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The Global Blood Industry Published on June 2013

Report Summary STUDY GOAL AND OBJECTIVES The goal of this study on the blood industry is to describe and analyze the current markets for blood products, blood tests and blood processing equipment, as well as present important new developments affecting every aspect of this industry. In addition, the report provides, an analysis of market value forecasted through 2017 in constant dollars and participating company profiles. The study covers the major aspects of blood and plasma collection/transfusion including autologous donations, apheresis, fractionation, blood salvage and stem cells. The major plasma products such as coagulation factors, human serum albumin, and immunoglobulins are analyzed as well. The scope and character of the blood-testing segment is constantly changing so the impact of new products, technologies and equipment are analyzed. The study also covers federal regulation of the blood supply, blood system management, an analysis of the companies serving these markets, the international developments in blood banking and related areas, as well as research and patents that will affect the future of the blood industry. REASONS FOR DOING THIS STUDY A safe and adequate blood supply is essential to the practice of modern medicine. The U.S. blood industry is safe and blood supplies are usually adequate. New advances, particularly in the area of automation, have enhanced both safety and blood availability and it is the purpose of this study to detail these advances and their impact on the blood industry. Since BCC first looked at this market in 2001 there have been mergers, consolidations and acquisitions among the major companies as well as advances in technology that have allowed for obtaining more red blood cells from fewer donors. Technological advances have also allowed for greater economies and increased safety in the blood supply. CONTRIBUTION OF THE STUDY AND INTENDED AUDIENCE With its broad scope and in-depth analyses, this study will prove to be a valuable resource to anyone involved with or interested in the blood industry. This study will provide information on these areas: ' Structure and current market size of the blood industry with forecasts through 2017. ' Blood usage patterns and trends. ' Government and regulatory controls. ' Impact of disease on the blood industry. ' Major players and their relative market share and market potential. ' Current product lines and examination of newly emerging products and technologies. ' State of the international markets for various blood and blood-related products. ' Newly issued patents relating to blood and disease screening technologies. Since the study provides business and technical information of a timely nature, it will prove valuable to a variety of readers, including industry executives, managers and planners, researchers, industry analysts, and investors. The projections, forecasts, and trend analyses found in this report provide readers with the necessary data and information for careful decision-making.

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>> Get this Report Now by email! SCOPE AND FORMAT This study encompasses the wide range of products and services that comprise the global blood industry marketplace. The U.S. market, the largest in the world, provides the primary market breakdown with supplemental information given for other select regions. The focus of the report is two-fold: first, blood for donation and the components and derived products from this blood and plasma, and second, products used to provide and support collection, processing and transfusion. Excluded from consideration are the clinical blood tests for diseases and conditions not involved in managing blood and plasma products. METHODOLOGY AND INFORMATION SOURCES Data for this study were collected using both primary and secondary data research techniques. Literature searches of various sources including scientific, medical and business publications and databases were conducted. On-line databases and government sources were consulted as well. Extensive interviews with industry personnel, scientists, professional and trade organizations, government agency personnel, observers, scientists, and industry professionals were conducted. Data collected were analyzed to determine specific findings and forecasts. Once these forecasts were obtained they were validated with industry experts. Since some segments of this report are not routinely measured, BCC derived estimates from a variety of analogous sources. Whenever market estimates are derived they are fully noted. It should be pointed out that while many factors were considered in constructing different models, the projections are ultimately speculative. As a composite of the opinions and assessments of interviewees, the author, other analysts, and secondary sources, these projections represent something of a consensus. However, all recognize that the relative importance of selected factors could change at any time with new technologies and new products, and thus change the direction of the market projections. All forecasts use constant 2013 dollars. ANALYST'S CREDENTIALS Melissa Elder is an experienced healthcare market analyst, specializing in prescription and over-the-counter pharmaceuticals, medical devices and emerging healthcare technologies. Ms. Elder has over 20 years of experience in the healthcare industry, specializing in market research for the past 15 years. This experience has given her substantial insight into pharmaceutical market analysis. Her work in the medical community, including emergency room medical training and healthcare information system coordination, has enhanced her ability to provide insight into many healthcare markets. REPORT HIGHLIGHTS This report provides: ' An overview of the structure and current market size of the global blood industry, including coverage of such segments as blood and plasma collection, blood and plasma processing, blood therapeutic products, plasma therapeutic products, and emerging trends and products ' Analyses of global market trends, with data from 2011 and 2012, and projections of compound annual growth rates (CAGRs) through 2017 ' Blood usage patterns and trends ' Government and regulatory controls ' The impact of diseases on the blood industry ' Current product lines and examination of newly emerging products and technologies ' Newly issued patents relating to blood therapeutics, processing, screening, and collection technologies ' Comprehensive company profiles of major players in the industry.

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Table of Content TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOAL AND OBJECTIVES 2 REASONS FOR DOING THIS STUDY 2 CONTRIBUTION OF THE STUDY AND INTENDED AUDIENCE 2 SCOPE AND FORMAT 3 METHODOLOGY AND INFORMATION SOURCES 3 ANALYST'S CREDENTIALS 3 RELATED BCC REPORTS 4 BCC ON-LINE SERVICES 4 DISCLAIMER 4 CHAPTER 2 SUMMARY 6 MAJOR FINDINGS 6 SUMMARY TABLE GLOBAL MARKET FOR BLOOD PRODUCTS, THROUGH 2017 ($ MILLIONS) 7 SUMMARY FIGURE GLOBAL MARKET FOR BLOOD PRODUCTS, 2010-2017 ($ MILLIONS) 7 CHAPTER 3 OVERVIEW 9 THE BLOOD INDUSTRY 9 BLOOD INDUSTRY TERMS AND ABBREVIATIONS[1] 9 HISTORY OF THE BLOOD INDUSTRY 12 TABLE 1 TIMELINE OF THE BLOOD INDUSTRY 13 BLOOD AND ITS COMPONENTS 14 PLASMA 15 TABLE 2 COMPOSITION OF BLOOD 16 CELLULAR ELEMENTS 16 Red and White Blood Cells 16 Platelets 17 IMMUNOGLOBULIN PRODUCTS 17 THE DANGERS OF TRANSFUSED BLOOD 17 TRANSFUSION ASSOCIATED RISKS 18 Diseases Contracted from Blood Transfusions and Related Identification Testing 18 TABLE 3 MAJOR DISEASES CONTRACTED FROM BLOOD TRANSFUSIONS, U.S. ANALYSIS 18 HIV/AIDS 20 TABLE 4 CBER LICENSED HIV DONOR SCREENING TESTS (LAST UPDATED JANUARY 17, 2013) 21

