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Cell Culture: The World Market for Media, Sera and Reagents, 3rd. Edition

ReportsnReports.com adds Kalorama Information Market Research Report “Cell Culture: The World Market for Media, Sera and Reagents, 3rd. Edition’’ to its store. Several cell culture-derived biopharmaceutical drugs were launched in the US and European markets in 2010. Biopharmaceuticals (recombinant proteins, monoclonal antibody and nucleic acid-based products) represent the fastest growing sector in the pharmaceutical industry. Driving the extraordinary interest in biopharmaceuticals is the ability of these large proteins to target diseases in a very specific manner, thus maximizing efficacy while minimizing side effects. Growth in the development and production of biopharmaceuticals is the most significant driver of the cell culture market. Biological products are developed from large and complex protein molecules, which require equally complex manufacturing methods and an array of analytical techniques. Protein-based biopharmaceuticals are invariably produced by an initial cell culture step (upstream processing), followed by product recovery, purification and formulation into final product format (downstream processing). This report analyzes the world market for the cell cultures used in these steps and the major trends driving this market. Forecasts and current market sizing are provided in three specific segments:  Media,  Sera, and  Reagents In addition to a thorough discussion of the technologies and techniques currently employed and emerging in the cell culture area, the Kalorama’s exhaustive report provides specific information on:      

Market Size, growth, and forecasts of the segments through 2015 Competitive Market Share by leading supplier as of 2010. Estimated Market Share by Region (North America, Europe, U.S.) Key Market Drivers and Restraints for suppliers, including discussions of biopharmaceutical pipelines, biomedical R&D directions, and the future of transgenic plant and animal production. Review of the various expression systems (Bacteria, Yeast, Insect, and Mammal) and the biopharmaceutical product manufactured by these systems Discussion of the preferences in media types vying for dominance in the market, including the following:

ADCF – animal derived component free media CD – chemically defined media CSFM – complete serum free medium PF – protein free media


SF – serum free media SFM – serum free medium  Major Trends Impacting the Market stem cell research (including plans of major companies)cell culture-based vaccine Production and generic bipharmaceuticals  Profiles of Leading Suppliers and information about M&A activities in recent years The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with key industry officials, consultants, and government personnel. These sources were the primary basis in gathering information specifically relating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company and cell culture supply company representatives included marketing directors, division managers, and product representatives. All Kalorama reports advertise the single user price, which limits access to one user. We also feature department and global pricing for reports that will be utilized by more than one user at your company. Please ask your sales representative or select the correct license on our website. Table Of Contents CHAPTER ONE: EXECUTIVE SUMMARY Scope and Methodology Cells for Biopharmaceutical Production Bacteria and Yeasts Systems Animal Cell Systems Insect Cell Systems Cell Lines and Cell Banks Fermentors and Bioreactors Stirred-Tank Reactors Airlift Fermentors Packed Bed Reactors Hollow-Fiber Reactor Disposable Systems Fermentation Processes Batch and Fed-Batch Fermentation Suspended vs. Anchored Cells Microencapsulation Cell Culture Environmen Functions and Components of Basal Media pH and Osmotic Pressure Energy Sources Nutrients Cell Culture Media Lysogeny broth (LB) Classical Media Serum-free Media


Protein-Free Media Chemically Defined Media Specialty Media Sera Reagents Shifting Towards Non-animal Derived Reagents Addressing Reagent Safety Issues World Cell Culture Market Cell Culture Market and Forecast Current and Future Trends CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT Growing Demand for Biopharmaceuticals Biopharmaceutical Market Development of Biopharmaceuticals Biopharmaceutical Product Approvals Biopharmaceutical Growth Increases Demand for Cell Culture Products A Brief History of Biotechnology Science of Genetic Manipulation From Petri Dish to Biopharmaceutical Upstream Bioprocessing: Cell Culture Expression Systems Cells for Biopharmaceutical Production Bacteria and Yeasts Systems Animal Cell System Insect Cell Systems Advantages/Disadvantages of Cell Culture Systems Cell Lines and Cell Banks Biopharmaceuticals Produced from Cell Culture Cell Culture Practices and Regulatory Guidelines Validation of Facilities Maintaining Sterilization Standards CHAPTER THREE: CELL CULTURE TECHNOLOGY Introduction and Overview Milestones in Cell Culture Development Cell Lines for Bioproduction Predominant Cell Lines Chinese Hamster Ovary (CHO) SP / , and NS HEK and PER. C Fermentors and Bioreactors Types of Bioreactors/Fermentors Stirred-tank Reactors Airlift Fermentors Packed Bed Reactors Hollow-fiber Reactor Disposable Systems Fermentation Processes


Batch and Fed-Batch Fermentation Suspended vs. Anchored Cells Microencapsulation Cell Culture Environment Functions and Components of Basal Media pH and Osmotic Pressure Energy Sources Nutrients Cell Culture Media Types of Media Lysogeny broth (LB) Classical Media Serum-free Media Protein-free Media Chemically Defined Media Specialty Media Sera Sources of Sera Bovine Serum Safety Issues and Regulations Shift to Serum-free Media Reagents Major Types of Biologic Reagents Amino Acids Growth Factors and Cytokines Albumin Transferrin Thrombin Growth Supplements Protease Inhibitor Attachment Factors Shifting Towards Non-animal Derived Reagents Addressing Reagent Safety Issues CHAPTER FOUR: CELL CULTURE MARKET; CURRENT AND FUTURE TRENDS Overview Cell Culture Market Market Drivers Cell Culture Market Forecast Segment Analysis Media Sera Reagents Cell Culture Suppliers’ Market Share current and future trends Shift to Serum-free and Animal Product-free Media Concomitant Need for Animal-derived Media Cell Culture-based Vaccine Production Cell Culture-based Vaccine on Market Stem Cell Research Driving Cell Culture Market


