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Market and Product Forecasts: Targeted Cancer Therapies - Trend towards personalized medicine will lead to market fragmentation

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Introduction The targeted therapies class boasts several of the top-selling anticancer brands, and has fueled most of the recent rapid growth of the oncology market as a whole. In the next decade, several blockbuster targeted therapies will undergo patent expiries and the market will become more fragmented as new targeted therapies are developed for niche populations. Features and benefits Sales forecasts of targeted cancer therapy brands over the period 2010-20 in the seven major pharmaceutical markets. Includes an overview of the overall targeted therapies market as well as country specific and brand specific forecasts. Analysis of the impact of generics and biosimilars on the marketed targeted cancer therapy brands over the forecast period 2010-20 Analysis of pharmacoeconomic constraints likely to affect sales growth in the seven major pharmaceutical markets. See More : Cancer Therapies Market and Product Forecasts Highlights Datamonitor forecasts the currently marketed targeted cancer therapies to achieve collective sales of $34.5bn by 2017 in the seven major markets (the US, Japan, France, Germany, Italy, Spain, and the UK), growing at a compound annual growth rate (CAGR) of 4.0% from 2010 to 2017. Datamonitor forecasts the sales value of currently marketed targeted cancer therapies will contract at a CAGR of 3.5% from 2017 to 2020, owing to patent expiries of some key brands in this class. Monoclonal antibodies will remain the dominant class in the targeted therapies market accounting for 62% of the sales of currently marketed targeted cancer therapies by 2020. Table Of Contents OVERVIEW Catalyst Summary


EXECUTIVE SUMMARY Strategic scoping and focus Datamonitor key findings Related reports MARKET DEFINITION Market definition for the targeted cancer therapies class Targeted cancer therapies by ATC class Targeted cancer therapies not included in this report Forecast methodology and assumptions Methodology flow Patent expiries Additional forecast methodology MARKET OVERVIEW AND CONTEXT Current and future market dynamics overview US forecast Japan forecast France forecast Germany forecast Italy forecast Spain forecast UK forecast PRODUCT FORECASTS Adcetris (brentuximab vedotin; Seattle Genetics/Takeda) Forecast assumptions Adcetris forecast 2010–20 Afinitor (everolimus; Novartis) Forecast assumptions Afinitor forecast 2010–20 Arzerra (ofatumumab; Genmab/GlaxoSmithKline) Forecast assumptions Arzerra forecast 2010–20 Avastin (bevacizumab; Roche/Chugai) Forecast assumptions Avastin forecast 2010–20 Caprelsa (vandetanib; AstraZeneca) Forecast assumptions Caprelsa forecast 2010–20 Erbitux (cetuximab; Eli Lilly/Bristol-Myers Squibb/Merck KGaA) Forecast assumptions Erbitux forecast 2010–20 Gleevec (imatinib; Novartis)


Forecast assumptions Gleevec forecast 2010–20 Herceptin (trastuzumab; Roche/Chugai) Forecast assumptions Herceptin forecast 2010–20 Iressa (gefitinib; AstraZeneca) Forecast assumptions Iressa forecast 2010–20 Nexavar (sorafenib; Bayer Schering/Onyx) Forecast assumptions Nexavar forecast 2010–20 Revlimid (lenalidomide; Celgene) Forecast assumptions Revlimid forecast 2010–20 Rituxan (rituximab; Biogen Idec/Roche/Chugai/Zenyaku Kogyo) Forecast assumptions Rituxan forecast 2010–20 Sprycel (dasatinib; Bristol-Myers Squibb) Forecast assumptions Sprycel forecast 2010–20 Sutent (sunitinib; Pfizer) Forecast assumptions Sutent forecast 2010–20 Tarceva (erlotinib; OSI Pharmaceuticals/Genentech/Roche) Forecast assumptions Tarceva forecast 2010–20 Tasigna (nilotinib; Novartis) Forecast assumptions Tasigna forecast 2010–20 Thalomid (thalidomide; Celgene) Forecast assumptions Thalomid forecast 2010–20 Torisel (temsirolimus; Pfizer) Forecast assumptions Torisel forecast 2010–20 Tykerb (lapatinib; GlaxoSmithKline) Forecast assumptions Tykerb forecast 2010–20 Vectibix (panitumumab; Amgen) Forecast assumptions Vectibix forecast 2010–20


