP. Exploring the optical window of myocardial tissue for localized laser ablation of ventricular tachycardia. Proc. IEEE-EMBS 1993; 3(3): 1602-1603. Svenson RH, Splinter R, Raja MYA, Littmann L, Chuang CH, Tuntelder JR, Thompson M, Dezern KR, Tatsis GP, Brucker GG. Low power density v.s. high power density photocoagulation of ventricular myocardium for cardiac arrhythmias. Observations supporting non-linear tissue optics. Proc. IEEE-EMBS 1992; 7(1): 318-319. Splinter R, Raja MYA, Svenson RH, Littmann L, Chuang CH, Tuntelder JR, Thompson M, Dezern KR, Tatsis GP. Non-linear optical phenomena in contact fiber laser-photocoagulation of myocardium. Proc. IEEE-EMBS 1992: 7(1) 316-317. Splinter R, Svenson RH, Littmann L, Tuntelder J, Thompson M, Tatsis GP, Chuang CH. Determination of optical properties in-situ from radial backscattering profile using a CCD camera. Proc. SPIE, Laser-tissue interaction III, 1992; Vol 1646: 376-382. Splinter R, Littmann L, Keijzer M, Tuntelder JR Chuang CH, Thompson M, Svenson RH, Tatsis GP. Predicting cw Nd:YAG photocoagulation lesion size in myocardium from Monte Carlo light simulations. Proc. ASME, Advances in Biological Heat and Mass Transfer, eds. McGrath JJ. 1991; HTD-Vol. 189/BED-vol. 18: 75-78. Splinter R, Littmann L, Marroum M-C, Svenson RH, Tuntelder JR, Chuang CH, Tatsis GP, Thompson M. Optical changes in myocardial tissue due to cw Nd:YAG irradiation. Proc. IEEEEMBS 1990; 12:1113-1114. Svenson RH, Littmann L, Splinter R, Selle JG, Gallagher JJ, Tatsis GP, Linder KD, Seifert KT. Application of lasers for arrhythmia ablation. Chapter 107. In: Cardiac Electrophysiology; From Cell to Bedside. Zipes DP, Jalife J (eds.). Philadelphia: W.B. Saunders, 1990: 986-997.. 1/24/2013

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Publications

Robert Splinter

ABSTRACTS Svenson RH, Splinter R, Moosdorf R, Selle J, Kassell J. Regional atrial electrical isolation. Lines of block created by laser photocoagulation: A possible intraoperative approach to atrial fibrillation. PACE 1999; 22(4), Part II: 774. Splinter R, d'Avila ALB, Scanavacca M, Sosa E, Svenson RH. Laser Irradiation of Chagasic heart, Feasibility study on the potential for deep laser photocoagulation in hearts with diffuse myocardial damage. XVth Brazilian Congress of Electrophysiology and First Arrhythmia Meeting of Mercosul. 1998; 176. Splinter R, Raja MYA, Svenson RH. Laser induced light-guides in tissue under high irradiance. Lasers Surg Med 1997; Suppl 9: 2-3. Splinter R, Selle JG, Eastman D, Geier B. In-situ laser valvulotomy in the distal veins of the leg. Lasers Surg Med 1997; Suppl 9: 11-11. Deshmukh H, Splinter R, Raja MYA, Hadzikadic M, Subramanian KR. Dynamic unconstrained three dimensional model for estimation of light distribution in turbid media. Lasers Surg Med 1997; Suppl 9: 2. Splinter R, Semenov SY, Nanney GA, Littmann L, Tuntelder L, Chuang CH, Svenson RH, Tatsis GP. Rate dependency of myocardial temperature distribution under cw Nd:YAG laser irradiation in in vitro situations: practice and theory. Lasers Surg Med 1994; Suppl 6: 4. Wu G, Littmann L, Svenson RH, Nanney GA,. Splinter R, Chuang CH, Tatsis GP, Thompson M, Dezern KR. Nd:YAG laser ablation of induced ventricular tachycardia guided by computerized three dimensional activation mapping in canines with subacute myocardial infarction. Lasers Surg Med 1995; Suppl 7: 11. Kempler P, Littmann L, Chuang CH, Dezern KR, Splinter R, Hayes WJ, Tuntelder JR, Wu G, Tatsis GP, Svenson RH. Nd:YAG laser photocoagulation of the right atrium in dogs. Lasers Surg Med 1994; Suppl 6: 10-11. Shukes S, Splinter R, Raja MYA, Svenson RH, Tuntelder JR, Dezern KR, Thompson M, Tatsis G. Determination of an optical window of myocardial tissue. Opt Soc Am Annual Meeting Technical Digest 1993; 93. Littmann L, Svenson RH, Brucker G, Chuang CH, Splinter R, Dezern K, Tuntelder JR, Thompson M, Tatsis GP. Comparative study on the efficacy and safety of transcatheter radiofrequency ablation and contact Neodymium-YAG laser photoablation of the left ventricular endocardium in dogs, PACE 1993; 16(4) Part II: 859. 1/24/2013