Life Technologies Sigma-Aldrich ThermoFisher Scientific Lonza Bioscience EMD Millipore BD Bioscience Impact of Generic Biopharmaceuticals on Cell Culture Market Impact of Transgenic Animals and Plants on the Cell Culture Market CHAPTER FIVE: COMPANY PROFILES Advanced Biotechnologies, Inc. History and Lines of Business Cell Culture Products and Services Affymetrix, Inc. History and Lines of Business Cell Culture Products Molecular Biology Enzymes Molecular Biology Kits and Reagents Purification Biochemicals PCR Reagents Financial Information AMRESCO, Inc. History and Lines of Business Cell Culture Products Analytical Biological Services Inc. History and Lines of Business Cell Culture Products Mammalian Cell Culture Cell in Microtiter Plates for HTS Primary Cultures Insect Cell Culture Athena Enzyme Services History and Lines of Buiness Cell Culture Products Atlanta Biologicals, Inc. History and Lines of Business Cell Culture Products Animal & Human Sera Media & Balanced Salts Supplements & Reagents Cell Separation Products BD Biosciences History and Lines of Business Cell Culture Products Financial Information BIOCHROM AG History and Lines of Business Cell Culture Products


Bioreclamation Inc History and Lines of Business Cell Culture Products Cell Essentials, Inc. History and Lines of Business Cell Culture Products CellGenix Technologie Transfer GmbH History and Lines of Business Cell Culture Products and Services ClonTech Laboratories, inc. History and Lines of Business Cell Culture Products EMD Millipore History and Lines of Business Cell Culture Products Financial Information Gemini Bio-Products History and Lines of Business Cell Culture Products Cell Culture Sera Human Sera Specialized Media Irvine Scientific History and Lines of Business Cell Culture Products Cell Culture Products Custom Media Program Express Media Service R&D Development Program Invitria History and Lines of Business Cell Culture Products Cellastim Lacromin Optiferrin ITSE Animal-free Zap-CHO Zap-Hybridoma J R Scientific, Inc. History and Development Cell Culture Products Life Technologies Corporation History and Lines of Business Cell Culture Products Financial Information Lonza Bioscience History and Lines of Business Cell Culture Products and Services Culture Media Development


Cell Line Creation Cell Banking Financial Information Mediatech, Inc. History and Lines of Business Cell Culture Products MP Biomedicals History and Lines of Business Cell Culture Products Novozymes Biopharma US Inc History and Lines of Business Cell Culture Products rAlbumin Albucult Albufuse and Albufuse Flex Yeast Expression Technology Growth Factors Bacillus-derived Hyaluronic Acid Purification Ligands Recombinant Tansferrin PAA labORATORIES, Inc. History and Lines of Business Cell Culture Products PromoCell GmbH History and Lines of Business Cell Culture Products Quality Biological, Inc. History and Lines of Business Cell Culture Products R&D Systems, Inc. History and Lines of Business Cell Culture Products SAFC Biosciences History and Lines of Business Cell Culture Products Financial Information SBH Sciences History and Lines of Business Cell Culture Products Selexis SA History and Lines of Business Cell Culture Products SeraCare Life Sciences, Inc. History and Lines of Business Cell Culture Products Financial Information Sera Laboratories International Ltd History and Lines of Business Cell Culture Products


Product Categories Thermo Fisher Scientific, Inc. History and Lines of Business Cell Culture Products Financial Information Wisent, Inc. History and Lines of Business Cell Culture Products LIST OF EXHIBITS CHAPTER ONE: EXECUTIVE SUMMARY Exhibit 1-1 : Worldwide Cell Culture Market Exhibit 1-2 : Cell Culture World Market Share, by Region, 2010 CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT Exhibit 2-1 : Biopharmaceutical Development by General Indication and Development Activity (Phase III through Registration) Exhibit 2-2 : Biopharmaceuticals Approved in the US and/or the EU, 2010 Exhibit 2-3 : Approximate times from Introduced Gene to Protein Production at Useable Levels Exhibit 2-4 : Disadvantages/Advantages of Cell Culture Systems Exhibit 2-5 : Selected Biopharmaceuticals Produced from Bacteria, Yeast and Mammalian Cells CHAPTER THREE: CELL CULTURE TECHNOLOGY Exhibit 3-1 : Selected Products/Companies Offering Alternatives to Animal Sera Products for Hybridoma, Myeloma and CHO cell lines CHAPTER FOUR: CELL CULTURE MARKET; CURRENT AND FUTURE TRENDS Exhibit 4-1 : Worldwide Cell Culture Market, 2005-2015 Exhibit 4-2 : Cell Culture World Market Share, by Region, 2010 Exhibit 4-3 : World Cell Culture Market by Segment: Media, Sera and Reagents, 2005-2015 Exhibit 4-4 : Cell Culture Market Share, 2010 Exhibit 4-5 : Selected Transgenic Products in Clinical Trials Latest Market Research Reports:     

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ReportsnReports – Cell Culture: The World Market for Media, Sera and Reagents, 3rd. Edition  

Several cell culture-derived biopharmaceutical drugs were launched in the US and European markets in 2010. Biopharmaceuticals (recombinant p...

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