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Melanoma: Interventional clinical trials activity 2006-2011 Published on January 2012

Report Summary

Executive Summary Clinical trials of interventions for melanoma were identified by a search of three databases. The search was limited to trials registered in the period Jan 2006-Dec 2011 inclusive. The following data were collected for all trials that met the inclusion criteria. ' links to clinical trial records, ' start and (envisaged) end date, ' phase, ' number of subjects (envisaged to be) enrolled, ' status (active/recruiting, suspended, terminated, withdrawn, completed, unknown), ' intervention(s), ' sponsors / developers of interventions. The above data are provided in full in Appendices 1-5 of this report, and indicate that there have been 467 relevant melanoma clinical trials over the last six years. These may be grouped into four broad categories: ' cell immunotherapies, ' non-cell immunotherapies, ' non-immunotherapeutic interventions, ' product extensions. The trials in each category may be further sub-divided into 4-5 subcategories, according to broad drug type. Of the 467 relevant trials, at least 301 were still active as of Dec 2011. The 301 active trials represented investigations of ~100 interventional targets (the exact number is debatable since the exact mechanism(s) of action of some agents is unclear, and in some cases the exact identity of the agent is not specified). These agents / targets are listed in full in Appendix 5, together with the numbers and phases of clinical trials in which each target or agent is involved. Of the ~100 interventional targets in active clinical trials, ten account for over half of all target investigations, and three account for ~25% of all target investigations. Note: 'Target investigation' means a clinical investigation of a given target; thus, a single clinical trial in which three drugs are being tested (each active against a different target) will comprise three target investigations. Note: Discrepancies between the total number of trials ('n') and the sum of the trials per phase, as listed in the Fig.s, are due to a small number of trials for which records are incomplete (phase unspecified).

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>> Get this Report Now by email! 1. Executive Summary 2 2. Objectives and methodology . 6 2.1 Objectives .... 6 2.2 Methodology .... 6 3. Melanoma interventional clinical trials 2006-2011: overview 7 3.1 All clinical trials . 7 3.2 Active clinical trials 9 4. Trials of cell immunotherapies . 11 4.1 All cell immunotherapy trials .. 12 4.2 Active cell immunotherapy trials . 13 5. Trials of non-cell immunotherapies .... 15 5.1 All non-cell immunotherapy trials 16 5.2 Active non-cell immunotherapy trials .... 17 6. Trials of non-immunotherapeutic interventions .... 19 6.1 All non-immunotherapy trials . 20 6.2 Active non-immunotherapy trials 21 7. Trials of product extensions 23 7.1 All product extension trials 24 7.2 Active product extension trials 25 APPENDICES: Data per trial (target, developer, link to trial record, phase, dates, enrolment, status) . 27 Appendix 1: Cell immunotherapy trials .. 28 Appendix 2: Non-cell immunotherapy trials 32 Appendix 3: Trials of non-immunotherapeutic interventions ... 39 Appendix 4: Product extension trials . 47 Appendix 5: All targets in active trials .... 54

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Melanoma: Interventional clinical trials activity 2006-2011