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Publications

Robert Splinter

Littmann L, Svenson RH, Brucker G, Splinter R, Chuang CH, Tuntelder JR, Dezern K, Thompson M, Tatsis GP. Percutaneous Neodymium:YAG laser photoablation of the ventricular tachycardia: A canine feasibility study. Circulation 1992; 86(4): I-192. Svenson RH, Littmann L, Splinter R, Brucker GG, Tuntelder JR, Dezern KR, Thompson M, Tatsis GP. Closed heart Nd:YAG laser ablation of ventricular tachycardia: Feasibility study in a canine model. PACE 1992; 15(4) part II: 581. Splinter R, Littmann L, Svenson RH, Brucker GG, Tuntelder JR, Thompson M, Chuang CH, Tatsis GP. Epicardial thermography during in-vivo endocardial laser photocoagulation. Lasers Surg Med 1992; Suppl 4: 19-20. Splinter R, Tuntelder JR, Pierce S, Thompson M, Chuang CH, Wilson BR, Svenson RH, Littmann L, Tatsis GP. Ultrasonic characterization of in-vivo photocoagulation lesion size in myocardium following Nd:YAG laser irradiation. Lasers Surg Med 1991; Suppl 3: 1991. Splinter R, Svenson RH, Littmann L, Hehrlein C, Tatsis GP, Tuntelder JR. In vitro optical properties of myocardium at 1064 m before and after Nd:YAG laser irradiation. Lasers Surg Med 1990; Suppl. 2: 63. Splinter R, Littmann L, Marroum M-C, Svenson RH, Tuntelder JR, Chuang CH, Tatsis GP, Thompson M. Optical changes in myocardial tissue due to cw Nd:YAG irradiation. Proc. IEEE Engineering in Medicine and Biology Society 1990; 12(3): 1113-1114. Splinter R, Svenson RH, Littmann L. Optical properties of myocardium at 1.064 Âľm before and after Nd:YAG laser irradiation. Presented at: Engineering Foundation; Future Directions for Lasers in Medicine and Surgery. February 1989 Littmann L, Svenson RH, Chuang CH, Tuntelder JR, Thompson M, Splinter R, Tatsis GP. Transcatheter laser photoablation of AV conduction from the aortic root. Circulation 1991; 84 Suppl II: II-712. Littmann L, Svenson RH, Chuang CH, Splinter R, Hehrlein C, Tuntelder JR, Thompson M, Tatsis GP. Contact epicardial lasing with neodymium-YAG: a new method of achieving deep myocardial photocoagulation in dogs. Lasers Surg Med 1991; Suppl 3: 14. Littmann L, Svenson RH, Chuang CH, Bharati S, Lev M, Hehrlein C, Splinter R, Tuntelder JR, Thompson M, Tatsis GP. Retrograde AV nodal conduction can be selectively eliminated by Neodymium:YAG laser photocoagulation in dogs. J Am Coll Cardiol 1991; 17: 175a. Wilson BH, Splinter R, Marroum M-C, Tatsis GP, Svenson RH, Papaioannou T, Litvack F, Grundfest W. Laser valvuloplasty of calcified aortic valves: a comparison of continuous wave and pulsed lasers. Circulation 1990; 82: III-79. 1/24/2013

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Publications

Robert Splinter

Hehrlein C, Chuang CH, Tuntelder JR, Splinter R, Littmann L, Svenson RH. Intimal hyperplasia after laser thermal angioplasty in canines with normal and reduced vascular runoff. Lasers Surg Med 1990; Suppl. 2: 14. Svenson RH, Littmann L, Linder K, Tatsis GP, Splinter R, Seifert K, Marroum M-C, Chuang CH. Myocardial Nd:YAG laser photocoagulation for ventricular arrhythmias. Depth of photocoagulation as a function of irradiated surface area: method for reaching deep arrhythmogenic foci. Lasers Surg Med 1989; Suppl 1: 10. Marijnissen JM, Splinter R, Storchi PRM, Star WM, Keijzer M, Van Gemert MJC. Determination of the optical properties of tissues: Comparison of two methods. Proc. European Laser Association 1986: p 45. --------PATENTS

United States Patents: •

5,920,390 Fiberoptic interferometer and associated method for analyzing tissue

6,862,542 Erythema measuring device

7,477,925 Erythema measuring device and method

Patent Application Publications •

US20090112198 Liquid Light Guide Catheter having Biocompatible Liquid Light Guide Medium

US20090125007 Intra-Vascular Device With Pressure Detection Capabilities Using Pressure Sensitive Material

US20090147257 Low-Loss Polarized Light Diversion - optical sensor that provides lateral viewing while maintaining light polarization

US20090171330 Tunable Nanaoparticle Tags to enhance Tissue Recognition

US20090254074 Liquid Light-Guide Catheter with Optically Diverging Tip

Provisional Patent Applications: 1/24/2013

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Publications Robert Splinter UNCC #04-047 Fabrication of Nanosensor DNA Microarray Chip (link: http://ott.uncc.edu/intel/inventions.cfm)

PROJECT LINKS: Symposium on Aortic Valve Sparing Surgery: http://www.heineman.org/committeepage.htm Rare Earth-Doped Nanocrystals for Biosensing and Imaging: http://www.utsa.edu/laserlab/Publications/PDFS/2008/Rare-Earth%20Doped%20Nanocrystals %20for%20Biosensing%20and%20Imaging.pdf

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Splinter, Robert - Publications  

publication list