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>> Get this Report Now by email! Hepatitis A 22 Hepatitis B 22 TABLE 5 CBER LICENSED SCREENING TESTS FOR HEPATITIS B (LAST UPDATED JANUARY 17, 2013) 23 Hepatitis C 23 TABLE 6 CBER LICENSED SCREENING TESTS FOR HEPATITIS C (LAST UPDATED JANUARY 17, 2013) 24 Hepatitis D 24 Hepatitis E 25 Human T-Cell Lymphotropic Virus-(HTLV-I, -II) 25 TABLE 7 CBER LICENSED SCREENING TESTS FOR HTLV-I AND HTLV-II (LAST UPDATED JANUARY 17, 2013) 26 Cytomegalovirus 26 TABLE 8 CBER LICENSED SCREENING TESTS FOR CMV (LAST UPDATED JANUARY 17, 2013) 27 West Nile Virus 27 TABLE 9 CBER LICENSED SCREENING TESTS FOR WEST NILE (LAST UPDATED JANUARY 17, 2013) 28 "Mad Cow Disease"-Creutzfeldt-Jakob Disease (CJD) 28 Syphilis 29 TABLE 10 CBER LICENSED SCREENING TESTS FOR SYPHILIS (LAST UPDATED JANUARY 17, 2013) 29 Chagas Disease 29 Chlamydia Trachomatis 31 TABLE 11 CBER LICENSED SCREENING TESTS FOR CHLAMYDIA (LAST UPDATED JANUARY 17, 2013) 32 Neisseria Gonorrhea 32 TABLE 12 CBER LICENSED SCREENING TESTS FOR GONORRHEA (LAST UPDATED JANUARY 17, 2013) 33 EFFORTS TO CREATE A VIRUS-FREE BLOOD SUPPLY 33 Plasma Treatments 33 Trinitrobutyl Phosphate and Sodium Cholate 33 Methylene Blue-treated Plasma 33 Amatosalen HCL-Treated Plasma 34 Platelet Treatments 34 RBCs 35 NEGATIVE REACTIONS FROM BLOOD TRANSFUSIONS 35 BLOOD/PLASMA COMPONENT RISKS 36 CHAPTER 4 THE BLOOD MANAGEMENT SYSTEM- BLOOD COLLECTION, PROCESSING AND USE 39 BLOOD COLLECTION 39 TYPES OF BLOOD ESTABLISHMENTS AND BLOOD FACILITIES 39 Major Facilities 39 Auxiliary Facilities 40 Transfusion Services 40 ORGANIZATIONS COLLECTING BLOOD 40

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>> Get this Report Now by email! TABLE 13 FDA REGISTERED BLOOD ESTABLISHMENTS BY STATE* AND POSSESSION 41 For-Profit Blood Collection 43 Plasma Collection Centers 43 National Donor Deferral Registry 43 Non-Profit Blood Collection 43 American Red Cross 44 Community Blood Banks 44 Hospitals 44 Other Blood Collection Sites 45 BLOOD DONATION DEMOGRAPHICS 45 Global Demographic Trends 45 TABLE 14 ESTIMATED GLOBAL POPULATION AND GROWTH RATE BY SELECTED AGE GROUP AND SELECTED YEARS, THROUGH 2030 (MILLIONS) 46 FIGURE 1 ESTIMATED GLOBAL POPULATION BY SELECTED AGE GROUP AND SELECTED YEARS, 2000-2030 (MILLIONS) 46 TABLE 15 GLOBAL POPULATION BY SELECTED COUNTRY, THROUGH 2015 (MILLIONS) 47 FIGURE 2 GLOBAL POPULATION BY SELECTED COUNTRY, 2010 AND 2015 (MILLIONS) 47 DONOR RECRUITMENT AND REGULATIONS 47 BLOOD SCREENING AND EVALUATION 48 METHODS FOR COLLECTING BLOOD FROM A DONOR 48 Manual Collection 48 Automated Collection 49 Plasmapheresis 49 Plateletpheresis 50 Leukopheresis 50 Red Blood Cell Apheresis 50 PLASMA COLLECTION 50 Commercial Nature of Plasmapheresis 51 Global Nature of the Plasma Industry 51 Plasma Fractionators 51 Distributors/Brokers 52 BLOOD TYPING AND TESTING FOR DISEASES 52 Blood Typing 52 TABLE 16 TESTS ROUTINELY PERFORMED ON BLOOD DONATIONS 53 TABLE 17 BLOOD TYPE ANTIGEN/ANTIBODY REACTIONS 54 Methods of Typing 54 Manual Blood Typing Methods 54 Slide/Tile Testing 54 Tube Testing 54 Microplate 55 Automated Blood Typing and Screening Methods 55 Blood Testing 55 Blood Storage 56 BLOOD PROCESSING 56 Preparation and Use of the Components 56

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>> Get this Report Now by email! Red Blood Cell Components 56 Platelets 56 Plasma 57 BLOOD TRANSFUSIONS 57 Transfusion in the U.S. 57 Testing before Transfusion 57 Manual Cross-Match Techniques 57 Major Cross-Match 57 Minor Cross-Match 58 Antibody Screen 58 Coombs Test 58 TYPES OF TRANSFUSIONS 58 Whole Blood 58 Packed Red Blood Cells 59 Platelets 59 Leukocytes 60 Fresh Frozen Plasma (FFP) 60 TABLE 18 SELECTED USES OF FFP 60 Cryoprecipitate 61 Coagulation Factors 61 TABLE 19 LISTING OF BLOOD PRODUCTS FOR THERAPEUTIC USE 61 Immune Serum Globulin/IMIG/IGIV 62 Factor VIII 62 Factor IX and Factor IX Complex 62 Factor VIIa 63 Fibrin/Thrombin 63 Therapeutic Apheresis 63 BLOOD MANAGEMENT ISSUES 63 AVAILABILITY ISSUES 63 BLOODLESS SURGERY 64 Bloodless Medicine and Surgery Hospital Directory 64 SAFETY ISSUES: RISK MANAGEMENT 71 TABLE 20 FACTORS TO REDUCE RISKS OF TRANSFUSION- ASSOCIATED DISEASES 71 Better Donor Screening 72 Better Viral Screening Tests 72 Get More Repeat Donors 72 Develop Better Viral Inactivation Processes 72 Selective Use of Blood Derivative Products 72 BLOOD TRANSFUSION FATALITIES 73 TABLE 21 TRANSFUSION-RELATED FATALITIES BY COMPLICATION, FY 2008-FY 2012 73 TABLE 22 FATALITIES NOT RELATED TO TRANSFUSION OR TRANSFUSION NOT RULED OUT, FY2008-FY2012 74 TABLE 23 POST-DONATION "NOT RULED OUT" FATALITY REPORTS BY DONATED PRODUCT, FY2008 THROUGH FY2012 74 CHAPTER 5 REGULATION OF THE BLOOD BUSINESS 76 REGULATION OF THE U.S. BLOOD BUSINESS 76

