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Oncology Drug Pathway Analyzer (Standard Version) Published on May 2012

Report Summary Get instant, interactive modeling on almost 3,000 cancer drugs and affected signaling pathways across close to 90 different cancer types. Drug targets and their pathways are the critical link between drugs and their role in the treatment of cancer. This highly unique interactive tool is based on BioSeeker's linking of hundreds of drug targets in many different types of cancer to a wide array of pathways. The included drugs are all from early stage development to market in maturity; also featuring ceased and suspended drugs. The Oncology Drug Pathway Analyzer is an interactive high level data tool to analyze several thousand drug-pathway connections in close to 90 different cancer indications on the fly. The tool lets you examine both single pathways and crosstalk between pathways of drugs and filter the included drugs per pathway by twelve drug specific parameters (i.e. Indication, Stage, Company, Molecular function etc.). The Oncology Drug Pathway Analyzer is a great facilitator to realize your position and options in drug development when utilizing pathways and it significantly cuts the amount of time it takes to do so. Read more below on how to bring out the power in your pipeline and start to quickly analyze the impact of emerging pathway data in cancer by getting your own version of the Oncology Drug Pathway Analyzer. Why you should use this tool: - Map the competition and find suitable benchmarking drugs based on specific pathways and drug properties - Reveal repositioning opportunities for your older, shelved drugs - Evaluate the progression and success of targeting certain pathways for the treatment of cancer - Investigate drugs which affect crosstalk between key pathways - Investigate different combination therapy options available to you in various cancer types. Use this tool to look for the most-efficient ways to combine your drug with other targeted agents. - Find possible adjuvant therapy settings with other drugs Real case scenario (combination therapy): In the March 20, 2012 issue of the journal Cancer Cell, researchers at The University of Texas MD Anderson Cancer Center reveal that the mTOR molecular pathway stimulates the activity of the Gli1 protein in the development and progression of esophageal cancer. Hitherto it is known that the Hedgehog pathway is the established pathway for activating Gli1. In experiments the researchers then went on to show that a combination of the mTOR inhibitor everolimus (Afinitor) and the Hedgehog inhibitor vismodegib (Erivedge) steeply reduced the tumor burden in a mouse model of esophageal adenocarcinoma. Our tool would in seconds let you know how many and which drug are available for potential drug combination therapies in affecting both the Hedgehog- and the mTOR pathway. It also would instantly tell you which drugs is available affecting both pathways. You could then further refine the results by up to eleven drug specific parameters (i.e. Indication, Stage, Company, Molecular function etc.). There after you can view in-depth progress reports on each of the drugs of interest to you (Pro version). The Oncology Drug Pathway Analyzer comes in two versions, Premium and Pro. The additional great feature of the Pro version is that it also gives you instant access to almost 3,000 up to date and extensive drug developmental profiles (at the low price of around 1

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Standard (6,900 EURO)Premium (9,900 EURO) Investigate Single Pathways or Crosstalk between Pathways Filter results via drug specific parameters See the Number of and Names of competing Companies targeting selected Pathways See the Number of, Name and Status of Drugs targeting selected Pathways Link-out enabled contents for in-depth pathway information and corporate information Charts and Graphs presenting pathway findings Target and Developmental Project information for each drug Print to PDF Report of pathway findings Nearly 3000 in-depth drug profile reports through a dynamic report generator BioSeeker delivers Oncology Drug Pathway Analyzer as an intelligent software application (see system requirements). This software requires no installation: - Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion) - Browser Application (Internet Explorer) - Internet access (to access related internet resources)

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Oncology Drug Pathway Analyzer (Standard Version)