Velcade (bortezomib; Takeda/Johnson & Johnson) Forecast assumptions Velcade forecast 2010–20 Votrient (pazopanib; GlaxoSmithKline) Forecast assumptions Votrient forecast 2010–20 Xalkori (crizotinib; Pfizer) Forecast assumptions Xalkori forecast 2010–20 Yervoy (ipilimumab; Bristol-Myers Squibb) Forecast assumptions Yervoy forecast 2010–20 Zelboraf (vemurafenib; Roche/Plexxikon) Forecast assumptions Zelboraf forecast 2010–20 BIBLIOGRAPHY Journal papers Websites Datamonitor reports APPENDIX Forecast methodology Volume and value forecast methodology Price assumptions Report methodology LIST OF TABLES Table: Definition of the targeted cancer therapies market, 2011 Table: Patent expiries for targeted cancer therapies, 2011 Table: Key branded and generic sales for the L1X3 antineoplastic monoclonal antibodies class in the seven major markets ($m), 2010–20 Table: Key branded and generic sales for the L1X4 antineoplastic protein kinase inhibitors class in the seven major markets ($m), 2010–20 Table: Key branded and generic sales for the L1X9 all other antineoplastics class in the seven major markets ($m), 2010–20 Table: Key branded and generic sales for the L4A0 immunosuppressive agents class in the seven major markets ($m), 2010–20 Table: Targeted therapy sales in the seven major markets, by class ($m), 2010–20 Table: Key branded and generic sales for the L1X3 antineoplastic monoclonal antibodies class in the US ($m), 2010–20 Table: Key branded and generic sales for the L1X4 antineoplastic protein kinase inhibitors class in the US ($m), 2010–20 Table: Key branded and generic sales for the L1X9 all other antineoplastics class in the US ($m), 2010–20


Table: Key branded and generic sales for the L4A0 immunosuppressive agents class in the US ($m), 2010–20 Table: Targeted therapy sales in the US, by class ($m), 2010–20 Table: Key branded and generic sales for the L1X3 antineoplastic monoclonal antibodies class in Japan ($m), 2010– 20 Table: Key branded and generic sales for the L1X4 antineoplastic protein kinase inhibitors class in Japan ($m), 2010–20 Table: Key branded and generic sales for the L1X9 all other antineoplastics class in Japan ($m), 2010–20 Table: Key branded and generic sales for the L4A0 immunosuppressive agents class in Japan ($m), 2010–20 Table: Targeted therapy sales in Japan, by class ($m), 2010–20 Table: Key branded and generic sales for the L1X3 antineoplastic monoclonal antibodies class in France ($m), 2010–20 Table: Key branded and generic sales for the L1X4 antineoplastic protein kinase inhibitors class in France ($m), 2010–20 Table: Key branded and generic sales for the L1X9 all other antineoplastics class in France ($m), 2010–20 Table: Key branded and generic sales for the L4A0 immunosuppressive agents class in France ($m), 2010–20 Table: Targeted therapy sales by class in France ($m), 2010–20 Table: Key branded and generic sales for L1X3 antineoplastic monoclonal antibodies class in Germany ($m), 2010– 20 Table: Key branded and generic sales for the L1X4 antineoplastic protein kinase inhibitors class in Germany ($m), 2010–20 Table: Key branded and generic sales for the L1X9 all other antineoplastics class in Germany ($m), 2010–20 Table: Key branded and generic sales for the L4A0 immunosuppressive agents class in Germany ($m), 2010–20 Table: Targeted therapy sales in Germany, by class ($m), 2010–20 Table: Key branded and generic sales for the L1X3 antineoplastic monoclonal antibodies class in Italy ($m), 2010– 20 Table: Key branded and generic sales for the L1X4 antineoplastic protein kinase inhibitors class in Italy ($m), 2010– 20 Table: Key branded and generic sales for the L1X9 all other antineoplastics class in Italy ($m), 2010–20 Table: Key branded and generic sales for the L4A0 immunosuppressive agents class in Italy ($m), 2010–20 Table: Targeted therapy sales in Italy, by class ($m), 2010–20 Table: Key branded and generic sales for the L1X3 antineoplastic monoclonal antibodies class in Spain ($m), 2010– 20 Table: Key branded and generic sales for the L1X4 antineoplastic protein kinase inhibitors class in Spain ($m), 2010–20 Table: Key branded and generic sales for the L1X9 all other antineoplastics class in Spain ($m), 2010–20 Table: Key branded and generic sales for the L4A0 immunosuppressive agents class in Spain ($m), 2010–20 Table: Targeted therapy sales in Spain, by class ($m), 2010–20 Table: Key branded and generic sales for the L1X3 antineoplastic monoclonal antibodies class in the UK ($m), 2010–20 Table: Key branded and generic sales for the L1X4 antineoplastic protein kinase inhibitors class in the UK ($m), 2010–20