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>> Get this Report Now by email! TABLE 24 FEDERAL ORGANIZATIONS RESPONSIBLE FOR U.S. BLOOD SAFETY 76 STATUTORY AUTHORITY OF THE FDA 77 Center for Biologics Evaluation and Research 77 chapter Office of Regulatory Affairs (ORA) 77 Office of Biologics, The Division of Blood and Blood Products 78 TABLE 25 FDA AUTHORITY IN REGULATING BLOOD BANKING AND BLOOD PRODUCTS 79 THE MAJOR REGULATIONS AND POLICY MATTERS CONCERNING THE U.S. BLOOD SUPPLY 79 The Clinical Laboratory Improvement Act of 1988 (CLIA) 79 The FDA'S Five Layers 80 Donor Screening 80 Blood Testing 80 Donor Deferral Lists 81 Quarantine 81 Problems and Deficiencies 81 The FDA Blood Action Plan 81 Team Biologics 81 Fuel, Phone Excise Taxes 82 HOW REGULATIONS GET IMPLEMENTED 82 Inspecting Blood Banks and Plasma Collection Facilities 82 TABLE 26 MAJOR AREAS OF CONCERN FOR INSPECTING BLOOD FACILITIES 83 OTHER ORGANIZATIONS INVOLVED IN BLOOD REGULATION 83 National Heart, Lung, and Blood Institute (NHLBI) 83 Blood Diseases and Resources Program 84 Occupational Safety and Health Administration (OSHA) 85 Health Care Financing Administration (HCFA) 85 The Department of Defense 85 State Regulatory Agencies 86 VOLUNTARY REGULATION BY PROFESSIONAL AND TRADE ASSOCIATIONS 86 American Association of Blood Banks 86 PPTA: Plasma Protein Therapeutics Association 87 America's Blood Centers (ABC) 88 THE EUROPEAN UNION (EU) BLOOD DIRECTIVE 88 The International Society for Blood Transfusion - ISBT 128 88 THE FUTURE OF BLOOD REGULATION 89 CHAPTER 6 THE GLOBAL BLOOD AND BLOOD PRODUCTS MARKET OVERVIEW 91 DRIVING FORCES OF THE INDUSTRY 91 FIGURE 3 VARIABLES INFLUENCING THE DYNAMICS OF DEMAND FOR BLOOD FOR TRANSFUSION 91 MARKET SUMMARY 92 FIGURE 4 BLOOD MARKET COST AND PRICING ANALYSIS 92 PRICING OF BLOOD 93 TABLE 27 ESTIMATED U.S. COST OF BLOOD COMPONENTS, THROUGH 2012 ($) 94 National Blood Exchange (NBE) 94 RBCs and Leuko-reduced RBCs 95

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>> Get this Report Now by email! Platelets 95 Random Donor Platelets 95 Fresh Frozen Plasma (FFP) 95 Cryoprecipitate 96 Washed Cells 96 Deglycerolized Cells 96 Granulocytes 96 Gamma-Irradiated Blood 96 PATTERNS OF TRANSFUSION PROCEDURES 96 Leuko-reduction 97 Impact of Autologous Donations 97 Types of Autologous Transfusions 98 Risks of PABD 99 CHAPTER 7 BLOOD INDUSTRY ANALYSIS 101 GLOBAL MARKETS FOR WHOLE BLOOD COLLECTIONS 101 LOCAL EFFORTS AND IMPROVEMENTS 101 Africa 102 South Africa 102 Asia 103 China 103 India 103 Japan 104 Pakistan 104 Islamic Republic of Iran 104 Sri Lanka 104 Vietnam 104 Europe 105 Britain 105 France 105 Germany 105 Russia 105 Netherlands 106 Switzerland 106 Turkey 106 North America and Caribbean 106 Canada 106 Haiti 107 Oceana Region 107 Australia 107 New Zealand 107 Cook Islands 107 South America 107 Argentina 107 Bolivia 108 Brazil 108 U.S. BLOOD COLLECTION DATA 108

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>> Get this Report Now by email! TABLE 28 U.S. BLOOD COLLECTION AND TRANSFUSION DATA, THROUGH 2017 (MILLION UNITS/PINTS) 109 FIGURE 5 U.S. BLOOD COLLECTION AND TRANSFUSION DATA, 2007-2017 (MILLION UNITS/PINTS) 109 GLOBAL MARKETS FOR SOURCE PLASMA COLLECTIONS 110 TABLE 29 PLASMA COLLECTIONS FOR THE U.S. AND OTHER MARKETS, THROUGH 2017 ($ BILLIONS, MILLIONS ML) 110 FIGURE 6 PLASMA COLLECTIONS FOR THE U.S. AND OTHER MARKETS, 2010-2017 (MILLION ML) 110 GLOBAL MARKETS FOR BLOOD THERAPEUTICS 111 TABLE 30 PLASMA PRODUCTS MARKET FOR THE U.S. AND OTHER MARKETS,* THROUGH 2017 ($ BILLIONS) 111 FIGURE 7 PLASMA PRODUCTS MARKET FOR THE U.S. AND OTHER MARKETS,* 2010'2017 ($ BILLIONS) 111 PLASMA AND PLASMA-DERIVED PRODUCTS 112 Plasma Therapeutic Products 112 TABLE 31 GLOBAL MARKET SIZE OF PLASMA THERAPEUTIC DERIVATIVES BY TYPE, THROUGH 2017 ($ MILLIONS) 112 FIGURE 8 GLOBAL MARKET SIZE OF PLASMA THERAPEUTIC DERIVATIVES BY TYPE, 2010-2017 (MILLIONS) 112 ALBUMIN AND PLASMA PROTEIN FRACTION (PPF) 113 FDA Notification Regarding Safety of Albumin Administration in the Critically Ill 114 Recombinant Human Albumin 114 Albumin Market Dynamics 114 TABLE 32 CURRENTLY MARKETED ALBUMIN AND PLASMA PROTEIN FRACTION (PPF) PRODUCTS (%) 115 Albumin and PPF Market Size 116 TABLE 33 GLOBAL MARKET FOR HUMAN SERUM ALBUMIN AND PPF BY REGION, THROUGH 2017 ($ MILLIONS) 116 FIGURE 9 GLOBAL MARKET FOR HUMAN SERUM ALBUMIN AND PPF BY REGION, 2010-2017 (MILLIONS) 116 Albumin and PPF Market Trends 117 CLOTTING FACTORS 118 TABLE 34 EXAMPLES OF COMMON BLOOD CLOTTING FACTORS 118 Hemophilia 119 TABLE 35 WORLDWIDE AND U.S. HEMOPHILIA STATISTICS, 2012 ESTIMATES 120 Market Demand and Market Size 120 TABLE 36 GLOBAL MARKET FOR PLASMA-DERIVED AND RECOMBINANT CLOTTING FACTORS, THROUGH 2017 (REVENUES IN $ MILLIONS) 120 FIGURE 10 GLOBAL MARKET FOR PLASMA-DERIVED AND RECOMBINANT CLOTTING FACTORS, 2010-2017 ($ MILLIONS) 121 TABLE 37 GLOBAL MARKET FOR PLASMA-DERIVED AND RECOMBINANT CLOTTING FACTORS BY REGION, THROUGH 2017 ($ MILLIONS) 121 FIGURE 11 GLOBAL MARKET FOR PLASMA-DERIVED AND RECOMBINANT CLOTTING FACTORS BY REGION, 2010-2017 (MILLIONS) 121 Factor VIII 122 TABLE 38 FDA APPROVED FACTOR VIII PRODUCTS 122

