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Respiratory Partnering Terms and Agreements Published on September 2012

Report Summary Summary The Respiratory Partnering Terms and Agreements report provides comprehensive understanding and unprecedented access to the respiratory partnering deals and agreements entered into by the worlds leading healthcare companies Description The Respiratory Partnering Terms and Agreements report provides comprehensive understanding and unprecedented access to the respiratory partnering deals and agreements entered into by the worlds leading healthcare companies.

The report provides a detailed understanding and analysis of how and why companies enter respiratory partnering deals. The majority of deals are discovery or development stage whereby the licensee obtains a right or an option right to license the licensors respiratory technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes.

Understanding the flexibility of a prospective partner's negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered ' contract documents provide this insight where press releases do not.

This report contains over 1,000 links to online copies of actual respiratory deals and contract documents as submitted to the Securities Exchange Commission by companies and their partners. Contract documents provide the answers to numerous questions about a prospective partner's flexibility on a wide range of important issues, many of which will have a significant impact on each party's ability to derive value from the deal.

The initial chapters of this report provide an orientation of respiratory dealmaking and business activities. Chapter 1 provides an introduction to the report.

Chapter 2 provides an overview of the trends in respiratory dealmaking since 2007 covering trends by year, deal type, stage of development, technology type and therapeutic indication. In addition the chapter includes an analysis of financial deal terms by stage at signing covering headline value, upfront payment, milestone payments and royalty rates. Analysis includes median values and

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Chapter 3 provides a review of the leading respiratory deals since 2007. Deals are listed by headline value, signed by bigpharma, most active bigpharma, and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract.

Chapter 4 provides a comprehensive listing of the top 50 bigpharma companies with a brief summary followed by a comprehensive listing of respiratory deals, as well as contract documents available in the public domain. Where available, each deal title links via Weblink to an online version of the actual contract document, providing easy access to each contract document on demand.

Chapter 5 provides comprehensive access to all respiratory deals since 2007 where a deal contract is available, providing the user with direct access to contracts as filed with the SEC regulatory authorities. Each deal title links via Weblink to an online version of the deal record contract document, providing easy access to each contract document on demand.

Chapter 6 provides a comprehensive directory of all respiratory partnering deals signed and announced since 2007. The chapter is organized by specific respiratory therapy focus. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

In addition, a comprehensive appendix is provided with each report of all respiratory partnering deals signed and announced since 2007. The appendices are organized by company A-Z, stage of development at signing, deal type (collaborative R&D, co-promotion, licensing etc) and technology type. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

The report also includes numerous tables and figures that illustrate the trends and activities in respiratory partnering and dealmaking since 2007.

In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of respiratory technologies and products.

Benefits Respiratory Partnering Terms and Agreements provides the reader with the following key benefits:

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>> Get this Report Now by email! 'In-depth understanding of respiratory deal trends since 2007 'Access respiratory deal headline, upfront, milestone and royalty data 'Research hundreds of actual contracts between respiratory partner companies 'Comprehensive access to over 1,000 links to actual respiratory deals entered into by the world's biopharma companies 'Indepth review of respiratory deals entered into by the leading fifty bigpharma companies 'Benchmark the key deal terms companies have agreed in previous deals 'Identify key terms under which companies partner respiratory opportunities 'Uncover companies actively partnering respiratory opportunities

Table of Content Executive Summary

Chapter 1 ' Introduction

Chapter 2 ' Trends in central nervous system dealmaking

2.1. Introduction 2.2. Central nervous system partnering over the years 2.3. Bigpharma central nervous system dealmaking activity 2.4. Bigpharma not active in Central nervous system 2.5. Central nervous system partnering by deal type 2.6. Central nervous system partnering by industry sector 2.7. Central nervous system partnering by stage of development 2.8. Central nervous system partnering by technology type 2.9. Central nervous system partnering by CNS indication 2.10. Average deal terms for central nervous system 2.10.1 Central nervous system headline values

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Chapter 3 ' Leading central nervous system deals

3.1. Introduction 3.2. Top central nervous system deals by value 3.3. Top central nervous system deals involving bigpharma

Chapter 4 ' Bigpharma central nervous system deals

4.1. Introduction 4.2. How to use bigpharma partnering deals 4.3. Bigpharma central nervous system partnering company profiles Abbott Actavis Allergan Amgen Aspen Pharmacare Astellas AstraZeneca Baxter International Bayer

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Chapter 5 ' Central nervous system partnering contracts directory

5.1. Introduction 5.2. By deal type Asset purchase Assignment Bigpharma outlicensing Co-development Collaborative R&D Co-market

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Chapter 6 ' Central nervous system dealmaking by indication

6.1. Introduction 6.2. Deals by therapeutic indication Central Nervous System

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Chapter 7 ' Partnering resource center