Table: Key branded and generic sales for the L1X9 all other antineoplastics class in the UK ($m), 2010–20 Table: Key branded and generic sales for the L4A0 immunosuppressive agents class in the UK ($m), 2010–20 Table: Targeted therapy sales in the UK, by class ($m), 2010–20 Table: Adcetris (brentuximab vedotin; Seattle Genetics/Takeda) sales, by country ($m), 2010–20 Table: Afinitor (everolimus; Novartis) sales, by country ($m), 2010–20 Table: Arzerra (ofatumumab; Genmab/GlaxoSmithKline) sales, by country ($m), 2010–20 Table: Avastin (bevacizumab; Roche/Chugai) sales, by country ($m), 2010–20 Table: Caprelsa (vandetanib; AstraZeneca) sales, by country ($m), 2010–20 Table: Erbitux (cetuximab; Eli Lilly/Bristol-Myers Squibb/Merck KGaA) sales, by country, ($m), 2010–20 Table: Gleevec (imatinib; Novartis) sales, by country ($m), 2010–20 Table: Herceptin (trastuzumab; Roche/Chugai) sales, by country ($m), 2010–20 Table: Iressa (gefitinib; AstraZeneca) sales, by country ($m), 2010–20 Table: Nexavar (sorafenib; Bayer Schering/Onyx) sales, by country ($m), 2010–20 Table: Revlimid (lenalidomide; Celgene) sales, by country ($m), 2010–20 Table: Rituxan (rituximab; Biogen Idec/Roche/Chugai/Zenyaku) sales, by country ($m), 2010–20 Table: Sprycel (dasatinib; Bristol-Myers Squibb) sales, by country ($m), 2010–20 Table: Sutent (sunitinib; Pfizer) sales, by country ($m), 2010–20 Table: Tarceva (erlotinib; OSI Pharmaceuticals/Genentech/Roche) sales, by country ($m), 2010–20 Table: Tasigna (nilotinib; Novartis) sales, by country ($m), 2010–20 Table: Thalomid (thalidomide; Celgene) sales, by country ($m), 2010–20 Table: Torisel (temsirolimus; Pfizer) sales, by country ($m), 2010–20 Table: Tykerb (lapatinib; GlaxoSmithKline) sales, by country ($m), 2010–20 Table: Vectibix (panitumumab; Amgen) sales, by country ($m), 2010–20 Table: Velcade (bortezomib; Takeda/Johnson & Johnson) sales, by country ($m), 2010–20 Table: Votrient (pazopanib; GlaxoSmithKline) sales, by country ($m), 2010–20 Table: Xalkori (crizotinib; Pfizer) sales, by country, ($m), 2010–20 Table: Yervoy (ipilimumab; Bristol-Myers Squibb) sales, by country ($m), 2010–20 Table: Zelboraf (vemurafenib; Roche/Plexxikon) sales, by country ($m), 2010–20 LIST OF FIGURES Figure: Company-reported sales-based forecast methodology, 2011 Figure: Unevented and evented company-reported sales-based forecast, 2011 Figure: Targeted cancer therapies market forecast across the seven major markets, by region ($m), 2010–20 Figure: Sales of targeted cancer therapies in the seven major markets, by class ($m), 2010–20 Figure: Sales of targeted cancer therapies in the US, by class ($m), 2010–20 Figure: Sales of targeted cancer therapies in Japan, by class ($m), 2010–20 Figure: Sales of targeted cancer therapies in France, by class ($m), 2010–20 Figure: Sales of targeted cancer therapies in Germany, by class ($m), 2010–20 Figure: Sales of targeted cancer therapies in Italy, by class ($m), 2010–2020 Figure: Sales of targeted cancer therapies in Spain, by class ($m), 2010–20 Figure: Sales of targeted cancer therapies in the UK, by class ($m), 2010–20 Figure: Adcetris (brentuximab vedotin; Seattle Genetics/Takeda) sales, by country ($m), 2010–20