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>> Get this Report Now by email! TABLE 39 GLOBAL MARKET SHARE OF FACTOR VIII COMPANIES, 2012 125 FIGURE 12 GLOBAL MARKET SHARE OF FACTOR VIII COMPANIES, 2012 (%) 125 FIGURE 13 GLOBAL MARKET SHARE OF FACTOR VIII BY HUMAN AND RECOMBINANT PRODUCTS, 2012 (%) 125 Factor IX 126 TABLE 40 FDA APPROVED FACTOR IX PRODUCTS 126 TABLE 41 GLOBAL MARKET SHARE OF FACTOR IX COMPANIES, 2012 (%/MILLIONS) 127 FIGURE 14 GLOBAL MARKET SHARE OF FACTOR IX COMPANIES, 2012 (%) 127 Factor VIIa 127 Biosimilar Factor VIIa Development 128 TABLE 42 FDA APPROVED FACTOR VII PRODUCTS 128 TABLE 43 GLOBAL MARKET SHARE OF FACTOR IX COMPANIES, 20121 (PERCENT/MILLIONS) 129 FIGURE 15 GLOBAL MARKET SHARE OF FACTOR IX COMPANIES, 2012 (%) 129 Prothrombin Complex Concentrates 129 TABLE 44 FDA APPROVED PROTHROMBIN COMPLEX CONCENTRATE PRODUCTS 130 IMMUNOGLOBULINS 130 IVIG 131 TABLE 45 SELECTED CONDITIONS TREATED BY IVIG 131 TABLE 46 FDA APPROVED IMMUNOGLOBULINS 132 Hyperimmunes 133 TABLE 47 FDA APPROVED HYPERIMMUNE IMMUNOGLOBULINS 133 Other 135 IMIG 135 Immunoglobulin Market Size 135 TABLE 48 GLOBAL MARKET FOR IMMUNOGLOBULINS, THROUGH 2017 ($ MILLIONS) 136 FIGURE 16 GLOBAL MARKET FOR IMMUNOGLOBULINS, 2010-2017 (MILLIONS) 136 TABLE 49 GLOBAL MARKET FOR IMMUNOGLOBULINS BY REGION, THROUGH 2017 ($ MILLIONS) 136 FIGURE 17 GLOBAL MARKET FOR IMMUNOGLOBULINS BY REGION, THROUGH 2017 ($ MILLIONS) 137 RSV 137 CMV Immunoglobulin 137 Hepatitis B Immune Globulin 138 Rho(D) Immunoglobulin 138 Tetanus Immunoglobulin (TIG) 138 Rabies Immunoglobulin 138 Varicella Immunoglobulin 139 Vaccinia Immune Globulin Intravenous (VIG) 139 Alpha-1-Proteinase Inhibitor 139 FIBRIN SEALANTS AND THROMBIN 140 TABLE 50 GLOBAL MARKET FOR FIBRIN SEALANTS AND THROMBIN, THROUGH 2017 ($ MILLIONS) 140 FIGURE 18 GLOBAL MARKET FOR FIBRIN SEALANTS AND THROMBIN, 2010-2017 ($ MILLIONS) 141 TABLE 51 GLOBAL MARKET FOR FIBRIN SEALANTS AND THROMBIN BY REGION, THROUGH 2017 ($ MILLIONS) 141 FIGURE 19 GLOBAL MARKET FOR FIBRIN SEALANTS AND THROMBIN BY REGION,

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>> Get this Report Now by email! 2010-2017 ($ MILLIONS) 142 ANTITHROMBIN III 142 TABLE 52 GLOBAL MARKET FOR ANTITHROMBIN, THROUGH 2017 ($ MILLIONS) 143 FIGURE 20 GLOBAL MARKET FOR ANTITHROMBIN, 2010-2017 ($ MILLIONS) 143 TABLE 53 GLOBAL MARKET FOR ANTITHROMBIN BY REGION, THROUGH 2017 ($ MILLIONS) 143 FIGURE 21 GLOBAL MARKET FOR ANTITHROMBIN BY REGION, 2010-2017 ($ MILLIONS) 143 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS 144 TABLE 54 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS, THROUGH 2017 ($ MILLIONS) 144 FIGURE 22 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS, 2010-2017 ($ MILLIONS) 144 TABLE 55 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS, THROUGH 2017 ($ MILLIONS) 146 FIGURE 23 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS, 2010-2017 ($ MILLIONS) 146 TYPES OF TESTING 146 POLYMERASE CHAIN REACTION (PCR) AMPLIFICATION 147 TABLE 56 SELECTED PCR DONOR SCREENING TESTS 147 NUCLEIC ACID AMPLIFICATION TEST (NAT) 147 TABLE 57 SELECTED NAT DONOR SCREENING TESTS 148 IMMUNOASSAY 148 TABLE 58 SELECTED IMMUNOASSAY DONOR SCREENING TESTS 149 MARKET SIZE BLOOD TESTING PRODUCTS FOR DONOR SCREENING 150 TABLE 59 THE GLOBAL BLOOD DONOR SCREENING TESTING MARKET BY TYPE OF TESTS, THROUGH 2017 ($ MILLIONS) 150 FIGURE 24 GLOBAL BLOOD DONOR SCREENING TESTING MARKET BY TYPE, 2010-2017 ($ MILLIONS) 150 MARKET PARTICIPANTS DONOR SCREENING PRODUCTS 151 TABLE 60 SELECTED SUPPLIERS: MAJOR DONOR SCREENING TEST AREAS 151 BLOOD TYPING 152 MARKET SIZE 0F BLOOD TYPING 152 TABLE 61 THE GLOBAL MARKET FOR BLOOD TYPING INSTRUMENTS AND SUPPLIES BY TYPE, THROUGH 2017 ($ MILLIONS) 153 FIGURE 25 THE GLOBAL MARKET FOR BLOOD TYPING INSTRUMENTS AND SUPPLIES BY TYPE, 2010-2017 ($ MILLIONS) 153 MARKET STRUCTURE AND PARTICIPANTS 153 Manual Typing Methods 154 Automated Blood Typing 154 Immucor 154 Ortho 155 Olympus 155 GLOBAL MARKETS FOR BLOOD PROCESSING EQUIPMENT AND ASSOCIATED PRODUCTS 156 TABLE 62 GLOBAL MARKET FOR BLOOD COLLECTION AND PROCESSING EQUIPMENT AND CONSUMABLES, THROUGH 2017 ($ MILLIONS) 156 FIGURE 26 GLOBAL MARKET FOR BLOOD COLLECTION AND PROCESSING

