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Research INKlings

October 2012

Biomedical Research Excellence Awards Transform MUSC Research

Dr. Keith Kirkwood

Dr. Roger Markwald

The Medical University of South Carolina (MUSC) is now home to four National Institutes of Health (NIH) Centers of Biomedical Research Excellence (COBRE) awards, totaling more than $27 million. COBRE is a component of the Institutional Development Award (IDeA) program, which encourages health-related research and supports faculty development and research infrastructure. MUSC was recently recognized for its research achievements with unprecedented, simultaneous COBRE renewals for three centers, including cardiovascular, oral health, and lipidomics research. The COBRE for Oral Health Research [P30 GM103331] is focused on training researchers to become established investigators and academic leaders in the College of Dental Medicine's oral and craniofacial health research program.

Dr. Kenneth Tew

Dr. Rick Schnellmann

The COBRE in Lipidomics and Pathobiology [P30 GM103339] focuses on mentoring junior investigators to establish research programs on the role of bioactive lipids in human disease development and progression, such as in cancer, neurodegeneration, and angiogenesis. In 2011, MUSC received a fourth COBRE award, a partnership between

the Colleges of Medicine and Pharmacy, to

establish a Center in Oxidants, Redox Balance and Stress Signaling [P20 GM103542]. Redox biology and stress signaling play a critical role in a number of diseases including organ damage and cancer. In addition to developing a strong foundation in key targeted research areas, the COBRE awards also provide resources for acquiring and supporting a number of advanced technologies and equipment. Continued on page 2

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The COBRE in Cardiovascular Developmental Biology [P30 GM103342] is an active partnership between MUSC and the University of South Carolina to conduct fundamental studies of cardiovascular developmental biology and determine how these mechanisms can be applied to adult cardiovascular diseases and stem cellbased regenerative medicine.

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Center for Innovation and Entrepreneurship Awards Transform Research

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Revised Financial Conflict Of Interest (FCOI) Regulations Impact Peggy Schachte Research Mentor Awards

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SC Life Sciences Conference

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Quick Reference Tool

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Resources & Scientific Environment


Research Inklings

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Center for Innovation and Entrepreneurship G. Thomas Finnegan has joined the Medical University of South Carolina as the Director of the Center for Innovation and Entrepreneurship fulfilling the vision of the Strategic Plan. Entrepreneurship will bring nontraditional economic resources and visibility to MUSC, contribute to public welfare and economic development in South Carolina and beyond, and demonstrate the successful application of university research to health care needs. Entrepreneurial activity demands encouragement, incentive, recognition, and coordination to flourish and grow. For our endeavors to be successful, a shift in culture at every level is needed. A culture of ethical entrepreneurialism facilitates the development of high quality innovations and technological advances in the fields of health, education, and research, while maintaining fairness, teamwork, core values, and ethical principles. To realize these goals, we look to intersections – across professions and disciplines, with other research centers, and with experienced entrepreneurs. Essential to building and maintaining these relationships, MUSC spawned the creation of the new Center for Innovation and Entrepreneurialism. The center will serve as a gateway for partner engagement as well as a resource for our entrepreneurial health and biomedical scientists. Only through cultural change within the institution and renewed engagement with external partners will MUSC truly become an entrepreneurial university. Mr. Finnegan served as the Vice President of Finance and Corporate Development at Introgen Therapeutics, a publicly traded biotech company (NASD: INGN) based in Austin, Texas. His primary responsibilities were to head the finance and business development functions. After taking Introgen public, Tom raised over $120 million of public and private capital for the Company. In addition to his wealth of experience gained in Texas, Mr. Finnegan has continued his involvement in the startup of companies since moving to Charleston a few years ago. He has negotiated the license of several technologies, advised start-ups (many at MUSC), funded companies, wrote business plans and formed several companies in which he played an active management role. Mr. Finnegan’s office, conveniently located on the first floor of the new Bioengineering Building, will enhance interaction with faculty interested in innovation and entrepreneurship.