7.1. Online partnering 7.2. Partnering events 7.3. Further reading on dealmaking

About Wildwood Ventures Current Partnering Current Agreements Recent titles from CurrentPartnering Order Form ' Reports Order Form ' Therapy Reports

Appendices

Appendix 1 ' Directory of central nervous system deals by company A-Z 2007-2012 Appendix 2 ' Directory of central nervous deals by deal type 2007-2012 Appendix 3 ' Directory of central nervous system deals by stage of development 2007-2012

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Table of figures

Figure 1: Central nervous system partnering since 2007 Figure 2: Bigpharma ' top 50 ' Central nervous system deals 2007 to 2012 Figure 3: Bigpharma Central nervous system deal frequency ' 2007 to 2012 Figure 4: Inactive bigpharma in CNS 2007-2012 Figure 5: Central nervous system partnering by deal type since 2007 Figure 6: Central nervous system partnering by industry sector since 2007 Figure 7: Central nervous system partnering by stage of development since 2007 Figure 8: Central nervous system partnering by technology type since 2007 Figure 9: Central nervous system partnering by CNS target since 2007 Figure 10: Central nervous system deals with a headline value Figure 11: Central nervous system deal headline value distribution, US$million ' discovery stage Figure 12: Central nervous system deal headline value distribution, US$million ' preclinical stage Figure 13: Central nervous system deal headline value distribution, US$million ' phase I stage Figure 14: Central nervous system deal headline value distribution, US$million ' phase II stage Figure 15: Central nervous system deal headline value distribution, US$million ' phase III stage Figure 16: Central nervous system deal headline value distribution, US$million ' regulatory stage Figure 17: Central nervous system deal headline value distribution, US$million ' marketed stage Figure 18: Summary median headline value by stage of development, 2007-2012 Figure 19 Central nervous system deals with upfront payment values Figure 20: Central nervous system deal upfront payment distribution, US$million ' discovery stage

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Figure 21: Central nervous system deal upfront payment distribution, US$million ' preclinical stage Figure 22: Central nervous system deal upfront payment distribution, US$million ' phase I stage Figure 23: Central nervous system deal upfront payment distribution, US$million ' phase II stage Figure 24: Central nervous system deal upfront payment distribution, US$million ' phase III stage Figure 25: Central nervous system deal upfront payment distribution, US$million ' regulatory stage Figure 26: Central nervous system deal upfront payment distribution, US$million ' marketed stage Figure 27: Summary median upfront payments by stage of development, 2007-2012 Figure 28: Central nervous system deals with milestone payments Figure 29: Central nervous system deal milestone distribution, US$million ' discovery stage Figure 30: Central nervous system deal milestone distribution, US$million ' preclinical stage Figure 31: Central nervous system deal milestone distribution, US$million ' phase I stage Figure 32: Central nervous system deal milestone distribution, US$million ' phase II stage Figure 33: Central nervous system deal milestone distribution, US$million ' phase III stage Figure 34: Central nervous system deal milestone distribution, US$million ' regulatory stage Figure 35: Central nervous system deal milestone distribution, US$million ' marketed stage Figure 36: Central nervous system deals with royalty rates, % Figure 37: Central nervous system deal royalty rate distribution, US$million ' discovery stage Figure 38: Central nervous system deal royalty rate distribution, US$million ' preclinical stage Figure 39: Central nervous system deal royalty rate distribution, US$million ' phase I stage Figure 40: Central nervous system deal royalty rate distribution, US$million ' phase II stage Figure 41: Central nervous system deal royalty rate distribution, US$million ' phase III stage Figure 42: Central nervous system deal royalty rate distribution, US$million ' regulatory stage Figure 44: Summary median royalty rate by stage of development, 2007-2012 Figure 45: Top central nervous system deals by value since 2007

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Figure 46: Top central nervous system deals signed by bigpharma value since 2007 Figure 47: Online partnering resources Figure 48: Forthcoming partnering events Executive Summary

Chapter 1 ' Introduction

Chapter 2 ' Trends in central nervous system dealmaking

2.1. Introduction 2.2. Central nervous system partnering over the years 2.3. Bigpharma central nervous system dealmaking activity 2.4. Bigpharma not active in Central nervous system 2.5. Central nervous system partnering by deal type 2.6. Central nervous system partnering by industry sector 2.7. Central nervous system partnering by stage of development 2.8. Central nervous system partnering by technology type 2.9. Central nervous system partnering by CNS indication 2.10. Average deal terms for central nervous system 2.10.1 Central nervous system headline values 2.10.2 Central nervous system upfront payments 2.10.3 Central nervous system milestone payments 2.10.4 Central nervous system royalty rates

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3.1. Introduction 3.2. Top central nervous system deals by value 3.3. Top central nervous system deals involving bigpharma