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>> Get this Report Now by email! EQUIPMENT AND CONSUMABLES, 2010-2017 ($ MILLIONS) 156 TABLE 63 GLOBAL MARKET FOR BLOOD AND PLASMA COLLECTION AND TRANSFUSION PRODUCTS, THROUGH 2017 ($ MILLIONS) 158 FIGURE 27 GLOBAL MARKET FOR BLOOD AND PLASMA COLLECTION AND TRANSFUSION PRODUCTS, 2010-2017 ($ MILLIONS) 158 COLLECTION PRODUCTS 158 TABLE 64 GLOBAL MARKET FOR COLLECTION PRODUCTS BY TYPE, THROUGH 2017 ($ MILLIONS) 159 FIGURE 28 GLOBAL MARKET FOR COLLECTION PRODUCTS BY TYPE, 2010-2017 ($ MILLIONS) 159 BLOOD AND PLASMA COLLECTION SUPPLIES 159 Plasma Collection Sets 160 Blood Bags 160 PLASMA AND BLOOD COLLECTION EQUIPMENT 160 Blood Salvage 161 Other Collection Equipment 161 MARKET PARTICIPANTS 161 Haemonetics 161 PCS2 161 Cymbal 161 MCS+ 8150 System 161 MCS+ 9000 System 162 Cell Saver Systems 162 OrthoPAT System 162 ACP 215 System 162 Fresenius Kabi/Fenwal, Inc. 162 Apheresis Collections 163 Autopheresis-C 163 Alyx Component Collection System 163 Amicus Separator 163 Aurora 163 Terumo BCT 163 TRANSFUSION PRODUCTS 164 TABLE 65 GLOBAL MARKET FOR TRANSFUSION PRODUCTS BY TYPE, THROUGH 2017 ($ MILLIONS) 164 FIGURE 29 GLOBAL MARKET FOR TRANSFUSION PRODUCTS BY TYPE, 2010-2017 ($ MILLIONS) 164 Transfusion SetsIn 165 Blood Filter Market 165 Transfusion Equipment 165 Accessories 165 CHAPTER 8 BLOOD RESEARCH AND DEVELOPMENT 167 DEDICATED BLOOD RESEARCH FACILITIES 167 JEROME H. HOLLAND LABORATORY (ARC) 167 NATIONAL BLOOD FOUNDATION (NBF) 167 CENTER FOR BLOOD RESEARCH (CBR) 167

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>> Get this Report Now by email! BLOOD SUBSTITUTES 169 FIBRIN SEALANT AND GLUE 170 ALBUMIN AND IVIG TREATMENT FOR ALZHEIMER'S DISEASE 170 THE VETERINARY BLOOD MARKET 170 TABLE 66 REGIONAL VETERINARY BLOOD BANKS 171 CHAPTER 9 CORPORATE PROFILES 174 ABBOTT LABORATORIES 174 TABLE 67 ABBOTT'S SALES HISTORY, 2010-2012 ($ MILLIONS) 175 FIGURE 30 ABBOTT'S SALES HISTORY, 2010'2012 ($ MILLIONS) 175 BAXTER INTERNATIONAL, INC. 175 TABLE 68 BAXTER'S SALES HISTORY, 2010-2012 ($ MILLIONS) 176 FIGURE 31 BAXTER'S SALES HISTORY, 2010-2012 ($ MILLIONS) 176 BAYER AG 177 TABLE 69 BAYER'S SALES HISTORY, 2010-2012 ($ MILLIONS) 177 FIGURE 32 BAYER'S SALES HISTORY, 2010'2012 ($ MILLIONS) 177 BIO-RAD LABORATORIES, INC. 178 TABLE 70 BIO-RAD'S SALES HISTORY, 2010-2012 ($ MILLIONS) 179 FIGURE 33 BIO-RAD'S SALES HISTORY, 2010-2012 ($ MILLIONS) 179 CSL BEHRING 179 TABLE 71 CSL LIMITED'S SALES HISTORY, 2010-2012 ($ MILLIONS) 180 FIGURE 34 CSL LIMITED'S SALES HISTORY, 2010-2012 ($ MILLIONS) 180 ENTEGRION, INC. 180 GRIFOLS INTERNATIONAL, S.A./TALECRIS 181 TABLE 72 GRIFOLS' SALES HISTORY, 2010-2012 ($ MILLIONS) 182 FIGURE 35 GRIFOLS' SALES HISTORY, 2010-2012 ($ MILLIONS) 182 HAEMONETICS CORPORATION 183 TABLE 73 HAEMONETICS' SALES HISTORY, 2010-2012 ($ MILLIONS) 183 FIGURE 36 HAEMONETICS' SALES HISTORY 2010-2012 ($ MILLIONS) 183 HOLOGIC GEN-PROBE, INC. 184 TABLE 74 HOLOGIC'S SALES HISTORY, 2010-2012 ($ MILLIONS) 185 FIGURE 37 HOLOGIC'S SALES HISTORY 2010-2012 ($ MILLIONS) 185 NOVO NORDISK A/S 185 TABLE 75 NOVO NORDISK'S SALES HISTORY, 2010-2012 ($ MILLIONS) 186 FIGURE 38 NOVO NORDISK'S SALES HISTORY, 2010-2012 ($ MILLIONS) 186 OCTAPHARMA AG 187 TABLE 76 OCTAPHARMA'S SALES HISTORY, 2010-2012 ($ MILLIONS) 187 FIGURE 39 OCTAPHARMA'S SALES HISTORY, 2010-2012 ($ MILLIONS) 187 OMRIX BIOPHARMACEUTICALS, LTD. 188 TABLE 77 JOHNSON & JOHNSON'S SALES HISTORY, 2010-2012 ($ MILLIONS) 189 FIGURE 40 JOHNSON & JOHNSON'S SALES HISTORY, 2010-2012 ($ MILLIONS) 189 PFIZER, INC. 189 TABLE 78 PFIZER'S SALES HISTORY, 2010-2012 ($ MILLIONS) 190 FIGURE 41 PFIZER'S SALES HISTORY, 2010-2012 ($ MILLIONS) 190 ROCHE HOLDING LTD. 191 TABLE 79 ROCHE'S SALES HISTORY, 2010-2012 ($ MILLIONS) 191 FIGURE 42 ROCHE'S SALES HISTORY, 2010-2012 ($ MILLIONS) 191