Awards Transform Research continued from page 1 MUSC Associate Provost for Research Stephen Lanier, Ph.D., said, “The programmatic initiatives involving the Centers of Biomedical Research Excellence and related infrastructure development grants from the National Institutes of Health have simply been transformative for MUSC and have played important roles in the dramatic growth of research programs at the university over the last 10 years.” According to Fred Taylor, Ph.D., NIH IDeA program official, MUSC exemplifies what the COBRE program was meant to do for health-related research. “The next phase of support will enable the centers to enhance and extend these activities, thereby continuing to make important contributions to improving research capacity and health in South Carolina, the region, and the nation."


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Research Inklings

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Revised Financial Conflict Of Interest (FCOI) Regulations Impact MUSC’s Office of Research and Sponsored Programs (ORSP) has created a new web page outlining the revised Public Health Service (PHS) financial conflict of interest (FCOI) regulations. Some of the most important and significant changes affecting the proposal submission process are highlighted below. The electronic Proposal Data Sheet (ePDS) has been changed to require MUSC Principal Investigators to certify to a complete listing of ALL MUSC personnel working on the proposed project. This complete listing of ALL MUSC personnel on the ePDS will allow ORSP staff to cross reference (via system to system interface) the COI database and ensure a current disclosure is on file with the MUSC Conflict of Interest Office. Another change to the ePDS requires MUSC Principal Investigators to acknowledge they understand that now ALL NONMUSC contributors or External

Contributors (i.e. subrecipients, consultants, etc.) working on the proposal must complete the required External Contributor FCOI Certification Form and submit to MUSC’s ORSP. If any of the External Contributor(s) contained in the MUSC proposal are listed on the Federal Demonstration Partnership (FDP) FCOI Institutional Clearinghouse link, then none of the new FCOI related forms are required of the External Contributor. Appearing on this FDP Clearinghouse would indicate an organization or institution is fully PHS FCOI compliant. MUSC is listed on this FDP Clearinghouse link. Given the new PHS FCOI requirements at the proposal stage, ORSP must have a completed and approved ePDS and any required FCOI related forms prior to proposal submission to the funding entity.

viewed at the following link (http://academicdepartments.mus c.edu/research/orsp/orsp_coi.ht ml). ORSP encourages everyone involved with research and the submission of research proposals to review these important and necessary changes affecting the proposal submission process. As always, all proposals should be submitted to ORSP at least three (3) days prior to the sponsor’s deadline. Please visit the above referenced link for specific details; or if you have questions, please call your assigned Grants Administrator within ORSP or call 843.792.3838 for assistance.

The website highlights how the FCOI changes impact the proposal submission process and may be

Quick Links • • • • • • •

ORSP COI web page & Information MUSC’s Main COI web page & Information MUSC’s External Contributor Financial Conflict of Interest (FCOI) Certification Form MUSC’s COI Disclosure Form NIH’s Financial Conflict of Interest page FDP Clearinghouse list of PHS FCOI compliant entities FDP Main web page (to download official invitation to join FDP Clearinghouse)


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Peggy Schachte Research Mentor Awards In 2012, the Medical University of South Carolina Board of Trustees established a program to recognize individual faculty who have excelled in mentoring fellow faculty members in obtaining research support from private and public organizations or government agencies. This award was established by an endowment from the College of Medicine in honor of Margaret P. (Peggy) Schachte, who founded and served as director of the MUSC Office of Research Development from 1993 to 2009. During her tenure, Peggy recognized the significance of research mentorship and played a major role in initiating and championing research mentorship activities at MUSC. Dr. Jeannette O. Andrews, Professor and Associate Dean for Research in the College of Nursing, and Dr. Judy R. Dubno, Professor in the Department of Otolaryngology, Head and Neck Surgery in the College of Medicine, were recipients of the 2012 Peggy Schachte Research Mentor Award. They were honored at the annual Faculty Convocation on August 21, 2012. Dr. Andrews established an infrastructure to promote research development and mentorship in the College of Nursing (CON). This included individual and group meetings with junior faculty, monthly “Research for Lunch” mock grant reviews and bi-weekly think tank sessions. The college’s research committee established a CON Research Day for doctoral students, providing mentoring for presentations at regional and national meetings. Dr. Andrews also has brought in visiting nursing research leaders to meet with faculty, staff, and doctoral students to provide guidance on research projects. Dr. Andrews’ impact on research within the CON has been dramatic. College of Nursing is ranked 30th among all colleges of nursing in the National Institute of Health’s (NIH) annual ranking of research funding in 2011. A prominent auditory scientist in the College of Medicine, Dr. Dubno has distinguished herself as an exemplary educator, researcher and mentor. She has extensive professional service including journal reviews, and has been funded by the National Institutes of Health and other agencies for more than 25 years. Dr. Dubno has mentored approximately 50 students and junior faculty members, 27 in the last three years alone. Faculty members supporting her nomination noted, it is the quality of their relationship with Dr. Dubno that matters. A hallmark of this institution, she bears the spirit of cooperation and congeniality among faculty members. In addition to the Peggy Schachte Research Mentor Award, faculty awards were given to honorees in four categories: distinguished faculty service, teaching excellence, outstanding clinician and developing scholar. The keynote speaker for the event was Dr. Perry Halushka, Dean of the College of Graduate Studies. He presented “From Discovery to Improved Therapeutics: The Role of Entrepreneurialism.” Congratulations to this year’s recipients for their outstanding contributions to teaching, research, mentoring, and patient care.