Figure: Afinitor (everolimus; Novartis) sales, by country ($m), 2010–20 Figure: Arzerra (ofatumumab; Genmab/GlaxoSmithKline) sales, by country ($m), 2010–20 Figure: Avastin (bevacizumab; Roche/Chugai) sales, by country ($m), 2010–20 Figure: Caprelsa (vandetanib; AstraZeneca) sales, by country ($m), 2010–20 Figure: Erbitux (cetuximab; Eli Lilly/Bristol-Myers Squibb/Merck KGaA) sales, by country ($m), 2010–20 Figure: Gleevec (imatinib; Novartis) sales, by country ($m), 2010–20 Figure: Herceptin (trastuzumab; Roche/Chugai) sales, by country ($m), 2010–20 Figure: Iressa (gefitinib; AstraZeneca) sales, by country ($m), 2010–20 Figure: Nexavar (sorafenib; Bayer Schering/Onyx) sales, by country ($m), 2010–20 Figure: Revlimid (lenalidomide; Celgene) sales, by country ($m), 2010–20 Figure: Rituxan (rituximab; Biogen Idec/Roche/Chugai/Zenyaku) sales, by country ($m), 2010–20 Figure: Sprycel (dasatinib; Bristol-Myers Squibb) sales, by country ($m), 2010–20 Figure: Sutent (sunitinib; Pfizer) sales, by country ($m), 2010–20 Figure: Tarceva (erlotinib; OSI Pharmaceuticals/Genentech/Roche) sales, by country ($m), 2010–20 Figure: Tasigna (nilotinib; Novartis) sales, by country ($m), 2010–20 Figure: Thalomid (thalidomide; Celgene) sales, by country ($m), 2010–20 Figure: Torisel (temsirolimus; Pfizer) sales, by country ($m), 2010–20 Figure: Tykerb (lapatinib; GlaxoSmithKline) sales, by country ($m), 2010–20 Figure: Vectibix (panitumumab; Amgen) sales, by country ($m), 2010–20 Figure: Velcade (bortezomib; Takeda/Johnson & Johnson) sales, by country ($m), 2010–20 Figure: Votrient (pazopanib; GlaxoSmithKline) sales, by country ($m), 2010–20 Figure: Xalkori (crizotinib; Pfizer) sales, by country ($m), 2010–20 Figure: Yervoy (ipilimumab; Bristol-Myers Squibb) sales, by country ($m), 2010–20 Figure: Zelboraf (vemurafenib; Roche/Plexxikon) sales, by country ($m), 2010–20 Related Market Research Reports: Epidemiology: Peripheral Neuropathic Pain – A common co-morbidity for HIV, diabetes, and herpes zoster Epidemiology: Influenza – Incident cases expected to remain stable due to low vaccination rates The Future of Skincare: Consumption trends and product preferences Express Benchmarking 2011 – Belgium Express Benchmarking 2011 – Finland Express Benchmarking 2011 – Germany Express Benchmarking 2011 – the Netherlands Express Benchmarking 2011 – Italy Express Benchmarking 2011- France Express Benchmarking 2011 – Austria Express Benchmarking 2011 – Czech Republic


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