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>> Get this Report Now by email! CHAPTER 10 TECHNOLOGY 194 CLASSICAL FRACTIONATION METHODS 194 COHN FRACTIONATION 194 ADVANCED FRACTIONATION METHODS 194 AMPLIFICATION METHODS 195 POLYMERASE CHAIN REACTION (PCR) 195 NUCLEIC AMPLIFICATION TECHNOLOGY (NAT) 195 IMMUNOASSAY 195 ENZYME IMMUNOASSAY (EIA) 195 Basic EIA 196 FIGURE 43 THE BASIC ENZYME IMMUNOASSAY (EIA) PROCESS 196 Alternate EIA Methods 196 Second-Antibody Precipitation Method 196 Double-Antibody Sandwich Method 197 Reverse-Sandwich Method 197 Reverse-Sandwich Inhibition Method 197 CHAPTER 11 PATENT ANALYSIS 199 PATENT ANALYSIS 199 TABLE 80 RECENTLY ISSUED PATENTS 200 TABLE 81 PATENTS BY COUNTRY OF ORIGIN 200 TABLE 82 RECENT PATENTS BY COMPANY 201 FRESENIUS MEDICAL CARE 202 ORTHO-CLINICAL DIAGNOSTICS, INC. 202 ABBOTT LABORATORIES 202 CERNER INNOVATION, INC. 202 CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES 203 GELANUS B.V. 203 MICRONICS, INC. 203 TERUMO KABUSHIKI KAISHA 204 PATENT EXAMPLES 204 RECENT PATENTS 204 Blood Transfusions : Six Patents 204 Blood Bank : Three Patents 207 Blood Donor : Two Patents 208 CHAPTER 12 APPENDIX A GUIDANCE FOR INDUSTRY RECOGNITION AND USE OF A STANDARD FOR THE UNIFORM LABELING OF BLOOD AND BLOOD COMPONENTS 211 INTRODUCTION 211 REPORTING REQUIREMENTS FOR LICENSED ESTABLISHMENTS 211 FDA LICENSED ESTABLISHMENTS 211 CHAPTER 13 APPENDIX B MAJOR SOURCES OF INFORMATION 245

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>> Get this Report Now by email! ABAXIS, INC. 245 ABBOTT LABORATORIES 245 ALBUMIN BIOSCIENCE 245 ALERE, INC. 245 ALFA SCIENTIFIC DESIGNS, INC. 245 AMERICAN RED CROSS 245 ARKRAY, INC. 246 ARYOGEN BIOPHARMA CO. 246 BAYER AG 246 BECKMAN COULTER, INC. 246 BECTON, DICKINSON, & CO. 246 BIOMERIEUX FRANCE 247 BIO-RAD LABORATORIES, INC. 247 BRISTOL-MYERS SQUIBB CO. 247 BTNX, INC. 247 CANGENE CORP. 247 CHARTER MEDICAL, LTD. 247 CHURCH & DWIGHT CO., INC. 248 CSL BEHRING 248 DANAHER CORP./RADIOMETER 248 ENTEGRION, INC. 248 FORA CARE, INC. 248 FUJIREBIO DIAGNOSTICS, INC. 248 GAMBRO INC. 249 G.E. HEALTHCARE LTD. 249 GLAXOSMITHKLINE PLC 249 GRIFOLS INTERNATIONAL, S.A. 249 GTC BIOTHERAPEUTICS/REVO BIOLOGICS 249 HAEMOTRONIC S.P.A. 250 HEMOCUE AB 250 HOLOGIC GEN-PROBE, INC. 250 IMMUCOR, INC. 250 INTERNATIONAL TECHNIDYNE CORP. 250 JANT PHARMACAL CORP. 250 JOHNSON & JOHNSON 251 KEDRION S.P.A 251 NATIONAL GENETICS INSTITUTE 251 NEXTRON MEDICAL TECHNOLOGIES 251 NIPRO DIAGNOSTICS, INC. 251 NOVA BIOMEDICAL CORP. 251 NOVARTIS AG 252 NOVO NORDISK A/S 252 NOVOZYMES BIOPHARMA, INC. 252 OCTAPHARMA AG 252 OMRIX BIOPHARMACEUTICALS, LTD. 252 OPK BIOTECH LLC 252 ORASURE TECHNOLOGIES, INC. 253 PALL CORP. 253

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>> Get this Report Now by email! PFIZER, INC. 253 PHAMATECH, INC. 253 PRINCETON BIOMEDITECH CORPORATION 253 QUEST DIAGNOSTICS 253 QUIDEL CORP. 254 RESPONSE BIOMEDICAL CORP. 254 ROCHE 254 SA SCIENTIFIC, LTD. 254 SEKISUI DIAGNOSTICS 254 SIEMENS MEDICAL SOLUTIONS 255 SPECTRAL DIAGNOSTICS 255 STANBIO LABORATORY 255 TRINITY BIOTECH PLC 255 ZEUS SCIENTIFIC, INC. 255 CHAPTER 14 APPENDIX C GLOBAL BLOOD DONATION SOURCES 257 AMERICAN ASSOCIATION OF BLOOD BANKS 257 AMERICAN FRIENDS OF MAGEN DAVID ADOM 257 ARMED SERVICES BLOOD PROGRAM 257 ASSOCIATION OF VOLUNTARY ITALIAN BLOOD DONORS 257 AUSTRALIAN RED CROSS 257 CANADIAN BLOOD SERVICES 258 HEARTLAND BLOOD CENTERS 258 HONG KONG RED CROSS 258 INDIAN RED CROSS SOCIETY 258 IRISH NATIONAL BLOOD CENTRE 258 JAPANESE RED CROSS SOCIETY 258 NATIONAL BLOOD SERVICE 259 NEW ZEALAND BLOOD SERVICE 259 SOUTH AFRICAN NATIONAL BLOOD SERVICE 259 WORLD HEALTH ORGANIZATION 259

LIST OF TABLES SUMMARY TABLE GLOBAL MARKET FOR BLOOD PRODUCTS, THROUGH 2017 ($ MILLIONS) 7 TABLE 1 TIMELINE OF THE BLOOD INDUSTRY 13 TABLE 2 COMPOSITION OF BLOOD 16 TABLE 3 MAJOR DISEASES CONTRACTED FROM BLOOD TRANSFUSIONS, U.S. ANALYSIS 18 TABLE 4 CBER LICENSED HIV DONOR SCREENING TESTS (LAST UPDATED JANUARY 17, 2013) 21 TABLE 5 CBER LICENSED SCREENING TESTS FOR HEPATITIS B (LAST UPDATED JANUARY 17, 2013) 23 TABLE 6 CBER LICENSED SCREENING TESTS FOR HEPATITIS C (LAST UPDATED