Chapter 4 ' Bigpharma central nervous system deals

4.1. Introduction 4.2. How to use bigpharma partnering deals 4.3. Bigpharma central nervous system partnering company profiles Abbott Actavis Allergan Amgen Aspen Pharmacare Astellas AstraZeneca Baxter International Bayer Bayer Healthcare Bayer Schering Pharma Biogen Idec Boehringer Ingelheim

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Chapter 5 ' Central nervous system partnering contracts directory

5.1. Introduction 5.2. By deal type Asset purchase Assignment Bigpharma outlicensing Co-development Collaborative R&D Co-market Contract service Co-promotion Development Distribution

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Chapter 6 ' Central nervous system dealmaking by indication

6.1. Introduction 6.2. Deals by therapeutic indication Central Nervous System Cerebral palsy Creutzfeldt Jakob disease Dizziness Epilepsy

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Chapter 7 ' Partnering resource center

7.1. Online partnering 7.2. Partnering events 7.3. Further reading on dealmaking

About Wildwood Ventures Current Partnering Current Agreements Recent titles from CurrentPartnering Order Form ' Reports Order Form ' Therapy Reports

Appendices

Appendix 1 ' Directory of central nervous system deals by company A-Z 2007-2012 Appendix 2 ' Directory of central nervous deals by deal type 2007-2012 Appendix 3 ' Directory of central nervous system deals by stage of development 2007-2012 Appendix 4 ' Directory of central nervous system deals by technology type 2007-2012 Appendix 5 ' Deal type definitions

Table of figures

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Figure 1: Central nervous system partnering since 2007 Figure 2: Bigpharma ' top 50 ' Central nervous system deals 2007 to 2012 Figure 3: Bigpharma Central nervous system deal frequency ' 2007 to 2012 Figure 4: Inactive bigpharma in CNS 2007-2012 Figure 5: Central nervous system partnering by deal type since 2007 Figure 6: Central nervous system partnering by industry sector since 2007 Figure 7: Central nervous system partnering by stage of development since 2007 Figure 8: Central nervous system partnering by technology type since 2007 Figure 9: Central nervous system partnering by CNS target since 2007 Figure 10: Central nervous system deals with a headline value Figure 11: Central nervous system deal headline value distribution, US$million ' discovery stage Figure 12: Central nervous system deal headline value distribution, US$million ' preclinical stage Figure 13: Central nervous system deal headline value distribution, US$million ' phase I stage Figure 14: Central nervous system deal headline value distribution, US$million ' phase II stage Figure 15: Central nervous system deal headline value distribution, US$million ' phase III stage Figure 16: Central nervous system deal headline value distribution, US$million ' regulatory stage Figure 17: Central nervous system deal headline value distribution, US$million ' marketed stage Figure 18: Summary median headline value by stage of development, 2007-2012 Figure 19 Central nervous system deals with upfront payment values Figure 20: Central nervous system deal upfront payment distribution, US$million ' discovery stage Figure 21: Central nervous system deal upfront payment distribution, US$million ' preclinical stage Figure 22: Central nervous system deal upfront payment distribution, US$million ' phase I stage Figure 23: Central nervous system deal upfront payment distribution, US$million ' phase II stage Figure 24: Central nervous system deal upfront payment distribution, US$million ' phase III stage

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Figure 25: Central nervous system deal upfront payment distribution, US$million ' regulatory stage Figure 26: Central nervous system deal upfront payment distribution, US$million ' marketed stage Figure 27: Summary median upfront payments by stage of development, 2007-2012 Figure 28: Central nervous system deals with milestone payments Figure 29: Central nervous system deal milestone distribution, US$million ' discovery stage Figure 30: Central nervous system deal milestone distribution, US$million ' preclinical stage Figure 31: Central nervous system deal milestone distribution, US$million ' phase I stage Figure 32: Central nervous system deal milestone distribution, US$million ' phase II stage Figure 33: Central nervous system deal milestone distribution, US$million ' phase III stage Figure 34: Central nervous system deal milestone distribution, US$million ' regulatory stage Figure 35: Central nervous system deal milestone distribution, US$million ' marketed stage Figure 36: Central nervous system deals with royalty rates, % Figure 37: Central nervous system deal royalty rate distribution, US$million ' discovery stage Figure 38: Central nervous system deal royalty rate distribution, US$million ' preclinical stage Figure 39: Central nervous system deal royalty rate distribution, US$million ' phase I stage Figure 40: Central nervous system deal royalty rate distribution, US$million ' phase II stage Figure 41: Central nervous system deal royalty rate distribution, US$million ' phase III stage Figure 42: Central nervous system deal royalty rate distribution, US$million ' regulatory stage Figure 44: Summary median royalty rate by stage of development, 2007-2012 Figure 45: Top central nervous system deals by value since 2007 Figure 46: Top central nervous system deals signed by bigpharma value since 2007 Figure 47: Online partnering resources Figure 48: Forthcoming partnering events

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