Mandjalia Soro 2 Mandjalia Soro Biology 110 assignment March 31, 2010
Biological Effect of DCCD on ATP production
Most of the ATP that are used by all living cells are produced in the mitochondria, and any accidental ingestion of the poisons DCCD will inhibit the production of ATP that will be required to keep cells alive. Accordingly, Harry has taken in DCCD and is experiencing severe fatigue because he only produces 4 ATP molecules per molecule of glucose. Since there is evidence of pyruvate and that Acetyl CoA along with NADH and NAD+ are observed to normal, it is save to conclude that the production of ATP is been inhibited at the level of the electron transport chain or ETC in the mitochondria. However, the production of ATP requires the establishment of H+ gradients across the inner mitochondria membrane by special complexes labeled I through IV along the ETC. These hydrogen pumps, as their name denote, power the establishment of the H+ gradients across the membrane. Because Harry has drunken DCCD, the poison has gone directly to ETC blocking the movement of electrons that fuels the activities of these complexes. In one classic experiment a researcher by the name of Jordana P. Panatto along with colleagues subjected a rat to acetaminophen which attacked the complexes along the ETC in the mitochondria and consequence inhibited the production of ATP. Panatto and his colleagues concluded that activities of cytochromes, complex III and IV, have been inhibited thereby
Mandjalia Soro 2 shouting down the production of ATP. (Panatto, J., Jeremias, I., Ferreira, G., Ramos, N., Rochi, N., Gonรงalves, C., Daufenbach, J., Jeremias, G., Carvalho-silva, M., Rezin, G., Scaini, G., & Streck, E. 2011). In addition, the Brooker text book mentions that some chemical like synide can inhibit the flow of electrons and eventually leached a lethal effect on the complexes alone the ETC (Brooker 145). The role of the ETC can never be underestimated because most the ATP required to keep cells alive are produce in this region.
Panatto, J., Jeremias, I., Ferreira, G., Ramos, N., Rochi, N., Gonรงalves, C., Daufenbach, J., Jeremias, G., Carvalho-silva, M., Rezin, G., Scaini, G., & Streck, E.. (2011). Inhibition of mitochondrial respiratory chain in the brain of rats after hepatic failure induced by acetaminophen. Molecular and Cellular Biochemistry, 350(1-2), 149-154. Retrieved March 30, 2011, from ProQuest Health and Medical Complete. (Document ID: 2292289421