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>> Get this Report Now by email! JANUARY 17, 2013) 24 TABLE 7 CBER LICENSED SCREENING TESTS FOR HTLV-I AND HTLV-II (LAST UPDATED JANUARY 17, 2013) 26 TABLE 8 CBER LICENSED SCREENING TESTS FOR CMV (LAST UPDATED JANUARY 17, 2013) 27 TABLE 9 CBER LICENSED SCREENING TESTS FOR WEST NILE (LAST UPDATED JANUARY 17, 2013) 28 TABLE 10 CBER LICENSED SCREENING TESTS FOR SYPHILIS (LAST UPDATED JANUARY 17, 2013) 29 TABLE 11 CBER LICENSED SCREENING TESTS FOR CHLAMYDIA (LAST UPDATED JANUARY 17, 2013) 32 TABLE 12 CBER LICENSED SCREENING TESTS FOR GONORRHEA (LAST UPDATED JANUARY 17, 2013) 33 TABLE 13 FDA REGISTERED BLOOD ESTABLISHMENTS BY STATE* AND POSSESSION 41 TABLE 14 ESTIMATED GLOBAL POPULATION AND GROWTH RATE BY SELECTED AGE GROUP AND SELECTED YEARS, THROUGH 2030 (MILLIONS) 46 TABLE 15 GLOBAL POPULATION BY SELECTED COUNTRY, THROUGH 2015 (MILLIONS) 47 TABLE 16 TESTS ROUTINELY PERFORMED ON BLOOD DONATIONS 53 TABLE 17 BLOOD TYPE ANTIGEN/ANTIBODY REACTIONS 54 TABLE 18 SELECTED USES OF FFP 60 TABLE 19 LISTING OF BLOOD PRODUCTS FOR THERAPEUTIC USE 61 TABLE 20 FACTORS TO REDUCE RISKS OF TRANSFUSION- ASSOCIATED DISEASES 71 TABLE 21 TRANSFUSION-RELATED FATALITIES BY COMPLICATION, FY 2008-FY 2012 73 TABLE 22 FATALITIES NOT RELATED TO TRANSFUSION OR TRANSFUSION NOT RULED OUT, FY2008-FY2012 74 TABLE 23 POST-DONATION "NOT RULED OUT" FATALITY REPORTS BY DONATED PRODUCT, FY2008 THROUGH FY2012 74 TABLE 24 FEDERAL ORGANIZATIONS RESPONSIBLE FOR U.S. BLOOD SAFETY 76 TABLE 25 FDA AUTHORITY IN REGULATING BLOOD BANKING AND BLOOD PRODUCTS 79 TABLE 26 MAJOR AREAS OF CONCERN FOR INSPECTING BLOOD FACILITIES 83 TABLE 27 ESTIMATED U.S. COST OF BLOOD COMPONENTS, THROUGH 2012 ($) 94 TABLE 28 U.S. BLOOD COLLECTION AND TRANSFUSION DATA, THROUGH 2017 (MILLION UNITS/PINTS) 109 TABLE 29 PLASMA COLLECTIONS FOR THE U.S. AND OTHER MARKETS, THROUGH 2017 ($ BILLIONS, MILLIONS ML) 110 TABLE 30 PLASMA PRODUCTS MARKET FOR THE U.S. AND OTHER MARKETS,* THROUGH 2017 ($ BILLIONS) 111 TABLE 31 GLOBAL MARKET SIZE OF PLASMA THERAPEUTIC DERIVATIVES BY TYPE, THROUGH 2017 ($ MILLIONS) 112 TABLE 32 CURRENTLY MARKETED ALBUMIN AND PLASMA PROTEIN FRACTION (PPF) PRODUCTS (%) 115 TABLE 33 GLOBAL MARKET FOR HUMAN SERUM ALBUMIN AND PPF BY REGION, THROUGH 2017 ($ MILLIONS) 116 TABLE 34 EXAMPLES OF COMMON BLOOD CLOTTING FACTORS 118 TABLE 35 WORLDWIDE AND U.S. HEMOPHILIA STATISTICS, 2012 ESTIMATES 120 TABLE 36 GLOBAL MARKET FOR PLASMA-DERIVED AND RECOMBINANT CLOTTING FACTORS, THROUGH 2017 (REVENUES IN $ MILLIONS) 120 TABLE 37 GLOBAL MARKET FOR PLASMA-DERIVED AND RECOMBINANT CLOTTING

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>> Get this Report Now by email! FACTORS BY REGION, THROUGH 2017 ($ MILLIONS) 121 TABLE 38 FDA APPROVED FACTOR VIII PRODUCTS 122 TABLE 39 GLOBAL MARKET SHARE OF FACTOR VIII COMPANIES, 2012 125 TABLE 40 FDA APPROVED FACTOR IX PRODUCTS 126 TABLE 41 GLOBAL MARKET SHARE OF FACTOR IX COMPANIES, 2012 (%/MILLIONS) 127 TABLE 42 FDA APPROVED FACTOR VII PRODUCTS 128 TABLE 43 GLOBAL MARKET SHARE OF FACTOR IX COMPANIES, 20121 (PERCENT/MILLIONS) 129 TABLE 44 FDA APPROVED PROTHROMBIN COMPLEX CONCENTRATE PRODUCTS 130 TABLE 45 SELECTED CONDITIONS TREATED BY IVIG 131 TABLE 46 FDA APPROVED IMMUNOGLOBULINS 132 TABLE 47 FDA APPROVED HYPERIMMUNE IMMUNOGLOBULINS 133 TABLE 48 GLOBAL MARKET FOR IMMUNOGLOBULINS, THROUGH 2017 ($ MILLIONS) 136 TABLE 49 GLOBAL MARKET FOR IMMUNOGLOBULINS BY REGION, THROUGH 2017 ($ MILLIONS) 136 TABLE 50 GLOBAL MARKET FOR FIBRIN SEALANTS AND THROMBIN, THROUGH 2017 ($ MILLIONS) 140 TABLE 51 GLOBAL MARKET FOR FIBRIN SEALANTS AND THROMBIN BY REGION, THROUGH 2017 ($ MILLIONS) 141 TABLE 52 GLOBAL MARKET FOR ANTITHROMBIN, THROUGH 2017 ($ MILLIONS) 143 TABLE 53 GLOBAL MARKET FOR ANTITHROMBIN BY REGION, THROUGH 2017 ($ MILLIONS) 143 TABLE 54 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS, THROUGH 2017 ($ MILLIONS) 144 TABLE 55 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS, THROUGH 2017 ($ MILLIONS) 146 TABLE 56 SELECTED PCR DONOR SCREENING TESTS 147 TABLE 57 SELECTED NAT DONOR SCREENING TESTS 148 TABLE 58 SELECTED IMMUNOASSAY DONOR SCREENING TESTS 149 TABLE 59 THE GLOBAL BLOOD DONOR SCREENING TESTING MARKET BY TYPE OF TESTS, THROUGH 2017 ($ MILLIONS) 150 TABLE 60 SELECTED SUPPLIERS: MAJOR DONOR SCREENING TEST AREAS 151 TABLE 61 THE GLOBAL MARKET FOR BLOOD TYPING INSTRUMENTS AND SUPPLIES BY TYPE, THROUGH 2017 ($ MILLIONS) 153 TABLE 62 GLOBAL MARKET FOR BLOOD COLLECTION AND PROCESSING EQUIPMENT AND CONSUMABLES, THROUGH 2017 ($ MILLIONS) 156 TABLE 63 GLOBAL MARKET FOR BLOOD AND PLASMA COLLECTION AND TRANSFUSION PRODUCTS, THROUGH 2017 ($ MILLIONS) 158 TABLE 64 GLOBAL MARKET FOR COLLECTION PRODUCTS BY TYPE, THROUGH 2017 ($ MILLIONS) 159 TABLE 65 GLOBAL MARKET FOR TRANSFUSION PRODUCTS BY TYPE, THROUGH 2017 ($ MILLIONS) 164 TABLE 66 REGIONAL VETERINARY BLOOD BANKS 171 TABLE 67 ABBOTT'S SALES HISTORY, 2010-2012 ($ MILLIONS) 175 TABLE 68 BAXTER'S SALES HISTORY, 2010-2012 ($ MILLIONS) 176 TABLE 69 BAYER'S SALES HISTORY, 2010-2012 ($ MILLIONS) 177 TABLE 70 BIO-RAD'S SALES HISTORY, 2010-2012 ($ MILLIONS) 179 TABLE 71 CSL LIMITED'S SALES HISTORY, 2010-2012 ($ MILLIONS) 180