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Quick Reference Tool The Medical University of South Carolina (MUSC) research centers and institutes bring together the right mix of expertise to answer the tough questions in science and society. MUSC is made up of a strong infrastructure of centers and institutes, helping teams of scholars and scientists produce their finest work.

SC Life Sciences Conference Join entrepreneurs, researchers, and industry leaders from 600 life sciences businesses from South Carolina and surroundings areas to attend the What Next: SC Life Science Conference scheduled for November 14-15, 2012 in Greenville. Featured Speakers for this year’s conference include:     

Mr. J. Walker Smith, Executive Chairman The Futures Company Dr. Leroy Hood, Founder Institute of Systems Biology Dr. Jeffrey Shuren, Director FDA Center for Devices and Radiological Health Mr. Brent Del Monte, Vice President, BIO Federal Government Relations Mr. Daniel D. Adams, Chairman Protein Sciences

For more information and to register for the conference visit www.scbio.org.

Research INKlings is an on-line monthly newsletter prepared by the Office of Research Development providing research news, policy changes and other relevant information for MUSC faculty, staff and students. Research INKlings is published in February, April, August, October and December.

The Office of Research Development (ORD) has provided a new and fundamental addition to the research website: a detailed list of the MUSC’s many centers, COBREs, cores and facilities, institutes and more. With a quick click (http://academicdepartments.musc.edu/r esearch/centers_inst2.html), you now have access to a comprehensive list that provides direct access to MUSC’s centers, COBRE’s, university cores and facilities, institutes, SmartState Centers of Economic Excellence (collaborative centers with the University of South Carolina and/or Clemson University), Hollings Cancer Center Shared Resources, and University Research Resources Facilities (URRFs).


Research inklings

OCTOBER 2012

Resources and Scientific Environment The Office of Research Development (ORD) has compiled institutional information about the Medical University of South Carolina, primarily to assist faculty, staff, and trainees in preparing the Resources section for proposals. Formerly known as the "institutional boilerplate", the reconstructed, and newly named, Resources and Scientific Environment provides brief descriptions of major elements and initiatives to serve as a guide for faculty as they develop the resources and facilities portion of their proposal. Relevant information from these descriptions can be used to demonstrate to reviewers that MUSC provides an environment conducive to your proposed research. To keep this resource current, ORD would like to reach out to faculty and administrators of the various colleges and departments to replace outdated information with current and up-to-date content that will be useful in preparing grant proposals. The Resources and Scientific Environment booklet and website also serve as a central location for MUSC’s research infrastructure, providing descriptions and links to research administration and support available here at MUSC, along with descriptions of cores and facilities. This format will is highly navigable and visual, making it much easier for faculty and administrators to create their resources section. Associate Provost for Research Stephen Lanier, Ph.D. said, “This booklet is a great resource for faculty and staff providing a road map for new faculty at MUSC and providing up to date information that could be included in grant proposals.” The new Resources and Scientific Environment information will undoubtedly be an invaluable tool for faculty, staff, and trainees. Every effort has been made by ORD to include current information about all entities of MUSC in Resources and Environment, but it you would like to update your core, facility, or provide suggestions, please contact the Office of Research Development at 843.792.5828 or email huttow@musc.edu.


Research INKlings, October 2012 issue  
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