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>> Get this Report Now by email! TABLE 72 GRIFOLS' SALES HISTORY, 2010-2012 ($ MILLIONS) 182 TABLE 73 HAEMONETICS' SALES HISTORY, 2010-2012 ($ MILLIONS) 183 TABLE 74 HOLOGIC'S SALES HISTORY, 2010-2012 ($ MILLIONS) 185 TABLE 75 NOVO NORDISK'S SALES HISTORY, 2010-2012 ($ MILLIONS) 186 TABLE 76 OCTAPHARMA'S SALES HISTORY, 2010-2012 ($ MILLIONS) 187 TABLE 77 JOHNSON & JOHNSON'S SALES HISTORY, 2010-2012 ($ MILLIONS) 189 TABLE 78 PFIZER'S SALES HISTORY, 2010-2012 ($ MILLIONS) 190 TABLE 79 ROCHE'S SALES HISTORY, 2010-2012 ($ MILLIONS) 191 TABLE 80 RECENTLY ISSUED PATENTS 200 TABLE 81 PATENTS BY COUNTRY OF ORIGIN 200 TABLE 82 RECENT PATENTS BY COMPANY 201

LIST OF FIGURES SUMMARY FIGURE GLOBAL MARKET FOR BLOOD PRODUCTS, 2010-2017 ($ MILLIONS) 7 FIGURE 1 ESTIMATED GLOBAL POPULATION BY SELECTED AGE GROUP AND SELECTED YEARS, 2000-2030 (MILLIONS) 46 FIGURE 2 GLOBAL POPULATION BY SELECTED COUNTRY, 2010 AND 2015 (MILLIONS) 47 FIGURE 3 VARIABLES INFLUENCING THE DYNAMICS OF DEMAND FOR BLOOD FOR TRANSFUSION 91 FIGURE 4 BLOOD MARKET COST AND PRICING ANALYSIS 92 FIGURE 5 U.S. BLOOD COLLECTION AND TRANSFUSION DATA, 2007-2017 (MILLION UNITS/PINTS) 109 FIGURE 6 PLASMA COLLECTIONS FOR THE U.S. AND OTHER MARKETS, 2010-2017 (MILLION ML) 110 FIGURE 7 PLASMA PRODUCTS MARKET FOR THE U.S. AND OTHER MARKETS,* 2010'2017 ($ BILLIONS) 111 FIGURE 8 GLOBAL MARKET SIZE OF PLASMA THERAPEUTIC DERIVATIVES BY TYPE, 2010-2017 (MILLIONS) 112 FIGURE 9 GLOBAL MARKET FOR HUMAN SERUM ALBUMIN AND PPF BY REGION, 2010-2017 (MILLIONS) 116 FIGURE 10 GLOBAL MARKET FOR PLASMA-DERIVED AND RECOMBINANT CLOTTING FACTORS, 2010-2017 ($ MILLIONS) 121 FIGURE 11 GLOBAL MARKET FOR PLASMA-DERIVED AND RECOMBINANT CLOTTING FACTORS BY REGION, 2010-2017 (MILLIONS) 121 FIGURE 12 GLOBAL MARKET SHARE OF FACTOR VIII COMPANIES, 2012 (%) 125 FIGURE 13 GLOBAL MARKET SHARE OF FACTOR VIII BY HUMAN AND RECOMBINANT PRODUCTS, 2012 (%) 125 FIGURE 14 GLOBAL MARKET SHARE OF FACTOR IX COMPANIES, 2012 (%) 127 FIGURE 15 GLOBAL MARKET SHARE OF FACTOR IX COMPANIES, 2012 (%) 129 FIGURE 16 GLOBAL MARKET FOR IMMUNOGLOBULINS, 2010-2017 (MILLIONS) 136 FIGURE 17 GLOBAL MARKET FOR IMMUNOGLOBULINS BY REGION, THROUGH 2017 ($ MILLIONS) 137 FIGURE 18 GLOBAL MARKET FOR FIBRIN SEALANTS AND THROMBIN, 2010-2017 ($ MILLIONS) 141

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>> Get this Report Now by email! FIGURE 19 GLOBAL MARKET FOR FIBRIN SEALANTS AND THROMBIN BY REGION, 2010-2017 ($ MILLIONS) 142 FIGURE 20 GLOBAL MARKET FOR ANTITHROMBIN, 2010-2017 ($ MILLIONS) 143 FIGURE 21 GLOBAL MARKET FOR ANTITHROMBIN BY REGION, 2010-2017 ($ MILLIONS) 143 FIGURE 22 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS, 2010-2017 ($ MILLIONS) 144 FIGURE 23 GLOBAL MARKETS FOR BLOOD TYPING AND SCREENING PRODUCTS, 2010-2017 ($ MILLIONS) 146 FIGURE 24 GLOBAL BLOOD DONOR SCREENING TESTING MARKET BY TYPE, 2010-2017 ($ MILLIONS) 150 FIGURE 25 THE GLOBAL MARKET FOR BLOOD TYPING INSTRUMENTS AND SUPPLIES BY TYPE, 2010-2017 ($ MILLIONS) 153 FIGURE 26 GLOBAL MARKET FOR BLOOD COLLECTION AND PROCESSING EQUIPMENT AND CONSUMABLES, 2010-2017 ($ MILLIONS) 156 FIGURE 27 GLOBAL MARKET FOR BLOOD AND PLASMA COLLECTION AND TRANSFUSION PR

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